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Production rate is an increasingly important factor in the deployment of metal additive manufacturing (AM) throughout industry. To address the perceived low production rate of metal AM systems based on single-laser powder bed fusion (L-PBF), several companies now offer systems in which melting has been parallelised by the introduction of multiple, independently controlled laser beams. Nevertheless, a full set of studies is yet to be conducted to benchmark the efficiency of multi-laser systems and, at the same time, to verify if the mechanical properties of components are compromised due to the increase in build rate. This study addresses the described technology gaps and presents a 4-beam L-PBF system operating in “single multi” (SM) mode (SM-L-PBF) where each of the four lasers is controlled so that it melts all of a particular components’ layers and produces specimens for comparison with standard L-PBF specimens from the same machine. That is all four lasers making all of some of the parts were compared to a single-laser manufacturing all of the parts. Build parameters were kept constant throughout the manufacturing process and the material used was Inconel 625 (IN625). Stress-relieving heat treatment was conducted on As-built (AB) specimens. Both AB and heat-treated (HT) specimen sets were tested for density, microstructure, tensile strength and hardness. Results indicate that the stress-relieving heat treatment increases specimen ductility without compromising other mechanical properties. SM-L-PBF has achieved a build rate of 14 cm 3 /h when four 200 W lasers were used to process IN625 at a layer thickness of 30 μm. An increase in the build rate of 2.74 times (build time reduction: 63%) has been demonstrated when compared to that of L-PBF, with little to no compromises in specimen mechanical properties. The observed tensile properties exceed the American Society for Testing Materials (ASTM) requirements for IN625 (by a margin of 22 to 26% in the 0.2% offset yield strength). Average specimen hardness and grain size are in the same order as that reported in literatures. The study has demonstrated that a multi-laser AM system opens up opportunities to tackle the impasse of low build rate in L-PBF in an industrial setting and that at least when operating in single mode there is no detectable degradation in the mechanical and crystallographic characteristics of the components produced.

Introduction: Hereditary angioedema (HAE) patients (both diagnosed and undiagnosed) commonly present to the emergency department (ED). Presenting symptoms (swelling and pain) may be erroneously attributed to common allergic and gastrointestinal conditions resulting in major delays in diagnosis and appropriate treatment. No published tools currently exist for HAE screening and management in undiagnosed disease. The overall goal of the study was to develop a HAE-RT tool for ED settings. Methods: A two-phase mixed methods approach was used to develop the HAE-RT Tool including: Phase 1: A Delphi Study [HAE specialists (N=9) and National Patient Advocacy Group Members (N=3)] was conducted to reach consensus (80% agreement) on predictor variables to include. Phase 2: A retrospective chart review was conducted to assess the predictive findings of the predictor variables. A convenient sample of patients presenting with angioedema (with and without HAE) between January 2012 January 2017 were included in the study. Results: Of the 12 experts invited, 9 (75%) participated in the Delphi study. Of 8 HAE-specific predictive variables, 4 reached consensuses including: (1) recurrent angioedema; (2) absence of urticaria; (3) past recurrent abdominal pain/swelling; (4) response to allergic therapy. The retrospective study included 85 patients (N=46 with HAE; N=39 non-HAE; overall 72% female). HAE patients were significantly more likely to have a family history of HAE (72% vs 0%; P<0.0001); previous recurrent angioedema (96%; P<0.009); present with no hives (91%; P<0.036); previous recurrent abdominal pain (80%; P<0.0001); and only 2% responded positively to allergy treatments (P<0.0001). Conclusion: Our study emphasizes the importance of key stakeholder involvement and feedback to facilitate the prioritization of important information that must be included in the design of an HAE-RT tool. The next step is to observe the effect of the HAE-RT tool on patient triage in the ED.

\"Combines advances in understanding virulence and evolution in three distinct fields; oomyctes, fungi and protozoan parasites - The first book to synthesizes advances in functional and comparative genomics represented in primary scientific literature for this topic. - Summarizes genetic tools in a diverse set of pathogenic organisms\"--

The Internet/WWW has made it possible to easily access quantities of information never available before. However, both the amount of information and the variation in quality pose obstacles to the efficient use of the medium. Artificial intelligence techniques can be useful tools in this context. Intelligent systems can be applied to searching the Internet and data-mining, interpreting Internet-derived material, the human-Web interface, remote condition monitoring and many other areas.This volume presents the latest research on the interaction between intelligent systems (neural networks, adaptive and connectionist paradigms, fuzzy and rule-based systems, intelligent agents) and the Internet/WWW. It surveys both the employment of intelligent systems to facilitate and enhance the use of the Internet, and applications where the Internet is a channel through which intelligent techniques are applied.

Measurements of the double-differential π ± production cross-section in the range of momentum 100 MeV/c≤p< 800 MeV/c and angle 0.35 rad ≤θ<  2.15 rad in proton–beryllium, proton–aluminium and proton–lead collisions are presented. The data were taken with the HARP detector in the T9 beam line of the CERN PS. The pions were produced by proton beams in a momentum range from 3 GeV/c to 12.9 GeV/c hitting a target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident particles were identified by an elaborate system of beam detectors. Results are obtained for the double-differential cross-sections d 2 σ/dpdθ at six incident proton beam momenta (3 GeV/c, 5 GeV/c, 8 GeV/c, 8.9 GeV/c (Be only), 12 GeV/c and 12.9 GeV/c (Al only)) and compared to previously available data.

Background: Demand for health care services is rising while newly licensed nurses vacate employment positions at alarming rates. Healthcare leadership has called for an increased diversification of the healthcare workforce, but the workplace experience of nonwhite nurses in the first years has not been assessed. Methods: This study utilized a quantitative cross-sectional survey design. The sample was limited to newly licensed nurses with no prior experience as a nurse. Linear regression models were constructed to determine which personal and structural attributes are associated with turnover intention, stratified by race and ethnicity. Hierarchical, backwards stepwise selection was used to build the final model. Results: The majority of respondents were white English-speaking females, never married, holding a BSN and working in an acute care hospital. Nurses who speak a language other than English at home are treated more poorly than primary English speakers. Hispanics are most likely to report a negative work environment, a hostile climate, general incivility and inappropriate jokes. Turnover intention was associated with months at the current job, a negative work environment including experiencing incivility, not having enough time to do the things that must be done, and confidence in the ability to do one’s job list. Blacks are likely to report a high turnover intention but remain in the current job while acknowledging a hostile environment and general incivility. Many nurses employed in non-acute care settings are nonwhite, report higher workload scores and high patient assignments. Conclusions: Nonwhite nurses report negative work environments and high intention to leave but remain in their jobs. Among the full sample of newly licensed nurses, months at the current job, a negative work environment, including experiencing incivility, not having enough time to do the things that must be done, and confidence in the ability to do one’s job were associated with turnover intention. Efforts to diversify the workforce must include education to prepare minority nurses for the environment they may encounter, including uncivil behavior and high workloads. Policy initiatives must address the treatment of new nurses and support new nurses as they transition to the professional role.

Measurements of the double-differential π± production cross-section in the range of momentum 100 MeV/c≤p< 800 MeV/c and angle 0.35 rad ≤θ< 2.15 rad in proton-beryllium, proton-aluminium and proton-lead collisions are presented. The data were taken with the HARP detector in the T9 beam line of the CERN PS. The pions were produced by proton beams in a momentum range from 3 GeV/c to 12.9 GeV/c hitting a target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident particles were identified by an elaborate system of beam detectors. Results are obtained for the double-differential cross-sections d2σ/dpdθ at six incident proton beam momenta (3 GeV/c, 5 GeV/c, 8 GeV/c, 8.9 GeV/c (Be only), 12 GeV/c and 12.9 GeV/c (Al only)) and compared to previously available data.

The influence and importance of the International Bureau have never been greater than they are today and there seems little doubt that its position will be enhanced in the future. The rapid development of science and technological industry during recent decades has placed heavy demands on fundamental metrology to keep ahead of immediate needs. This trend is likely to increase. Other organizations also have an important role to play in measurement and its ultimate application. However, if the International Bureau conserves its competence, the fact that it has always envisaged its role as that of providing leadership in the development of an international scientific consensus rather than developing and imposing its own ideas, combined with the authority that is conferred only by international treaty, will assure its position as the international focus for world measurement. Inevitably this will call for expansion of the Bureau's activities. Not all demands made on it will be legitimate or wise. It will be the responsibility of the International Committee to keep the situation under continuous study and bring imaginative yet prudent recommendations to the Conference.

A neutrino factory would provide a high flux beam of electron and muon neutrinos with well understood energy and flavour composition for detailed studies of neutrino oscillations. Such a beam requires a large number of muons and hence pions, which would be provided by a proton driver and pion production target. The optimal design of such a pion production target and the necessary pion capture system need accurate knowledge of hadron production at energies of several GeV. HARP, a large acceptance particle spectrometer of conventional design, aims to measure hadron production cross sections on thin and thick nuclear targets in the range of beam momentum 2-15 GeV/c in order to provide the desired data.