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"Huang, Shaoying"
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Analysis of proto-type Tarim Basin in the late Precambrian and the dynamic mechanism of its evolution
2023
Tarim Basin has undergone an intricate tectonic evolution history ever since its formation from two discrete terranes in Neoproterozoic rather than in the Paleoproterozoic. More precisely, the amalgamation is assumed to happen during 1.0–0.8 Ga based on plate affinity. As the beginning of a unified Tarim block, studies of Tarim Basin in the Precambrian are basic and important. After the amalgamation of south and north paleo-Tarim terranes, Tarim block was experiencing a complicated tectonic process of being affected by mantle plume related to the breakup of Rodinia supercontinent in the south, and compressed by the Circum-Rodinia Subduction System in the north. The breakup of Rodinia supercontinent finished in the late Sinian Period, leading Kudi Ocean and Altyn Ocean to open and separating Tarim block from itself. According to the residual strata thickness, drilling data, and lithofacies distribution, the proto-type basin and tectono-paleogeographic maps of Tarim Basin in the late Nanhua Period and Sinian Period are reconstructed. With these maps, the characteristics of the rifts are revealed. Two rift systems were developed inside the unified Tarim Basin in the Nanhua Period and Sinian Period, one back-arc rift system in the northern margin and the other aulacogen system in the southern margin. The azimuth distribution of the rifts in Quruqtagh showed a predominant NE-SW trend, and the rifts in Aksu trended mainly NW-SE, while the rifts in Tiekelike trended SW-NE. With a three-dimensional elastic FEM (Finite Element Method) model that includes all rifts and deposited areas in Tarim Basin, applying the southern subduction and northern mantle upwelling properly to get the paleotectonic mian stress axes and the differential stress field, the dynamic mechanisms of rifts evolution are proved to be related to the peripheral tectonic environment mentioned above.
Journal Article
Favorable QTLs from Oryza longistaminata improve rice drought resistance
2022
Background
Drought is the major abiotic stress to rice grain production under unpredictable changing climatic environments. Wild rice of
O. longistaminata
show diverse responses and strong tolerance to stress environments. In order to identify whether the
O. longistaminata
can improve the rice drought resistance or not, a BIL population of 143 BC
2
F
20
lines derived from the cross between the cultivar rice 9311 and
O. longistaminata
were assessed under stress of 20% PEG6000.
Results
In total, 28 QTLs related to drought resistance based on eight agronomic traits of seedlings were identified. Of which, thirteen QTLs including two QTLs for leaf drying, one QTL for leaf rolling, one QTL for leaf number, five QTLs for dry weight of root, two QTLs for dry weight of shoot, one QTL for maximum root length and two QTLs for maximum shoot length were derived from
O. longistaminata
. What’s more,
qDWR8.1
for dry weight of root was repeatedly detected and fine-mapped to an interval about 36.2 Kb. The unique allele of MH08g0242800 annotated as ATP-dependent Clp protease proteolytic subunit from
O. longistaminata
was suggested as the candidate gene for drought resistance. Further, six representative BIL lines were stably characterized showing significantly stronger drought resistance than 9311 based on principle component analysis, they each contained 2 ~ 5 QTLs including
qDWR8.1
from
O. longistaminata
.
Conclusions
Together, our results indicate that the QTLs from
O. longistaminata
can effectively enhance the drought tolerance of rice, showing great potential value in breeding of elite rice varieties, which will lay a novel insight into the genetic network for drought tolerance of rice.
Journal Article
Genetic mapping of the rice ionome in leaves and grain: identification of QTLs for 17 elements including arsenic, cadmium, iron and selenium
by
Price, Adam H.
,
Xiong, Lizhong
,
Meharg, Andrew A.
in
Agronomy. Soil science and plant productions
,
Alleles
,
Analysis
2010
Research into the composition of cereal grains is motivated by increased interest in food quality. Here multi-element analysis is conducted on leaves and grain of the Bala x Azucena rice mapping population grown in the field. Quantitative trait loci (QTLs) for the concentration of 17 elements were detected, revealing 36 QTLs for leaves and 41 for grains. Epistasis was detected for most elements. There was very little correlation between leaf and grain element concentrations. For selenium, lead, phosphorus and magnesium QTLs were detected in the same location for both tissues. In general, there were no major QTL clusters, suggesting separate regulation of each element. QTLs for grain iron, zinc, molybdenum and selenium are potential targets for marker assisted selection to improve seed nutritional quality. An epistatic interaction for grain arsenic also looks promising to decrease the concentration of this carcinogenic element.
Journal Article
Quantitative Trait Locus Mapping of Salt Tolerance in Wild Rice Oryza longistaminata
2022
Salt stress is one of the most severe adverse environments in rice production; increasing salinization is seriously endangering rice production around the world. In this study, a rice backcross inbred line (BIL) population derived from the cross of 9311 and wild rice Oryza longistaminata was employed to identify the favorable genetic loci of O. longistaminata for salt tolerance. A total of 27 quantitative trait loci (QTLs) related to salt tolerance were identified in 140 rice BILs, and 17 QTLs formed seven QTL clusters on different chromosomes, of which 18 QTLs were derived from O. longistaminata, and a QTL for salt injury score (SIS), water content of seedlings (WCS) under salt treatment, and relative water content of seedlings (RWCS) was repeatedly detected and colocalized at the same site on chromosome 2, and a cytochrome P450 86B1 (MH02t0466900) was suggested as the potential candidate gene responsible for the salt tolerance based on sequence and expression analysis. These findings laid the foundation for further improving rice salt tolerance through molecular breeding in the future.
Journal Article
EFFECT OF ARTIFICIAL INTELLIGENCE ON ONE-TO-ONE EMOTIONAL REGULATION AND PSYCHOLOGICAL INTERVENTION SYSTEM OF MIDDLE SCHOOL STUDENTS
2022
Abstract
Background
This study discusses the effectiveness of artificial intelligence in one-to-one psychological intervention system for middle school students. The purpose of this study is to determine whether middle school students have enough trust in AI machines, to explore their internal psychology, and to evaluate the intervention effect of AI in middle school students' one-to-one psychological intervention system.
Subjects and Methods
76 eighth grade students from two parallel classes in the same grade were randomly assigned to the same teacher. The research tools used include two sets of autonomic nerve detectors produced by South Korean medicore company and two sets of self-developed artificial intelligence one-to-one psychological intervention systems, including two artificial intelligence robots Xiaoxin and two emotional bracelets. 36 students in the intervention group received one-on-one intervention of artificial intelligence robot Xiaoxin, and t-test was conducted on physical stress, psychological stress, stress index, sympathetic nerve activity, stress resistance and average heart rate. Test participants can effectively alleviate psychological stress and prevent depression. The data showed that the DASS-21 comprehensive score of subjects participating in the test was 1.7 times that of subjects not participating in the test. In contrast, without participation, they are more likely to show depression, anxiety and stress, and tend to be passive in simple coping styles. The improved method can effectively alleviate the psychological pressure of employees and improve the ability to actively deal with pressure.
Results
Except for the four indexes of nerve stress and sympathetic nerve activity, P < 0.001. After the intervention, the average heart rate, physical stress and stress index decreased significantly, while the anti stress ability increased significantly. Statistical analysis shows that the one-to-one intervention of artificial intelligence robot Xiaoxin can effectively alleviate students' physical stress and stress index, and improve students' stress resistance. The intermediary effect analysis of emotional arousal found that the direct effect of anger on MCT fluency was significant, B = 3.80, P < 0.001, CI = [1.99, 5.62], and the indirect effect of arousal on MCT fluency was significant, B = 0.58, CI = [0.08, 1.66]; The direct effect of anger on MCT anger was significant, B = 6.08, P < 0.001, CI = [3.26, 8.89], and the indirect effect of arousal on MCT anger was significant, B = 0.80, CI = [0.08, 2.41]; The direct effect of anger on MCT harmfulness was significant, B = 0.42, P = 0.004, CI = [0.14, 0.69], and the indirect effect of arousal on MCT harmfulness was not significant, B = 0.03, CI = [− 0.03, 0.18]. The direct effect of anger on aut fluency was significant, B = 2.58, P = 0.032, CI = [0.23, 4.92], and the indirect effect of arousal on aut fluency was significant, B = 1.22, CI = [0.27, 2.62]); The direct effect of anger on aut novelty was significant, B = 4.60, P = 0.008, CI = [1.23, 7.96], and the indirect effect of arousal on aut novelty was significant, B = 1.79, CI = [0.42, 3.91] (see Figure 4D). The above results show that emotional arousal plays a partial mediating role in the influence of anger on the fluency and novelty of malicious creativity and general creativity, but it has no mediating role in the influence of anger on the harmfulness of malicious creativity.
Conclusion
Artificial intelligence one-to-one psychological intervention system is effective. Among the 38 students in the intervention group, this shows that most students have a high sense of trust in the artificial intelligence robot Xiaoxin. This sense of trust is enough to make the artificial intelligence one-to-one psychological intervention system play the role of psychological intervention. We should fully understand the important position of artificial intelligence robot in emotional factors, actively improve its role psychological ability, pay special attention to its impact on life attitude and healthy behavior, and be a healthy self-manager, coordinator and collaborator. According to the psychological characteristics of these groups, we should actively and flexibly organize colorful activities, strive to create a relaxed and harmonious living atmosphere, create a friendly and mutually beneficial emotional artificial intelligence relationship, encourage and guide these groups, adjust their psychology to the best state, and promote the healthy development of their good cognition and life.
Journal Article
Proteomic analysis of lysine 2-hydroxyisobutyryl in SLE reveals protein modification alteration in complement and coagulation cascades and platelet activation Pathways
by
Kuang, Chaoying
,
Liu, Fanna
,
Lin, Hua
in
2-Hydroxyisobutyrylation
,
Activation
,
Autoimmune diseases
2023
Background
Post-translational modifications (PTMs) are considered to be an important factor in the pathogenesis of Systemic lupus erythematosus (SLE). Lysine 2-hydroxyisobutyryl (Khib), as an emerging post-translational modification of proteins, is involved in some important biological metabolic activities. However, there are poor studies on its correlation with diseases, especially SLE.
Objective
We performed quantitative, comparative, and bioinformatic analysis of Khib proteins in Peripheral blood mononuclear cells (PBMCs) of SLE patients and PBMCs of healthy controls. Searching for pathways related to SLE disease progression and exploring the role of Khib in SLE.
Methods
Khib levels in SLE patients and healthy controls were compared based on liquid chromatography tandem mass spectrometry, then proteomic analysis was conducted.
Results
Compared with healthy controls, Khib in SLE patients was up-regulated at 865 sites of 416 proteins and down-regulated at 630 sites of 349 proteins. The site abundance, distribution and function of Khib protein were investigated further. Bioinformatics analysis showed that Complement and coagulation cascades and Platelet activation in immune-related pathways were significantly enriched, suggesting that differentially modified proteins among them may affect SLE.
Conclusion
Khib in PBMCs of SLE patients was significantly up- or down-regulated compared with healthy controls. Khib modification of key proteins in the Complement and coagulation cascades and Platelet activation pathways affects platelet activation and aggregation, coagulation functions in SLE patients. This result provides a new direction for the possible significance of Khib in the pathogenesis of SLE patients.
Journal Article
Evaluation of Fiber-Reinforced Modular Soft Actuators for Individualized Soft Rehabilitation Gloves
by
Wang, Yuanyuan
,
Tortós Vinocour, Pablo E.
,
Nishimura, Reiji
in
Actuators
,
Cartilage
,
Connectors
2022
Applying soft actuators to hand motion assist for rehabilitation has been receiving increasing interest in recent years. Pioneering research efforts have shown the feasibility of soft rehabilitation gloves (SRGs). However, one important and practical issue, the effects of users’ individual differences in finger size and joint stiffness on both bending performance (e.g., Range of motion (ROM) and torque) and the mechanical loads applied to finger joints when the actuators are placed on a patient’s hand, has not been well investigated. Moreover, the design considerations of SRGs for individual users, considering individual differences, have not been addressed. These, along with the inherent safety of soft actuators, should be investigated carefully before the practical use of SRGs. This work aimed to clarify the effects of individual differences on the actuator’s performance through a series of experiments using dummy fingers designed with individualized parameters. Two types of fiber-reinforced soft actuators, the modular type for assisting each joint and conventional (whole-finger assist) type, were designed and compared. It was found that the modular soft actuators respond better to individual differences set in the experiment and exhibit a superior performance to the conventional ones. By suitable connectors and air pressure, the modular soft actuators could cope with the individual differences with minimal effort. The effects of the individualized parameters are discussed, and design considerations are extracted and summarized. This study will play an important role in pushing forward the SRGs to real rehabilitation practice.
Journal Article
Towards an Extensive Thumb Assist: A Comparison between Whole-Finger and Modular Types of Soft Pneumatic Actuators
2022
Soft pneumatic actuators used in robotic rehabilitation gloves are classified into two types: whole-finger actuators with air chambers that cover the entire finger and modular actuators with chambers only above the finger joints. Most existing prototypes provide enough finger flexion support, but insufficient independent thumb abduction or opposition support. Even the latest modular soft actuator realized thumb abduction with a sacrifice of range of motion (RoM). Moreover, the advantages and disadvantages of using the two types of soft actuators for thumb assistance have not been made clear. Without an efficient thumb assist, patients’ options for hand function rehabilitation are very limited. Therefore, the objective of this study was to design a modular actuator (M-ACT) that could support multiple degrees of freedom, compare it with a whole-finger type of thumb actuator with three inner chambers (3C-ACT) in terms of the RoM, force output of thumb flexion, and abduction, and use an enhanced Kapandji test to measure both the kinematic aspect of the thumb (Kapandji score) and thumb-tip pinch force. Our results indicated superior single-DoF support capability of the M-ACT and superior multi-DoF support capability of the 3C-ACT. The use of the 3C-ACT as the thumb actuator and the M-ACT as the four-finger actuator may be the optimal solution for the soft robotic glove. This study will aid in the progression of soft robotic gloves for hand rehabilitation towards real rehabilitation practice.
Journal Article