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"Holzwarth, Werner"
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I wish I were a--
A meerkat wishes he were as silly, strong, and mighty as the other animals, but when trouble arrives it is the chimpanzee, the bear, and the lion who envy the meerkat.
Book
Multiplexed histology analyses for the phenotypic and spatial characterization of human innate lymphoid cells
Innate lymphoid cells (ILCs) emerge in the last few years as important regulators of immune responses and biological processes. Although ILCs are mainly known as tissue-resident cells, their precise localization and interactions with the microenvironment are still unclear. Here we combine a multiplexed immunofluorescence technique and a customized computational, open-source analysis pipeline to unambiguously identify CD127
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ILCs in situ and characterize these cells and their microenvironments. Moreover, we reveal the transcription factor IRF4 as a marker for tonsillar ILC3, and identify conserved stromal landmarks characteristic for ILC localization. We also show that CD127
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ILCs share tissue niches with plasma cells in the tonsil. Our works thus provide a platform for multiparametric histological analysis of ILCs to improve our understanding of ILC biology.
Innate lymphoid cells (ILCs) are important regulators of biological processes. Here the authors combine multiplexed imaging and computational pipelines to reveal tonsillar IRF4
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ILC3s, and to identify conserved stromal landmarks for ILC localization, thereby providing a platform for future ILC studies.
Journal Article
Modern art
Modern matters: A blow-by-blow account of groundbreaking modernism The modern art adventure began roughly 150 years ago in Paris. A circle of painters, whom we now know as Impressionists, began painting pictures with rapid, often impasto, strokes. They turned to everyday street life for subjects, instead of overblown heroic scenes, and they escaped the power of the establishment salon by organizing their own independent exhibitions. After this first assault on standard academic practice, there was no holding back. In a constant desire to challenge, innovate, and inspire, one modernist style supplanted the next: Symbolism, Expressionism, Futurism, Dada, Abstract Art, renewed Realism, Surrealism, Abstract Expressionism, Pop, Minimal and Conceptual Art. This indispensable overview traces the restless energy of modern art with a year-by-year succession of the groundbreaking artworks that shook standards, and broke down barriers. Each of these stand-out pieces is accompanied by a text profiling the artist and discussing the importance of their work. Introductory essays, meanwhile, explain the most significant modernist movements.
Book