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The widespread applications of the wireless Internet of Things (IoT) is one of the leading factors in the emerging of Big Data. Huge amounts of data need to be transferred and processed. The bandwidth and latency of data transfers have posed a new challenge for traditional computing systems. Under Big Data application scenarios, the movement of large scales of data would influence performance, power efficiency, and reliability, which are the three fundamental attributes of a computing system. Thus, changes in the computing paradigm are demanding. Processing-in- Memory (PIM), aiming at placing computation as close as possible to memory, has become of great interest to academia as well as industries. In this work, we propose a programming paradigm for PIM architecture that is suitable for wireless IoT applications. A data-transferring mechanism and middleware architecture are presented. We present our methods and experiences on simulation-platform design, as well as FPGA demo design, for PIM architecture. Typical applications in IoT, such as multimedia and MapReduce programs, are used as demonstration of our method’s validity and efficiency. The programs could successfully run on the simulation platform built based on Gem5 and on the FPGA demo. Results show that our method could largely reduce power consumption and execution time for those programs, which is very beneficial in IoT applications.

BK polyomavirus (BKPyV) causes severe urinary tract diseases, including BKPyV-associated nephropathy (BKPyVN) and ureteric stenosis, in immunocompromised individuals such as renal transplant recipients. Effective antiviral therapies for BKPyV infection remain an unmet clinical need. While the interferon-stimulated gene 20 (ISG20) exhibits broad-spectrum antiviral activity against RNA viruses, its role and mechanisms against DNA viruses are poorly defined. This study demonstrates, for the first time, potent antiviral activity of ISG20 against BKPyV. This restriction was observed with both endogenous levels of ISG20 and upon overexpression, and this effect was confirmed by ISG20 knockout and immunofluorescence imaging. We observed that ISG20 expression is dynamically regulated during BKPyV infection: it is upregulated both during early infection and by expression of the viral large T antigen (LT) alone. However, endogenous ISG20 expression becomes significantly suppressed during later stages of infection, coinciding with declining LT levels. The physical interaction between LT and both wild-type and mutant ISG20 suggests a potential viral strategy to sequester this restriction factor. These findings establish ISG20 as a novel host restriction factor against BKPyV and suggest that BKPyV employs LT-mediated mechanisms to evade or counteract ISG20’s antiviral effects. Our results elucidate a complex biphasic interplay between BKPyV and host innate immunity, identifying ISG20 as a potential therapeutic target for BKPyV-associated diseases.

With the widespread nature of wireless internet and internet of things, data have bloomed everywhere. Under the scenario of big data processing, privacy and security concerns become a very important consideration. This work focused on an approach to tackle the privacy and security issue of multimedia data/information in the internet of things domain. A solution based on Cryptographical Digital Signal Processor (CDSP), a Digital Signal Processor (DSP) based platform combined with dedicated instruction extension, has been proposed, to provide both programming flexibility and performance. We have evaluated CDSP, and the results show that the algorithms implemented on CDSP all have good performance. We have also taped out the platform designed for privacy and security concerns of multimedia transferring system based on CDSP. Using TSMC 55 nm technology, it could reach the speed of 360 MHz. Benefiting from its programmability, CDSP can be easily expanded to support more algorithms in this domain.

Upon infecting a bacterial host, phages can follow one of two developmental pathways: the lytic or lysogenic cycle. In the lysogenic state, prophages remain dormant, integrating into the bacterial genome and being vertically transmitted through binary fission. These prophages profoundly influence bacterial phenotypic and genetic diversity and contribute to the structuring of microbial communities. Here, we systematically assess the beneficial and detrimental impacts of prophage carriage in the clinical multilysogen Pseudomonas aeruginosa strain ZS-PA-05. Our results reveal marked variation in spontaneous induction frequencies among co-resident prophages and demonstrate prophage-driven phenotypic heterogeneity. By uncovering key aspects of prophage–host interactions, this study highlights the critical role of prophages in shaping the behavior of clinical isolates, particularly in the context of antimicrobial interventions such as antibiotic and phage therapies.

With the rapid development of heterogeneous network-on-chip (NoC), a vast amount of shared resources are integrated into NoC. Intense resource competition exists between CPUs and GPUs, leading to congestion and a decrease in overall network performance. Reasonable node placement can minimize network conflicts at the topology level. This paper first discusses the placement of shared last-level cache and memory controller, then selects a more rational placement method and optimizes the path. To solve the hot spots problem in center placement method, a task-based routing algorithm is designed to plan the path. Simulation results demonstrate that, compared to the traditional routing algorithm, the overall network latency is reduced by 9%, and the CPU performance is improved by 13.6%. Furthermore, a dynamic task-based routing algorithm is proposed. Compared to the static task routing algorithm, the overall network latency is reduced by 2.08%, and the CPU performance is improved by 4.09%.

This paper proposes FuMicro, a fused microarchitecture integrating both in-order superscalar and Very Long Instruction Word (VLIW) in a single core. A processor with FuMicro microarchitecture can work under alternative in-order superscalar and VLIW mode, using the same pipeline and the same Instruction Set Architecture (ISA). Small modification to the compiler is made to expand the register file in VLIW mode. The decision of mode switch is made by software, and this does not need extra hardware. VLIW code can be exploited in the form of library function and the users will be exposed under only superscalar mode; by this means, we can provide the users with a convenient development environment. FuMicro could serve as a universal microarchitecture for it can be applied to different ISAs. In this paper, we focus on the implementation of FuMicro with ARM ISA. This architecture is evaluated on gem5, which is a cycle accurate microarchitecture simulation platform. By adopting FuMicro microarchitecture, the performance can be improved on an average of 10%, with the best performance improvement being 47.3%, compared with that under pure in-order superscalar mode. The result shows that FuMicro microarchitecture can improve Instruction Level Parallelism (ILP) significantly, making it promising to expand digital signal processing capability on a General Purpose Processor.

Hyperuricemia exhibits a high incidence among individuals with diabetes; however, the significance of hyperuricemia and gout is often underestimated. This study aimed to assess the knowledge, attitude, and practice of hyperuricemia and gout among community health workers and patients with diabetes. Two questionnaires were designed to investigate knowledge, attitudes, and practices of hyperuricemia and gout among community health workers and patients with diabetes in Chenghua District, Chengdu, from August 2021 to January 2022. A total of 709 community health workers were included, whose average score was 17.74/30. Approximately half of general practitioners (GPs) demonstrated knowledge regarding the target serum uric acid levels for hyperuricemia and gout. Only 11.2% of GPs were fully aware of the preferred medicine for acute gout. The majority of GPs (86.7%) demonstrated limited awareness regarding the contraindications associated with colchicine, while a significant proportion (65.1%) lacked knowledge about the specific classes of drugs that inhibit uric acid synthesis. Among the 508 patients with diabetes included in this survey, 32.3% demonstrated awareness of hyperuricemia, while 60.8% exhibited knowledge regarding gout. The average score attained by these individuals was recorded at 7.21 out of a total of 26 points. The majority of patients with diabetes (87.8%) held the mistaken belief that hyperuricemia definitely led to the development of gout. Almost 66% agreed that a massage or a hot compress could be used when acute gouty arthritis attacks. The knowledge rate of hyperuricemia and gout among community health workers was moderate, while it was low in patients with diabetes.

Gaofeng Bird Banding Station is located between the Greater and Lesser Khingan Mountains,on the eastern side of the Nenjiang River valley in the northern Songnen Plain.From March 2001 to December 2015,48 197(1 676 in spring and 46 521 in autumn)common redpoll(Carduelis flammea)were banded in Nenjiang Gaofeng Forest District.The Gaofeng Forest District is a wintering ground and stopover site of common redpoll.The migration peak in autumn was concentrated in late October.The ratio of males to females was 2.2:1 in spring,and 1.6:1 in autumn,and the proportion of adult to sub-adult reached up to 0.15:1 in autumn.Recovery information showed that common redpoll travelled as far as 9 300 km(Nenjiang Gaofeng to Holland).The fastest migration speed can reach up to 222 km/d.In spring,numbers of birds banded was significantly positively correlated with average relative humidity,low evaporation,and pressure; and significantly negatively correlated with high evaporation and average wind speed.In autumn,number of banded bi

Nitric oxide (NO) is a short-lived signaling molecule that plays a pivotal role in cardiovascular system. Organic nitrates represent a class of NO-donating drugs for treating coronary artery diseases, acting through the vasodilation of systemic vasculature that often leads to adverse effects. Herein, we design a nitrate-functionalized patch, wherein the nitrate pharmacological functional groups are covalently bound to biodegradable polymers, thus transforming small-molecule drugs into therapeutic biomaterials. When implanted onto the myocardium, the patch releases NO locally through a stepwise biotransformation, and NO generation is remarkably enhanced in infarcted myocardium because of the ischemic microenvironment, which gives rise to mitochondrial-targeted cardioprotection as well as enhanced cardiac repair. The therapeutic efficacy is further confirmed in a clinically relevant porcine model of myocardial infarction. All these results support the translational potential of this functional patch for treating ischemic heart disease by therapeutic mechanisms different from conventional organic nitrate drugs. Nitric oxide (NO) is an important gaseous signaling molecule with multiple physiological roles in cardiovascular system. Here the authors develop a cardiac patch with NO releasing function that favors heart repair after myocardial infarction.

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease in the central nervous system (CNS). The NLRP3 inflammasome is considered an important regulator of immunity and inflammation, both of which play a critical role in MS. However, the underlying mechanism of NLRP3 inflammasome activation is not fully understood. Here we identified that the TRPV1 (transient receptor potential vanilloid type 1) channel in microglia, as a Ca 2+ influx-regulating channel, played an important role in NLRP3 inflammasome activation. Deletion or pharmacological blockade of TRPV1 inhibited NLRP3 inflammasome activation in microglia in vitro. Further research revealed that TRPV1 channel regulated ATP-induced NLRP3 inflammasome activation through mediating Ca 2+ influx and phosphorylation of phosphatase PP2A in microglia. In addition, TRPV1 deletion could alleviate mice experimental autoimmune encephalomyelitis (EAE) and reduce neuroinflammation by inhibiting NLRP3 inflammasome activation. These data suggested that the TRPV1 channel in microglia can regulate NLRP3 inflammasome activation and consequently mediate neuroinflammation. Meanwhile, our study indicated that TRPV1–Ca 2+ –PP2A pathway may be a novel regulator of NLRP3 inflammasome activation, pointing to TRPV1 as a potential target for CNS inflammatory diseases.