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Thailand plays a central economic and policy-making role in Southeast Asia. Although climate change adaptation is being mainstreamed in Thailand, a well-organized overview of the impacts of climate change and potential adaptation measures has been unavailable to date. Here we present a comprehensive review of climate-change impact studies that focused on the Thai water sector, based on a literature review of six sub-sectors: riverine hydrology, sediment erosion, coastal erosion, forest hydrology, agricultural hydrology, and urban hydrology. Our review examined the long-term availability of observational data, historical changes, projected changes in key variables, and the availability of economic assessments and their implications for adaptation actions. Although some basic hydrometeorological variables have been well monitored, specific historical changes due to climate change have seldom been detected. Furthermore, although numerous future projections have been proposed, the likely changes due to climate change remain unclear due to a general lack of systematic multi-model and multi-scenario assessments and limited spatiotemporal coverage of the study area. Several gaps in the research were identified, and ten research recommendations are presented. While the information contained herein contributes to state-of-the-art knowledge on the impact of climate change on the water sector in Thailand, it will also benefit other countries on the Indochina Peninsula with a similar climate.

In this study, an ensemble inflow-prediction system was developed for a hydropower-generation dam in the upper Sai River basin, and the accuracy of ensemble inflow prediction, which is important for efficient dam operation, was investigated. First, the Water and Energy Based Distributed Hydrological Model for Snow (WEB-DHM-S), a hydrological model developed for the Sai River basin, can represent the hydrological process from warm to cold seasons. Next, a system was developed on the Data Integration and Analysis System (DIAS) to predict inflows into the dam by inputting real-time meteorological data and ensemble rainfall forecast data into WEB-DHM-S. The WEB-DHM-S was calibrated and validated over a 3-year period from August 2015 to July 2018, and showed good agreement with observed inflows from base flow to peak flow and snowmelt runoff in each year. The results of inflow forecasting during frontal rainfall in August 2021 by inputting ensemble rainfall forecasts up to 39 h ahead showed that at the Inekoki Dam site, the total inflow (volume) to the peak was predicted with an accuracy of within 20% at 30 h, 24 h, 18 h, 12 h, and 6 h before the peak. These ensemble inflow forecasts can help optimize dam operations.

Increasing evidence indicates that iron cytotoxicity plays an important role in the pathogenesis of chronic hepatitis C (CHC). However, the biochemical effects of iron reduction therapy on CHC remain to be confirmed in a controlled study. This study aimed to test whether iron removal by repeated phlebotomy improves serum alanine aminotransferase (ALT) levels in patients with CHC. Patients were randomly assigned to an iron reduction therapy or control group. The patients in the treatment group received 3-month iron reduction therapy by biweekly phlebotomy, while the patients in the control group were followed up for 3 months with regular blood tests alone. Thirty-three patients completed the 3-month treatment, while 29 patients received the complete follow-up. The serum ALT levels were reduced from 118 +/- 79 to 73 +/- 39 IU/L in the treatment group, but did not change in the control group (106 +/- 45 versus 107 +/- 48 IU/L). Posttreatment enzyme activity was decreased significantly from the baseline. Furthermore, it was significantly lower than the 3-month control level. Although 5 patients withdrew from the study, none was affected by any side effects of repeated phlebotomy that required them to discontinue the treatment. This short-term controlled trial demonstrated the biochemical efficacy and safety of iron reduction therapy for patients with CHC.

Astrocytes are the predominant type of glia in the central nervous system and have long branched stem processes and peripheral astrocyte processes (PAPs) contacting neurons and other glial cells. In many cell types, cell morphology and motility depend on actin cytoskeleton. However, a common astrocyte culture method in serum-containing medium generated undesired fibroblast-like cells; thus, the roles of cytoskeletal proteins in astrocyte morphology and motility have not been well studied. Previously, we reported a culture method of chicken astrocytes forming structures similar to stem processes and PAPs. In the current study, we improved transfection methods retaining astrocyte morphology at low cell density, suitable for observing the behavior of proteins. Immunostaining and live imaging of plasma membrane-actin linking protein ezrin (a PAP marker) and another actin-binding protein lasp-2 (highly expressed in cultured astrocytes) demonstrated that our cultured astrocytes had microvillus protrusions, filopodia, lamellipodia, and focal adhesion-like elliptical structures, and the two proteins accumulated in different substructures. Our developed methods offer significant advantages for analyzing how astrocytes form stem processes and PAPs to access target cells.Competing Interest StatementThe authors have declared no competing interest.

We report the detection of 3 new extrasolar planets from the precise Doppler survey of G and K giants at Okayama Astrophysical Observatory. The host stars, namely, 18 Del (G6 III), xi Aql (K0 III) and HD 81688 (K0 III-IV), are located at the clump region on the HR diagram with estimated masses of 2.1-2.3 M_solar. 18 Del b has a minimum mass of 10.3 M_Jup and resides in a nearly circular orbit with period of 993 days, which is the longest one ever discovered around evolved stars. xi Aql b and HD 81688 b have minimum masses of 2.8 and 2.7 M_Jup, and reside in nearly circular orbits with periods of 137 and 184 days, respectively, which are the shortest ones among planets around evolved stars. All of the substellar companions ever discovered around possible intermediate-mass (1.7-3.9 M_solar) clump giants have semimajor axes larger than 0.68 AU, suggesting the lack of short-period planets. Our numerical calculations suggest that Jupiter-mass planets within about 0.5 AU (even up to 1 AU depending on the metallicity and adopted models) around 2-3 M_solar stars could be engulfed by the central stars at the tip of RGB due to tidal torque from the central stars. Assuming that most of the clump giants are post-RGB stars, we can not distinguish whether the lack of short-period planets is primordial or due to engulfment by central stars. Deriving reliable mass and evolutionary status for evolved stars is highly required for further investigation of formation and evolution of planetary systems around intermediate-mass stars.