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Synthesizing insights from a dynamic capability perspective and social network theory, this study identifies the factors influencing green innovation and examines the relationships between influencing factors, green innovation, and performance. This study uses structural equation modeling to test the research hypotheses. The results indicate that dynamic capability, coordination capability, and social reciprocity are significant drivers of green innovation, including green product innovation and green process innovation. Green product and process innovation have positive effects on environmental performance and organizational performance. These findings are relevant to firms in quest of green management and innovation.

Purpose Empirical evidences support the benefits of environmental innovation to improve performance. However, previous research has not considered the role of resource alignment in green supply chain management. To fill the research gap, this paper aims to identify resource alignment as a potential moderating mechanism and to examine the relationships between environmental innovation strategy, resource alignment and green innovation performance. Design/methodology/approach The empirical study uses a questionnaire approach designed to collect data. Regression analysis is used for hypotheses testing. Findings The findings indicate that environmental innovation strategy and resource alignment between partners are positively related to green innovation performance. This study also provides considerable support to the key contingent moderator of resource alignment. The positive effect of environmental innovation strategy on green innovation performance is stronger under the conditions of a higher level of resource alignment between partners. Research limitations/implications This study provides empirical support of the ecological modernization theory and integrates partner analysis literature and green management literature. Higher resource alignment may facilitate firms to develop environmental innovation strategy to attain green innovation performance. Practical implications Environmental innovation strategy enables firms to integrate ecological issues into their business operation. Managers could learn how to execute environmental incentive programs to promote sustainable development of green new product and green process. Managers need to pay attention to resource alignment that may have moderating influence on the performance outcomes of environmental innovation strategy. Originality/value This study highlights the importance of environmental innovation strategy and resource alignment in the process of green management and helps scholars and managers to better understand the moderator of resource alignment in quest of environmental innovation and green management.

Purpose There has been little research discussing the role that new product creativity plays in achieving alliance ambidexterity and how causal ambiguity may be a potential moderator in the association between new product creativity and alliance ambidexterity. The purpose of this study is to identify the contingent role of causal ambiguity and examine the relationships between new product creativity, causal ambiguity and alliance ambidexterity. Design/methodology/approach In this empirical study, a questionnaire approach is used to collect data, and moderated structural equation modeling is used to test the hypotheses. Findings The findings indicate that new product creativity has a positive influence on alliance ambidexterity, whereas causal ambiguity moderates these associations. When causal ambiguity increases, the positive impact of new product creativity on alliance ambidexterity is attenuated. Research limitations/implications This study integrates the ambidexterity literature and the alliance literature by applying the concept of ambidexterity to a strategic alliance context. The moderating role of causal ambiguity echoes previous research postulating causal ambiguity as a barrier to knowledge transfer in alliances. Given a higher level of causal ambiguity, firms face more difficulty when they attempt to develop new product creativity to achieve the desired level of alliance ambidexterity. Practical implications Managers could initiate incentive programs and build supportive environments that facilitate new product creativity. Firms will be capable of elaborating the potential of new product creativity to further facilitate alliance ambidexterity. Managers need to pay attention to causal ambiguity that may have a moderating influence on the relationship between new product creativity and alliance ambidexterity. Originality/value This study contributes to the synthesis of new product creativity and alliance ambidexterity and helps scholars and managers to better understand the moderating effect of causal ambiguity in the context of the innovation and ambidexterity literature.

Purpose - The purpose of this paper is to examine the mediating role of knowledge management in the relationship between social interaction and innovation performance.Design methodology approach - The population in the study is the Taiwanese firms listed in the China Credit Information Service Incorporation. A stratified random sampling method was used to select 176 firms in Taiwan. The usable response rate was 23.47 per cent. The study employed LISREL to test the hypothesized relationships in the path-analytic framework.Findings - The results indicate that social interaction is positively related to knowledge management. Knowledge management is, in turn, positively related to administrative and technical innovation performance. Further, the results provide evidence that knowledge management plays a mediating role between social interaction and innovation performance.Originality value - The study highlights the importance of social interaction and knowledge management in the process of innovation, and helps scholars and managers to better understand the mediator of knowledge management through which social interaction benefits innovation performance.

Summary RAD23 (RADIATION SENSITIVE23) proteins are a group of UBL‐UBA (ubiquitin‐like‐ubiquitin‐associated) proteins that shuttle ubiquitylated proteins to the 26S proteasome for breakdown. Drought stress is a major environmental constraint that limits plant growth and production, but whether RAD23 proteins are involved in this process is unclear. Here, we demonstrated that a shuttle protein, MdRAD23D1, mediated drought response in apple plants (Malus domestica). MdRAD23D1 levels increased under drought stress, and its suppression resulted in decreased stress tolerance in apple plants. Through in vitro and in vivo assays, we demonstrated that MdRAD23D1 interacted with a proline‐rich protein MdPRP6, resulting in the degradation of MdPRP6 by the 26S proteasome. And MdRAD23D1 accelerated the degradation of MdPRP6 under drought stress. Suppression of MdPRP6 resulted in enhanced drought tolerance in apple plants, mainly because the free proline accumulation is changed. And the free proline is also involved in MdRAD23D1‐mediated drought response. Taken together, these findings demonstrated that MdRAD23D1 and MdPRP6 oppositely regulated drought response. MdRAD23D1 levels increased under drought, accelerating the degradation of MdPRP6. MdPRP6 negatively regulated drought response, probably by regulating proline accumulation. Thus, “MdRAD23D1‐MdPRP6” conferred drought stress tolerance in apple plants.

In this article, COD, volatile phenol and ammonia nitrogen concentrations of the wastewater from semicarbon are reported as 38,000; 6,400 and 5,700 mg/L, respectively. According to the field test, when the pH of the wastewater is 9, the field test temperature is 20 °C, the adsorption time is 30 min and the optimal dosing ratio of nitrogen-doped gasification slag (HX-NGS) to the wastewater is 1:4, HX-NGS has the best removal effect on COD, volatile phenol and ammonia nitrogen in the wastewater from the semicarbon. The removal rates of COD, volatile phenol and ammonia nitrogen are 94, 91 and 85%, respectively, and the concentrations of the remaining COD, volatile phenol and ammonia nitrogen are 2,280, 576 and 855 mg/L, respectively, after regeneration, the material HX-NGS has a good effect on the treatment of the wastewater from the semicarbon. The reuse rate of the adsorption material is at least eight times. The adsorption effect of the material HX-NGS conforms to the mechanism law of dynamics and thermodynamics.

The early detection of cognitive decline in Parkinson’s disease is important for providing drug therapy and non-pharmacological management. The circulating microRNAs present in plasma are promising biomarkers of PD with dementia (PDD) due to their critical roles in synaptic plasticity and the regulation of neurodegeneration-associated proteins. In this study, we aimed to identify plasma microRNAs that may differentiate PD with or without cognitive impairment. Global microRNA expression was obtained from a discovery set of 123 participants who were divided into four groups, namely normal controls (HC), PD with no dementia (PDND), PD with mild cognitive impairment (PD-MCI), and PDD, using next-generation sequencing. The BOLD selector was used for microRNA candidate selection. Six miRNAs, namely miR-203a-3p, miR-626, miR-662, miR-3182, miR-4274, and miR-4295, were clustered as potential candidates for use in identifying PDND from PD-MCI. Another independent cohort of 120 participants was further recruited in a validation step in order to detect candidate microRNAs via droplet digital PCR (ddPCR), which was used for its high sensitivity in detecting low miRNA concentrations. Our results show that the ratio of miR-203a-3p/miR-16-5p, in which miR-16-5p was used as a reference control miRNA, was significantly increased in PDD compared to that seen in PD-MCI and PDND individually, and was negatively correlated with the MoCA scores (r = −0.237, p = 0.024) in patients with PD. However, there was no significant difference in the ratio of miR-203a-3p/miR-16-5p between HC and PDND, PD-MCI, or PDD individually. The ROC curve of the logistic regression model, factoring in the variables of age, the ratio of miR-203a-3p/miR-16-5p, and the UPDRS III score, demonstrated an AUC of 0.883. Our findings suggest that the ratio of miR-203a-3p/miR-16-5p, used with age and motor score, could be a predictor of dementia among PD patients.

The purpose of this paper is to investigate the effects of organizational climate and structure on knowledge management and firm innovativeness from the social capital and social network perspectives. The empirical study employed a questionnaire approach. The sample for this study was drawn from the population of the top 5,000 Taiwanese firms listed in the yearbook published by the China Credit Information Service Incorporation. Regression analysis was used to test the hypotheses in a sample of 146 Taiwanese firms. The findings suggest that knowledge management is positively related to firm innovativeness. In addition, the effect of knowledge management on innovativeness is positively moderated by supportive climate and decentralized, integrated, and less formalized structure. The study also examines the effects of organizational climate and structure on knowledge management and the results indicate that innovative and supportive climate are positively related to knowledge management. When the organizational structure is less formalized, more decentralized and integrated, knowledge management is more enhanced. Firms need to be aware of the critical role of organizational structure and climate in the transition process of knowledge management to innovative products or services. This study contributes to the literature by investigating the relationships among organizational contexts of climate and structure, knowledge management, and firm innovativeness from the social capital and social network perspectives.

Our previous reports proved that the structural protein σA of avian reovirus (ARV) is an energy activator which can regulate cellular metabolism that is essential for virus replication. This study has further demonstrated that the ARV protein σA is able to upregulate the HIF-1α/myc/glut1 pathway in three cancer cell lines (A549, B16-F10, and HeLa) to alter the metabolic pathway of host cells. Quantitative real-time RT-PCR and Western blotting results have revealed that σA protein could enhance both mRNA and the protein levels of HIF-1α, c-myc, and glut1 in these cancer cell lines. In this work, ATeam immunofluorescence staining was used to reveal that knockdown of HIF-1α, c-myc, and glut1 by shRNAs decreased cellular ATP levels. Our data reveal that the ARV σA protein can downregulate lactate fermentation and upregulate glutaminolysis. The σA protein upregulates glutaminase, which converts glutamate into the TCA cycle intermediate α-ketoglutarate, activating the TCA cycle. In the lactate fermentation pathway, ARV σA protein suppresses lactate dehydrogenase A (LDHA), implying the Warburg effect does not occur in these cancer cell lines. This study provides a novel finding revealing that ARV σA protein upregulates glycolysis and glutaminolysis to produce energy using the HIF-1α/c-myc/glut1 pathway to benefit virus replication in these cancer cell lines.

The PHLDA3 gene encodes a small 127 amino acid protein with a pleckstrin homology (PH)-only domain. The expression and significance of PHLDA3 in lung cancer remain unclear. Here, we investigated the role of PHLDA3 in tumor proliferation and invasion in lung adenocarcinoma. Immunohistochemistry and immunoblotting analyses were used to assess PHLDA3 expression in lung cancer tissues, and its correlation with clinicopathological factors in lung cancer. Plasmids encoding PHLDA3 and small interfering RNA against PHLDA3 were used to regulate the expression of PHLDA3 in lung cancer cells. Furthermore, the effects of PHLDA3 on lung cancer cell proliferation and invasion were investigated using the MTS, colony formation, Matrigel invasion, and wound healing assays. Co-immunoprecipitation analysis and inhibitors of both the Wnt signaling pathway and GSK3β were used to explore the regulatory mechanisms underlying the role of PHLDA3 in lung cancer cells. PHLDA3 was found to be overexpressed in lung cancer tissues, and its expression was correlated with poor outcomes in lung adenocarcinoma patients. PHLDA3 expression promoted the proliferation, invasion, and migration of lung cancer cells. Overexpression of PHLDA3 activated the Wnt signaling pathway and facilitated epithelial–mesenchymal transition. Inhibition of Wnt signaling pathway activity, using XAV-939, reversed the effects of PHLDA3 overexpression in lung cancer cells; moreover, PHLDA3 could bind to GSK3β. Inhibition of GSK3β activity, using CHIR-99021, restored the proliferative and invasive abilities of PHLDA3 knockdown cells. Our findings demonstrate that PHLDA3 is highly expressed in lung adenocarcinomas and is correlated with poor outcomes. Furthermore, it promotes the proliferation and invasion of lung cancer cells by activating the Wnt signaling pathway. This paper demonstrates that PHLDA3 is highly expressed in lung adenocarcinomas and correlates with poor outcome. PHLDA3, in conjunction with GSK3β, promotes the proliferation and invasion of lung cancer cells by activating the Wnt signaling pathway, and facilitates epithelial–mesenchymal transition.