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GroundBIRD is a ground-based experiment for a precise observation of the cosmic microwave background (CMB) polarizations. To achieve high sensitivity at large angular scales, we adopt three features in this experiment: fast rotation scanning, microwave kinetic inductance detector (MKID), and cold optics. The rotation scanning strategy has the advantage to suppress 1/ f noise. It also provides a large sky coverage of 40%, which corresponds to the large angular scales of l ∼ 6 . This allows us to constrain the tensor-to-scalar ratio by using low l B-mode spectrum. The focal plane consists of 7 MKID arrays for two target frequencies, 145 GHz and 220 GHz band. There are 161 pixels in total, of which 138 are for 145 GHz and 23 are for 220 GHz. This array is currently under development, and the prototype will soon be evaluated in telescope. The GroundBIRD telescope will observe the CMB at the Teide observatory. The telescope was moved from Japan to Tenerife and is now under test. We present the status and plan of the GroundBIRD experiment.

Microwave kinetic inductance detectors have a variety of potential applications in astronomical observations. We built a data acquisition system for kinetic inductance detectors combining a dedicated analog board and a commercially available digital board to meet the requirements of astronomical measurements, such as observation of the cosmic microwave background. This paper reports the status of the development of the data acquisition system. We have already achieved simultaneous readout through 120 channels using a direct down-conversion method to decode the signal. A variety of software has been developed and tested using the functionalities of the system and actual detectors.

In a previous study, we showed that levels of cell-free DNA (cfDNA) were significantly higher in sera of patients with hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) than in sera of non-HCC patients with HCV. To confirm this finding, we analysed serum cfDNA levels in a cohort of 96 patients with HCV-related HCC and in 100 HCV carriers without known HCC. Again we found that serum cfDNA levels were significantly higher in HCC patients than in HCV carriers (115.9±98.3 vs 34.4±40.4 ng ml −1 (mean±s.d.), P <0.0001). Of 87 eligible patients who underwent curative hepatectomy, those with a high cfDNA level had a significantly shorter overall survival (OS) time than those in whom the cfDNA level was not high. Cox proportional hazards model showed the cfDNA level to be an independent prognostic factor for OS and cancer recurrence in distant organs. Our results suggest that the serum cfDNA level reflects the metastatic potential of HCV-related HCC and that it can be a useful predictive biomarker for distant metastasis after curative surgery.

Precise measurements of polarization patterns in cosmic microwave background (CMB) provide deep knowledge about the begin of the Universe. The GroundBIRD experiment aims to measure the CMB polarization by using microwave kinetic inductance detector (MKID) arrays. The MKID is suited to multiplexing. One of our requirements is a MUX factor (the number of readout channels for a single wire pair) of at least 100. If we make frequency combs of the MKIDs with 2-MHz spacing, a bandwidth of 200 MHz satisfies 100 MUX. The analog electronics must consist of an analog-to-digital converter (ADC), digital-to-analog converter (DAC), and local oscillator. We developed our own analog electronics board “ RHEA .” Two outputs/inputs of DAC/ADC with a 200-MHz clock provide an effective bandwidth of 200 MHz. The RHEA allows us to measure both the amplitude and phase responses of each MKID simultaneously. These data are continuously sampled at a high rate (e.g., 1 kSPS) and with no dead time. We achieved 12 and 14 bits resolution for ADC and DAC, respectively. This corresponds to achieve that our electronics achieved low noise: 1/1000 compared with the detector noise. We also achieved low power consumption compared with that of other electronics development for other experiments. Another important feature is that the board is completely separated from the digital part. Each user can choose their preferred field-programmable array. With the combination of the Kintex-7 evaluation kit from Xilinx, we demonstrated readout of MKID response.

The GroundBIRD telescope aims to detect B-mode polarization of the cosmic microwave background radiation using the kinetic inductance detector array as a polarimeter. For the readout of the signal from detector array, we have developed a frequency division multiplexing readout system based on a digital down converter method. These techniques in general have the leakage problems caused by the crosstalks. The window function was applied in the field programmable gate arrays to mitigate the effect of these problems and tested it in algorithm level.

Cosmic microwave background (CMB) radiation is an afterglow from the Big Bang. CMB contains rich information about the early stage of the universe. In particular, odd-parity patterns ( B -mode) in the CMB polarization on a large angular scale would provide an evidence of the cosmic inflation. The aim of the GroundBIRD experiment is to observe the B -mode on large angular scales from the ground. One of the most novel characteristics of the telescope used for this experiment is its rapid rotational scanning technique. In addition, the telescope uses cold optics and microwave kinetic inductance detectors. We have developed a telescope mount with a three-axis rotation mechanism (azimuth, elevation, and boresight) and measured the vibration at the focal plane stage at 20 RPM scan rotation rate. We also performed focal plane detector tests on this mount. The tests confirmed the expected response from the geomagnetism associated with the mount rotation. We have also developed a design for the magnetic shields and a detector array on a 3-in wafer. The preparations to begin the observations at the Teide Observatory in the Canary Islands in 2018 are proceeding smoothly.

The kinetic inductance detector (KID) is a cutting-edge superconducting detector. The number of KID developers is growing. Most of them have switched from their previous study to superconducting technologies. Therefore, infrastructures for the fabrication of KIDs and cooling systems for their tests have already been established. However, readout electronics have to be newly prepared. Neither a commercial system nor low-cost standard electronics are available despite various attempts to create a standard one. We suggest the use of RedPitaya as readout electronics for the initial step of KID development, which is low cost ( ≈ 400 USD) and easy to set up. The RedPitaya consists of an all-programmable FPGA-CPU module and a dual-channel 14 bit DAC (ADC) to generate (measure) fast analog signals with 125 MSpS. Each port can be synchronized in-phase or quadrature-phase, and functions for generating and sampling analog signal are prepared. It is straightforward to construct vector network analyzer-like logic by using a combination of these default functions. Up-conversion and down-conversion of its frequency range are also possible by using commercial equipment, i.e., mixers, couplers, and a local oscillator. We implemented direct down-conversion logic on the RedPitaya, and successfully demonstrated KID signal measurements.

Our understanding of physics at very early Universe, as early as 10 −35 s after the Big Bang, relies on the scenario known as the inflationary cosmology. Inflation predicts a particular polarization pattern in the cosmic microwave background, known as the B -mode yet the strength of such polarization pattern is extremely weak. To search for the B -mode of the polarization in the cosmic microwave background, we are constructing an off-axis rotating telescope to mitigate systematic effects as well as to maximize the sky coverage of the observation. We will discuss the present status of the GroundBIRD telescope.

To identify the factors governing the dose-limiting toxicity in the gastrointestine (GI) and the antitumor activity after oral administration of capecitabine, a triple prodrug of 5-FU, in humans. The enzyme kinetic parameters for each of the four enzymes involved in the activation of capecitabine to 5-FU and its elimination were measured experimentally in vitro to construct a physiologically based pharmacokinetic model. Sensitivity analysis for each parameter was performed to identify the parameters affecting tissue 5-FU concentrations. The sensitivity analysis demonstrated that (i) the dihydropyrimidine dehydrogenase (DPD) activity in the liver largely determines the 5-FU AUC in the systemic circulation, (ii) the exposure of tumor tissue to 5-FU depends mainly on the activity of both thymidine phosphorylase (dThdPase) and DPD in the tumor tissues, as well as the blood flow rate in tumor tissues with saturation of DPD activity resulting in 5-FU accumulation, and (iii) the metabolic enzyme activity in the GI and the DPD activity in liver are the major determinants influencing exposure to 5-FU in the GI. The therapeutic index of capecitabine was found to be at least 17 times greater than that of other 5-FU-related anticancer agents, including doxifluridine, the prodrug of 5-FU, and 5-FU over their respective clinical dose ranges. It was revealed that the most important factors that determine the selective production of 5-FU in tumor tissue after capecitabine administration are tumor-specific activation by dThdPase, the nonlinear elimination of 5-FU by DPD in tumor tissue, and the blood flow rate in tumors.