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Racial segregation remains a persistent problem in U.S. schools. In this article, we examine how social psychological factors—in particular, individuals' perceptions of schools with varying demographic characteristics—may contribute to the ongoing structural problem of school segregation. We investigate the effects of school racial composition and several nonracial school characteristics on white parents' school enrollment decisions for their children as well as how racial stereotypes shape the school choice process. We use data from a survey-based experiment we designed to test \"pure race\" and \"racial proxy\" hypotheses regarding parents' enrollment preferences. We also use a measure of pro-white stereotype bias, both alone and in combination with school racial composition (percentage black). Using logistic regression analysis, we find support for the \"pure race\" hypothesis. The proportion of black students in a hypothetical school has a consistent and significant inverse association with the likelihood of white parents enrolling their children in that school net of the effects of the included racial proxy measures. In addition, higher levels of pro-white stereotype bias further inhibit enrollment, particularly in schools with higher proportions of black students. We discuss the implications of this research for policies aimed at mitigating racial segregation in U.S. schools.

Do African Americans, Hispanics, and non-Hispanic whites differ in their explanations of the socioeconomic divide separating blacks and whites in the United States? Have such explanations changed over time? To answer these questions, I use data from the 1977 to 2004 General Social Surveys (GSS) to map race/ethnic differences in support for, trends in, and the determinants of seven \"modes of explanation\" for blacks' disadvantage. Trends over time indicate the continuation of a long-standing decline in non-Hispanic whites' use of an ability-based (innate inferiority) explanation. Non-Hispanic whites' beliefs in a purely motivational and a purely educational explanation are increasing, however, along with the view that none of the explanations offered in the GSS explain blacks' disadvantage. African Americans and Hispanics also evidence increases in a purely motivational explanation, but they differ from non-Hispanic whites in demonstrating clear declines in structural beliefs-especially the perception that discrimination explains blacks' lower socioeconomic status. These conservative shifts in blacks' and Hispanics' beliefs result in greater similarity with non-Hispanic whites over time. Notably, however, significant \"static\" race/ethnic group differences remain: non-Hispanic whites score highest, and blacks lowest, on a purely motivational explanation, while African Americans are more likely than both non-Hispanic whites and Hispanics to endorse a discrimination-based explanation. I conclude by discussing the implications of these findings for racial policy support.

Wound healing is a highly coordinated spatiotemporal sequence of events involving several cell types and tissues. The process of wound healing requires strict regulation, and its disruption can lead to the formation of chronic wounds, which can have a significant impact on an individual’s health as well as on worldwide healthcare expenditure. One essential aspect within the cellular and molecular regulation of wound healing pathogenesis is that of reactive oxygen species (ROS) and oxidative stress. Wounding significantly elevates levels of ROS, and an array of various reactive species are involved in modulating the wound healing process, such as through antimicrobial activities and signal transduction. However, as in many pathologies, ROS play an antagonistic pleiotropic role in wound healing, and can be a pathogenic factor in the formation of chronic wounds. Whilst advances in targeting ROS and oxidative stress have led to the development of novel pre-clinical therapeutic methods, due to the complex nature of ROS in wound healing, gaps in knowledge remain concerning the specific cellular and molecular functions of ROS in wound healing. In this review, we highlight current knowledge of these functions, and discuss the potential future direction of new studies, and how these pathways may be targeted in future pre-clinical studies. This review highlights the cellular and molecular mechanisms in which ROS are involved in normal wound healing and chronic wound pathogenesis, as well as recent advances in therapeutic methods.

Ferromagnetic materials have been utilized as recording media in data storage devices for many decades. The confinement of a material to a two-dimensional plane is a significant bottleneck in achieving ultra-high recording densities, and this has led to the proposition of three-dimensional （3D） racetrack memories that utilize domain wall propagation along the nanowires. However, the fabrication of 3D magnetic nanostructures of complex geometries is highly challenging and is not easily achieved with standard lithography techniques. Here, we demonstrate a new approach to construct 3D magnetic nanostructures of complex geometries using a combination of two-photon lithography and electrochemical deposition. The magnetic properties are found to be intimately related to the 3D geometry of the structure, and magnetic imaging experiments provide evidence of domain wall pinning at the 3D nanostructured junction.

The issue of reparations to the descendants of persons enslaved in the United States is receiving increasing attention in both the public sphere (e.g., 2020 Presidential campaigns) and in academic circles. However, the term “reparations” often goes undefined in such discussions, despite the fact that different types of government action (e.g., an apology versus financial payments) are associated with varying levels of public opposition (or support). We also know little about how attitudes toward reparations explicitly targeting the consequences of slavery differ from attitudes toward more generic race-targeted policies. Drawing on data from an online survey of white Americans conducted in 2016, we examine how levels of opposition to a range of different race-targeted government actions varies by (1) the type and aims of the intervention, and (2) whites’ social locations and political orientations. Regarding policy type, whites are least opposed to selected symbolic reparations (e.g., a memorial to enslaved persons) and to policies designed to ensure “fair treatment” of black Americans in the workplace. Whites are most opposed to reparations in the form of direct financial payments to black Americans and to policies involving “preferential treatment” of blacks in the workplace. In addition, whites who are older, more conservative, and who view race relations as unimportant are most opposed to the reparations and other race-based policies we examine. We conclude with suggestions for future work on this timely topic.

Autonomous AI for diabetic eye examination is among the most validated and trusted medical AI systems, supported by extensive real-world evidence demonstrating safety, efficacy, improved outcomes, increased productivity, and cost savings. Yet its adoption remains limited. In contrast, commercially available off-the-shelf generative AI models (OTSAIs) are being rapidly tested in medical settings despite a lack of such real-world validation. These models have shown strong performance on medical reasoning tasks, prompting interest in their potential for clinical deployment. We evaluated four OTSAIs—GPT-4o and GPT-4o-mini (OpenAI, San Francisco, CA), Grok (xAI, San Francisco, CA), and Gemini (Google, Mountain View, CA)—on a specific diagnostic task: diabetic eye examination. The OTSAIs were bundled to ensure consistency, and performance was assessed using a level 3 reference standard, the publicly available Messidor-2 dataset. GPT-4o achieved the highest area under the receiver operator characteristic curve (AUC), 0.83. Grok achieved 0.63, and AUC was not calculable for Gemini. The AUC of retina specialists on the same task was estimated at 0.94, so the emergent performance of OTSAIs does not match that of clinical experts, nor does it approach FDA endpoints for consideration as a medical device. Nevertheless, as the performance of these OTSAIs approaches theoretical limits in the future, there might be a regulatory path through task-specific licensing by State Medical Boards for specific clinical tasks. This path may be modeled after licensing for physician assistants, where trust in the bundled OTSAI, to be used in an assistive fashion, is achieved through rigorous validation for safety and efficacy according to widely accepted regulatory considerations for both patient-facing AI, as well as for SaMD processes.

Mitochondria are intracellular organelles that play a critical role in numerous cellular processes including the regulation of metabolism, cellular stress response, and cell fate. Mitochondria themselves are subject to well-orchestrated regulation in order to maintain organelle and cellular homeostasis. Wound healing is a multifactorial process that involves the stringent regulation of several cell types and cellular processes. In the event of dysregulated wound healing, hard-to-heal chronic wounds form and can place a significant burden on healthcare systems. Importantly, treatment options remain limited owing to the multifactorial nature of chronic wound pathogenesis. One area that has received more attention in recent years is the role of mitochondria in wound healing. With regards to this, current literature has demonstrated an important role for mitochondria in several areas of wound healing and chronic wound pathogenesis including metabolism, apoptosis, and redox signalling. Additionally, the influence of mitochondrial dynamics and mitophagy has also been investigated. However, few studies have utilised patient tissue when studying mitochondria in wound healing, instead using various animal models. In this review we dissect the current knowledge of the role of mitochondria in wound healing and discuss how future research can potentially aid in the progression of wound healing research.

Three-dimensional nanostructured magnetic materials have recently been the topic of intense interest since they provide access to a host of new physical phenomena. Examples include new spin textures that exhibit topological protection, magnetochiral effects and novel ultrafast magnetic phenomena such as the spin-Cherenkov effect. Two-photon lithography is a powerful methodology that is capable of realising 3D polymer nanostructures on the scale of 100 nm. Combining this with postprocessing and deposition methodologies allows 3D magnetic nanostructures of arbitrary geometry to be produced. In this article, the physics of two-photon lithography is first detailed, before reviewing the studies to date that have exploited this fabrication route. The article then moves on to consider how non-linear optical techniques and post-processing solutions can be used to realise structures with a feature size below 100 nm, before comparing two-photon lithography with other direct write methodologies and providing a discussion on future developments.

Research conducted following natural disasters such as earthquakes, floods or hurricanes is crucial for improving relief interventions. Such research, however, poses ethical, methodological and logistical challenges for researchers. Oversight of disaster research also poses challenges for research ethics committees (RECs), in part due to the rapid turnaround needed to initiate research after a disaster. Currently, there is limited knowledge available about how RECs respond to and appraise disaster research. To address this knowledge gap, we investigated the experiences of REC members who had reviewed disaster research conducted in low- or middle-income countries. We used interpretive description methodology and conducted in-depth interviews with 15 respondents. Respondents were chairs, members, advisors, or coordinators from 13 RECs, including RECs affiliated with universities, governments, international organizations, a for-profit REC, and an ad hoc committee established during a disaster. Interviews were analyzed inductively using constant comparative techniques. Through this process, three elements were identified as characterizing effective and high-quality review: timeliness, responsiveness and rigorousness. To ensure timeliness, many RECs rely on adaptations of review procedures for urgent protocols. Respondents emphasized that responsive review requires awareness of and sensitivity to the particularities of disaster settings and disaster research. Rigorous review was linked with providing careful assessment of ethical considerations related to the research, as well as ensuring independence of the review process. Both the frequency of disasters and the conduct of disaster research are on the rise. Ensuring effective and high quality review of disaster research is crucial, yet challenges, including time pressures for urgent protocols, exist for achieving this goal. Adapting standard REC procedures may be necessary. However, steps should be taken to ensure that ethics review of disaster research remains diligent and thorough.

We utilize original survey data to examine factors influencing parental assessment of schools. When asked a series of questions about their evaluation of hypothetical schools in a survey experiment, respondents were given the option to select “don’t know” and explain in their own words what additional information they would want to know about the school in order to make their decision. Respondents were especially likely to answer “don’t know” in response to a question about school safety. We explore patterns of “don’t know” responses through analysis of the open-ended answers that respondents provided. Rather than focusing solely on school characteristics, open-ended responses reveal that parents tend to worry about crime and safety issues in the neighborhoods surrounding schools. We discuss the implications of these findings for education policy, school practice, and education research methods.