Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
3,045
result(s) for
"Jacobs, Ben"
Sort by:
All about flags
Do you know why the Union Jack is asymmetrical? Or why the Swiss flag is square? Can you tell the difference between the flag of Luxembourg and the flag of the Netherlands? Every nation in the world has a flag that in some way captures the essence of their culture and values in simple designs and colours. These flags evoke a sense of pride and belonging and teach us about how those countries view themselves. This atlas of flags around the world is packed with fascinating flag facts and engagingly brought to life in bright, bold illustrations.
BOOK
Pneumatosis Intestinalis and Intestinal Perforation in a Patient Receiving Tocilizumab
In this article, we report a case of pneumatosis intestinalis associated with tocilizumab use. This is a unique case and may explain the increased rate of idiopathic bowel perforation among patients taking tocilizumab.
Journal Article
213 Improving the investigation and management of papilloedema in an acute medical setting
AimTo streamline and improve the investigation of patients with papilloedema presenting to the acute medical take in a large teaching hospital.MethodsPatients seen on the acute medical take at the Royal London Hospital with suspected papil- loedema were identified retrospectively. A total of 19 patients were seen between April and November 2019. A number of modifiable delays to initial investigations and areas for improvement were identified from these data. A simple flowchart explaining key points in investigation and initial management of patients with papilloedema was devised and distributed to those involved in the acute take.ResultsThe identified areas for improvement included delays to lumbar puncture, failure to discuss management with neurologists after identification of raised intracranial pressure, and ensuring initial management was started in those with suspected idiopathic intracranial hypertension. There were also a number of instances in which papilloedema was not confirmed by an ophthalmologist prior to inap- propriate invasive investigations. Education and provision of better information to acute medics improved many of these outcomes.ConclusionA clear and easy to use flowchart for those involved in the acute take minimised errors identified and improved the initial investigation and management of papilloedema presenting to the acute medical take.catherine.hornby2@nhs.net
Journal Article
A genetic linkage map and improved genome assembly of the termite symbiont Termitomyces cryptogamus
Background
The termite-fungus symbiosis is an ancient stable mutualism of two partners that reproduce and disperse independently. With the founding of each termite colony the symbiotic association must be re-established with a new fungus partner. Complementarity in the ability to break down plant substrate may help to stabilize this symbiosis despite horizontal symbiont transmission. An alternative, non-exclusive, hypothesis is that a reduced rate of evolution may contribute to stabilize the symbiosis, the so-called Red King Effect.
Methods
To explore this concept, we produced the first linkage map of a species of
Termitomyces
, using genotyping by sequencing (GBS) of 88 homokaryotic offspring. We constructed a highly contiguous genome assembly using PacBio data and a de-novo evidence-based annotation. This improved genome assembly and linkage map allowed for examination of the recombination landscape and its potential effect on the mutualistic lifestyle.
Results
Our linkage map resulted in a genome-wide recombination rate of 22 cM/Mb, lower than that of other related fungi. However, the total map length of 1370 cM was similar to that of other related fungi.
Conclusions
The apparently decreased rate of recombination is primarily due to genome expansion of islands of gene-poor repetitive sequences. This study highlights the importance of inclusion of genomic context in cross-species comparisons of recombination rate.
Journal Article
