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Tocotrienols (T3) were neglected in the past; today, get attentions due to their antioxidant and none-antioxidant activity. The objective of this study was to evaluate the effects of the daily intake of 200 mg T3 added in canola oil over 8 weeks on microalbuminuria, inflammation, and nitrosative stress in type 2 diabetic patients. This study was a double-blinded, placebo-controlled, randomized trial. A total of 50 patients with T2DM and FBS >126 mg/dl treated by non-insulin hypoglycemic drugs were randomly assigned to receive either 15 ml T3-enriched canola oil (200 mg/day T3) or pure canola oil for 8 weeks. Urine microalbumin, volume and creatinine levels, serum hs-CRP, and nitric oxide (NO) levels were measured before and after intervention. From 50 patients participated in this study, 44 completed the study. There were no significant differences in baseline characteristics, dietary intake, and physical activity between groups. Urine microalbumin and serum hs-CRP were declined significantly in T3-treated group. At the end of the study, patients who treated with T3 had lower urine microalbumin (11 (9, 25) vs. 22 (15, 39.75) nmol/dl, P = 0.003) and hs-CRP changes (-10.91 ± 15.5 vs. -9.88 ± 27.5 Pg/ml, P = 0.048) than control group. A non-significant decrease was also observed in serum NO level in T3-treated group with no changes in urine volume and creatinine levels. These findings indicate that T3 leads to ameliorate proteinuria and can protect the kidney against inflammation (hs-CRP) and nitrosative stress (NO).

We aimed to determine the effect of PACS implementation on the radiologist reporting time and utilization of radiology services in a hospital in Iran. This study was conducted in three 6-month periods (before PACS implementation, immediately after the implementation, and 1 year after implementation). Data related to reporting time of CT examinations were collected from 5074 patients with 6613 examinations and compared using the Friedman test. The utilization rate of radiology services was conducted about CT scans and radiographies. Therefore, 17,862 patients with 36,321 radiographies and 7155 patients with 10,571 CT scans were evaluated, and the ratio of the number of examinations to the number of patients and patient days was compared in three periods. The mean of reporting time on CT scan examinations in the period of immediately after PACS was changed compared to the period of before PACS from 13.05 to 24.18 days and compared to 1 year after PACS implementation, to 4.14 days (P value < 0.05). The utilization rate in CT scans, 1 year after PACS increased at least 10% to 25% compared to the immediately after PACS and before implementing PACS. The utilization rate in radiographies, 1 year after PACS, increased at least 16% to 78% compared to the immediately after PACS and before PACS implementation. In conclusion, the mean of the radiologist reporting time for CT scans is significantly decreased by PACS in the long-term. Additionally, the utilization rate of radiology services is increased in the short- and long-term after PACS implementation in most examinations of CT scan and radiography examinations.

•Waist and hip circumference significantly were decreased in the intervention group, but there wasnot significant differences between two groups.•Body fat percent, low density lipoprotein levels and systolic blood pressure significantly were decreased in the intervention group.•A significant decrease was observed in body fat percent, hip circumference, fasting blood sugar and high density lipoprotein in the intervention group compared to the placebo group. Since, the main cause of death in Rheumatoid arthritis (RA) patients is the presence of type 2 diabetes, abnormal increase in blood lipids, blood pressure and obesity, the aim of this study was to assess the effects of Barberry on the anthropometric indices and metabolic profile in patients with RA. present study was a double-blinded, placebo-controlled randomized clinical trial. 70 active RA patients were randomly allocated into intervention or placebo group Participants received 6 capsules of 500 mg barberry extract or placebo for 3 months. Serum levels of fasting blood sugar (FBS), triglyceride (TG), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C), systolic and diastolic blood pressure and anthropometric factors were assessed at baseline and at the end of the trial. The results of intervention on 62 patients showed that weight, BMI, and conicity index increased in both groups, but this was significant only in the placebo group (p < 0.001). Waist and hip circumference were decreased in the intervention group and increased significantly in the placebo group (p < 0.001). Body fat percent (p = 0.04), LDL-C (p = 0.05) and SBP (p = 0.02) significantly were decreased in the intervention group. The results showed a significant decrease in body fat percent (p = 0.05), hip circumference (p < 0.001), FBS (p = 0.03) and HDL-C (p = 0.03) in the intervention group compared to the placebo. Conclusions: Overall, the results of this study demonstrated that the extract of Berberis Integerrima had beneficial effects on metabolic profile and anthropometric indices in RA patients.