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The pistachio tree (Pistacia vera) is globally renowned for its nutritious nuts, while its leaves remain an underutilized source of chemicals with significant potential value as food preservatives. Similar value may be found in the leaves of other wild Pistacia species common in Central Asia, the Levant, and around the Mediterranean. Some species’ leaves have been used as natural preservatives, demonstrating their effectiveness and highlighting their rich bioactive components. This review investigates the antioxidant and antimicrobial properties of Pistacia leaves, comparing both cultivated and wild species. A comprehensive search was performed across several scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar, utilizing a combination of keywords related to Pistacia species and their bioactive compounds. The inclusion criteria focused on articles published in English from 2017 till the end of June 2024, analyzing the antioxidant and antimicrobial activities of Pistacia leaves and employing relevant extraction methods. A total of 71 literature sources were included, covering species such as P. vera, P. atlantica, P. terebinthus, and others sourced from countries such as Iran, Turkey, and Italy. This review found that Pistacia leaves are rich in polyphenolic compounds and exhibit robust antioxidant and antimicrobial properties, with certain wild species outperforming P. vera, suggesting species-specific traits that enhance their preservative potential. The major findings indicate that extracts from wild species exhibit superior bioactivity, which could be harnessed for food preservation. These insights underscore the promising role of Pistacia leaves as natural food preservatives, with further research needed to address challenges in extraction and application. Exploring their synergistic effects with other preservatives could lead to innovative solutions in food preservation while fostering local economic growth.

Background Interspecific interactions among insect herbivores are common and important. Because they are surrounded by plant tissue (endophagy), the interactions between gall-formers and other herbivores are primarily plant-mediated. Gall-forming insects manipulate their host to gain a better nutrient supply, as well as physical and chemical protection form natural enemies and abiotic factors. Although often recognized, the protective role of the galls has rarely been tested. Results Using an experimental approach, we found that the aphid, Smynthurodes betae , that forms galls on Pistacia atlantica leaves, is fully protected from destruction by the folivorous processionary moth, Thaumetopoea solitaria . The moth can skeletonize entire leaves on the tree except for a narrow margin around the galls that remains intact (“trimmed galls”). The fitness of the aphids in trimmed galls is unharmed. Feeding trials revealed that the galls are unpalatable to the moth and reduce its growth. Surprisingly, S. betae benefits from the moth. The compensatory secondary leaf flush following moth defoliation provides new, young leaves suitable for further gall induction that increase overall gall density and reproduction of the aphid. Conclusions We provide experimental support for the gall defense hypothesis. The aphids in the galls are protracted by plant-mediated mechanisms that shape the interactions between insect herbivores which feed simultaneously on the same host. The moth increase gall demsity on re-growing defoliated shoots.

Wings are a crucial evolutionary trait of insects and constitute an important part of their sensory system. Phloem-feeding aphids specialising in particular host plant species require an efficient sensory system and locomotive abilities to find an appropriate plant to complete the life cycle. Wings (in winged morphs) play a crucial role in this dispersal, but the sensory part of their structure is neglected. Here, we review campaniform sensilla, responsible for sensing the mechanical deformations of wings, in the aphid subfamily Eriosomatinae, where many species are host-alternating, which requires distant flights. Based on light and scanning electron microscopy, we illustrate sensilla and their arrangement on wings in 10 species. We also provide a broader sensory background by correlating their number with other important olfactory and campaniform sensilla of the antennae and legs. We find a strong relation of forewing sensilla with olfactory receptors on antennae, but their number is specific for particular morphs, depending on the required flight effort, led by the abundance of the host plant. Morphs migrating to less abundant host have 1.15 to 1.77 more campaniform sensilla per 1 mm of forewing length than morphs migrating to more abundant host. Aphids reveal a relatively high number of sensilla on the distal part of the forewings, showing their importance for effective sensing the deformation of wing.

The diet of ungulates is often characterized by low protein levels and the presence of indigestible and defensive compounds. It also often lacks micronutrients (vitamins and minerals) essential for growth, health and reproduction. Ungulates select rich plant organs to compensate for nutrient shortages and may consume soil, faeces and even bones. It is common for ungulates to incidentally ingest plant-dwelling insects (PDI) while feeding. It is well known that insects contain protein and essential nutrients that can feed livestock, potentially replacing conventional feed. Based on this, we propose the ‘nutritional benefit of incidental ingestion’ hypothesis, suggesting that ungulates may nutritionally benefit from ingesting PDI while foraging. Based on evidence from the literature on PDI ingestion by ungulates and on the nutritional properties of different insects, we discuss how and whether the ingestion of PDI while foraging might improve the nutrient balance of ungulates and recommend a set of controlled experiments to test it. We provide a new and unfamiliar dimension of nutritional ecology, which is relevant to various grazing ecosystems. We propose to modify “trivial” food web structures, as direct trophic interactions between ungulates and PDI may hold greater significance for ungulate performance and behaviour.

This data paper describes the multinational Database of Flood Fatalities from the Euro-Mediterranean region FFEM-DB that hosts data of 2,875 flood fatalities from 12 territories (nine of which represent entire countries) in Europe and the broader Mediterranean region from 1980 to 2020. The FFEM-DB database provides data on fatalities’ profiles, location, and contributing circumstances, allowing researchers and flood risk managers to explore demographic, behavioral, and situational factors, as well as environmental features of flood-related mortality. The standardized data collection and classification methodology enable comparison between regions beyond administrative boundaries. The FFEM-DB is expandable, regularly updated, publicly available, and with anonymized data. The key advantages of the FFEM-DB compared to existing datasets containing flood fatalities are its high level of detail, data accuracy, record completeness, and the large sample size from an extended area.Measurement(s)flood mortality characteristics • condition (means of transport) • activity • accident place • accident dynamic • death cause • protective behavior • hazardous behaviorTechnology Type(s)data collectionFactor Type(s)demographics • country • administrative units • NUTS 1–3Sample Characteristic - Locationterritories in the Euro-Mediterranean region

Background Upon the detection of imminent peril, pea aphids ( Acyrthosiphon pisum ) often drop off their host plant. Dropping in response to insect enemies is intermittent in nature, but when a mammalian herbivore feeds on their host plant, a large mixed-age group of aphids usually drops off the plant at once. Aphids that reach the ground are confronted with new, hostile environmental conditions and must therefore quickly walk toward a suitable host plant. The longer it takes an aphid to reach a host plant, the more it is exposed to the risks of starvation, desiccation and predation. Results We found that young nymphs, which have limited mobility and high mortality on the ground, quickly climb on conspecific (not necessarily parental) adults and cling to them before the latter start walking in search of a plant. This “riding” behavior is likely to be adaptive for the nymphs, for it shortens their journey and the time they spend off a host plant. Adults however, seem to be irritated by the riding nymphs, as they often actively try to remove them. Conclusions After dropping from the host plant, young aphid nymphs travel at least part of the way back to a plant on the backs of adults. For the riding behavior to take place, nymphs need to successfully find adults and withstand removal attempts.

Whistling thorn acacia (Acacia (Vachellia) drepanolobium) forms nearly monospecific stands among woody species in black cotton soils in East Africa arid highlands. The tree defends itself against large mammal herbivores with spinescence and symbiotic ants. While these defenses have been extensively studied, little is known about the extent to which A. drepanolobium defense may benefit other plants growing in close association. We examined variation in herbaceous vegetation height, biomass, and composition between areas underneath A. drepanolobium canopies and the adjacent matrix in both fenced herbivore exclosures and unfenced areas. In unfenced areas, there was more tall herbaceous vegetation and biomass underneath tree canopies than away from tree canopies, while these differences were not significant in fenced exclosures. Both height and biomass of understory vegetation were negatively correlated with A. drepanolobium canopy height. Species richness was higher underneath tree canopies in both fenced and unfenced locations. In the unfenced locations, species evenness was lower underneath tree canopies than in the surrounding matrix, but the opposite was true in the fenced herbivore exclosures. The differences in herbaceous vegetation composition (Bray–Curtis dissimilarity index) between underneath tree and off tree locations were more pronounced in the unfenced areas than within the fenced herbivore exclosures. Our findings suggest that highly defended trees may moderate herbivore effects on herbaceous vegetation. To the extent that herbaceous vegetation underneath trees experiences protection from herbivory, such refugia microhabitats may serve as recolonization nuclei in attempts to restore chronically overgrazed systems. In areas facing intense herbivory pressure, heavily defended trees like Acacia drepanolobium may serve as nurse plants, creating refugia microhabitats for the growth of vulnerable plants. Such refugia habitats promote diversity across the landscape and may also serve as recolonization nuclei for rare species.

The direct trophic links between mammalian herbivores and plant-dwelling insects have been practically ignored. Insects are ubiquitous on plants consumed by mammalian herbivores and are thus likely to face the danger of being incidentally ingested by a grazing mammal. A few studies have shown that some herbivorous hemipterans are able to avoid this peril by dropping to the ground upon detecting the heat and humidity on the mammal's breath. We hypothesized that if this risk affects the entire plant-dwelling insect community, other insects that share this habitat are expected to develop similar escape mechanisms. We assessed the ability of three species (adults and larvae) of coccinellid beetles, important aphid predators, to avoid incidental ingestion. Both larvae and adults were able to avoid incidental ingestion effectively by goats by dropping to the ground, demonstrating the importance of this behavior in grazed habitats. Remarkably, all adult beetles escaped by dropping off the plant and none used their functional wings to fly away. In controlled laboratory experiments, we found that human breath caused 60-80% of the beetles to drop. The most important component of mammalian herbivore breath in inducing adult beetles and larvae to drop was the combination of heat and humidity. The fact that the mechanism of dropping in response to mammalian breath developed in distinct insect orders and disparate life stages accentuates the importance of the direct influence of mammalian herbivores on plant-dwelling insects. This direct interaction should be given its due place when discussing trophic interactions.

Large mammalian herbivores influence grassland ecosystems through plant consumption, return of excreta and trampling, and by altering nutrient cycles and soil properties. These herbivore‐mediated changes impact other animals in the habitat, particularly plant‐dwelling arthropods. While plant‐mediated effects of large mammalian herbivores on arthropod populations are well documented, direct effects, such as incidental ingestion of arthropods, remain understudied. Large mammalian herbivores incidentally ingest a variety of plant‐dwelling arthropods; however, it remains unclear how this interaction is influenced by the dietary choices of different mammal species within the same habitat. Using a DNA metabarcoding analysis of fecal samples, we investigated the ingestion of plant‐dwelling arthropods by sheep and cattle grazing in northeast Asian grasslands. Fecal samples were collected from replicated plots throughout the grazing season, including previously grazed and ungrazed plots. A COI marker was used to amplify arthropod DNA, followed by high‐throughput sequencing. Results revealed that both sheep and cattle ingest a variety of plant‐dwelling arthropods, including herbivores, parasitoids, and predators, with a high proportion of endophages (species developing in plant tissue). Significant differences were observed in ingestion between sheep and cattle—sheep (selective grazers) ingested a wider variety of plant‐dwelling arthropods compared to cattle, whose diet consisted primarily of grasses, highlighting the impact of dietary choices on arthropod ingestion. Grazing regime influenced the ingestion of plant‐dwelling arthropods in sheep, with differences observed between previously grazed and ungrazed plots. Our findings demonstrate that the ingestion of plant‐dwelling arthropods by large mammalian herbivores is a dynamic and widespread phenomenon, varying across mammalian species and seasons. In this study, a DNA metabarcoding analysis of fecal samples reveals the frequent incidental ingestion of plant‐dwelling arthropods by sheep and cattle foraging in the same habitat. Sheep and cattle ingest different varieties of arthropods. The incidental ingestion of arthropods by these large herbivores reflects their distinct dietary preferences.

Background: Correlations between development of hand–foot syndrome (HFS) and efficacy in patients receiving capecitabine (CAP)-containing therapy are reported in the literature. We explored the relationship between HFS and efficacy in patients receiving CAP plus bevacizumab (BEV) in the TURANDOT randomised phase III trial. Methods: Patients with HER2-negative locally recurrent/metastatic breast cancer (LR/mBC) who had received no prior chemotherapy for LR/mBC were randomised to BEV plus paclitaxel or BEV–CAP until disease progression or unacceptable toxicity. This analysis included patients randomised to BEV–CAP who received ⩾1 CAP dose. Potential associations between HFS and both overall survival (OS; primary end point) and progression-free survival (PFS; secondary end point) were explored using Cox proportional hazards analyses with HFS as a time-dependent covariate (to avoid overestimating the effect of HFS on efficacy). Landmark analyses were also performed. Results: Among 277 patients treated with BEV–CAP, 154 (56%) developed HFS. In multivariate analyses, risk of progression or death was reduced by 44% after the occurrence of HFS; risk of death was reduced by 56%. The magnitude of effect on OS increased with increasing HFS grade. In patients developing HFS within the first 3 months, median PFS from the 3-month landmark was 10.0 months vs 6.2 months in patients without HFS. Two-year OS rates were 63% and 44%, respectively. Conclusions: This exploratory analysis indicates that HFS occurrence is a strong predictor of prolonged PFS and OS in patients receiving BEV–CAP for LR/mBC. Early appearance of HFS may help motivate patients to continue therapy.