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Pedestrian detection from a drone-based images has many potential applications such as searching for missing persons, surveillance of illegal immigrants, and monitoring of critical infrastructure. However, it is considered as a very challenge computer vision problem due to the variations in camera point of view, distance from pedestrian, changes in illuminations and weather conditions, variation in the surrounding objects, as well as present of human-like objects. Recently, deep learning-based models are getting more attention, and they have proven a great success in many object detection problems such as the detection of faces, breast masses, and vehicles. As such, this work aims to develop a deep learning-based model that will be applied for the problem of pedestrian detection from a drone-based images. Particularly, faster region-based convolutional neural network (Faster R-CNN) will be used to search for the present of a pedestrian inside the captured drone-based images. To assess the performances, a total of 1500 images were collected by S30W drone and these images were captured at different places, with various views and weather conditions, and at daytime and night-time. Results show that Faster R-CNN was able to achieve a promising result with 98% precision, 99% recall, and 98% F 1 measure. Further analysis has been conducted by comparing the outcomes of Faster R-CNN with YOLO deep model on UAV123 publicly available dataset. The reported results indicated that both detection models almost reported very similar results.