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Reducing unnecessary preoperative testing remains a pressing concern for general practitioners in the UK, and their practices, which often host this activity.1

The 21-gene Recurrence Score assay is validated to predict recurrence risk and chemotherapy benefit in hormone-receptor-positive (HR+) invasive breast cancer. To determine prospective breast-cancer-specific mortality (BCSM) outcomes by baseline Recurrence Score results and clinical covariates, the National Cancer Institute collaborated with Genomic Health and 14 population-based registries in the the Surveillance, Epidemiology, and End Results (SEER) Program to electronically supplement cancer surveillance data with Recurrence Score results. The prespecified primary analysis cohort was 40–84 years of age, and had node-negative, HR+, HER2-negative, nonmetastatic disease diagnosed between January 2004 and December 2011 in the entire SEER population, and Recurrence Score results ( N =38,568). Unadjusted 5-year BCSM were 0.4% ( n =21,023; 95% confidence interval (CI), 0.3–0.6%), 1.4% ( n =14,494; 95% CI, 1.1–1.7%), and 4.4% ( n =3,051; 95% CI, 3.4–5.6%) for Recurrence Score <18, 18–30, and ⩾31 groups, respectively ( P <0.001). In multivariable analysis adjusted for age, tumor size, grade, and race, the Recurrence Score result predicted BCSM ( P <0.001). Among patients with node-positive disease (micrometastases and up to three positive nodes; N =4,691), 5-year BCSM (unadjusted) was 1.0% ( n =2,694; 95% CI, 0.5–2.0%), 2.3% ( n =1,669; 95% CI, 1.3–4.1%), and 14.3% ( n =328; 95% CI, 8.4–23.8%) for Recurrence Score <18, 18–30, ⩾31 groups, respectively ( P <0.001). Five-year BCSM by Recurrence Score group are reported for important patient subgroups, including age, race, tumor size, grade, and socioeconomic status. This SEER study represents the largest report of prospective BCSM outcomes based on Recurrence Score results for patients with HR+, HER2-negative, node-negative, or node-positive breast cancer, including subgroups often under-represented in clinical trials. Diagnostics: Gene test predicts death from breast cancer A common gene-panel test can help to predict the likelihood of women with breast cancer dying from the disease. Valentina Petkov at the US National Cancer Institute in Maryland and her colleagues studied a form of breast cancer that responds to hormone therapy in more than 44,500 American patients with and without spread to the lymph nodes. At diagnosis, all had taken a genomic test called Oncotype DX, which estimates the likelihood of breast-cancer recurrence on the basis of expression data from 21 genes. The team found that the test’s ‘recurrence score’ was strongly associated with the chance of death from breast cancer — independent of patient age, tumor size and tumor grade. The study provides the best evidence to date that Oncotype DX can be used to predict mortality risk, including for racial minority and other under-represented groups.

In the original version of the published article, line three of the third paragraph of the methods stated “Excluding patients with micrometastatic disease, the 5-year BCSM for patients with Recurrence Score results <18 and 1–3 positive nodes (n = 2,617) was 1.3% (95% CI, 0.6–2.9%).” To improve clarity this statement has been replaced with “Excluding patients with micrometastatic disease, there were 2,617 patients with 1–3 positive nodes. Of these, 1,487 also had Recurrence Score results <18 with 5-year BCSM of 1.3% (95% CI, 0.6–2.9%).” The original version of the published article also contained an error in the second sentence of the Figure 2 legend describing the mutation status of the patient population examined. The sentence in the original published version of the article stated “Patients with HR+, HER2-positive, node-negative…” this has been changed to “Patients with HR+, HER2-negative, node-negative…”. This has been corrected in the PDF and HTML versions of this paper.

The disappointment is because while Frankel got to retire to stud, my immediate retirement of spring barley drilling and digging out drain ends doesn't really bear comparison. Future projects include more land drainage while continuing to look at expanding the formed area.

All field and establishment trials were conducted next to roads, as the added pressure of the certain neighbourly ridicule in the event of a failure meant I got it right. [...]I am going to continue with my policy of summer cover cropping some land, this year next to the road, in order to guarantee 0% blackgrass seed return and a prompt entry into winter wheat to return to a more settled rotation.

Unfortunately, my first planning application for the new machinery shed on the farm could not be validated because I had failed to include floorplans.

The farm is equipped with mainly American machinery, which is designed to be periodically rebuilt, and I am fed up with scraping my knuckles in a grain store in the middle of winter, so a heated area will be a luxury.

[...]much so that I have come up with a new way of determining a field's suitability to be drilled; if you have to scrape the soil from your boots when re-entering the tractor cab, it is time to go home and find the gin bottle. Since the autumn equinox we have had our annual influx of hare coursers, who appear to have been actively recruiting more members over the summer.

Despite the headline yield being low, the reduction in herbicide spend of 22% from last year due to the late planting could well make this a more profitable approach in future.