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Creativity and psychotic states in exceptional people : the work of Murray Jackson
\"Creativity and Psychotic States in Exceptional People tells the story of the lives of four exceptionally gifted individuals: Vincent van Gogh, Vaslav Nijinsky, Jose Saramago and John Nash. Previously unpublished chapters by Murray Jackson are set in a contextual framework by Jeanne Magagna, revealing the wellspring of creativity in the subjects' emotional experiences and delving into the nature of psychotic states which influence and impede the creative process. Jackson and Magagna aim to illustrate how psychoanalytic thinking can be relevant to people suffering from psychotic states of mind and provide understanding of the personalities of four exceptionally talented creative individuals. Present in the text are themes of loving and losing, mourning and manic states, creating as a process of repairing a sense of internal damage and the use of creativity to understand or run away from oneself. The book concludes with a glossary of useful psychoanalytic concepts. Creativity and Psychotic States in Exceptional People will be fascinating reading for psychiatrists, psychotherapists and psychoanalysts, other psychoanalytically informed professionals, students and anyone interested in the relationship between creativity and psychosis\"-- Provided by publisher.
Book
Weathering the Storms
In a series of fascinating supervisory case studies the author draws on Kleinian concepts and Scandinavian clinical experience to show how a psychotherapeutic approach can, through a combination of empathy and sound theory, stabilise, contain, integrate and tame the unnamable terrors and compulsions of psychosis.
eBook
Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood
Background: Much of the existing animal literature on the devaluation task suggests that prior repeated exposure to drugs of abuse during adulthood can impair goal-directed action, but the literature on human drug users is mixed. Also, the initiation of drug use often occurs during adolescence, but examinations of the effects of drug exposure during adolescence on behavior in the devaluation task are lacking. Methods: We examined whether repeated exposure during adolescence to amphetamine (3 mg/kg injections every-other day from post-natal day 27–45) or ketamine (twice daily 30 mg/kg injections from post-natal day 35–44) would impair behavior in a devaluation test when tested drug-free in adulthood. Rats were trained to press a left lever with a steady cue-light above it for one reinforcer and a right lever with a flashing cue-light above it for a different reinforcer. We tested whether any impairments in goal-directed action could be overcome by compensation between strategies by giving rats information based on lever-location and cue-lights during the test that was either congruent (allowing compensation) or incongruent (preventing compensation between strategies) with the configurations during training. Results: Our results provided no evidence for impairment of goal-directed action during adulthood after adolescent amphetamine or ketamine exposure. Conclusions: We discuss possible reasons for this discrepancy with the prior literature, including (1) the age of exposure and (2) the pattern in the previous literature that most previous demonstrations of drug exposure impairing devaluation in laboratory animals may be attributed to either drug-associated cues present in the testing environment and/or accelerated habit learning in tasks that predispose laboratory animals towards habit formation with extended training (with training procedures that should resist the formation of habits in the current experiment). However, additional research is needed to examine the effects of these factors, as well a potential role for the particular doses and washout periods to determine the cause of our finding of no devaluation impairment after drug exposure.
Journal Article
Unimaginable storms
A distillation of many years' work on a therapeutic milieu ward of the Maudsley Hospital, in which psychotic patients were treated with an integrated combination of psychiatric and psychological care anchored in the use of advanced psychoanalytic concepts of psychosis. Compelling clinical material is reproduced to help illuminate the meaning of illnesses such as paranoid schizophrenia, catatonia, psychotic anorexia and manic-depression. Several depth interviews by Murray Jackson, an authority on the application of psycho-analytic thought to the problems of psychosis, are reproduced for the first time.
eBook
Unimaginable storms
A distillation of many years' work on a therapeutic milieu ward of the Maudsley Hospital, in which psychotic patients were treated with an integral combination of psychiatric and psychological care anchored in the use of advanced psychoanalytic concepts of psychosis. Compelling clinical material is reproduced to help illuminate the meaning of illnesses such as paranoid schizophrenia, catatonia, psychotic anorexia and manic-depression. Several depth interviews by the author, an authority on the application of psycho-analytic thought to the problems of psychosis are reproduced for the first time.
eBook
Unimaginable storms
A distillation of many years` work on a therapeutic milieu ward of the Maudsley Hospital, in which psychotic patients were treated with an integral combination of psychiatric and psychological care anchored in the use of advanced psychoanalytic concepts of psychosis. Compelling clinical material is reproduced to help illuminate the meaning of illnesses such as paranoid schizophrenia, catatonia, psychotic anorexia and manic-depression. Several depth interviews by Murray Jackson, an authority on the application of psycho-analytic thought to the problems of psychosis are reproduced for the first time.
eBook
β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents
Alcohol use disorders (AUDs) impose an enormous societal and financial burden, and world-wide, alcohol misuse is the 7
leading cause of premature death
. Despite this, there are currently only 3 FDA approved pharmacological treatments for the treatment of AUDs in the United States. The neurotensin (Nts) system has long been implicated in modulating behaviors associated with alcohol misuse. Recently, a novel compound, SBI-553, that biases the action of Nts receptor 1 (NTSR1) activation, has shown promise in preclinical models of psychostimulant misuse. Here we investigate the efficacy of this compound to alter ethanol-mediated behaviors in a comprehensive battery of experiments assessing ethanol consumption, behavioral responses to ethanol, sensitivity to ethanol, and ethanol metabolism. Additionally, we investigated behavior in avoidance and cognitive assays to monitor potential side effects of SBI-553. We find that SBI-553 reduces binge-like ethanol consumption in mice without altering avoidance behavior or novel object recognition. We also observe sex-dependent differences in physiological responses to sequential ethanol injections in mice. In rats, we show that SBI-553 attenuates sensitivity to the interoceptive effects of ethanol (using a Pavlovian drug discrimination task). Our data suggest that targeting NTSR1 signaling may be promising to attenuate alcohol misuse, and adds to a body of literature that suggests NTSR1 may be a common downstream target involved in the psychoactive effects of multiple reinforcing substances.
Journal Article
