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The rise of antimicrobial-resistant bacterial infections is a crucial health concern in the 21st century. In particular, antibiotic-resistant Pseudomonas aeruginosa causes difficult-to-treat infections associated with high morbidity and mortality. Unfortunately, the number of effective therapeutic interventions against antimicrobial-resistant P. aeruginosa infections continues to decline. Therefore, discovery and development of alternative treatments are necessary. Here, we present pre-clinical efficacy studies on an anti- P. aeruginosa therapeutic monoclonal antibody. Using hybridoma technology, we generated a monoclonal antibody and characterized its binding to P. aeruginosa in vitro using ELISA and fluorescence correlation spectroscopy. We also characterized its function in vitro and in vivo against P. aeruginosa . The anti- P. aeruginosa antibody (WVDC-5244) bound P. aeruginosa clinical strains of various serotypes in vitro , even in the presence of alginate exopolysaccharide. In addition, WVDC-5244 induced opsonophagocytic killing of P. aeruginosa in vitro in J774.1 murine macrophage, and complement-mediated killing. In a mouse model of acute pneumonia, prophylactic administration of WVDC-5244 resulted in an improvement of clinical disease manifestations and reduction of P. aeruginosa burden in the respiratory tract compared to the control groups. This study provides promising pre-clinical efficacy data on a new monoclonal antibody with therapeutic potential for P. aeruginosa infections.

Level III (Grades 11-13) The hm Learning and Study Skills Program: Level III was designed to provide an introduction to learning and study skills for high school juniors and seniors and beginning college students through a series of activity-oriented units.

High school students, whether preparing for college or career, need to learn greater independence and efficiency in their learning. Rather than simply teach them how to study, the hm Program emphasizes the need to understand their learning style, empowering them to adapt to new situations throughout their lives. They will learn how to improve their memory, glean more from discussions, prepare for exams, expand their vocabulary, and more. A Teacher's Guide is also available. See complete information at https://rowman.com/ISBN/9781475821635.

Level III (Grades 11-13) The hm Learning and Study Skills Program: Level III was designed to provide an introduction to learning and study skills for high school juniors and seniors and beginning college students through a series of activity-oriented units. It is structured on the assumption that an activity-oriented lesson is the most effective instructional strategy for the teaching of study skills: more succinctly, that \"learning by doing\" is the best way \"study smart.\"Learning and study skills are important for learning. They are methods and ways of doing things that help make learning easier. Understanding how to study can also facilitate learning by assisting students as they complete assignments correctly and efficiently during a specified period of time. Just like any other skill, knowing how to learn and study proficiently must be learned and practiced over time. The Program has been designed to help students learn more efficiently and effectively.

Level III (Grades 11-13) The hm Learning and Study Skills Program: Level III was designed to provide an introduction to learning and study skills for high school juniors and seniors and beginning college students through a series of activity-oriented units. It is structured on the assumption that an activity-oriented lesson is the most effective instructional strategy for the teaching of study skills: more succinctly, that \"learning by doing\" is the best way \"study smart.\" Learning and study skills are important for learning. They are methods and ways of doing things that help make learning easier. Understanding how to study can also facilitate learning by assisting students as they complete assignments correctly and efficiently during a specified period of time. Just like any other skill, knowing how to learn and study proficiently must be learned and practiced over time. The Program has been designed to help students learn more efficiently and effectively.

Level III (Grades 11-13) The hm Learning and Study Skills Program: Level III was designed to provide an introduction to learning and study skills for high school juniors and seniors and beginning college students through a series of activity-oriented units.

The superintendent's role has shifted from one that was primarily focused on management, to one that now includes more accountability, student achievement, and instructional leadership functions along with management. For many districts, evaluation procedures of the chief executive have not kept pace with this movement; consequently, an updated state recommended evaluation tool is long overdue. The Missouri Department of Elementary and Secondary Education (MDESE) established an ad hoc committee, which will be referred to as the state committee for the remainder of this project, to review and revise the 1986 version of the Performance Based Superintendent Evaluation (PBSE), and proposed an updated instrument aligned with national standards. Upon adoption, it would replace the 1986 model, currently endorsed by MDESE. Under Missouri statute, MDESE is required to provide suggested guidelines for an evaluation instrument. After conducting surveys and interviews with school board members and superintendents who piloted a draft of the proposed PBSE, the learning team analyzed and developed recommendations for review and revision by the state committee. Further, the learning team developed a model implementation plan of the proposed PBSE instrument for potential use by Missouri school boards. The final goal is the adoption and implementation of a new PBSE by MDESE to replace the 1986 model. The proposed PBSE will address accountability standards, the increased focus on student achievement, and the changing role of the superintendent as the instructional leader of a school district.

The superintendent's role has shifted from one that was primarily focused on management, to one that now includes more accountability, student achievement, and instructional leadership functions along with management. For many districts, evaluation procedures of the chief executive have not kept pace with this movement; consequently, an updated state recommended evaluation tool is long overdue. The Missouri Department of Elementary and Secondary Education (MDESE) established an ad hoc committee, which will be referred to as the state committee for the remainder of this project, to review and revise the 1986 version of the Performance Based Superintendent Evaluation (PBSE), and proposed an updated instrument aligned with national standards. Upon adoption, it would replace the 1986 model, currently endorsed by MDESE. Under Missouri statute, MDESE is required to provide suggested guidelines for an evaluation instrument. After conducting surveys and interviews with school board members and superintendents who piloted a draft of the proposed PBSE, the learning team analyzed and developed recommendations for review and revision by the state committee. Further, the learning team developed a model implementation plan of the proposed PBSE instrument for potential use by Missouri school boards. The final goal is the adoption and implementation of a new PBSE by MDESE to replace the 1986 model. The proposed PBSE will address accountability standards, the increased focus on student achievement, and the changing role of the superintendent as the instructional leader of a school district.

The superintendent’s role has shifted from one that was primarily focused on management, to one that now includes more accountability, student achievement, and instructional leadership functions along with management. For many districts, evaluation procedures of the chief executive have not kept pace with this movement; consequently, an updated state recommended evaluation tool is long overdue. The Missouri Department of Elementary and Secondary Education (MDESE) established an ad hoc committee, which will be referred to as the state committee for the remainder of this project, to review and revise the 1986 version of the Performance Based Superintendent Evaluation (PBSE), and proposed an updated instrument aligned with national standards. Upon adoption, it would replace the 1986 model, currently endorsed by MDESE. Under Missouri statute, MDESE is required to provide suggested guidelines for an evaluation instrument. After conducting surveys and interviews with school board members and superintendents who piloted a draft of the proposed PBSE, the learning team analyzed and developed recommendations for review and revision by the state committee. Further, the learning team developed a model implementation plan of the proposed PBSE instrument for potential use by Missouri school boards. The final goal is the adoption and implementation of a new PBSE by MDESE to replace the 1986 model. The proposed PBSE will address accountability standards, the increased focus on student achievement, and the changing role of the superintendent as the instructional leader of a school district.