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Tropical cyclones (TCs) are hazardous natural disasters. Because TC intensification is significantly controlled by atmosphere and ocean environments, changes in these environments may cause changes in TC intensity. Changes in surface and subsurface ocean conditions can both influence a TC’s intensification. Regarding global warming, minimal exploration of the subsurface ocean has been undertaken. Here we investigate future subsurface ocean environment changes projected by 22 state-of-the-art climate models and suggest a suppressive effect of subsurface oceans on the intensification of future TCs. Under global warming, the subsurface vertical temperature profile can be sharpened in important TC regions, which may contribute to a stronger ocean coupling (cooling) effect during the intensification of future TCs. Regarding a TC, future subsurface ocean environments may be more suppressive than the existing subsurface ocean environments. This suppressive effect is not spatially uniform and may be weak in certain local areas. Changing atmospheric and oceanic environments under the effects of a warming climate are likely to influence the intensity of tropical cyclones. Here, the authors analyse 22 state-of-the-art climate models and show that future subsurface ocean environments might further suppress cyclone intensification.

The present study investigates the role of intraseasonal oscillation (ISO) on the South China Sea (SCS) summer monsoon onset based on the daily reanalysis data for a 33-year period from 1979 to 2011. The SCS summer monsoon (SCSSM) onset always occurs during the developing phase of ISO at which the ISO develops from inactive convection and easterly anomalies to active convection and westerly anomalies. In the SCSSM onset season (April–July), the change rate of the zonal winds of ISO over the SCS is around twice as large as the increase rate of the climatological westerly winds. Therefore, the monsoon onset, which is a process requiring the westerly winds to increase up to a certain threshold, only occurs during ISO’s developing phase. Furthermore, the monsoon onsets tend to occur at the active (inactive) convection and developing phase of ISO in the early (late) onset years. In the early-onset years, a strong active phase of ISO is needed to prompt monsoon onset because of the undeveloped climatological easterly winds at the onset period, whereas in the late-onset years the developed climatological westerly winds will prompt the monsoon onset as long as the suppressive role of the inactive phase of ISO starts relieving. Due to the constraint of ISO’s developing phase on the SCSSM onset, an earlier ISO’s developing phase occurring in the monsoon onset season will induce an earlier SCSSM onset. The low-frequency variation, with a period greater than 90 days, can also modify the role of ISO’s developing phase, especially when the developing phase of ISO occurs at the early season of the monsoon onset.

This experiment aimed to evaluate the effects of using sugarcane bagasse (SB) as a substitute for soybean hulls and wheat bran in the diet of pregnant sows on their reproductive performance and gut microbiota. A total of seventy-two primiparous sows were randomly divided into four treatment groups, with eighteen replicates of one sow each. The sows were fed a basal diet supplemented with 0% (CON), 5%, 10%, and 15% SB to replace soybean hulls from day 57 of gestation until the day of the end of the gestation period. The results showed that SB contains higher levels of crude fiber (42.1%) and neutral detergent fiber (81.3%) than soybean hulls, and it also exhibited the highest volumetric expansion when soaked in water (50 g expanding to 389.8 mL) compared to the other six materials we tested (vegetable scraps, soybean hulls, wheat bran, rice bran meal, rice bran, and corn DDGS). Compared with the CON, 5% SB significantly increased the litter birth weight of piglets. Meanwhile, 10% and 15% SB significantly increased the rates of constipation and reduced the contents of isobutyric acid and isovaleric acid in feces. Furthermore, 10% and 15% SB significantly disturbed gut microbial diversity with increasing Streptococcus and decreasing Prevotellaceae_NK3B31-group and Christensenellaceae_R-7-group genera in feces. Interestingly, Streptococcus had a significant negative correlation with isobutyric acid, isovaleric acid, and fecal score, while Prevotellaceae_NK3B31-group and Christensenellaceae_R-7-group had a positive correlation with them. In conclusion, our study indicates that 5% SB can be used as an equivalent substitute for soybean hulls to improve the reproductive performance of sows without affecting their gut microbiota.

Background Auricular acupressure (AA) has been viewed as a promising approach to managing chemotherapy-induced nausea and vomiting (CINV) but relevant research evidence has been inconclusive. This study aimed to examine the effects of AA on CINV in breast cancer (BC) patients undergoing chemotherapy. Methods A preliminary randomized controlled trial was conducted in 114 BC patients. Participants were randomly allocated to a true AA group ( n  = 38), a sham AA group ( n  = 38), and a standard care group ( n  = 38). All the participants were provided with standard antiemetic treatment and care, while the true AA group and the sham AA group received an additional 5-day true AA and a 5-day sham AA, respectively. Acute and delayed CINV were assessed by using the MASCC Antiemesis Tool (MAT), anticipatory nausea and vomiting were measured by the Index of Nausea, Vomiting, and Retching (INVR), and patients’ quality of life (QoL) was evaluated by the Functional Assessment of Cancer Therapy-Breast (FACT-B). Results Both the true and sham AA groups reported improved CINV outcomes than the standard care group, with the true AA demonstrating larger effects than the sham comparison. The true and sham AA groups had higher complete response (CR) rates of CINV when compared with the standard care group, with the difference in the CR of acute CINV achieving statistical significance ( p  = 0.03). Both the true and sham AA groups demonstrated lower incidence and severity of acute CINV compared with the standard care group with the among-group difference reaching statistical significance for the occurrence ( p  = 0.04) and severity ( p  = 0.001) of acute nausea. No significant differences in anticipatory CINV and QoL were found among the groups. Conclusion The use of AA plus standard antiemetic treatment and care was superior to the use of standard antiemetic treatment and care alone in managing CINV among BC patients receiving chemotherapy. The antiemetic effects of AA were identified to be more profound in improving acute CINV, particularly acute nausea. The antiemetic effects of AA were deemed to be a mixture of specific treatment effects and placebo effects, and the placebo effects were very large and even reached clinical significance. Trial registration ClinicalTrials.gov; NCT02403037 ; Registered March 31, 2015.

BackgroundGranzyme K (GZMK) is a serine protease known for its perforin-dependent cytotoxicity. However, the non-cytotoxic role of GZMK in lung adenocarcinoma (LUAD) remains largely elusive.MethodsMultiomics datasets were integrated to investigate the clinical relevance of GZMK and its association with programmed death-ligand 1 (PD-L1) in LUAD. Recombinant human GZMK (rhGzmK) was applied in tumor-CD8+ T cell co-culture systems, with its effects on PD-L1 expression and CD8+ T-cell function evaluated via flow cytometry. Key signaling proteins were analyzed by Western blotting. To evaluate the therapeutic potential of GZMK inhibition, a selective GZMK inhibitor was combined with anti-programmed cell death protein 1 (anti-PD-1) therapy in both C57BL/6 and human peripheral blood mononuclear cells (huPBMC)-reconstituted NVSG humanized mouse models. Finally, multiplex immunofluorescence analysis was conducted on paired pretreatment and post-treatment specimens from a clinical cohort of patients with LUAD receiving immunotherapy to assess the spatial dynamics of GZMK expression in response to treatment.ResultsGZMK upregulated PD-L1 expression on tumor cells and enhanced PD-L1/PD-1 binding. Furthermore, GZMK promoted CD8+ T-cell dysfunction through the induction of apoptosis, the promotion of CD8+ T-cell exhaustion and suppression of proliferation. Mechanistically, cleavage of F2R-like trypsin receptor 1 (F2RL1) by GZMK activated the AKT Serine/Threonine Kinase (AKT) /glycogen synthase kinase-3β/β-catenin and Janus kinase 2/signal transducer and activator of transcription 1 (JAK2/STAT1) pathways, triggering nuclear accumulation of β-catenin and phosphorylated STAT1, which ultimately drove PD-L1 transcription. Additionally, F2RL1 signaling upregulated COPS8, stabilizing PD-L1 through inhibition of its ubiquitin-mediated degradation. In vivo, pharmacological inhibition of GZMK synergized with anti-PD-1 therapy to suppress tumor growth and enhance CD8+ T-cell infiltration and function. Clinically, high baseline GZMK expression correlated with an improved response to immunotherapy, and anti-PD-1 treatment modulated the spatial distribution of GZMK within the tumor microenvironment.ConclusionIn the absence of perforin, GZMK acquires an immunosuppressive function through F2RL1 activation on tumor cells, which in turn promotes the formation of an immune-suppressive niche. Accordingly, combined targeting of the GZMK/F2RL1 axis and the PD-1/PD-L1 pathway represents a promising synergistic strategy to overcome immune evasion in LUAD.

Yield stress, as the key parameter to characterize the network strength of waxy oil, is important to the petroleum pipeline safety. Reducing the yield stress of waxy oil is of great significance for flow assurance. In this study, the effect of alternating magnetic field (intensity, frequency) on the yield stress of a waxy model oil with nanocomposite pour point depressant (NPPD) is systematically investigated. An optimum magnetic field intensity and frequency is found for the reduction in yield stress. When adding with NPPD, the heterogeneous nucleation of NPPD contributes to the reduction in yield stress for waxy model oil. Interestingly, the magnetic field is helpful for the modification of yield stress at a lower frequency and intensity before the optimal value; however, the modification is found to be weakened when the magnetic field is further increased after the optimal value. Possible explanation is proposed that the aggregation morphology of wax crystal would be altered and results in the release of wrapped oil phase from the network structure under the magnetic field.

In this paper, we mainly summarize and review the progresses in recent climatological studies (by CMSR, IAP/CAS and some associated domestic and international institutions) on the interannual and interdecadal variabilities of monsoon troughs and their impacts on tropical cyclones and typhoons (TCs) geneses over the western North Pacific Ocean. The climatological characteristics of monsoon troughs and four types of circulation patterns favorable to TCs genesis over the western North Pacific Ocean in summer and autumn are given in this paper. It is also shown in this paper that the monsoon trough over the western North Pacific Ocean has obvious interannual and interdecadal variabilities. Especially, it is revealed in this paper that the interannual and interdecadal variabilities of the monsoon trough over the western North Pacific Ocean influence the TCs genesis not only through the impact on distributions of the vorticity in the lower troposphere and the divergence in the upper troposphere, the water vapor in the mid- and lower troposphere and the vertical shear of wind fields between the upper and lower troposphere over the western North Pacific Ocean, but also through the dynamical effects of the transition between convectively coupled tropical waves and providing disturbance energy. Besides, some climatological problems associated with TCs activity over the western North Pacific Ocean that need to be studied further are also pointed out in this paper.

In the present work, the interaction mechanism of specific polyelectrolyte multilayers (PEMs), fabricated by layer-by-layer deposition of polydiallyldimethylammonium chloride (PDDA) and poly(sodium 4-styrenesulfonate) (PSS), is studied using atomic force microscopy. The underwater oil-repellency of PSS-capped PEMs was further explored by measuring the interaction forces between tetradecane droplets and PEMs-coated silica substrates under various salinities. The force curves were analyzed following the Stokes–Reynolds–Young–Laplace theoretical model. Desirable consistency was achieved between the experimental and theoretical calculations at low NaCl concentrations (0.1 mM and 1 mM); however, underestimation of the attractive force was found as the NaCl concentration increases to moderate (10 mM) and high (100 mM) levels. Discrepancy analyses and incorporated features toward a reduced surface charge density were considered based on the previous findings of the orientation of anionic benzenesulfonate moieties (Liu et al. in Angew Chem Int Ed 54(16):4851–4856, 2015. https://doi.org/10.1002/anie.201411992 ). Short-range steric hindrance interactions were further introduced to simulate “brush” effect stemming from nanoscale surface roughness. It is demonstrated in our work that the PSS-capped PEMs remains a stable underwater lipophobicity against high salinity, which renders it potential application in surface wetting modification and anti-fouling.

The influence of the interannual variation of cross-equatorial flow (CEF) on tropical cyclogenesis over the western North Pacific (WNP) is examined in this paper by using the tropical cyclone (TC) best track data from the Joint Typhoon Warning Center and the JRA-25 reanalysis dataset. The results showed that the number of TCs forming to the east of 140°E over the southeastern part of the western North Pacific (WNP) is in highly positive correlation with the variation of the CEF near 125°E and 150°E, i.e., the number of tropical cyclogeneses increases when the cross-equatorial flows are strong. Composite analyses showed that during the years of strong CEF, the variations of OLR, vertical wind shear between 200-850 hPa, 850 hPa relative vorticity and 200 hPa divergence are favorable for tropical cyclogenesis to the east of 140°E over the tropical WNP, and vice versa. Moreover, it is also discussed from the view of barotropic energy conversion that during the years of strong CEF, an eastward-extended monsoon trough leads to the rapid growth of eddy kinetic energy over the eastern part of WNP, which is favorable for tropical cyclogenesis; but during the years of weak CEF, the monsoon trough is located westward in the western part of the WNP, consistent with the growth area of eddy kinetic energy. As a result, there are fewer TC geneses over the eastern part of WNP. Besides, the abrupt strengthening of a close-by CEF 2-4 days before tropical cyclogenesis may be the one of its triggers.

Based on the satellite data from the National Oceanic and Atmospheric Administration and the NCEP/NCAR reanalysis data, the variation of the intensity of convection over the Intertropical Convergence Zone （ITCZ） in summer and its impacts on tropical cyclones are studied. In this paper, an intensity index of the ITCZ is proposed according to Outgoing Longwave Radiation （OLR） in the region of （5°-20°N, 120°-150°E） in the western North Pacific （WNP）. Then strong and weak ITCZ years are classified and different variables during the strong/weak ITCZ years are analyzed. The composite results show that the ITCZ anomaly is connected to the general atmospheric circulation and SST distribution. In the strong ITCZ years, the subtropical anticyclone weakens and shifts northward. Besides, there is salient cyclonic anomaly at the low level and anticyclonic anomaly at the high level. SST patterns in the preceding winter resemble to those of La Nifia. It could persist into the succeeding summer. However, it is opposite in the weak ITCZ years. The impact of the ITCZ anomaly on the tropical cyclone （TC） formation and track is also discussed. There are more TCs over the WNP （5°-20°N, 120°-150°E） in the strong ITCZ years and there is a significant increase in the northward recurving TCs. In the weak ITCZ years, fewer TCs occur and the frequency of the northwestward track is higher.