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"Ivan, M"
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Success as a financial advisor
In step-by-step detail, Success as a Financial Advisor For Dummies covers how a current or would-be financial advisor can maximize their professional success through a series of behaviors, activities, and specific client-centric value propositions. In a time when federal regulators are changing the landscape on the standard of care that financial services clients should expect from their advisors, this book affords professionals insight on how they can be evolving their practices to align with the regulatory and technological trends currently underway.
Book
Cancer immunotherapy: the beginning of the end of cancer?
These are exciting times for cancer immunotherapy. After many years of disappointing results, the tide has finally changed and immunotherapy has become a clinically validated treatment for many cancers. Immunotherapeutic strategies include cancer vaccines, oncolytic viruses, adoptive transfer of ex vivo activated T and natural killer cells, and administration of antibodies or recombinant proteins that either costimulate cells or block the so-called immune checkpoint pathways. The recent success of several immunotherapeutic regimes, such as monoclonal antibody blocking of cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD1), has boosted the development of this treatment modality, with the consequence that new therapeutic targets and schemes which combine various immunological agents are now being described at a breathtaking pace. In this review, we outline some of the main strategies in cancer immunotherapy (cancer vaccines, adoptive cellular immunotherapy, immune checkpoint blockade, and oncolytic viruses) and discuss the progress in the synergistic design of immune-targeting combination therapies.
Journal Article
Duality defects in E8
A
bstract
We classify all non-invertible Kramers-Wannier duality defects in the
E
8
lattice Vertex Operator Algebra (i.e. the chiral (
E
8
)
1
WZW model) coming from ℤ
m
symmetries. We illustrate how these defects are systematically obtainable as ℤ
2
twists of invariant sub-VOAs, compute defect partition functions for small
m
, and verify our results against other techniques. Throughout, we focus on taking a physical perspective and highlight the important moving pieces involved in the calculations. Kac’s theorem for finite automorphisms of Lie algebras and contemporary results on holomorphic VOAs play a role. We also provide a perspective from the point of view of (2+1)d Topological Field Theory and provide a rigorous proof that all corresponding Tambara-Yamagami actions on holomorphic VOAs can be obtained in this manner. We include a list of directions for future studies.
Journal Article
The Maisky diaries : the wartime revelations of Stalin's ambassador in London
The terror and purges of Stalin's Russia in the 1930s discouraged Soviet officials from leaving documentary records let alone keeping personal diaries. A remarkable exception is the unique diary assiduously kept by Ivan Maisky, the Soviet ambassador to London between 1932 and 1943. This selection from Maisky's diary, never before published in English, grippingly documents Britain's drift to war during the 1930s, appeasement in the Munich era, negotiations leading to the signature of the Ribbentrop-Molotov Pact, Churchill's rise to power, the German invasion of Russia, and the intense debate over the opening of the second front.
Book
Duality defects in E 8
Abstract We classify all non-invertible Kramers-Wannier duality defects in the E 8 lattice Vertex Operator Algebra (i.e. the chiral (E 8)1 WZW model) coming from ℤ m symmetries. We illustrate how these defects are systematically obtainable as ℤ2 twists of invariant sub-VOAs, compute defect partition functions for small m, and verify our results against other techniques. Throughout, we focus on taking a physical perspective and highlight the important moving pieces involved in the calculations. Kac’s theorem for finite automorphisms of Lie algebras and contemporary results on holomorphic VOAs play a role. We also provide a perspective from the point of view of (2+1)d Topological Field Theory and provide a rigorous proof that all corresponding Tambara-Yamagami actions on holomorphic VOAs can be obtained in this manner. We include a list of directions for future studies.
Journal Article
The Maisky diaries : red ambassador to the Court of St James's, 1932-1943
\"The terror and purges of Stalin's Russia in the 1930s discouraged Soviet officials from leaving documentary records let alone keeping personal diaries. A remarkable exception is the unique diary assiduously kept by Ivan Maisky, the Soviet ambassador to London between 1932 and 1943. This selection from Maisky's diary, never before published in English, grippingly documents Britain's drift to war during the 1930s, appeasement in the Munich era, negotiations leading to the signature of the Ribbentrop Molotov Pact, Churchill's rise to power, the German invasion of Russia, and the intense debate over the opening of the second front\"-- Provided by publisher.
Book
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
A majority of cancers fail to respond to immunotherapy with antibodies targeting immune checkpoints, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) or programmed death-1 (PD-1)/PD-1 ligand (PD-L1). Cancers frequently express transforming growth factor-β (TGFβ), which drives immune dysfunction in the tumor microenvironment by inducing regulatory T cells (Tregs) and inhibiting CD8
+
and T
H
1 cells. To address this therapeutic challenge, we invent bifunctional antibody–ligand traps (Y-traps) comprising an antibody targeting CTLA-4 or PD-L1 fused to a TGFβ receptor II ectodomain sequence that simultaneously disables autocrine/paracrine TGFβ in the target cell microenvironment (
a
-CTLA4-TGFβRII
ecd
and
a
-PDL1-TGFβRII
ecd
).
a
-CTLA4-TGFβRII
ecd
is more effective in reducing tumor-infiltrating Tregs and inhibiting tumor progression compared with CTLA-4 antibody (Ipilimumab). Likewise,
a
-PDL1-TGFβRII
ecd
exhibits superior antitumor efficacy compared with PD-L1 antibodies (Atezolizumab or Avelumab). Our data demonstrate that Y-traps counteract TGFβ-mediated differentiation of Tregs and immune tolerance, thereby providing a potentially more effective immunotherapeutic strategy against cancers that are resistant to current immune checkpoint inhibitors.
Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immune tolerance and enhance the efficacy of these antibodies.
Journal Article
مبادئ العلاقات الدولية
\"يطرح الوضع العربي الراهن مسائل كثيرة على الفكر السياسي في ما يخص مفاهيم : الدولة والسيادة والعنف والحرب والثورة والإرهاب وحقوق الإنسان والتدخل الخارجي والمسائل العابرة للحدود في عالم اليوم المعلوم. هذا الكتاب يدرس هذه المفاهيم وغيرها كثير بطريقة أكاديمية سلسة تجعل منه دليلا للمهتم بالشأن العام عند كل محطة، سواء كانت وطنية أو إقليمية أو دولية.لقد بذل الباحثان الأمريكيان كارين أ. منغست وإيفان م. أريغون. تفت جهدا يستحق الثناء لتقديم عرضا تاريخيا لمبادئ العلاقات الدولية تظهر التطور الكبير الذي شهدته هذه العلاقات عبر الانتقال إلى الدولة الحديثة وفي العقود التي أعقبت الحرب العالمية الثانية. سيجد القارئ نفسه أنه مشدود إلى الرواية التاريخية لمسائل تهمه في الوقت الحاضر، وإلى أدوات تحليل تمكنه من دراسة الحدث الذي يطرأ بطريقة موضوعية على المستويات الفردية والوطنية والدولية. وستشده جدة المسائل المعاصرة التي يدرسها وفق منظورات المدارس الفكرية : والوقعية والليبرالية والراديكالية والبنائية. إنه يجمع ما بين النظرية والتطبيق.إن هذا الكتاب المتخصص جدا هو ضالة الباحث الأكاديمي لكن عرضه السلس سيمكن القارئ العام من تحديث معلوماته بطريقة سهلة تجعله قادرا على فهم الأحداث التي تدور في العالم ومدى تأثيرها في شأنه الفردي.\".
Book
Lycopene Deficiency in Ageing and Cardiovascular Disease
Lycopene is a hydrocarbon phytochemical belonging to the tetraterpene carotenoid family and is found in red fruit and vegetables. Eleven conjugated double bonds predetermine the antioxidant properties of lycopene and its ability to scavenge lipid peroxyl radicals, reactive oxygen species, and nitric oxide. Lycopene has a low bioavailability rate and appears in the blood circulation incorporated into chylomicrons and other apo-B containing lipoproteins. The recent body of evidence suggests that plasma concentration of lycopene is not only a function of intestinal absorption rate but also lycopene breakdown via enzymatic and oxidative pathways in blood and tissues. Oxidative stress and the accumulation of reactive oxygen species and nitric oxide may represent a major cause of lycopene depletion in ageing, cardiovascular disease, and type 2 diabetes mellitus. It has been shown recently that low carotenoid levels, and especially decreased serum lycopene levels, are strongly predictive of all-cause mortality and poor outcomes of cardiovascular disease. However, there is a poor statistical association between dietary and serum lycopene levels which occurs due to limited bioavailability of lycopene from dietary sources. Hence, it is very unlikely that nutritional intervention alone could be instrumental in the correction of lycopene and carotenoid deficiency. Therefore, new nutraceutical formulations of carotenoids with enhanced bioavailability are urgently needed.
Journal Article