Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
49
result(s) for
"Ike, Robert"
Sort by:
Sjögren’s disease activity associates with cardiovascular disease and monoclonal gammopathy: a university cohort study of disease activity and comorbidities
BackgroundWe used the University of Wisconsin cohort to determine the extent to which the EULAR Sjögren’s syndrome disease activity index (ESSDAI) was associated with comorbidities that contribute to mortality.MethodsOur University of Wisconsin, Madison cohort had 111 patients with Sjögren’s Disease (SjD) by 2016 ACR/EULAR criteria and 194 control patients with sicca. Our study was performed from March 1st, 2020 through April 1st, 2023. We collected data using a standardized collection tool, including components of the Charlson Comorbidity Index (CCI). Stratifying our SjD patients by ESSDAI < 5 and ESSDAI ≥ 5, we assessed differences in comorbidities associated with mortality.ResultsAt time of SjD diagnosis, the ESSDAI ≥ 5 group had increased odds of peripheral vascular disease compared to controls (OR 10.17; 95% CI 1.18–87.87). Patients with a current ESSDAI ≥ 5 were more likely to have a myocardial infarction compared to controls (OR 9.87; 95% CI 1.17–83.49). SjD patients had increased prevalence of monoclonal gammopathy compared to controls (9.3% vs 0.5%, p < 0.001). SjD patients with high ESSDAI at diagnosis had greater prevalence of monoclonal gammopathy compared to the SjD patients with a low ESSDAI (16% vs 5%, p = .04). As reported elsewhere, the ESSDAI ≥ 5 group had increased odds of chronic pulmonary disease (OR 4.37; 95% CI 1.59–11.97).ConclusionWe found high ESSDAI scores were associated with worse cardiovascular outcomes, specifically peripheral vascular disease and myocardial infarction. Furthermore, monoclonal gammopathy was more frequent in SjD patients compared to sicca controls, supporting screening for monoclonal gammopathy in the appropriate clinical scenario.Key Points• High ESSDAI scores are associated with worse cardiovascular outcomes, specifically peripheral vascular disease and myocardial infarction.• Monoclonal gammopathy is more frequent in SjD patients than sicca controls, supporting screening for monoclonal gammopathy in the appropriate clinical scenario.
Journal Article
Genome-wide association analysis identifies three psoriasis susceptibility loci
James Elder and colleagues report meta-analyses of two psoriasis genome-wide association studies with replication in additional cohorts. They make use of imputation using both the HapMap and initial 1000 Genomes Project datasets and identify three new psoriasis susceptibility loci.
We carried out a meta-analysis of two recent psoriasis genome-wide association studies
1
,
2
with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on
P
value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at
NOS2
(rs4795067, combined
P
= 4 × 10
−11
), one at
FBXL19
(rs10782001, combined
P
= 9 × 10
−10
) and one near
PSMA6
-
NFKBIA
(rs12586317, combined
P
= 2 × 10
−8
). All three loci were also associated with psoriatic arthritis (rs4795067, combined
P
= 1 × 10
−5
; rs10782001, combined
P
= 4 × 10
−8
; and rs12586317, combined
P
= 6 × 10
−5
) and purely cutaneous psoriasis (rs4795067, combined
P
= 1 × 10
−8
; rs10782001, combined
P
= 2 × 10
−6
; and rs12586317, combined
P
= 1 × 10
−6
). We also replicated a recently identified
3
association signal near
RNF114
(rs495337, combined
P
= 2 × 10
−7
).
Journal Article
Still Consider the Source
A 50-year-old man presented to the clinic with fever, chills, and generalized weakness that he had had for three weeks. He also noticed pain and swelling in his right hand and left elbow, a weight loss of about 4.5 kg, and occasional upper abdominal pressure. He had no nausea, vomiting, diarrhea, dyspnea, or dysuria.
A 50-year-old man presented to the clinic with fever, chills, and generalized weakness that he had had for three weeks. He also noticed pain and swelling in his right hand and left elbow, a weight loss of about 4.5 kg, and occasional upper abdominal pressure.
Foreword
In this
Journal
feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows.
Stage
A 50-year-old man presented to the clinic with fever, chills, and generalized weakness that he had had for three weeks. He also noticed pain and swelling in his right hand and left elbow, a weight loss of about 4.5 kg, and occasional pressure in the upper abdominal area. He said that he had not had nausea, vomiting, diarrhea, dyspnea, or dysuria.
Response
Fever is a manifestation of many infectious, collagen vascular, and malignant diseases. The weight loss and generalized weakness probably indicate a systemic disorder; his joint discomfort suggests an inflammatory arthritis. Arthritis can be a sign of either . . .
Journal Article
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-kB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense. [PUBLICATION ABSTRACT]
Journal Article
The impact of direct reading instruction for middle school students at Newfield Middle School, Newfield, New York
The researcher investigated the impact of time in direct reading instruction (DRI) for middle school students (n = 345). The comparison group had only English language arts (ELA). The treatment group had ELA and time in DRI. ANOVA was used to analyze time in DRI, gender, and special education on achievement following DRI on the New York State Intermediate English Assessment (NYSIELAA). There was a significant increase (p ≤ .05) in special education scores. Effect sizes were large for special education student performance (2.79), and male performance (1.39). Female scores decreased after DRI (−.48). A matched-pair t test showed a significant ( p ≤ .001) gain on the Degrees of Reading Power (DRP) test for treatment vs. comparison groups after 2 years of ELA and DRI.
Dissertation
Norflox or Norflex?
To the Editor:
Recently, the trade name for omeprazole was changed from Losec to Prilosec after several physicians noted incidents in which prescriptions written for Losec were instead dispensed with Lasix.
1
2
3
We report a similar confusion between a popular new antibiotic, the fluoroquinolone norfloxacin, and a muscle relaxant, orphenadrine. Although the trade name for norfloxacin is Noroxin, it is frequently abbreviated as \"norflox,\" which can lead to confusion with orphenadrine, the trade name for which is Norflex. We have noted two cases of such confusion.
In one case, a 60-year-old woman with end-stage liver disease was prescribed norfloxacin as . . .
Journal Article
