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Integration of energy crops into agricultural landscapes could promote sustainability if they are placed in ways that foster multiple ecosystem services and mitigate ecosystem disservices from existing crops. We conducted a modeling study to investigate how replacing annual energy crops with perennial energy crops along Wisconsin waterways could affect a variety of provisioning and regulating ecosystem services. We found that a switch from continuous corn production to perennial-grass production decreased annual income provisioning by 75%, although it increased annual energy provisioning by 33%, decreased annual phosphorous loading to surface water by 29%, increased below-ground carbon sequestration by 30%, decreased annual nitrous oxide emissions by 84%, increased an index of pollinator abundance by an average of 11%, and increased an index of biocontrol potential by an average of 6%. We expressed the tradeoffs between income provisioning and other ecosystem services as benefit-cost ratios. Benefit-cost ratios averaged 12.06 GJ of additional net energy, 0.84 kg of avoided phosphorus pollution, 18.97 Mg of sequestered carbon, and 1.99 kg of avoided nitrous oxide emissions for every $1,000 reduction in income. These ratios varied spatially, from 2- to 70-fold depending on the ecosystem service. Benefit-cost ratios for different ecosystem services were generally correlated within watersheds, suggesting the presence of hotspots--watersheds where increases in multiple ecosystem services would come at lower-than-average opportunity costs. When assessing the monetary value of ecosystem services relative to existing conservation programs and environmental markets, the overall value of enhanced services associated with adoption of perennial energy crops was far lower than the opportunity cost. However, when we monitized services using estimates for the social costs of pollution, the value of enhanced services far exceeded the opportunity cost. This disparity between recoverable costs and social value represents a fundamental challenge to expansion of perennial energy crops and sustainable agricultural landscapes.

The global food system is essential for the health and wellbeing of society, but is also a major cause of environmental damage. Some impacts, such as on climate change, have been the subject of intense recent inquiry, but others, such as on air quality, are not as well understood. Here, we systematically synthesize the literature to identify the impacts on ambient PM2.5 (particulate matter with diameter ⩽2.5 μm), which is the strongest contributor to premature mortality from exposure to air pollution. Our analysis indicates that the life-cycle of the global food system (pre-production, production, post-production, consumption and waste management) accounts for 58% of anthropogenic, global emissions of primary PM2.5, 72% of ammonia (NH3), 13% of nitrogen oxides (NO x ), 9% of sulfur dioxide (SO2), and 19% of non-methane volatile organic compounds (NMVOC). These emissions result in at least 890 000 ambient PM2.5-related deaths, which is equivalent to 23% of ambient PM2.5-related deaths reported in the Global Burden of Disease Study 2015. Predominant contributors include livestock and crop production, which contribute >50% of food-related NH3 emissions, and land-use change and waste burning, which contribute up to 95% of food-related primary PM2.5 emissions. These findings are largely underestimated given the paucity of data from the post-production and consumption stages, total underestimates in NH3 emissions, lack of sector-scale analysis of PM2.5-related deaths in South America and Africa, and uncertainties in integrated exposure-response functions. In addition, we identify mitigation opportunities—including shifts in food demand, changes in agricultural practices, the adoption of clean and low-energy technologies, and policy actions—that can facilitate meeting food demand with minimal PM2.5 impacts. Further research is required to resolve sectoral-scale, region-specific contributions to PM2.5-related deaths, and assess the efficiency of mitigation strategies. Our review is positioned to inform stakeholders, including scientists, engineers, policymakers, farmers and the public, of the health impacts of reduced air quality resulting from the global food system.

Meeting society's energy needs through bioenergy feedstock production presents a significant and urgent challenge, as it can aid in achieving energy independence goals and mitigating climate change. With federal biofuel production standards to be met within the next decade, and with no commercial scale production or markets currently in place, many questions regarding the sustainability and social feasibility of bioenergy still persist. Clarifying these uncertainties requires the incorporation of biogeochemical, biophysical, and socioeconomic modeling tools. Chapter 2 validated the biogeochemical cycling model AGRO-BGC by comparing model estimates with empirical observations from corn and perennial C 4 grass systems across Wisconsin and Illinois. AGRO-BGC, in its first application to an annual cropping system, was found to be a robust model for simulating carbon dynamics of an annual cropping system. Chapter 3 investigated the long-term implications of bioenergy feedstock harvest on soil productivity and erosion in annual corn and perennial switchgrass agroecosystems using AGRO-BGC and the soil erosion model RUSLE2. Modeling environments included biophysical landscape characteristics and management practices of bioenergy feedstock production systems. This study found that intensifying aboveground residue harvest reduces soil productivity over time, and the magnitude of these losses is greater in corn than in switchgrass systems. Results of this study will aid in the design of sustainable bioenergy feedstock management practices. Chapter 4 provided evidence that combining biophysical crop canopy characteristics with satellite-derived vegetation indices offers suitable estimates of crop canopy phenology for corn and soybeans in Southwest Wisconsin farms. LANDSAT based vegetation indices, when combined with a light use efficiency model, provide yield estimates in agreement with farmer reports, providing an efficient and accurate means of estimating crop yields from satellite data. The most important stakeholder in bioenergy sustainability and feasibility research is the farmer. Chapter 5 identified and measured the influence of bioenergy feedstock choice drivers using logistic regression choice models constructed from survey and geospatial data. The strongest choice drivers among farmers willing to participate in a proposed bioenergy feedstock production program included socioeconomic, biophysical, and environmental attitudes. Outcomes of this research will be useful in designing further bioenergy policy and economic incentives.

Integration of energy crops into agricultural landscapes could promote sustainability if they are placed in ways that foster multiple ecosystem services and mitigate ecosystem disservices from existing crops. We conducted a modeling study to investigate how replacing annual energy crops with perennial energy crops along Wisconsin waterways could affect a variety of provisioning and regulating ecosystem services. We found that a switch from continuous corn production to perennial-grass production decreased annual income provisioning by 75%, although it increased annual energy provisioning by 33%, decreased annual phosphorous loading to surface water by 29%, increased below-ground carbon sequestration by 30%, decreased annual nitrous oxide emissions by 84%, increased an index of pollinator abundance by an average of 11%, and increased an index of biocontrol potential by an average of 6%. We expressed the tradeoffs between income provisioning and other ecosystem services as benefit-cost ratios. Benefit-cost ratios averaged 12.06 GJ of additional net energy, 0.84 kg of avoided phosphorus pollution, 18.97 Mg of sequestered carbon, and 1.99 kg of avoided nitrous oxide emissions for every $1,000 reduction in income. These ratios varied spatially, from 2- to 70-fold depending on the ecosystem service. Benefit-cost ratios for different ecosystem services were generally correlated within watersheds, suggesting the presence of hotspots - watersheds where increases in multiple ecosystem services would come at lower-than-average opportunity costs. When assessing the monetary value of ecosystem services relative to existing conservation programs and environmental markets, the overall value of enhanced services associated with adoption of perennial energy crops was far lower than the opportunity cost. However, when we monitized services using estimates for the social costs of pollution, the value of enhanced services far exceeded the opportunity cost. This disparity between recoverable costs and social value represents a fundamental challenge to expansion of perennial energy crops and sustainable agricultural landscapes.

Age-related episodic memory decline is characterized by striking heterogeneity across individuals. Hippocampal pattern completion is a fundamental process supporting episodic memory. Yet, the degree to which this mechanism is impaired with age, and contributes to variability in episodic memory, remains unclear. We combine univariate and multivariate analyses of fMRI data from a large cohort of cognitively normal older adults (N=100) to measure hippocampal activity and cortical reinstatement during retrieval of trial-unique associations. Trial-wise analyses revealed that (a) hippocampal activity scaled with reinstatement strength, (b) cortical reinstatement partially mediated the relationship between hippocampal activity and associative retrieval, (c) older age weakened cortical reinstatement and its relationship to memory behaviour. Moreover, individual differences in the strength of hippocampal activity and cortical reinstatement explained unique variance in performance across multiple assays of episodic memory. These results indicate that fMRI indices of hippocampal pattern completion explain within- and across-individual memory variability in older adults.

The UK IBD Genetics Consortium and the Wellcome Trust Case Control Consortium 2 report results of a genome-wide association study of ulcerative colitis. They identify three new loci associated with the disease, including the HNF4A region on 20q13. Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 × 10 −5 were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one biologically relevant candidate gene, on chromosomes 20q13 ( HNF4A ; P = 3.2 × 10 −17 ), 16q22 ( CDH1 and CDH3 ; P = 2.8 × 10 −8 ) and 7q31 ( LAMB1 ; P = 3.0 × 10 −8 ). Of note, CDH1 has recently been associated with susceptibility to colorectal cancer, an established complication of longstanding ulcerative colitis. The new associations suggest that changes in the integrity of the intestinal epithelial barrier may contribute to the pathogenesis of ulcerative colitis.

The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model. Using whole genome microarray and proteomic analyses from two independent Space Shuttle missions, we identified evolutionarily conserved molecular pathways in Salmonella that respond to spaceflight under all media compositions tested. Identification of conserved regulatory paradigms opens new avenues to control microbial responses during the infection process and holds promise to provide an improved understanding of human health and disease on Earth.

Background/ObjectivesObesity in pregnancy has been associated with increased childhood cardiometabolic risk and reduced life expectancy. The UK UPBEAT multicentre randomised control trial was a lifestyle intervention of diet and physical activity in pregnant women with obesity. We hypothesised that the 3-year-old children of women with obesity would have heightened cardiovascular risk compared to children of normal BMI women, and that the UPBEAT intervention would mitigate this risk.Subjects/MethodsChildren were recruited from one UPBEAT trial centre. Cardiovascular measures included blood pressure, echocardiographic assessment of cardiac function and dimensions, carotid intima-media thickness and heart rate variability (HRV) by electrocardiogram.ResultsCompared to offspring of normal BMI women (n = 51), children of women with obesity from the trial standard care arm (n = 39) had evidence of cardiac remodelling including increased interventricular septum (IVS; mean difference 0.04 cm; 95% CI: 0.018 to 0.067), posterior wall (PW; 0.03 cm; 0.006 to 0.062) and relative wall thicknesses (RWT; 0.03 cm; 0.01 to 0.05) following adjustment. Randomisation of women with obesity to the intervention arm (n = 31) prevented this cardiac remodelling (intervention effect; mean difference IVS −0.03 cm (−0.05 to −0.008); PW −0.03 cm (−0.05 to −0.01); RWT −0.02 cm (−0.04 to −0.005)). Children of women with obesity (standard care arm) compared to women of normal BMI also had elevated minimum heart rate (7 bpm; 1.41 to 13.34) evidence of early diastolic dysfunction (e prime) and increased sympathetic nerve activity index by HRV analysis.ConclusionsMaternal obesity was associated with left ventricular concentric remodelling in 3-year-old offspring. Absence of remodelling following the maternal intervention infers in utero origins of cardiac remodelling.Clinical trial registry name and registration numberThe UPBEAT trial is registered with Current Controlled Trials, ISRCTN89971375.

Measurements of photosynthesis at saturating irradiance and CO₂ partial pressure, A max, “adjusted” normalised difference vegetation index, R aNDVI, and photochemical reflectance index, R PRI, were made on trees sampled along a soil chronosequence to investigate the relationship between carbon uptake and ecosystem development in relation to nutrient availability. Measurements were made on the three most dominant species at six sites along the sequence in South Westland, New Zealand with soil age ranging from <6 to 120,000 years resulting from the retreat of the Franz Josef glacier. The decrease in soil phosphorus availability with increasing soil age and high soil nitrogen availability at the two youngest sites, due to the presence of a nitrogen-fixing species, provided marked differences in nutrient availability. Mean A max was high at the two youngest sites, then decreased markedly with increasing site age. Analysis of the data for individual species within sites revealed separation of groups of species in the response of A max to N m and P m, suggesting complex interactions between the two nutrients. There were strong linear relationships for leaf-level R aNDVI and R PRI with A max, at high irradiance, showing that measurements of reflectance indices can be used to estimate A max for foliage with a range in morphology and nutrient concentrations. Notwithstanding the change in species composition from angiosperms to conifers with increasing site age, the presence of nitrogen-fixing species, the variability in foliage morphology from flat leaves to imbricate scales and a wide range in foliar nitrogen and phosphorus concentrations, there were strong positive linear relationships between site average A max and foliage nitrogen, N m, and phosphorus, P m, concentrations on a foliage mass basis. The results provide insights to interpret the regulation of photosynthesis across natural ecosystems with marked gradients in nitrogen and phosphorus availability.