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Photon upconversion is an anti-Stokes process in which an absorption of a photon leads to a reemission of a photon at an energy higher than the excitation energy. The upconversion photoemission has been already demonstrated in rare earth atoms in glasses, semiconductor quantum wells, nanobelts, carbon nanotubes and atomically thin semiconductors. Here, we demonstrate a room temperature upconversion photoluminescence process in a monolayer semiconductor WS 2 , with energy gain up to 150 meV. We attribute this process to transitions involving trions and many phonons and free exciton complexes. These results are very promising for energy harvesting, laser refrigeration and optoelectronics at the nanoscale. Two-dimensional materials show promise for photon upconversion processes due to their strong photon-exciton and phonon-exciton interactions. Here, the authors report room temperature upconversion photoluminescence in monolayer WS 2 with high energy gain up to 150 meV based on variable temperature.

Persistent meandering of the jet stream can cause atmospheric blocking of prevailing eastward winds and result in weather extremes such as heat waves in the midlatitudes. Nakamura and Huang interpret the poorly understood origins of these systems as the meteorological equivalents of traffic congestion on a highway and show how they can be described by analogous mathematical theory. Climate change may affect the frequency of blocking as well as its geographic distribution, reflecting a simultaneous shift in the structure of the stationary atmospheric waves and the regional capacity of the jet stream. Science , this issue p. 42 Waves in the jet stream reveal the close similarity between atmospheric blocking and traffic congestion on a highway. Atmospheric blocking due to anomalous, persistent meandering of the jet stream often causes weather extremes in the mid-latitudes. Despite the ubiquity of blocking, the onset mechanism is not well understood. Here we demonstrate a close analogy between blocking and traffic congestion on a highway by using meteorological data and show that blocking and traffic congestion can be described by a common mathematical theory. The theory predicts that the jet stream has a capacity for the flux of wave activity (a measure of meandering), just as the highway has traffic capacity, and when the capacity is exceeded, blocking manifests as congestion. Stationary waves modulate the jet stream’s capacity for transient waves and localize block formation. Climate change likely affects blocking frequency by modifying the jet stream’s proximity to capacity.

Using Cluster data, we investigate the electric structure of a dipolarization front (DF) – the ion inertial length (c/ωpi) scale boundary in the Earth's magnetotail formed at the front edge of an earthward propagating flow with reconnected magnetic flux. We estimate the current density and the electron pressure gradient throughout the DF by both single‐spacecraft and multi‐spacecraft methods. Comparison of the results from the two methods shows that the single‐spacecraft analysis, which is capable of resolving the detailed structure of the boundary, can be applied for the DF we study. Based on this, we use the current density and the electron pressure gradient from the single‐spacecraft method to investigate which terms in the generalized Ohm's law balance the electric field throughout the DF. We find that there is an electric field at ion inertia scale directed normal to the DF; it has a duskward component at the dusk flank of DF but a dawnward component at the dawn flank of DF. This electric field is balanced by the Hall (j × B/ne) and electron pressure gradient (∇ Pe/ne) terms at the DF, with the Hall term being dominant. Outside the narrow DF region, however, the electric field is balanced by the convection (Vi × B) term, meaning the frozen‐in condition for ions is broken only at the DF itself. In the reference frame moving with the DF the tangential electric field is almost zero, indicating there is no flow of plasma across the DF and that the DF is a tangential discontinuity. The normal electric field at the DF constitutes a potential drop of ∼1 keV, which may reflect and accelerate the surrounding ions. Key Points We calculate E at DF using single‐ and four‐ spacecraft methods Normal E is balanced by the Hall (dominant) and pressure gradient terms At dawn flank, E is dawnward; At dusk flank, E is duskward

The occurrence rate of earthward‐propagating dipolarization fronts (DFs) is investigated in this paper based on the 9 years (2001–2009) of Cluster 1 data. For the first time, we select the DF events by fitting the characteristic increase inBzusing a hyperbolic tangent function. 303 earthward‐propagating DFs are found; they have on average a duration of 4 s and aBz increase of 8 nT. DFs have the maximum occurrence at ZGSM ≈ 0 and r ≈ 15 RE with one event occurring every 3.9 hours, where r is the distance to the center of the Earth in the XYGSM plane. The maximum occurrence rate at ZGSM ≈ 0 can be explained by the steep and large increase of Bz near the central current sheet, which is consistent with previous simulations. Along the r direction, the occurrence rate increases gradually from r ≈ 20 to r ≈ 15 RE but decreases rapidly from r ≈ 15 to r ≈ 10 RE. This may be due to the increasing pileup of the magnetic flux from r ≈ 20 to r ≈ 15 RE and the strong background magnetic field at r <∼13 RE, where the magnetic field changes from the tail‐like to dipolar shape. The maximum occurrence rate of DFs (one event per 3.9 hours) is comparable to that of substorms, indicating a relation between the two. Key Points Nine years (2001‐2009) of Cluster 1 data are analyzed and 303 DFs are found DF events are selected based on fitting Bz using a hyperbolic tangent function Occurrence rate of DFs (1 event per 3.9 hours) and substorms are comparable

A number of patient-specific and leukemia-associated factors are related to the poor outcome in older patients with acute myeloid leukemia (AML). However, comprehensive studies regarding the impact of genetic alterations in this group of patients are limited. In this study, we compared relevant mutations in 21 genes between AML patients aged 60 years or older and those younger and exposed their prognostic implications. Compared with the younger patients, the elderly had significantly higher incidences of PTPN11 , NPM1 , RUNX1 , ASXL1 , TET2 , DNMT3A and TP53 mutations but a lower frequency of WT1 mutations. The older patients more frequently harbored one or more adverse genetic alterations. Multivariate analysis showed that DNMT3A and TP53 mutations were independent poor prognostic factors among the elderly, while NPM1 mutation in the absence of FLT3 /ITD was an independent favorable prognostic factor. Furthermore, the status of mutations could well stratify older patients with intermediate-risk cytogenetics into three risk groups. In conclusion, older AML patients showed distinct genetic alterations from the younger group. Integration of cytogenetics and molecular mutations can better risk-stratify older AML patients. Development of novel therapies is needed to improve the outcome of older patients with poor prognosis under current treatment modalities.

Although the clinical features of the Isocitrate dehydrogenase 2 ( IDH2 ) mutation in acute myeloid leukemia (AML) have been characterized, its prognostic significance remains controversial and its stability has not been investigated. We analyzed 446 adults with primary non-M3 AML and found IDH2 R172, R140 and IDH1 R132 mutations occurred at a frequency of 2.9, 9.2 and 6.1%, respectively. Compared with wild-type IDH2 , mutation of IDH2 was associated with higher platelet counts, intermediate-risk or normal karyotype and isolated +8, but was inversely correlated with expression of HLA-DR, CD34, CD15, CD7 and CD56, and was mutually exclusive with WT1 mutation and chromosomal translocations involving core-binding factors. All these correlations became stronger when IDH1 and IDH2 mutations were considered together. Multivariate analysis revealed IDH2 mutation as an independent favorable prognostic factor. IDH2 − / FLT3 -ITD + genotype conferred especially negative impact on survival. Compared with IDH2 R140 mutation, IDH2 R172 mutation was associated with younger age, lower white blood cell count and lactate dehydrogenase level, and was mutually exclusive with NPM1 mutation. Serial analyses of IDH2 mutations at both diagnosis and relapse in 121 patients confirmed high stability of IDH2 mutations. In conclusion, IDH2 mutation is a stable marker during disease evolution and confers favorable prognosis.

This paper investigates the formation and evolution of deep convection inside the east–west oriented rainbands associated with a low-level jet (LLJ) in Typhoon Morakot (2009). With the typhoon center to the northwest of Taiwan, the westerly LLJ occurred as a result from the interaction of typhoon circulation with the southwest monsoon flow, which supplied the water vapor for the extreme rainfall (of ~ 1000 mm) over southwestern Taiwan. The Cloud-Resolving Storm Simulator with 1 km grid spacing was used to simulate the event, and it successfully reproduced the slow-moving rainbands, the embedded cells, and the dynamics of merger and back-building (BB) on 8 August as observed. Our model results suggest that the intense convection interacted strongly with the westerly LLJ that provided reversed vertical wind shear below and above the jet core. Inside mature cells, significant dynamical pressure perturbations (p'd) are induced with positive (negative) p'd at the western (eastern) flank of the updraft near the surface and a reversed pattern aloft (> 2 km). This configuration produced an upward-directed pressure gradient force (PGF) to the rear side and favors new development to the west, which further leads to cell merging as the mature cells slowdown in eastward propagation. The strong updrafts also acted to elevate the jet and enhance the local vertical wind shear at the rear flank. Additional analysis reveals that the upward PGF there is resulted mainly by the shearing effect but also by the extension of upward acceleration at low levels. In the horizontal, the upstream-directed PGF induced by the rear-side positive p'd near the surface is much smaller, but can provide additional convergence for BB development upstream. Finally, the cold-pool mechanism for BB appears to be not important in the Morakot case, as the conditions for strong evaporation in downdrafts do not exist.

Conventionally, acute myeloid leukemia (AML) patients are categorized into good-, intermediate- and poor-risk groups according to cytogenetic changes. However, patients with intermediate-risk cytogenetics represent a largely heterogeneous population regarding treatment response and clinical outcome. In this study, we integrated cytogenetics and molecular mutations in the analysis of 318 patients with de novo non-M3 AML who received standard chemotherapy. According to the mutation status of eight genes, including NPM1 , CEBPA , IDH2 , RUNX1 , WT1 , ASXL1 , DNMT3A and FLT3 , that had prognostic significance, 229 patients with intermediate-risk cytogenetics could be refinedly stratified into three groups with distinct prognosis ( P <0.001); patients with good-risk genotypes had a favorable outcome (overall survival, OS, not reached) similar to those with good-risk cytogenetics, whereas those with poor-risk genotypes had an unfavorable prognosis (OS, 10 months) similar to those with poor-risk cytogenetics (OS, 13.5 months), and the remaining patients with other genotypes had an intermediate outcome (OS, 25 months). Integration of cytogenetic and molecular profiling could thus reduce the number of intermediate-risk AML patients from around three-fourth to one-fourth. In conclusion, integration of cytogenetic and molecular changes improves the prognostic stratification of AML patients, especially those with intermediate-risk cytogenetics, and may lead to better decision on therapeutic strategy.

Background/Objectives: The prevalence of metabolic syndrome (MetS) and obesity has increased worldwide, as well as in Taiwan, particularly in women aged>40 years. The purpose of this study was to elucidate the effects of a calorie-restriction diet (CR) supplemented with protein and n-3 polyunsaturated fatty acids (PUFAs) on women with MetS. Subjects/Methods: A total of 143 eligible female participants were recruited and assigned to four dietary interventions such as 1500-kcal CR, calorie-restriction meal-replacement diet (CRMR), calorie-restriction diet with fish oil supplementation (CRF) and calorie-restriction meal-replacement diet with fish oil supplementation (CRMRF). The changes in anthropometric measures, metabolic profiles, inflammatory response and the Z-score of severity of MetS were evaluated. Results: Among 143 female MetS patients enrolled, 136 patients completed the 12-week study. After the 12-week dietary interventions, we observed reductions in body weight (BW), body mass index (BMI) and waist circumference (WC) in all groups. BMI and triglyceride (TG) levels decreased significantly in the CRMR, CRF and CRMRF groups, but not in the CR group. The homeostasis model assessment of insulin resistance (HOMA-IR) had significantly improved in all four groups, and the levels of interleukin-6 (IL-6) and C-reactive protein (CRP) had significantly decreased in the CRF and CRMRF groups. Following the interventions, the changes in waist circumference (WC), mean arterial pressure (MAP), fasting blood glucose (FBG), TGs, HOMA-IR, CRP and IL-6 significantly correlated with the reductions in Z-score of MetS severity. Conclusions: Our study results indicate that a calorie-restriction dietary intervention combined with various macronutrients can reduce the severity of MetS in women and increase recovery from MetS by almost twofold in comparison with a CR alone.

The Kolmogorov scaling in the inertial range of scales is a distinct characteristic of fully developed turbulence, and studying it offers valuable insights into the evolution of turbulence. In this work, we perform a statistical survey of the power spectra with the Kolmogorov scaling in Saturn's magnetosphere using Cassini measurements. Two cases study show that both magnetic‐field and electron density spectra exhibit f −5/3 at the MHD scales. The statistical analysis reveals a wide‐ranging and abundant presence of Kolmogorov spectra throughout magnetosphere, observed across all local times. Interestingly, the occurrence rate of these Kolmogorov‐like events within Saturn's magnetosphere surpasses that observed in the planetary magnetosheath. The measurements of magnetic compressibility for the Kolmogorov‐like events show the dominance of incompressible Alfvénic turbulence (44.64%) with respect to magnetosonic‐like one (6.94%). In addition, the source and evolution of the turbulent fluctuations are further discussed. Plain Language Summary Turbulence is ubiquitous in space and astrophysical plasmas, such as the solar wind, planetary magnetospheres, and the interstellar medium. Plasma turbulence has been widely studied in the solar wind and planetary magnetosheaths, but much less in the planetary magnetospheres. In the solar wind, power spectral density of the magnetic field fluctuations generally follows the so‐called Kolmogorov spectrum f −5/3 at the magnetohydrodynamic (MHD) scales, which suggests a fully developed turbulent state. In this study, we have discovered the widespread presence of Kolmogorov spectra in the Saturn's magnetosphere. The spatial distribution and nature of turbulent fluctuation for the Kolmogorov‐like events are also investigated in detail. Key Points Magnetic field and electron density spectra have Kolmogorov scaling of f −5/3 at MHD scales in Saturn's magnetosphere The spatial distribution of the Kolmogorov spectra within Saturn's magnetosphere reveals the extensive occurrence of Kolmogorov‐like events The fluctuations for Kolmogorov‐like events are dominated by Alfvénic modes (44.64%) with respect to magnetosonic‐like one (6.94%)