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Due to the efforts by numerous ground-based surveys and NASA's Kepler and Transiting Exoplanet Survey Satellite (TESS), there will be hundreds, if not thousands, of transiting exoplanets ideal for atmospheric characterization via spectroscopy with large platforms such as James Webb Space Telescope and ARIEL. However their next predicted mid-transit time could become so increasingly uncertain over time that significant overhead would be required to ensure the detection of the entire transit. As a result, follow-up observations to characterize these exoplanetary atmospheres would require less-efficient use of an observatory's time-which is an issue for large platforms where minimizing observing overheads is a necessity. Here we demonstrate the power of citizen scientists operating smaller observatories (≤1 m) to keep ephemerides \"fresh,\" defined here as when the 1 uncertainty in the mid-transit time is less than half the transit duration. We advocate for the creation of a community-wide effort to perform ephemeris maintenance on transiting exoplanets by citizen scientists. Such observations can be conducted with even a 6 inch telescope, which has the potential to save up to ∼10,000 days for a 1000-planet survey. Based on a preliminary analysis of 14 transits from a single 6 inch MicroObservatory telescope, we empirically estimate the ability of small telescopes to benefit the community. Observations with a small-telescope network operated by citizen scientists are capable of resolving stellar blends to within 5″/pixel, can follow-up long period transits in short-baseline TESS fields, monitor epoch-to-epoch stellar variability at a precision 0.67% 0.12% for a 11.3 V-mag star, and search for new planets or constrain the masses of known planets with transit timing variations greater than two minutes.

Due to the efforts by numerous ground-based surveys and NASA’s Kepler and Transiting Exoplanet Survey Satellite (TESS), there will be hundreds, if not thousands, of transiting exoplanets ideal for atmospheric characterization via spectroscopy with large platforms such as James Webb Space Telescope and ARIEL. However their next predicted mid-transit time could become so increasingly uncertain over time that significant overhead would be required to ensure the detection of the entire transit. As a result, follow-up observations to characterize these exoplanetary atmospheres would require less-efficient use of an observatory’s time—which is an issue for large platforms where minimizing observing overheads is a necessity. Here we demonstrate the power of citizen scientists operating smaller observatories (⪕1m) to keep ephemerides “fresh,” defined here as when the 1σ uncertainty in the mid-transit time is less than half the transit duration. We advocate for the creation of a community-wide effort to perform ephemeris maintenance on transiting exoplanets by citizen scientists. Such observations can be conducted with even a 6 inch telescope, which has the potential to save up to ∼10,000 days for a 1000-planet survey. Based on a preliminary analysis of 14 transits from a single 6 inch MicroObservatory telescope, we empirically estimate the ability of small telescopes to benefit the community. Observations with a small-telescope network operated by citizen scientists are capable of resolving stellar blends to within 5″/pixel, can follow-up long period transits in short-baseline TESS fields, monitor epoch-to-epoch stellar variability at a precision 0.67% ± 0.12% for a 11.3 V-mag star, and search for new planets or constrain the masses of known planets with transit timing variations greater than two minutes.

Los principios de la terapia del dolor han cambiado notablemente desde la aparición de la IASP (Asociación Internacional para el Estudio del Dolor) en 1973. En esa época, se usaban mucho la pentazocina, la meperidina, etc. Sus propiedades influían en cada aspecto de la terapia del dolor y producían complicaciones como insuficiencia renal, delirium, depresión respiratoria, excitación en las salas de recuperación, náuseas, vómitos, abstinencia y tolerancia, razón por la que han sido descontinuados. Estamos pasando la fase de uso de opioides y debemos examinar otros métodos. La esperanza de que pueda surgir algún compuesto que no se base en los conceptos de los últimos doscientos años anima aún a la investigación de los más diversos agentes como las fenciclidinas, neurolépticos, esteroides y bloqueadores de receptores de NMDA. En muchos laboratorios, están en marcha análisis neurofarmacológicos y bioquímicos, por ejemplo, de remimazolam o parches de buprenorfina de duración prolongada (Norspan 10 mg), y los algólogos esperan ávidamente los resultados para la incorporación de los mismos en la terapia del dolor. A pesar de lo anterior, el principiante debe conocer perfectamente las bases de la algología, pues los aspectos del tratamiento del dolor agudo, algunos síndromes y el tratamiento agudo del cáncer son el motivo de esta edición que conserva muchas características que se seguirán perfeccionando en futuras ediciones.

Due to the efforts by numerous ground-based surveys and NASA's Kepler and TESS, there will be hundreds, if not thousands, of transiting exoplanets ideal for atmospheric characterization via spectroscopy with large platforms such as JWST and ARIEL. However their next predicted mid-transit time could become so increasingly uncertain over time that significant overhead would be required to ensure the detection of the entire transit. As a result, follow-up observations to characterize these exoplanetary atmospheres would require less-efficient use of an observatory's time---which is an issue for large platforms where minimizing observing overheads is a necessity. Here we demonstrate the power of citizen scientists operating smaller observatories (\\(\\le\\)1-m) to keep ephemerides \"fresh\", defined here as when the 1\\(\\sigma\\) uncertainty in the mid-transit time is less than half the transit duration. We advocate for the creation of a community-wide effort to perform ephemeris maintenance on transiting exoplanets by citizen scientists. Such observations can be conducted with even a 6-inch telescope, which has the potential to save up to \\(\\sim\\)10,000~days for a 1000-planet survey. Based on a preliminary analysis of 14 transits from a single 6-inch MicroObservatory telescope, we empirically estimate the ability of small telescopes to benefit the community. Observations with a small-telescope network operated by citizen scientists are capable of resolving stellar blends to within 5''/pixel, can follow-up long period transits in short-baseline TESS fields, monitor epoch-to-epoch stellar variability at a precision 0.67\\%\\(\\pm\\)0.12\\% for a 11.3 V-mag star, and search for new planets or constrain the masses of known planets with transit timing variations greater than two minutes.

We characterized polysubstance use burden and associations with mental health problems across demographic subgroups of PWH. In 2018–2020, as part of a primary care-based intervention study, PWH in care at three medical centers in Kaiser Permanente Northern California were screened for depression (PHQ-9≥10), anxiety (GAD-2≥3), and substance use (Tobacco, Alcohol, Prescription medication, and other Substance use [TAPS]≥1 per substance). We used Poisson regression to estimate prevalence ratios (PRs) comparing polysubstance use prevalence (TAPS≥1 for ≥2 substances) between PWH with positive screens for depression or anxiety vs. neither, among all PWH, and stratified by race/ethnicity and age (restricted to men), adjusting for sociodemographics, CD4, and HIV load. Screened PWH (N = 2865) included 92% men, 56% White, 19% Black, and 15% Hispanic PWH, with a median age of 55 years. Overall, polysubstance use prevalence was 26.4% (95% CI 24.9%-28.1%). PWH with depression or anxiety (n = 515) had an adjusted polysubstance use PR of 1.26 (1.09–1.46) vs. PWH with neither (n = 2350). Adjusted PRs were 1.47 (1.11–1.96), 1.07 (0.74–1.54), and 1.10 (0.85–1.41) among Black, Hispanic, and White men, respectively. Adjusted PRs did not differ by age group. Interventions should consider jointly addressing mental health and substance use problems and potential drivers, e.g. stigma or socioeconomic factors.

We characterized polysubstance use burden and associations with mental health problems across demographic subgroups of PWH. In 2018-2020, as part of a primary care-based intervention study, PWH in care at three medical centers in Kaiser Permanente Northern California were screened for depression (PHQ-9≥10), anxiety (GAD-2≥3), and substance use (Tobacco, Alcohol, Prescription medication, and other Substance use [TAPS]≥1 per substance). We used Poisson regression to estimate prevalence ratios (PRs) comparing polysubstance use prevalence (TAPS≥1 for ≥2 substances) between PWH with positive screens for depression or anxiety vs. neither, among all PWH, and stratified by race/ethnicity and age (restricted to men), adjusting for sociodemographics, CD4, and HIV load. Screened PWH (N = 2865) included 92% men, 56% White, 19% Black, and 15% Hispanic PWH, with a median age of 55 years. Overall, polysubstance use prevalence was 26.4% (95% CI 24.9%-28.1%). PWH with depression or anxiety (n = 515) had an adjusted polysubstance use PR of 1.26 (1.09-1.46) vs. PWH with neither (n = 2350). Adjusted PRs were 1.47 (1.11-1.96), 1.07 (0.74-1.54), and 1.10 (0.85-1.41) among Black, Hispanic, and White men, respectively. Adjusted PRs did not differ by age group. Interventions should consider jointly addressing mental health and substance use problems and potential drivers, e.g. stigma or socioeconomic factors.