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"Jackson, P."
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Python
Python stirs and slithers out from her shelter, smelling the air with her forked tongue. It's time to molt her dull scales and reveal the glistening snake underneath. Gliding along a tree, she stops and watches very, very closely as a bird drops onto a branch -- and escapes the razor-sharp teeth just in time. But Python is hungry, so she slides on to stalk new prey. Combining informative facts, expressive illustrations, and a lyrical, mesmerizing narrative, here is a book to captivate anyone fascinated by this iconic creature.
Book
Sport policy in small states
For small nations like Grenada, New Zealand and Norway, medal counts relative to population are increasingly touted as the most meaningful comparisons with sporting superpowers China, the United States and Germany. In acknowledging that 60% of the world's states have populations of less than 10 million and 48% of these have less than 5 million inhabitants, this book explores how the 'minnows' can build or sustain their sport programmes.
Book
Arterial thrombosis—insidious, unpredictable and deadly
The formation of blood clots—thrombosis—at sites of atherosclerotic plaque rupture is a major clinical problem despite ongoing improvements in antithrombotic therapy. Progress in identifying the pathogenic mechanisms regulating arterial thrombosis has led to the development of newer therapeutics, and there is general anticipation that these treatments will have greater efficacy and improved safety. However, major advances in this field require the identification of specific risk factors for arterial thrombosis in affected individuals and a rethink of the 'one size fits all' approach to antithrombotic therapy.
Journal Article
Global probabilistic projections of extreme sea levels show intensification of coastal flood hazard
Global warming is expected to drive increasing extreme sea levels (ESLs) and flood risk along the world’s coastlines. In this work we present probabilistic projections of ESLs for the present century taking into consideration changes in mean sea level, tides, wind-waves, and storm surges. Between the year 2000 and 2100 we project a very likely increase of the global average 100-year ESL of 34–76 cm under a moderate-emission-mitigation-policy scenario and of 58–172 cm under a business as usual scenario. Rising ESLs are mostly driven by thermal expansion, followed by contributions from ice mass-loss from glaciers, and ice-sheets in Greenland and Antarctica. Under these scenarios ESL rise would render a large part of the tropics exposed annually to the present-day 100-year event from 2050. By the end of this century this applies to most coastlines around the world, implying unprecedented flood risk levels unless timely adaptation measures are taken.
Extreme sea levels are a flood risk along the world’s coastlines. Here the authors carry out probabilistic projections of extreme sea levels and show that for the present century coastal flood hazards will increase significantly along most of the global coastlines.
Journal Article
Sugars, signalling, and plant development
Like all organisms, plants require energy for growth. They achieve this by absorbing light and fixing it into a usable, chemical form via photosynthesis. The resulting carbohydrate (sugar) energy is then utilized as substrates for growth, or stored as reserves. It is therefore not surprising that modulation of carbohydrate metabolism can have profound effects on plant growth, particularly cell division and expansion. However, recent studies on mutants such asstimpyorramosa3have also suggested that sugars can act as signalling molecules that control distinct aspects of plant development. This review will focus on these more specific roles of sugars in development, and will concentrate on two major areas: (i) cross-talk between sugar and hormonal signalling; and (ii) potential direct developmental effects of sugars. In the latter, developmental mutant phenotypes that are modulated by sugars as well as a putative role for trehalose-6-phosphate in inflorescence development are discussed. Because plant growth and development are plastic, and are greatly affected by environmental and nutritional conditions, the distinction between purely metabolic and specific developmental effects is somewhat blurred, but the focus will be on clear examples where sugar-related processes or molecules have been linked to known developmental mechanisms.
Journal Article
Charlie Joe Jackson's guide to planet girl
\"Everyone has a girlfriend except Charlie Joe! But he won't be left in the dust. Look out for make-ups, break-ups, and hilarious romance tips as Charlie Joe figures out this crazy little thing called love\"-- Provided by publisher.
Book
A new era for understanding amyloid structures and disease
The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition of amyloid fibrils, collectively known as amyloidosis, is associated with many pathological conditions that can be associated with ageing, such as Alzheimer disease, Parkinson disease, type II diabetes and dialysis-related amyloidosis. However, elucidation of the atomic structure of amyloid fibrils formed from their intact protein precursors and how fibril formation relates to disease has remained elusive. Recent advances in structural biology techniques, including cryo-electron microscopy and solid-state NMR spectroscopy, have finally broken this impasse. The first near-atomic-resolution structures of amyloid fibrils formed in vitro, seeded from plaque material and analysed directly ex vivo are now available. The results reveal cross-β structures that are far more intricate than anticipated. Here, we describe these structures, highlighting their similarities and differences, and the basis for their toxicity. We discuss how amyloid structure may affect the ability of fibrils to spread to different sites in the cell and between organisms in a prion-like manner, along with their roles in disease. These molecular insights will aid in understanding the development and spread of amyloid diseases and are inspiring new strategies for therapeutic intervention.
Journal Article