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"Jack, Stuart"
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Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial
Chronic pelvic pain (CPP) affects 2.1-24% of women. Frequently, no underlying pathology is identified, and the pain is difficult to manage. Gabapentin is prescribed for CPP despite no robust evidence of efficacy. We performed a pilot trial in two UK centres to inform the planning of a future multicentre RCT to evaluate gabapentin in CPP management. Our primary objective was to determine levels of participant recruitment and retention. Secondary objectives included estimating potential effectiveness, acceptability to participants of trial methodology, and cost-effectiveness of gabapentin. Women with CPP and no obvious pelvic pathology were assigned to an increasing regimen of gabapentin (300-2700 mg daily) or placebo. We calculated the proportion of eligible women randomised, and of randomised participants who were followed up to six months. The analyses by treatment group were by intention-to-treat. Interviews were conducted to evaluate women's experiences of the trial. A probabilistic decision analytical model was used to estimate cost-effectiveness. Between September 2012-2013, 47 women (34% of those eligible) were randomised (22 to gabapentin, 25 to placebo), and 25 (53%) completed six-month follow-up. Participants on gabapentin had less pain (BPI difference 1.72 points, 95% CI:0.07-3.36), and an improvement in mood (HADS difference 4.35 points, 95% CI:1.97-6.73) at six months than those allocated placebo. The majority of participants described their trial experience favorably. At the UK threshold for willingness-to-pay, the probabilities of gabapentin or no treatment being cost-effective are similar. A pilot trial assessing gabapentin for CPP was feasible, but uncertainty remains, highlighting the need for a large definitive trial.
Journal Article
Re St Anselm's Church, Kennington Cross
This petition concerned proposals for major re-ordering works to this Grade II listed church, consecrated in 1933. Of particular interest was the fate of two substantial paintings based on Pilgrim's Progress by Norman Adams, installed in 1972, whose removal was required by the main works proposed. Each painting covered a substantial part of one side of the church above the nave arcades. They were described as being of national importance.
Journal Article
Re St Michael and All Angels, Bampton
This Grade 1-listed mediaeval church had a substantial Georgian reredos. It dominated the east end of the church, hiding three-quarters of the plain-glazed east window. In 2012 a faculty permitted its temporary removal to another location in the church while essential works were done to the chancel. Following this, the consequent increase in light coming from the windows was welcomed by petitioners, and fragments of medieval wall painting were discovered behind plasterwork which the reredos had previously protected. The petitioners now wished to make the temporary removal of the reredos permanent, relocating it to hang above the west door.
Journal Article
Re St Mary the Virgin, Stebbing
In the course of its consideration of a petition for a faculty for a significant re-ordering project, the court commented on the proper approach to such petitions in order to assist their progress through the faculty process.
Journal Article
Re St Michael and All Angels, Bampton
This Grade 1-listed mediaeval church had a substantial Georgian reredos. It dominated the east end of the church, hiding three-quarters of the plain-glazed east window. In 2012 a faculty permitted its temporary removal to another location in the church while essential works were done to the chancel. Following this, the consequent increase in light coming from the windows was welcomed by petitioners, and fragments of medieval wall painting were discovered behind plasterwork which the reredos had previously protected. The petitioners now wished to make the temporary removal of the reredos permanent, relocating it to hang above the west door.
Journal Article
Re St Mary the Virgin, Stebbing
In the course of its consideration of a petition for a faculty for a significant re-ordering project, the court commented on the proper approach to such petitions in order to assist their progress through the faculty process.
Journal Article
Re St Mary the Virgin, Stebbing
In the course of its consideration of a petition for a faculty for a significant re-ordering project, the court commented on the proper approach to such petitions in order to assist their progress through the faculty process.
Journal Article
Re St Anselm's Church, Kennington Cross
This petition concerned proposals for major re-ordering works to this Grade II listed church, consecrated in 1933. Of particular interest was the fate of two substantial paintings based on Pilgrim's Progress by Norman Adams, installed in 1972, whose removal was required by the main works proposed. Each painting covered a substantial part of one side of the church above the nave arcades. They were described as being of national importance.
Journal Article
Re St Michael and All Angels, Bampton
This Grade 1-listed mediaeval church had a substantial Georgian reredos. It dominated the east end of the church, hiding three-quarters of the plain-glazed east window. In 2012 a faculty permitted its temporary removal to another location in the church while essential works were done to the chancel. Following this, the consequent increase in light coming from the windows was welcomed by petitioners, and fragments of medieval wall painting were discovered behind plasterwork which the reredos had previously protected. The petitioners now wished to make the temporary removal of the reredos permanent, relocating it to hang above the west door.
Journal Article