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Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in clinical trials, may be the single outcome reflective of patient priorities when living with a health condition. HRQoL is a multi-dimensional concept that reflects the degree to which a health condition interferes with participation in and fulfillment of important life areas. HRQoL is intended to capture the composite degree of physical, physiologic, psychological, and social impairment resulting from symptom burden, patient-perceived disease severity, and treatment side effects. Diminished HRQoL expectedly correlates to worsening disability and death; but interventions addressing HRQoL are linked to increased survival. Sarcoidosis, being a multi-organ system disease, is associated with a diffuse array of manifestations resulting in multiple symptoms, complications, and medication-related side effects that are linked to reduced HRQoL. Diminished HRQoL in sarcoidosis is related to decreased physical function, pain, significant loss of income, absence from work, and strain on personal relationships. Symptom distress can result clearly from a sarcoidosis manifestation (e.g., ocular pain, breathlessness, cough) but may also be non-specific, such as pain or fatigue. More complex, a single non-specific symptom, e.g., fatigue may be directly sarcoidosis-derived (e.g., inflammatory state, neurologic, hormonal, cardiopulmonary), medication-related (e.g., anemia, sleeplessness, weight gain, sub-clinical infection), or an indirect complication (e.g., sleep apnea, physical deconditioning, depression). Identifying and distinguishing underlying causes of impaired HRQoL provides opportunity for treatment strategies that can greatly impact a patient’s function, well-being, and disease outcomes. Herein, we present a reference manual that describes the current state of knowledge in sarcoidosis-related HRQoL and distinguish between diverse causes of symptom distress and other influences on sarcoidosis-related HRQoL. We provide tools to assess, investigate, and diagnose compromised HRQoL and its influencers. Strategies to address modifiable HRQoL factors through palliation of symptoms and methods to improve the sarcoidosis health profile are outlined; as well as a proposed research agenda in sarcoidosis-related HRQoL.

Background: Inspired by intense challenges encountered by patients and clinicians, we examined the experiences of living with sarcoidosis in three of the hardest impacted English-speaking cities during the early COVID-19 pandemic: London, New Orleans, and New York. Methods: A multi-disciplinary, multi-national research team including 6 patient leaders conducted qualitative investigations with analyses rooted in grounded theory. Recruitment occurred by self-referral through patient advocacy groups. Results: A total of 28 people living with sarcoidosis participated. The majority of patients had multi-system and severe sarcoidosis. Dominant themes were consistent across groups with differences expressed in spirituality and government and health systems. Racial, gender, and able-bodied inequity were voiced regarding healthcare access and intervention, societal interactions, and COVID-19 exposure and contraction. Agreement regarding extreme disruption in care and communication created concern for disability and survival. Concerns of COVID-19 exposure triggering new sarcoidosis cases or exacerbating established sarcoidosis were expressed. Pre-COVID-19 impediments in sarcoidosis healthcare delivery, medical knowledge, and societal burdens were intensified during the pandemic. Conversely, living with sarcoidosis cultivated personal and operational preparedness for navigating the practicalities and uncertainties of the pandemic. Optimism prevailed that knowledge of sarcoidosis, respiratory, and multi-organ diseases could provide pathways for COVID-19-related therapy and support; however, remorse was expressed regarding pandemic circumstances to draw long-awaited attention to multi-organ system and respiratory conditions. Conclusion: Participants expressed concepts warranting infrastructural and scientific attention. This framework reflects pre- and intra-pandemic voiced needs in sarcoidosis and may be an agent of sensitization and strategy for other serious health conditions. A global query into sarcoidosis will be undertaken.

A maintenance worker for the village of Pesotum who recalls nighttime in Vietnam: \"At 11 p.m. one night a sniper was firing at us from the jungle. I could see the rounds hit in front of us. It was a lot different than being back at home shooting at pheasants.\" The Gibson City resident, who served during both Operation Enduring Freedom and Operation Iraqi Freedom and met her husband in the service, and says living in a small town, \"you can find peace.\" A former postmaster in Monticello who saw combat in Korea and \"only got scared once. I got scared the first day I got there, and I stayed scared until the last day I left.\"

Dale Velk, Champaign Jason Frericks, Champaign Robert K. O'Daniell, Champaign

I am surrounded by talented people with a zest for a job well done and the creativity and persistence to pull it off time and again. I've been here since 1978, and it's always been like this. I've covered only one trial, but it was a hell of a spectacle: A man was acquitted of killing two men whose bodies were found inside a marijuana-strewn U-Haul trailer in the parking lot of a small Urbana apartment complex. I'm still embarrassed by every mistake, and those I'd desperately love to forget will always be with me.

  I personally get a few suggestions a month for our ebooks, although most of them seem to be for the 3M product, not My Media Mall. I do select all of the titles on 3M for our library. We currently have a number of ways to get an ebook at CPL. Besides My Media Mall, which has the largest selection, there is also 3M (easy to use -- lots of popular titles), Hoopla (great for no-waiting audiobooks and music), Biblioboard (has independent publishers and local authors), and the checkout-able Kindles (which are divided by genre).

  The Federal Trade Commission, which oversees the list, says these aren't isolated. The FTC is required to file a report on the do-not-call list every two years with Congress. The most recent report, filed last fall, notes that technology -- including internet phone call capability, as well as the ability to fake a caller ID number -- allows for \"very high volumes of illegal calls without significant expense ... and in a manner that makes it difficult for the FTC and other law enforcement agencies to find them.\"

  Thanks for reader Cindy Dorner for the Thundershirt and melatonin suggestions. The Thundershirt doesn't help Bruiser, unfortunately, but I've heard others have success with them. Here's what [Kelly Ballantyne], a diplomate of the American College of Veterinary Behaviorists who provides services through Veterinary Behavior at Illinois, a Chicago-based practice that is part of the University of Illinois College of Veterinary Medicine, said: Rick Danzl/The News-GazetteMike [Mike Howie]/The News-Gazette Bruiser the dog doesn<

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