Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
200
result(s) for
"Inagaki, Yusuke"
Sort by:
Eyeshield 21
Fearful Sena Kobayakawa has been running away from bullies all his life, but when he puts on special football gear, he attains unbelievable speed that may just help him become a legendary high school football star.
Book
Correlation between varus-type knee osteoarthritis severity and hindfoot alignment: Analysis of radiographs in the long-leg weight-bearing anteroposterior view
In knee osteoarthritis, the subtalar joint undergoes valgus and varus contractions to compensate for deformities in the knee joint. In this cross-sectional study, we investigated the relationship between varus-type knee osteoarthritis severity and hindfoot alignment severity by concurrently assessing varus-type knee osteoarthritis severity and hindfoot alignment using radiographs in the long-leg weight-bearing anteroposterior view.
A total of 114 patients with knee osteoarthritis graded Kellgren-Lawrence II or higher (128 knees) and 30 healthy controls (31 knees) underwent long-leg weight-bearing anteroposterior imaging for 1 year. Four angles were measured on radiographs in the long-leg weight-bearing anteroposterior view: the femorotibial angle; tibial calcaneal angle; tibial anterior surface angle; and talocrural joint angle between the tibial plafond and talar dome on weight-bearing. Group comparisons were conducted for each Kellgren-Lawrence classification, which was used to classify the severity of knee osteoarthritis at each measured angle. One-way analysis of variance was used to test the results.
The mean tibial calcaneal angles were 9.7°, 11.3°, 8.8°, and 9.8° in controls and in patients with Kellgren-Lawrence grades II, III, and IV, respectively (p < 0.05). The mean femorotibial angles were 175.6°, 176.8°, 180.3°, and 186.2° in controls and in patients with Kellgren-Lawrence grades II, III, and IV, respectively (p < 0.05). On weight-bearing, the tibial anterior surface angle and the talocrural joint angle between the tibial plafond and talar dome varied according to severity level.
In varus-type knee osteoarthritis cases, defined in accordance with the Kellgren-Lawrence classification, hindfoot alignment leaned toward valgus. As the severity of knee osteoarthritis progressed, the valgus of the hindfoot alignment reduced. While future longitudinal analyses are necessary, these observations indicate both potential compensatory changes and their limitations in varus-type knee osteoarthritis.
Journal Article
Relationship between fall history and toe grip strength in older adults with knee osteoarthritis in Japan: A cross-sectional study
Knee osteoarthritis (KOA), one of the most common musculoskeletal diseases in older adults, is associated with a high incidence of falls. Similarly, toe grip strength (TGS) is associated with a history of falls in older adults; however, the relationship between TGS and falls in older adults with KOA who are at risk of falling is not known. Therefore, this study aimed to determine if TGS is associated with a history of falls in older adults with KOA.
The study participants, older adults with KOA scheduled to undergo unilateral total knee arthroplasty (TKA), were divided into two groups: non-fall (n = 256) and fall groups (n = 74). Descriptive data, fall-related assessments, modified Fall Efficacy Scale (mFES), radiographic data, pain, and physical function including TGS were evaluated. The assessment was conducted on the day before performing TKA. Mann-Whitney and chi-squared tests were performed to compare the two groups. Multiple logistic regression analysis was performed to determine the association of each outcome with the presence or absence of falls.
Mann-Whitney U test revealed that the fall group had statistically significantly lower height, TGS on the affected and unaffected sides, and mFES. Multiple logistic regression analysis revealed that the incidence of fall history is associated with TGS on the affected side; the weaker the affected TGS of the KOA, the more likely the individual is to fall.
Our results indicate that TGS on the affected side is related to a history of falls in older adults with KOA. The significance of evaluating TGS among patients with KOA in routine clinical practice was demonstrated.
Journal Article
Expert and public perceptions of gene-edited crops: attitude changes in relation to scientific knowledge
This study empirically examined expert and public attitudes toward applying gene editing to agricultural crops compared with attitudes toward other genetic modification and conventional breeding technologies. Regulations regarding the application of gene editing on food are being debated around the world. New policy measures often face issues of public acceptance and consensus formation; however, reliable quantitative evidence of public perception toward such emerging breeding technologies is scarce. To fill this gap, two web-based surveys were conducted in Japan from December 2016 to February 2017. Participants (N = 3197) were categorised into three groups based on the domain-specific scientific knowledge levels (molecular biology experts, experts in other fields, and lay public). Statistical analysis revealed group differences in risk, benefit, and value perceptions of different technologies. Molecular biology experts had higher benefit and value perceptions, as well as lower risk perceptions regarding new technologies (gene editing and genetic modification). Although the lay public tended to have more favourable attitudes toward gene editing than toward genetic modification, such differences were much smaller than the differences between conventional breeding and genetic modification. The experts in other fields showed some characteristics that are similar to the experts in molecular biology in value perceptions, while showing some characteristics that are similar to the lay public in risk perceptions. The further statistical analyses of lay attitudes revealed the influence of science literacy on attitudinal change toward crops grown with new breeding technologies in benefit perceptions but not in risk or value perceptions. Such results promoted understanding on distinguishing conditions where deficit model explanation types are valid and conditions where they are not.
Journal Article
Evaluation of psychological changes using facial emotion analysis in postoperative rehabilitation treatment for patients with upper gastrointestinal cancer: A prospective study
Rehabilitation after radical gastrectomy or esophagectomy for upper gastrointestinal cancer can improve physical function and quality of life; however, objective day-to-day measures of psychological change are lacking. We aimed to test whether facial emotion analysis can quantitatively evaluate patients’ emotional responses before and after each rehabilitation session and whether these changes relate to conventional subjective/physiological stress markers and discharge physical outcomes. We conducted a single-center prospective observational study of 32 patients who underwent radical gastrectomy or esophagectomy between August 2024 and February 2025. Immediately before and after each rehabilitation session, 30 s iPad video interviews (median, six per patient) were recorded and analyzed using MAL Face Emotion software to obtain normalized scores (0%–100%) for Neutral, Happy, Sad, Angry, and Surprised emotions. Subjective stress (0–100 mm visual analog scale) and salivary α-amylase activity were collected concurrently; discharge physical function was assessed using the 6 min walk distance and Five Times Sit-to-Stand tests. Pre- and post-session values were compared using Wilcoxon signed-rank tests, and associations were examined with age-adjusted regression and Spearman correlation. Thirty-one patients completed the study without adverse events. After rehabilitation, the Happy score increased (median +3.5%, p = 0.013) and stress decreased (−1.5 mm, p = 0.025), whereas salivary α-amylase and other emotions were unchanged. Changes in the Happy score (p = 0.21) and stress (p = 0.19) did not predict discharge physical function, whereas changes in the Sad score correlated moderately with changes in salivary α-amylase (ρ = 0.45). The findings of this single-center study provide preliminary evidence supporting the feasibility of facial emotion analysis as a non-invasive, quantitative tool for real-time psychological monitoring during postoperative rehabilitation. Furthermore, our results demonstrate its potential to support a more personalized delivery of cancer rehabilitation.
Journal Article
The first management using intubation of a nasogastric tube with Gastrografin enterography or long tube for non-strangulated acute small bowel obstruction: a multicenter, randomized controlled trial
BackgroundGastrointestinal decompression is generally applied to a non-strangulated acute small bowel obstruction (NSASBO). Although long tube (LT) placement and administration of Gastrografin through a nasogastric tube (NGT-G) have shown advantages over NGT alone in previous studies, no studies appear to have compared LT and NGT-G.MethodsIn this multicenter, randomized controlled trial, patients with NSASBO were randomly assigned to receive LT or NGT-G between July 2016 and November 2018 at 11 Japanese institutions. The primary endpoint was non-inferiority of NGT-G compared to LT for non-surgery rate, and the lower limit of the 95% confidence interval for the non-surgery rate (−15%) was set as the lower margin for inferiority of NGT-G compared to LT.ResultsIn total, 223 patients (LT group, n = 111; NGT-G group, n = 112) were analyzed in the present trial. The non-surgery rate was 87.4% in the LT group and 91.1% in the NGT-G group, with a 3.7% difference between NGT-G and LT (95.3%CI − 5.55 to 12.91; non-inferiority P = 0.00002923). On the other hand, the non-surgery rate with pure NGT-G alone (76.8%) that represents non-cross-over NGT-G without subsequent LT was significantly lower than that with LT (P = 0.039). Median procedure time was significantly shorter with NGT-G (1 min) than with LT (25 min; P < 0.001), whereas no significant differences in mortality or hospital stay were noted between groups.ConclusionNGT-G is an effective alternative to LT as a first-line treatment for NSASBO. A sequential strategy comprising NGT-G followed by LT might offer a new standard for NSASBO.Clinical trials registrationThis trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (umin.ac.jp/ctr Identifier: UMIN000022669) prior to the start of this trial.
Journal Article
Relationship between history of falls and foot pressure centre parameters during gait and stance in patients with lower-limb osteoarthritis
The risk of falls increases with age, particularly in patients with osteoarthritis (OA). We aimed to investigate the relationships of fall history and spatiotemporal parameters in patients with hip and knee OA. This cross-sectional study included 51 patients with hip or knee OA. Fall history over the past year was recorded, and the centre of pressure (COP) parameters of gait and standing were assessed using the FDM-T treadmill. Comparisons were made between the fall and non-fall groups. Compared with the non-fall group, the fall group exhibited significant posterior displacement of the COP intersection during gait (
p
= 0.001). In hip OA patients, significant age, anterior‒posterior symmetry, and variability differences were observed. In knee OA patients, anterior‒posterior symmetry and lateral variability showed significant between-group differences. This study revealed a significant association between posterior COP displacement during gait and fall history. This parameter may serve as a novel fall indicator. Further prospective studies are needed to determine its predictive value for fall prevention.
Journal Article
MgO-enhanced β-TCP promotes osteogenesis in both in vitro and in vivo rat models
Allogeneic bone grafts are used to treat bone defects in orthopedic surgery, but the osteogenic potential of artificial bones remains a challenge. In this study, we developed a β-tricalcium phosphate (β-TCP) formulation containing MgO, ZnO, SrO, and SiO
2
and compared its bone-forming ability with that of β-TCP without biological elements. We prepared β-TCP discs with 60% porosity containing 1.0 wt% of these biological elements. β-TCP scaffolds were loaded with bone marrow-derived mesenchymal stem cells (BMSC) from 7-week-old male rats and cultured for 2 weeks. ALP activity and mRNA expression of osteogenic markers were evaluated. In addition, scaffolds were implanted subcutaneously in rats and analyzed after 7 weeks. In vitro, the MgO group showed lower Ca concentrations and higher osteogenic marker expression compared to controls. In vivo, the MgO group showed higher ALP activity compared to controls, and RT-qPCR analysis showed significant expression of
BMP2
and
VEGF
. Histopathology, fluorescent immunostaining, and micro-CT also showed relatively better bone formation in the MgO group. β-TCP with MgO may enhance bone morphology in vitro and in vivo and improve the prognosis of patients with substantial and refractory bone defects.
Journal Article
Age-stratified trajectories of patient-reported outcomes and perioperative safety after robot-assisted radical prostatectomy: a prospective multicenter cohort study
As life expectancy increases, a growing number of older adults undergo radical prostatectomy for localized prostate cancer; however, longitudinal age-specific functional outcomes remain insufficiently characterized. We conducted a prospective multicenter cohort study evaluating age-stratified trajectories of patient-reported outcomes (PROs) assessed using the Expanded Prostate Cancer Index Composite (EPIC) and perioperative complications following robot-assisted radical prostatectomy (RARP). A total of 604 patients were categorized into three age groups (< 65, 65–74, and ≥ 75 years). PROs were assessed using the EPIC at baseline and at 1, 3, 6, and 12 months postoperatively, and longitudinal changes were analyzed using linear mixed-effects models. Urinary function declined transiently after surgery in all age groups and substantially recovered by 12 months, with no significant differences between men aged ≥ 75 years and younger patients. Sexual function decreased irrespective of age, although younger patients maintained higher absolute scores after nerve-sparing procedures. In contrast, sexual bother demonstrated an age-dependent pattern, with minimal change observed in men aged ≥ 75 years. Perioperative complication rates did not differ significantly across age groups. These findings suggest that chronological age alone should not preclude consideration of RARP in appropriately selected elderly patients and provide evidence supporting individualized surgical decision-making in an aging population.
Journal Article
Decreased renal function increases the nighttime urine volume rate by carryover of salt excretion to the nighttime
To determine the pathophysiology of nocturnal polyuria associated with renal dysfunction, patients who underwent laparoscopic nephrectomy were prospectively studied. The diurnal variation in urine volume, osmolality, and salt excretion were measured on preoperative day 2 and postoperative day 7. The factors associated with an increase in the nighttime urine volume rate with decreased renal function were evaluated using multiple linear regression analysis. Forty-nine patients were included. The estimated glomerular filtration rate decreased from 73.3 ± 2.0 to 47.2 ± 1.6 mL/min/1.73 m
2
(
P
< 0.01) and the nighttime urine volume rate increased from 40.6% ± 2.0% to 45.3% ± 1.5% (
P
= 0.04) with nephrectomy. The nighttime urine osmolality decreased from 273 ± 15 to 212 ± 10 mOsm/kg and the nighttime salt excretion rate increased from 38.7% ± 2.1% to 48.8% ± 1.7% (both
P
< 0.01) with nephrectomy. Multiple linear regression analysis showed that the increase in the nighttime urine volume rate was strongly affected by the increase in the nighttime salt excretion rate. A decrease in renal function causes an increase in the nighttime urine volume rate, mainly because of an increase in nighttime salt excretion.
Trial registration number: UMIN000036760 (University Hospital Medical Information Network Clinical Trials Registry).
Date of registration: From 1 June 2019 to 31 October 2020.
Journal Article