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Climate change brings an increase in temperatures and a higher frequency of heatwaves. Both have been linked to a rise in suicide rates and violent crime on a population level. However, little is known about the link between mental health and ambient temperatures on an individual level and for particular subgroups. Overheating poses health risks to children and disturbs sleep; leading to the expectation that parents are more worried about their homes getting too hot than non-parents. Two online survey studies (N = 1000 each) were conducted in the UK and the US to understand to what extent parents and an age-matched comparison group without children are worried about overheating and how they differ in their mitigation actions. Findings did not support the main hypotheses around greater overheating worry amongst parents in general, mothers or those with very young children. However, parents indicated a greater likelihood to upgrade or install air-conditioning (US) and to get electric fans (UK). Parents in the UK indicated using more mitigation options to cope with overheating than non-parents. Parents in the US, whilst not reporting doing more actions, were more likely to use air-conditioning to deal with overheating than non-parents. Finally, those parents who mentioned health impacts on children as a reason for worry about overheating, were more concerned about overheating than parents who had other reasons than children’s health as a reason for being concerned about overheating. In summary, parental status might have implications for cooling energy use and concern for children’s health might increase overheating worry; however, many open questions remain.

Climate change brings an increase in temperatures and a higher frequency of heatwaves. Both have been linked to a rise in suicide rates and violent crime on a population level. However, little is known about the link between mental health and ambient temperatures on an individual level and for particular subgroups. Overheating poses health risks to children and disturbs sleep; leading to the expectation that parents are more worried about their homes getting too hot than non-parents. Two online survey studies (N = 1000 each) were conducted in the UK and the US to understand to what extent parents and an age-matched comparison group without children are worried about overheating and how they differ in their mitigation actions. Findings did not support the main hypotheses around greater overheating worry amongst parents in general, mothers or those with very young children. However, parents indicated a greater likelihood to upgrade or install air-conditioning (US) and to get electric fans (UK). Parents in the UK indicated using more mitigation options to cope with overheating than non-parents. Parents in the US, whilst not reporting doing more actions, were more likely to use air-conditioning to deal with overheating than non-parents. Finally, those parents who mentioned health impacts on children as a reason for worry about overheating, were more concerned about overheating than parents who had other reasons than children's health as a reason for being concerned about overheating. In summary, parental status might have implications for cooling energy use and concern for children's health might increase overheating worry; however, many open questions remain.

The winter of 2022/23 has seen large increases in energy prices and in the cost of living in many countries around the world, including Great Britain. Here, we report the results of two surveys, combining cross-sectional and longitudinal analysis, in a sample of about 5400 British households. One survey was conducted early in 2023, the other when participants had signed up to an ongoing research study in the past five years. Thermostat settings were about 1°C lower during the cost-of-living crisis than before, and householders were more likely to turn the heating off when the home was unoccupied. The effort to save energy increased compared to pre-cost-of-living-crisis levels. Using the in-home display more in the cost-of-living crisis than before correlated with greater effort to save energy, supporting the notion that displaying energy data can be a useful tool for energy reductions. Finding it difficult to keep comfortably warm in the home and struggling with meeting heating costs were linked to lower wellbeing, strengthening evidence links between cold, damp, and hard-to-heat homes and negative mental health outcomes. About 40% of respondents lowered the flow temperature of the boiler which might imply that highly tailored information campaigns can be effective in changing behaviour.

Lesbian, gay, bisexual, and transgender (LGBT) adolescents are at increased risk for substance use, relative to their heterosexual counterparts. Although previous research has demonstrated that experiences of anti-LGBT harassment, discrimination, and victimization may explain some of this disparity, little is known about the mechanisms whereby such mistreatment leads to substance abuse. This study aimed to examine whether mechanisms suggested by the Social Development Model might explain the links between school-based victimization and substance use in this population. Five hundred and four ethnically diverse LGBT adolescents ages 14–19 reported their experiences with school victimization, substance abuse, school bonding, and deviant peer group affiliation. Anti-LGBT victimization in school was associated with substance abuse, and although causality cannot be established, structural equation modeling confirmed that the data are consistent with a theoretical model in which this association was mediated by increased affiliation with deviant peers. Preventive interventions for LGBT adolescents must not only attempt to make schools safer for these youth, but also help keep them engaged in healthy peer groups when they are confronted with mistreatment in school.

Investigations in Ferguson, Missouri, revealed that many individuals, particularly Black people, entered the criminal justice system for relatively minor offenses, missed court appearances, or failure to pay fines. Municipal courts were focused on revenue generation, which led to aggressive enforcement of municipal codes. Although subsequent reforms were passed, little is known about whether and how the legislative changes influenced the law-in-action in the municipal courts. Using data from qualitative interviews with St. Louis area residents and regional court actors, as well as court observations, this article documents the legal structure of municipal courts in the region after Ferguson. We address how the parochial nature of municipal courts in St. Louis County perpetuates the financial marginalization of residents through the layering of punishment, and how the state legal structure further facilitates control, even after reform.

Fossil fuels dominate domestic heating in temperate climates. In the EU, domestic space heating accounts for around 20% of final energy demand. Reducing domestic demand temperatures would reduce energy demand. However, cold exposure has been shown to be associated with adverse health conditions. Using an observational dataset of 77,762 UK Biobank participants, we examine the standard deviation of experienced temperature (named here thermal variety) measured by a wrist worn activity and temperature monitor. After controlling for covariates such as age, activity level and obesity, we show that thermal variety is 0.15°C 95% CI [0.07-0.23] higher for participants whose health satisfaction was 'extremely happy' compared to 'extremely unhappy'. Higher thermal variety is also associated with a lower risk of having morbidities related to excess winter deaths. We argue that significant CO2 savings would be made by increasing thermal variety and reducing domestic demand temperatures in the healthiest homes. However, great care is needed to avoid secondary health impacts due to mould and damp. Vulnerable households should receive increased attention.

Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 and EBNA 3A/B/C latency genes and the ability to transform B cells in vitro. While most T1 EBV strains contain the \"prototype\" form of the BZLF1 immediate-early promoter (\"Zp-P\"), all T2 strains contain the \"Zp-V3\" variant, which contains an NFAT binding motif and is activated much more strongly by B-cell receptor signalling. Whether B cells infected with T2 EBV are more lytic than cells infected with T1 EBV is unknown. Here we show that B cells infected with T2 EBV strains (AG876 and BL5) have much more lytic protein expression compared to B cells infected with T1 EBV strains (M81, Akata, and Mutu) in both a cord blood-humanized (CBH) mouse model and EBV-transformed lymphoblastoid cell lines (LCLs). Although T2 LCLs grow more slowly than T1 LCLs, both EBV types induce B-cell lymphomas in CBH mice. T1 EBV strains (M81 and Akata) containing Zp-V3 are less lytic than T2 EBV strains, suggesting that Zp-V3 is not sufficient to confer a lytic phenotype. Instead, we find that T2 LCLs express much higher levels of activated NFATc1 and NFATc2, and that cyclosporine (an NFAT inhibitor) and knockdown of NFATc2 attenuate constitutive lytic infection in T2 LCLs. Both NFATc1 and NFATc2 induce lytic EBV gene expression when combined with activated CAMKIV (which is activated by calcium signaling and activates MEF2D) in Burkitt Akata cells. Together, these results suggest that B cells infected with T2 EBV are more lytic due to increased activity of the cellular NFATc1/c2 transcription factors in addition to the universal presence of the Zp-V3 form of BZLF1 promoter.

During the COVID-19 pandemic, a significant number of healthcare workers have been infected with SARS-CoV-2. However, there remains little knowledge regarding large droplet dissemination during airway management procedures in real life settings. 12 different airway management procedures were investigated during routine clinical care. A high-speed video camera (1000 frames/second) was for imaging. Quantitative droplet characteristics as size, distance traveled, and velocity were computed. Droplets were detected in 8/12 procedures. The droplet trajectories could be divided into two distinctive patterns (type 1/2). Type 1 represented a ballistic trajectory with higher speed large droplets whereas type 2 represented a random trajectory of slower particles that persisted longer in air. The use of tracheal cannula filters reduced the amount of droplets. Respiratory droplet patterns generated during airway management procedures follow two distinctive trajectories based on the influence of aerodynamic forces. Speaking and coughing produce more droplets than non-invasive ventilation therapy confirming these behaviors as exposure risks. Even large droplets may exhibit patterns resembling the fluid dynamics smaller airborne aerosols that follow the airflow convectively and may place the healthcare provider at risk.

Objectives. We examined the 6-month cumulative incidence of anti-gay harassment, discrimination, and violence among young gay/bisexual men and documented their associations with mental health. Methods. Gay/bisexual men from 3 cities in the southwestern United States completed self-administered questionnaires. Results. Thirty-seven percent of men reported experiencing anti-gay verbal harassment in the previous 6 months; 11.2% reported discrimination, and 4.8% reported physical violence. Men were more likely to report these experiences if they were younger, were more open in disclosing their sexual orientation to others, and were HIV positive. Reports of mistreatment were associated with lower self-esteem and increased suicidal ideation. Conclusions. Absent policies preventing anti-gay mistreatment, empowerment and community-building programs are needed for young gay/bisexual men to both create safe social settings and help them cope with the psychological effects of these events.

Probation is the most commonly imposed correctional sanction, is often accompanied by supplementary costs, and can be operated by the state or private companies. Private probation is a unique sanction used in lower courts, most often for misdemeanor offenses, and is managed by third-party actors. We focus on documenting the process and unique costs of private probation, including the rituals of compliance and proportionality of punishment. We use data from interviews with individuals on private probation and local criminal justice officials as well as evidence from court ethnographies in Georgia and Missouri. For individuals on private probation, payment of monetary sanctions is a crucial way of demonstrating compliance. Yet the financial burden of added costs for supervision and monitoring creates substantial challenges.