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Conflict resolution in Asia : mediation and other cultural models
\"Examines the role of mediation and other cultural conflict resolution models in Asia. The contributors use various countries as case studies to analyze how traditional, indigenous, and culturally based conflict resolution processes interact with more formal legal systems to address conflicts\"-- Provided by publisher.
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The effect of simvastatin–Acalypha indica Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet
Objective: The study aimed to determine the effect of Acalypha indica Linn. (AI) root extract and a combination of simvastatin–AI on improving the fatty pancreas in Sprague–Dawley rats induced with a high fructose and cholesterol diet. Materials and Methods: Twenty-four male Sprague–Dawley rats were induced with a high fruc¬tose and cholesterol diet for 4 weeks before being divided into four groups. Each group receiving treatments consisting of simvastatin only, A. indica extracts only, or simvastatin–A. indica extract combination. A histological examination was conducted to determine the effect of each treatment. Also, one-way analysis of variance (ANOVA) and post-hoc Bonferroni test were conducted to assess the comparison of groups from the histological examination. Results: Significant improvement was found in fatty pancreas between rats without therapy and rats treated with simvastatin therapy (p = 0.024, 95% CI: 0.038–0.696), and also between rats without treatment and rats treated with simvastatin–A. indica extract combination therapy (p = 0.000, 95% CI: 0.241–0.873) using one-way ANOVA and the post-hoc Bonferroni test. Conclusions: The results of the combination of simvastatin–A. indica Linn. root extracts treatment showed a synergistic effect on the improvement of fatty pancreas, but further research is needed to find potential adverse effects on the interaction of these two substrates to confirm the safe use of this treatment.
Journal Article
Dengue incidence and length of viremia by RT-PCR in a prospective observational community contact cluster study from 2005–2009 in Indonesia
Dengue has become a major global health threat since being recognized three centuries ago. Important gaps remain in understanding the transmission dynamics of dengue virus (DENV) infection. This study reports the results of a prospective observational cluster study that investigated the incidence of symptomatic and asymptomatic infections and length of viremia among close community contacts of hospitalized DENV-infected patients.
Between 2005 and 2009, dengue-confirmed cases (n = 97) admitted to Hasan Sadikin Hospital in Bandung, Indonesia, were enrolled as index cases. Subsequently, twenty close community contacts (n = 1928) living with and around the index cases were included and followed up for up to 14 days. Body temperature was measured daily; blood samples were collected every 3-4 days and when reported fever. DENV infection was confirmed using Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR), IgM rapid test, and Enzyme-linked Immunosorbent Assay (ELISA). Among the 1928 community contacts, a total of 72 (3.7%) acute DENV infections were diagnosed, which equates to an incidence of 636 cases per 1,000 person-years (95% Confidence interval (CI) 588 to 687 cases per 1,000 person-years). Twenty-nine cases (40%) were symptomatic (22 dengue fever (DF) & 7 dengue hemorrhagic fever (DHF)), and 43 (60%) were asymptomatic. Primary and secondary DENV infections were detected in 18 (25%) and 54 (75%) subjects. Among the RT-PCR positives, viremia was observed as early as seven days before fever onset and converted to negative as late as seven days after the onset of fever.
DENV infections are common among close community contacts of hospitalized dengue patients. The high number of asymptomatic infections and the observation that viremia precedes the onset of fever for up to seven days highlight the importance of unrecognized dengue transmission and the need for improved transmission control.
Journal Article
Microplastic abundance and distribution in surface water and sediment collected from the coastal area
BACKGROUND AND OBJECTIVES: Rapid development has increased the microplastics discharges into marine environments, including coastal waters at Jakarta Bay, Indonesia. This study is proposed to assess microplastics abundance and distribution in surface water and sediment from coastal water at Jakarta Bay. METHODS: The samples were collected from 12 locations representing Ancol, Muara Baru, and Muara Angke- Muara Karang. Samples of water and sediment were extracted to obtain the microplastics. The microplastics were identified based on their morphology (shape) and numbered for their abundance. The polymer of microplastics was determined using Raman Spectrophotometer. FINDINGS: The results showed that microplastics were successfully identified and counted in water and sediment samples at all collection points. The number of microplastics was 1532 particles in the water sample and 1419 particles in the sediment sample. The shape of microplastics observed in the water and sediment samples were fibers, films, fragments, and pellets. Among those, fiber and film were the most dominant microplastic detected both in surface water and sediment in all locations. Three polymers, namely polyethylene, polypropylene, and polystyrene, were detected in the microplastic samples. These findings prove that microplastics with their various types are capable contaminate the aquatic environment. CONCLUSION: The most common microplastics shapes in sediment were fiber (55.7%) > film (31.1%) > fragment (9.9%) > pellet (3.2%) and for the surface water were film (53.5%) > fiber (33.9%) > fragment (7.8%) > pellet (4.7%). The abundance of microplastics in the sediment (166.8 particles/kg, 95%CI: 148.0-185.0) was significantly higher (p < 0.05) than in surface water (70.9 particles/L, 95%CI: 55.6-86.2). The abundance of microplastics was significantly different among locations (p < 0.05, F = 2.115), with microplastics in sediments were higher in Ancol, and Muara Angke - Muara Karang have the highest microplastics in surface water. These results can provide valuable information on which parts of the Jakarta Bay areas should be prioritized first regarding microplastics management.
Journal Article
Community empowerment of waste management in the urban environment: More attention on waste issues through formal and informal educations
BACKGROUND AND OBJECTIVES: Indonesia's economic growth is estimated to be driven by high levels of consumption which lead to large amounts of waste. Education is required to raise environmental awareness among the population as it is one of the ways to overcome the waste issue, especially in urban areas, which are the engines of economic growth. This study aims to determine whether the higher levels of education have a greater impact on citizens regarding environmental concerns such as littering. METHODS: The study took logistics regression on the primary data survey from 7 cities (Jakarta, Jambi, Muaro Jambi, Ambon, Padang, Surabaya, and Tasikmalaya) in Indonesia during 2019-2021. The survey includes 563 observations on the household level, involving a total of 2,349 respondents. The logistic regression predicts the likelihood of urban citizens to litter, given their socio-economic backgrounds and existing littering behavior and environmental awareness. FINDINGS: This study found that education did not affect decreasing the value of littering behavior as expected since it is estimated that an increase of 1 year in school will increase the probability of littering by 0.0189. Formal education is not enough to decrease the probability of littering behavior on the individual level. In contrast, informal education taught on keeping a clean environment matters is better than conventional formal education. Besides that, having self-initiative on environmental caring and good habits from childhood will decrease the probability of littering on an individual level. An individual has a self-initiative, the probability of littering will be 0.1732 times lower than those who do not have self-initiative. This study also found that per capita income and per capita expenditure in big cities in Indonesia ranged between USD 156,903 and USD 116,857. These economic factors affect the behavior of citizens not to litter. The per capita expenditure increasing by USD 1 per person per day will decrease the probability of littering by-0.0468. However, these factors are not enough to minimize the littering behavior since the disposal place availability becomes another keys factor in decreasing littering behavior on urban citizens. CONCLUSION: The government should also focus on building citizens' behavior regarding waste management awareness especially building good habits since childhood and individual initiative, simultaneously implementing the programs to reduce waste production.
Journal Article
Evaluation of inhibitor activity of bacterial sialidase from Clostridium perfringens against Newcastle disease virus in the cell culture model using chicken embryo fibroblast
Objective: The Newcastle disease virus (NDV) is an infectious disease that causes very high eco¬nomic losses due to decreased livestock production and poultry deaths. The vaccine’s ineffec¬tiveness due to mutation of the genetic structure of the virus impacts obstacles in controlling the disease, especially in some endemic areas. This study aimed to provide an alternative treatment for NDV infection by observing the viral replication inhibitor activity of Clostridium perfringens sialidase in primary chicken embryo fibroblast (CEF) cells. Materials and Methods: The virus was adapted in CEF monolayer cells, then collected thrice using the freeze–thaw method and stored at −20°C for the next step in the challenge procedure. C. perfringens crude sialidase was obtained, but it was further purified via stepwise elution in ion exchange using Q Sepharose® Fast Flow and affinity chromatography with oxamic acid agarose. The purified sialidase was tested for its toxicity, ability to breakdown sialic acid, stopping viral replication, and how treated cells expressed their genes. Results: According to this study, purified C. perfringens sialidase at dosages of 187.5, 93.75, and 46.87 mU effectively hydrolyzes CEF cells’ sialic acid and significantly inhibits viral replication on the treated cells. However, sialidase dosages of 375 and 750 mU affected the viability of mono¬layer CEF cells. Interestingly, downregulation of toll-like receptor (TLR)3 and TLR7 (p < 0.05) in the sialidase-treated group indicates viral endocytosis failure. Conclusions: By stopping endocytosis and viral replication in host cells, sialidase from C. perfrin¬gens can be used as an alternative preventive treatment for NDV infection.
Journal Article