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A 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P. ovale s.l. -infected erythrocytes in the spleen parenchyma compared to the general circulation. Infected erythrocytes also accumulated in small extra-splenic blood vessels, suggesting cytoadherence.

Atovaquone/proguanil is frequently prescribed among travellers to malaria-endemic areas. Side effects most commonly include headaches and gastrointestinal symptoms. Nevertheless, physicians should be aware of possible rare severe cutaneous adverse reactions, in order to facilitate the diagnosis and interrupt the drug rapidly if suspected.

Lyme borreliosis is known to be endemic in temperate countries of the Northern hemisphere but is rarely reported in other regions of the world. Here, we describe a rare diagnosis in a traveller returning from India, who presented with two erythema migrans.

The risk of dengue emergence in France this summer is likely and must be considered in preparedness planning. The risk could arise from international visitors but also French travellers returning from epidemic areas. The French preparedness and response plan and the importance of international surveillance after the Olympics are highlighted.

We report the spectrum of skin diseases in returning international travellers seen in our department, with the participation of a dermatologist for each consultation. Of 135 dermatoses (60% appearing abroad), 33.3% were considered as tropical, and 44–52% were related to arthropod exposure, highlighting the need and importance of anti-mosquito measures.

Rabies is a vaccine-preventable zoonotic disease which causes thousands of deaths every year, mainly in Asia and Africa, and dogs are the main source of human cases. Although rabies is rare in international travellers, rabies exposure is relatively frequent and the number of travellers seeking post-exposure treatment may rise as international travel continues to increase. We aimed to better understand the characteristics of travellers exposed to rabies abroad, in order to deliver targeted advice and rabies vaccination during pre-travel clinics. During 2018–2022, we studied all returning travellers who attended a single travel clinic in Paris, France, for animal exposures abroad and requiring rabies post-exposure prophylaxis (n = 2916). During the study period, 2916 returning travellers were included, and 59.7 % of exposures occurred in Southeast Asia (mainly Thailand and Indonesia) and North-Africa. Dogs were predominantly responsible for exposures, but the animals involved varied significantly according to the region visited and the age of the traveller. Monkey exposures were more frequently reported in Asia, and cat exposures in North Africa and among children. Exposures were reported as unprovoked in 22.9 % of cases, and 91 % of travellers had not received anti-rabies vaccines before travelling. Travellers to rabies endemic countries should benefit from more targeted information based on the region visited, the animals they are likely to encounter, and the age of the travellers. Critically, they should be counselled on the importance of avoiding contact with animals, the long-lasting benefit of pre-travel rabies vaccination, and the need for adequate post-exposure prophylaxis. •Almost 60 % of animal exposures occurred in Southeast Asia and Norh Africa.•Animal species varied according to the region visited and the age of the traveller.•Exposures were unprovoked in less than one-quarter of cases.•35 % of travellers with severe injuries did not receive any rabies immunoglobulin.•Travellers need more targeted prevention information.

Gnathostomiasis is a foodborne parasitic zoonosis known to be endemic in Southeast Asia, India, Central and South America, with recent cases reported in Zambia, Botswana and South Africa. We report a case of gnathostomiasis acquired in Madagascar and alert clinicians of the emerging risk in southern Africa.

Abstract Background Humanitarian aid workers are exposed to deployment-related health threats. Identifying subgroups at a higher risk of infection in this diverse population could help optimize prevention. Methods We carried out a retrospective study based on anonymized data of humanitarian aid workers that visited our clinic for a post-deployment visit between 1 January 2018 and 31 December 2021. We conducted a descriptive analysis of basic demographic data, self-reported risk exposure and health problems encountered during deployment extracted from a standard questionnaire. Results The questionnaire was administered to 1238 aid workers during 1529 post-deployment medical consultations. The median age was 37.2 years (IQR 31.7–44.3), and 718/1529 (47.0%) were female aid workers. The median duration of deployment was 6 months (IQR 3–12 months). Most deployments (1321/1529 (86.4%)) were for a medical organization and in Sub-Saharan Africa (73.2%). The most common risk exposures were contact with freshwater in schistosomiasis endemic regions (187/1308 (14.3%)), unprotected sexual contact with a person other than a regular partner (138/1529 (9.0%)), suspected rabies exposure (56/1529 (3.7%)) and accidental exposure to blood (44/1529 (2.9%)). Gastrointestinal problems (487/1529 (31.9%)), malaria (237/1529 (15.5%)) and respiratory tract infections (94/1529 (6,2%)) were the most encountered health problems. Fifteen volunteers (1%) were hospitalized during deployment and 19 (1.2%) repatriated due to health problems. Adherence to malaria chemoprophylaxis was poor, only taken according to the prescription in 355 out of 1225 (29.0%) of aid workers for whom prophylaxis was indicated. Conclusion Humanitarian aid workers deployed abroad encounter significant rates of health problems and report a high level of risk exposure during their deployment, with the risks being greatest among younger people, those deployed to rural areas, and those working for non-medical organizations. These findings help guide future pre-deployment consultations, to increase awareness and reduce risk behaviour during deployment, as well as focus on adherence to medical advice such as malaria chemoprophylaxis.

Abstract We present a case of Erysipelothrix rhusiopathiae spondylodiscitis in an otherwise healthy man, occurring 1 year after exposure. The patient was cured after 6 weeks of treatment with amoxicillin followed by ciprofloxacin without surgery. Erysipelothrix rhusiopathiae can cause severe osteoarticular infections with a delayed presentation following exposure to the pathogen.

The global resurgence of measles is a threat to measles elimination campaigns. Measles importations by international travelers have been identified as a risk factor for outbreaks. We reviewed measles cases among international travelers and migrants reported to the GeoSentinel network. From May 2019 through June 2025, GeoSentinel recorded 53 measles cases among travelers imported into 15 different countries. Travelers of all age groups were affected, and 74 % were 21 years or older. Thirty-three travelers (61 %) were hospitalized. Seventy-nine percent of cases reported no or unknown history of vaccination against measles. Against a background of increasing numbers of measles cases and outbreaks globally, GeoSentinel observed a stable trend of measles importations by international travelers. Measles caused considerable morbidity among travelers. Immunization effectively prevents measles in more than 97 % of individuals. Pretravel consultations provide an important opportunity to promote vaccination coverage for all vaccine-preventable diseases, including measles.