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"Hutton, Thomas"
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Planning on the edge : Vancouver and the challenges of reconciliation, social justice, and sustainable development
\"Vancouver is one of the most intensely studied medium-sized cities in the world and heralded everywhere as a model for sustainable development. In Planning on the Edge, nationally and internationally renowned planning scholars, activists, and Indigenous leaders assess whether the city's reputation is warranted. While recognizing the many successes of the 'Vancouverism' model, the contributors acknowledge that the forces of globalization and speculative property development have increased social inequality and housing insecurity since the 1980s in the city and the region. To determine the city's prospects for overcoming these problems, they look at city planning from all angles and perspectives, including planning for the Indigenous population, environmental and disaster planning, housing and migration, and transportation and water management. Together, they provide a comprehensive and integrative profile of Vancouver's development history and planning record. By looking at policies at the local, provincial, and federal levels and taking reconciliation with Indigenous peoples into account, Planning on the Edge highlights the kinds of policies and practices needed to reorient Vancouver's development trajectory along a more environmentally sound and equitable path.\"-- Provided by publisher.
Book
Effect of Antibiotic Therapy on the Density of Vancomycin-Resistant Enterococci in the Stool of Colonized Patients
In case–control studies, colonization and infection with vancomycin-resistant enterococci have been associated with exposure to vancomycin,
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–
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third-generation cephalosporins,
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–
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antibiotics that are active against anaerobes,
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,
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–
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ciprofloxacin,
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and aminoglycosides.
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The microbiologic basis for these associations is not well defined. If some antibiotics promote colonization and infection more than others that are equally effective, limiting the use of these agents may limit the spread of vancomycin-resistant enterococci.
We previously examined the effect of various antibiotics on intestinal colonization with vancomycin-resistant enterococci in mice.
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In mice with established colonization, as evidenced by the high density of vancomycin-resistant enterococci in stool, . . .
Journal Article
Post-industrialism, Post-modernism and the Reproduction of Vancouver's Central Area: Retheorising the 21st-century City
Planning and local policies, informed recurrently by theories of transformative urban development, have represented influential (and at times decisive) agencies of change in Vancouver's metropolitan core. A commitment to principles of post-industrialism in the 1970s, realised through the conversion of False Creek South from an obsolescent industrial site to a medium-density, mixed-income residential landscape, effectively broke the mould of the mid-century urban core. The seminal Central Area Plan (approved 1991) enabled the comprehensive reordering of inner-city space, exemplified by a post-modern diversity, complexity and interdependency of territory and land use, and a strategic reversal of the employment-housing imbalance in the core. The city has broadly succeeded in asserting public interests as contingencies of change within the core, but these processes have created new social conflicts, tensions and displacements, as well as a glittering and paradigmatic 21st-century central city. In theoretical terms, the Vancouver experience marks a clear break from the classic model of the post-industrial city, the latter typified by a monocultural, office-based economy, extreme spatial asymmetries of investment and development and modernist form and imagery. At the same time, emergent production clusters, residential mega-projects and spaces of consumption and spectacle in the central area present marked contrasts to the spatial disorder and chaotic patterns of 'incipient' post-modernism, underscoring an exigent need for innovative and integrative retheorisation.
Journal Article
Automated Network Services for Exascale Data Movement
The Large Hadron Collider (LHC) experiments distribute data by leveraging a diverse array of National Research and Education Networks (NRENs), where experiment data management systems treat networks as a “blackbox” resource. After the High Luminosity upgrade, the Compact Muon Solenoid (CMS) experiment alone will produce roughly 0.5 exabytes of data per year. NREN Networks are a critical part of the success of CMS and other LHC experiments. However, during data movement, NRENs are unaware of data priorities, importance, or need for quality of service, and this poses a challenge for operators to coordinate the movement of data and have predictable data flows across multi-domain networks. The overarching goal of SENSE (The Software-defined network for End-to-end Networked Science at Exascale) is to enable National Labs and universities to request and provision end-to-end intelligent network services for their application workflows leveraging SDN (Software-Defined Networking) capabilities. This work aims to allow LHC Experiments and Rucio, the data management software used by CMS Experiment, to allocate and prioritize certain data transfers over the wide area network. In this paper, we will present the current progress of the integration of SENSE, Multi-domain end-to-end SDN Orchestration with QoS (Quality of Service) capabilities, with Rucio, the data management software used by CMS Experiment.
Journal Article
β-Lactam Antibiotics and Gastrointestinal Colonization with Vancomycin-Resistant Enterococci
We studied the effect of different subcutaneously administered β-lactam antibiotics on the establishment of gastrointestinal colonization by vancomycin-resistant Enterococcus faecium C68 in a mouse model. Aztreonam, cefazolin, cefepime, and, to a lesser extent, ceftazidime, which neither have significant antienterococcal activity nor are secreted into human bile at high concentrations, did not promote significant vancomycin-resistant enterococci (VRE) colonization. Piperacillin-tazobactam, which has antienterococcal activity and is secreted in human bile at high concentrations, inhibited colonization after limited exposure to the inoculum but was associated with progressively increased VRE colony counts in stool samples after repeated exposure to the VRE inoculum. Ceftriaxone and cefotetan, which lack antienterococcal activity but are secreted into human bile at high concentrations, were associated with rapid and high-level colonization. These data suggest that the risk of VRE colonization varies during exposure to different β-lactam antimicrobial agents and that the risk is related to biliary concentration and antienterococcal activity of the specific β-lactam.
Journal Article
Situating the New Economy: Contingencies of Regeneration and Dislocation in Vancouver's Inner City
The purpose of this paper is to make an argument about the importance of geographical context and contingency in the emergence of the new economy within the inner city. Using a case study of Vancouver, it is suggested, first, that its new economy has emerged precisely out of the peculiar trajectory of the city and is bound up with a staples economy, branch plant corporate offices, transnationalism, and mega-project orientation. Secondly, to illustrate the importance of situation and site, the paper focuses on two of Vancouver's inner-city locales: Yaletown, on the margins of the Downtown South, a former industrial and warehousing district now regarded as the epicentre of Vancouver's new economy; and Victory Square, the former commercial heart of the early Vancouver, for many years experiencing disinvestment and decline, but now on the cusp of a major revitalisation which threatens to displace long-established social cohorts.
Journal Article
New Economic Spaces in Asian Cities
The East and Southeast Asia region constitutes the world's most compelling theatre of accelerated globalization and industrial restructuring. Following a spectacular realization of the 'industrialization paradigm' and a period of services-led growth, the early twenty-first century economic landscape among leading Asian states now comprises a burgeoning 'New Economy' spectrum of the most advanced industrial trajectories, including finance, the knowledge economy and the 'new cultural economy'. In an agenda-setting volume, New Economic Spaces in Asian Cities draws on stimulating research conducted by a new generation of urban scholars to generate critical analysis and theoretical insights on the New Economy phenomenon within Asia.
New industry formation and the transformation of older economic practices constitute instruments of development, as well as signifiers of larger processes of change, expressed in the reproduction of space in the city. Asia's major cities become the key staging areas for the New Economy, driven by the growing wealth of an urban middle and professional class, higher education institutions, city-based inter-regional movements and urban mega-projects. New Economic Spaces in Asian Cites animates this New Economy discourse by means of vibrant storylines of instructive cities and sites, including cases studies situated in cities such as Tokyo, Seoul, Shanghai, Beijing, Shenzhen, and Singapore. Theoretical and normative issues associated with the emergence of the new cultural economy are the subject of the book's context-setting chapters, and each case study presents an evocative narrative of development interdependencies and exemplary outcomes on the ground.
New Economic Spaces in Asian Cities offers a vivid contribution to our understanding of the ongoing transformation of Asia's urban system, including the critical intersections of global and local-regional dynamics in processes
eBook
In Vitro Antienterococcal Activity Explains Associations between Exposures to Antimicrobial Agents and Risk of Colonization by Multiresistant Enterococci
We compared ceftriaxone and piperacillin-tazobactam at doses ranging from 0.1 to 2 times the human equivalent daily dose (HEDD), to determine their impact on gastrointestinal colonization by ampicillin- and vancomycinresistant Enterococcus faecium C68 in a mouse model. Ceftriaxone failed to promote colonization at doses up to 0.25 times the HEDD, whereas piperacillin-tazobactam promoted colonization at doses up to 0.5 times the HEDD. Ceftriaxone promoted colonization at doses at least 0.5 times the HEDD, whereas piperacillin-tazobactam inhibited colonization at doses at least 0.75 times the HEDD. Both piperacillin-tazobactam and ceftriaxone inhibited colonization by an enterococcal strain devoid of low-affinity penicillin-binding protein-5 (significantly increasing its susceptibility to these agents), at doses that promoted colonization by E. faecium C68. These results support a model in which the impact that different β-lactam agents have on colonization by VRE is related to the level of the β-lactam agent's intrinsic antienterococcal activity against the colonizing strain.
Journal Article
