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Cancer has been one of the biggest silent killers during the 20ths and 21st centuries. In addition to this disease, one of the social factors that promote the chances of having diseases is stress. Recent studies have shown that chronic stress can lead to gastric cancer by activating adrenergic signaling pathway which plays a fundamental role in tumorigenesis. Furthermore, the plasma levels of catecholamines and cortisol elevate in stressful situations. These hormones play a role in inducing progress and metastasis of gastric carcinoma. Stress management has been a vital factor for the people of this century. Although stress is not well-explained clearly, recent studies have shown that people with low income, loads of work, family problems, etc. are of environmentally challenging and present a high possibility of being victim to gastric neoplasms and other diseases.