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As a promising hydrogen carrier, formic acid (HCOOH) is renewable, safe and nontoxic. Although noble-metal-based catalysts have exhibited excellent activity in HCOOH dehydrogenation, developing non-noble-metal heterogeneous catalysts with high efficiency remains a great challenge. Here, we modulate oxygen coverage on the surface of Ti 3 C 2 T x MXenes to boost the catalytic activity toward HCOOH dehydrogenation. Impressively, Ti 3 C 2 T x MXenes after treating with air at 250 °C (Ti 3 C 2 T x -250) significantly increase the amount of surface oxygen atoms without the change of crystalline structure, exhibiting a mass activity of 365 mmol·g −1 ·h −1 with 100% of selectivity for H 2 at 80 °C, which is 2.2 and 2.0 times that of commercial Pd/C and Pt/C, respectively. Further mechanistic studies demonstrate that HCOO* is the intermediate in HCOOH dehydrogenation over Ti 3 C 2 T x MXenes with different coverages of surface oxygen atoms. Increasing the oxygen coverage on the surface of Ti 3 C 2 T x MXenes not only promotes the conversion from HCOO* to CO 2 * by lowering the energy barrier, but also weakens the adsorption energy of CO 2 and H 2 , thus accelerating the dehydrogenation of HCOOH. Developing non-noble-metal heterogeneous catalysts with high efficiency in HCOOH dehydrogenation is significant for the acquisition of hydrogen, but remains a great challenge. Here, the authors modulate oxygen coverage of Ti 3 C 2 T x MXenes to boost the catalytic activity toward HCOOH dehydrogenation.

Photocatalytic hydrogen production from biomass is a promising alternative to water splitting thanks to the oxidation half-reaction being more facile and its ability to simultaneously produce solar fuels and value-added chemicals. Here, we demonstrate the coproduction of H 2 and diesel fuel precursors from lignocellulose-derived methylfurans via acceptorless dehydrogenative C−C coupling, using a Ru-doped ZnIn 2 S 4 catalyst and driven by visible light. With this chemistry, up to 1.04 g g catalyst −1  h −1 of diesel fuel precursors (~41% of which are precursors of branched-chain alkanes) are produced with selectivity higher than 96%, together with 6.0 mmol g catalyst −1  h −1 of H 2 . Subsequent hydrodeoxygenation reactions yield the desired diesel fuels comprising straight- and branched-chain alkanes. We suggest that Ru dopants, substituted in the position of indium ions in the ZnIn 2 S 4 matrix, improve charge separation efficiency, thereby accelerating C−H activation for the coproduction of H 2 and diesel fuel precursors. Biomass can be used to scavenge photogenerated holes in photocatalytic hydrogen production, but the oxidized molecules that form are not always useful products. Here, the authors use Ru-ZnIn 2 S 4 to photocatalyse the dehydrogenative C−C coupling of lignocellulose-derived methylfurans, forming both hydrogen and diesel fuel precursors.

High-sensitivity tactile perception is vital for precise robotic operations in human-machine interactions (HMI). Currently, state-of-the-art tactile perception relies on electrical sensors which demand complex circuits and decoding components, leading to increased energy consumption and susceptibility to electromagnetic interference. Hence, the utilization of human-perceptible signals, such as visible light, as the transmission medium is necessary. Inspired by the mechano-electro-optical transduction mechanism in dinoflagellate bioluminescence, here we propose a self-powered optical tactile sensing system (SOTS) for converting the electrical signal of pressure sensing into visible luminescent intensity, thereby enabling the wireless transmission and visualization of tactile information. The proposed SOTS features an ultrahigh sensitivity (22.4 kPa −1 ) and an ultralow detection limit (10 Pa) in optical tactile sensing with the ultra-wide dynamic range across 5 orders of magnitude (0.01-100 kPa), opening promising avenues for ultrasensitive feedback and intuitive understanding of haptic perception in future HMI. Electrical tactile sensors suffer from high energy consumption and signal interference. Here, the authors present a bioinspired self-powered optical tactile sensor that transduces pressure into light intensity for wireless tactile visualization.

Our earlier research indicated that chitosan-gentamicin conjugate (CS-GT) possesses superior antimicrobial activity and good water solubility. To develop CS-GT-based scald dressings, the antibacterial properties of CS-GT were further studied, and the biosafety of CS-GT and the healing mechanism of CS-GT hydrogel was systematically explored in this article. It was found that cell viability shows a declined inclination with the prolonged culture time and the increased concentration of CS-GT. After three day’s culture, the cell viability could still remain at 79.72% when CS-GT concentration was as high as 1000 μg/mL. On the other hand, the hemolysis rate of CS-GT was lower than 5% when its concentration is 800 μg/mL. Therefore CS-GT has good cytocompatibility and hemocompatibility. A wound-healing experiment has shown that the skin healing rate of CS-GT hydrogel was the highest at 99.61%, followed by the positive control (wet burn ointment) 94.98%, GT hydrogel 87.50%, and matrix 77.39%. The blank control group, however, possessed the lowest healing rate of 75.45%. Further analysis indicated that CS-GT hydrogel could promote the synthesis of total protein (TP) in skin granulation tissue, resulting in the enhanced hydroxyproline (HYP) content, which facilitated collagen fibrogenesis, reduced cytokine expression in an inflammatory response, and, ultimately, accelerated wound healing. To sum up, CS-GT hydrogel is a promising scald dressing.

The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in stressful conditions. Here, we demonstrate that NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), also known as mitochondrial acyl carrier protein, acts as a powerful cardio-protector by conferring greater capacity and efficiency of mitochondrial energy metabolism. In particular, NDUFAB1 not only serves as a complex I subunit, but also coordinates the assembly of respiratory complexes I, II, and III, and supercomplexes, through regulating iron-sulfur biosynthesis and complex I subunit stability. Cardiac-specific deletion of Ndufab1 in mice caused defective bioenergetics and elevated ROS levels, leading to progressive dilated cardiomyopathy and eventual heart failure and sudden death. Overexpression of Ndufab1 effectively enhanced mitochondrial bioenergetics while limiting ROS production and protected the heart against ischemia-reperfusion injury. Together, our findings identify that NDUFAB1 is a crucial regulator of mitochondrial energy and ROS metabolism through coordinating the assembly of respiratory complexes and supercomplexes, and thus provide a potential therapeutic target for the prevention and treatment of heart failure.

To investigate the ability of the ratio of blood urea nitrogen (BUN) to serum albumin ratio (BAR) in patients with sepsis in intensive care units (ICUs) to predict the prognosis of short-and long-term death. Data are from the Marketplace for Intensive Care Medical Information IV (MIMIC-IV v2.0) database for patients with sepsis as defined by SEPSIS-3. The primary outcome was 30-day mortality and the secondary outcome was 360-day mortality. Kaplan–Meier (KM) survival curves were plotted to describe differences in BAR mortality in different subgroups and area under the curve (AUC) analysis was performed to compare the predictive value of sequential organ failure assessment (SOFA), BAR, blood urea nitrogen (BUN) and albumin. Multivariate Cox regression models and subgroup analysis were used to determine the correlation between BAR and 30-day mortality and 360-day mortality. A total of 7656 eligible patients were enrolled in the study with a median BAR of 8.0 mg/g, including 3837 in the ≤ 8.0 group and 3819 in the BAR > 8.0 group, with 30-day mortality rates of 19.1% and 38.2% ( P  < 0.001) and 360-day mortality rates of 31.1% and 55.6% ( P  < 0.001). Multivariate Cox regression models showed an increased risk of death for 30-day mortality (HR = 1.219, 95% CI 1.095–1.357; P  < 0.001) and 360-day mortality (HR = 1.263, 95% CI 1.159–1.376; P  < 0.001) in the high BAR group compared to the low BAR group. For the 30-day outcome, the area under the curve (AUC) was 0.661 for BAR and 0.668 for 360-day BAR. In the subgroup analysis, BAR remained an isolated risk factor for patient death. As a clinically inexpensive and readily available parameter, BAR can be a valuable forecaster of prognosis in patients with sepsis in the intensive care unit.

Human–AI collaboration has attracted interest from both scholars and practitioners. However, the relationships in human–AI teamwork have not been fully investigated. This study aims to research the influencing factors of trust in AI teammates and the intention to cooperate with AI teammates. We conducted an empirical study by developing a research model of human–AI collaboration. The model presents the influencing mechanisms of interactive characteristics (i.e., perceived anthropomorphism, perceived rapport, and perceived enjoyment), environmental characteristics (i.e., peer influence and facilitating conditions), and personal characteristics (i.e., self-efficacy) on trust in teammates and cooperative intention. A total of 423 valid surveys were collected to test the research model and hypothesized relationships. The results show that perceived rapport, perceived enjoyment, peer influence, facilitating conditions, and self-efficacy positively affect trust in AI teammates. Moreover, self-efficacy and trust positively relate to the intention to cooperate with AI teammates. This study contributes to the teamwork and human–AI collaboration literature by investigating different antecedents of the trust relationship and cooperative intention.

Background Spontaneous functional recovery occurs during the acute phase after stroke onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism underlying spontaneous recovery and identifying potential strategies to promote functional rehabilitation after stroke are very important. The CD200/CD200R signaling pathway plays an important role in neurological recovery by modulating synaptic plasticity during multiple brain disorders. However, the effect and mechanism of action of the CD200/CD200R pathway in spontaneous functional recovery after stroke are unclear. Methods In this study, we used a transient middle cerebral artery occlusion (MCAO) model in rats to investigate the function of CD200/CD200R signaling in spontaneous functional recovery after stroke. We performed a battery of behavioral tests (Longa test, adhesive removal test, limb-use asymmetry test, and the modified grip-traction test) to evaluate sensorimotor function after intracerebroventricular (i.c.v.) injection with CD200 fusion protein (CD200Fc) or CD200R blocking antibody (CD200R Ab) post-stroke. Density and morphology of dendritic spines were analyzed by Golgi staining. Microglia activation was evaluated by immunofluorescence staining. Western blot was used to detect the levels of protein and the levels of mRNA were measured by qPCR. Results Our study demonstrated that sensorimotor function, synaptic proteins, and structures were gradually recovered and CD200R was transiently upregulated in ipsilateral cortex after stroke. Synapse-related proteins and dendritic spines were preserved, accompanied by sensorimotor functional recovery, after stereotaxic CD200Fc injection post-stroke. In addition, CD200Fc restrained microglia activation and pro-inflammatory factor release (such as Il-1 , Tnf-α , and Il-6 ) after MCAO. On the contrary, CD200R Ab aggravated sensory function recovery in adhesive removal test and further promoted microglia activation and pro-inflammatory factor release (such as Il-1 ) after MCAO. The immune-modulatory effect of CD200/CD200R signaling might be exerted partly by its inhibition of the MAPK pathway. Conclusions This study provides evidence that the CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity via inhibition of microglia activation and inflammatory factor release.

Quasi-one-dimensional covalent organic frameworks have emerged as promising platforms for photochemical energy conversion due to their low density of basal sites, abundant edge sites, and dual-chain-like structure. However, the development of quasi-one-dimensional covalent organic frameworks in photocatalysis is still highly hindered by their limited linkage chemistry. Herein, we report an enaminone-linked quasi-one-dimensional covalent organic framework. The polar enaminone bonds together with dual-chain-like structure endow enaminone-linked quasi-one-dimensional covalent organic framework with broad light adsorption and effective excitonic dissociation abilities. Significantly, a high CO yield of 3045 μmol g -1 with approximately 100% selectivity was achieved in a 24 h reaction under gas-solid conditions. More interestingly, the hydrogen atom on nitrogen site in enaminone bond could assist in the activation of CO 2 molecule via hydrogen-bond interaction. This interaction leads to the strongest adsorption ability for CO 2 and the lowest energy barrier for the rate-determining step during CO 2 reduction over enaminone-linked quasi-one-dimensional covalent organic framework compared to those over mixture-linked quasi-one-dimensional covalent organic framework and imine-linked quasi-one-dimensional covalent organic framework counterparts. All of these factors directly contribute to the enhanced activity of enaminone-linked quasi-one-dimensional covalent organic framework in the photocatalytic CO 2 reduction to CO. This study reports a new kind of En-Q1DCOF. The polar enaminone bonds and dual-chain-like structure endow En-Q1DCOF excellent photoelectric conversion performance. Furthermore, the N-site H atom in enaminone facilitates CO₂ activation via H-bonding.

Dendrobium huoshanense , a traditional medicinal and food homologous plant, belongs to the family Orchidaceae and has a long history of medicinal use. It is reported that the stem of D. huoshanense has a variety of bioactive ingredients such as polysaccharides, flavonoids, sesquiterpenes, phenols, etc. These bioactive ingredients make D. huoshanense remarkable for its pharmacological effects on anti-tumor, immunomodulation, hepatoprotective, antioxidant, and anticataract activities. In recent years, its rich pharmacological activities have attracted extensive attention. However, there is no systematic review focusing on the chemical compositions and pharmacological effects of D. huoshanense . Therefore, the present review aims to summarize current research on the chemical compositions and pharmacological activities of D. huoshanense . This study provides valuable references and promising ideas for further investigations of D. huoshanense .