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Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct inflammatory disease models. GSTO1-1 deficiency ameliorates the inflammatory response stimulated by LPS and attenuates the inflammatory impact of a high fat diet on glucose tolerance and insulin resistance. In contrast, GSTO1-1 deficient mice show a more severe inflammatory response and increased escape of bacteria from the colon into the lymphatic system in a dextran sodium sulfate mediated model of inflammatory bowel disease. These responses are similar to those of TLR4 and MyD88 deficient mice in these models and confirm that GSTO1-1 is critical for a TLR4-like pro-inflammatory response in vivo . In wild-type mice, we show that a small molecule inhibitor that covalently binds in the active site of GSTO1-1 can be used to ameliorate the inflammatory response to LPS. Our findings demonstrate the potential therapeutic utility of GSTO1-1 inhibitors in the modulation of inflammation and suggest their possible application in the treatment of a range of inflammatory conditions.

Saab will show the first production-based engine to use pure bioethanol fuel at next month's Geneva motor show. The new engine will be displayed in the Saab Biopower 100 Concept, based on a Saab 9-5 Sport Estate. Toyota Australia's multi-billion-dollar export program reached new heights this week with the 500,000th Camry being sent to the Middle East. About 65 per cent of all the four-cylinder Camrys exported from Australia go to Saudi Arabia, Kuwait, Bahrain, Oman, Qatar, and the United Arab Emirates. \"The new Camry is the backbone of Toyota Australia's total export program,\" Toyota Australia president and CEO Ted Okada says, \"We are confident of reaching an export target of more than 90,000 cars in 2007.\"

The engine is the 1.5-litre with 80kW power. YRX has leather- clad steering wheel and shift lever, six-stack CD and 15-inch alloy wheels. Recommended for any Yaris is the $750 safety pack, adding front-seat side airbags, full-length curtain airbags and driver's knee airbag. The starter Jazz GLi with 1339cc, 61kW engine is now $15,990 and includes airconditioning (previously GLi was $15,390 plus $2000 for airconditioning). Jazz GLi now gets full-size spare wheel, keyless entry, LED rear lights and chrome touches. Jazz VTi ($17,990) and VTI-S ($20,390) with 1.5-litre, 81kW engine has those new bits plus turn indicators in outside mirrors. Honda charges $2000 for automatic transmission on Jazz GLi and $2300 on VTi and VTi-S.