Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
6,772
result(s) for
"Ilyas"
Sort by:
Genomics and Functional Genomics of Alzheimer's Disease
Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to its long clinical course and lack of an effective treatment, AD has become a major public health problem in the USA and worldwide. Due to variation in age-at-onset, AD is classified into early-onset (< 60 years) and late-onset (≥ 60 years) forms with early-onset accounting for only 5–10% of all cases. With the exception of a small number of early-onset cases that are afflicted because of high penetrant single gene mutations in APP, PSEN1, and PSEN2 genes, AD is genetically heterogeneous, especially the late-onset form having a polygenic or oligogenic risk inheritance. Since the identification of APOE as the most significant risk factor for late-onset AD in 1993, the path to the discovery of additional AD risk genes had been arduous until 2009 when the use of large genome-wide association studies opened up the discovery gateways that led the identification of ~ 95 additional risk loci from 2009 to early 2022. This article reviews the history of AD genetics followed by the potential molecular pathways and recent application of functional genomics methods to identify the causal AD gene(s) among the many genes that reside within a single locus. The ultimate goal of integrating genomics and functional genomics is to discover novel pathways underlying the AD pathobiology in order to identify drug targets for the therapeutic treatment of this heterogeneous disorder.
Journal Article
Thermal behavior of the Klein Gordon oscillator in a dynamical noncommutative space
We investigate the thermal properties of the Klein–Gordon oscillator in a dynamical noncommutative space. These properties are determined via the partition function, which is derived using the Euler–Maclaurin formula. Analytical expressions for the partition function, free energy, internal energy, entropy, and specific heat capacity of the deformed system are obtained and numerically evaluated. The distinct roles of dynamical and flat noncommutative spaces in modulating these properties are rigorously examined and compared. Furthermore, visual representations are provided to illustrate the influence of the deformations on the system’s thermal behavior. The findings highlight significant deviations in thermal behavior induced by noncommutativity, underscoring its profound physical implications.
Journal Article
Critical Review on Polylactic Acid: Properties, Structure, Processing, Biocomposites, and Nanocomposites
Composite materials are emerging as a vital entity for the sustainable development of both humans and the environment. Polylactic acid (PLA) has been recognized as a potential polymer candidate with attractive characteristics for applications in both the engineering and medical sectors. Hence, the present article throws lights on the essential physical and mechanical properties of PLA that can be beneficial for the development of composites, biocomposites, films, porous gels, and so on. The article discusses various processes that can be utilized in the fabrication of PLA-based composites. In a later section, we have a detailed discourse on the various composites and nanocomposites-based PLA along with the properties’ comparisons, discussing our investigation on the effects of various fibers, fillers, and nanofillers on the mechanical, thermal, and wear properties of PLA. Lastly, the various applications in which PLA is used extensively are discussed in detail.
Journal Article
The effects of different aeration strategies on the performance of constructed wetlands for phosphorus removal
The effects of different aeration methods such as tidal flow (TF), effluent recirculation (ER), and artificial aeration (AA) on the performance of vertical-flow constructed wetland (VFCW), horizontal-flow constructed wetland (HFCW), and hybrid constructed wetland (HCW) are extensively and critically evaluated in this review paper. Aerated constructed wetlands (CWs) demonstrate superior performance compared with non-aerated systems. The removal of total phosphorus (TP) showed substantial variation among different types of CWs and aeration strategies, with mean and standard deviation of 68 ± 20% estimated from all reviewed studies on aerated systems. The TF-VFCW designated the highest removal efficiency and removal rate of 88 ± 6% and 2.6 ± 2.5 g m
−2
day
−1
, respectively, followed by the ER-HCW with values of 79 ± 18% and 1.3 ± 0.7 g m
−2
day
−1
, respectively. The superior performance of TF-VFCW could be attributed to a positive effect of TF in rejuvenating the wetland with fresh air, thus enhancing dissolved oxygen (DO) in the system, and augmenting phosphorus precipitation and adsorption to the substrate. A positive correlation of TP and orthophosphate (PO
4
3-
-P) with DO indicates that the improvement in DO levels due to redox manipulation with aeration strategies facilitates the phosphorous removal processes (e.g., through precipitation and adsorption to the substrate). The conflicting results on the impact of AA and ER reported by many studies need the cautious interpretation of their impact and require further studies. Only few studies have examined the impact of oxidation-reduction potential on phosphorous removal, which requires more attention in future research, as it appears as an important factor in enhancing the phosphorus removal.
Journal Article
Intensification of constructed wetlands for land area reduction: a review
The large land area requirement of constructed wetlands (CWs) is a major limitation of its application especially in densely populated and mountainous areas. This review paper provides insights on different strategies applied for the reduction of land area including stack design and intensification of CWs with different aeration methods. The impacts of different aeration methods on the performance and land area reduction were extensively and critically evaluated for nine wetland systems under three aeration strategies such as tidal flow (TF), effluent recirculation (ER), and artificial aeration (AA) applied on three types of CWs including vertical flow constructed wetland (VFCW), horizontal flow constructed wetland (HFCW), and hybrid constructed wetland (HCW). The area reduction and pollutant removal efficiency showed substantial variation among different types of CWs and aeration strategies. The ER-VFCW designated the smallest footprint of 1.1 ± 0.5 m
2
PE
−1
(population equivalent) followed by TF-VFCW with the footprint of 2.1 ± 1.8 m
2
PE
−1
, and the large footprint was of AA-HFCW (7.8 ± 4.7 m
2
PE
−1
). When footprint and removal efficiency both are the major indicators for the selection of wetland type, the best options for practical application could be TF-VFCW, ER-HCW, and AA-HCW. The data and results outlined in this review could be instructive for futures studies and practical applications of CWs for wastewater treatment, especially in land-limited regions.
Journal Article