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"Jacoby, Susan"
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Never say die : the myth and marketing of the new old age
In a narrative that combines the intensely personal with social, economic, and historical analysis, Jacoby turns an unsparing eye on the marketers of longevity--pharmaceutical companies, lifestyle gurus, and scientific businessmen who suggest that there will soon be a \"cure\" for the \"disease\" of aging.
Book
3,3′-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancer cells by generation of reactive oxygen species
Context: A major problem in the treatment of cancer is the development of toxic side effects and resistance to chemotherapy. The use of plant compounds to overcome resistance and prevent toxicity is a potential strategy for treatment.
Objective: We evaluated whether 3,3′-diindolylmethane (DIM) enhanced the sensitivity of breast cancer cells to docetaxel (DOC).
Materials and methods: MDA-MB231 and Sk-BR-3 cells were treated with and without 25 or 50 µM of DIM and 1 nM of DOC for 48 and 72 h, respectively. MTT assay was used to measure cell survival. Apoptosis and intracellular reactive oxygen species (ROS) were determined by flow cytometry. The expression of proteins regulating ROS production and apoptosis was evaluated by immunoblotting technique.
Results: Combining 25 µM of DIM with 1 nM DOC decreased cell survival by 42% in MDA-MB231 cells and 59% in Sk-BR-3 cells compared to control, DIM, or DOC (p ≤ 0.05). The combination treatment increased apoptosis over 20% (p ≤ 0.01) in both cell lines, which was associated with decreased Bcl-2, increased Bax, cleaved PARP and activated JNK (p ≤ 0.01). ROS production increased by 46.5% in the MDA-MB231 and 29.3% in Sk-BR-3 cells with the combination compared to DIM or DOC alone. Pretreating cells with N-acetyl-cysteine or Tiron abrogated the anti-survival effect of the combination. The increase in ROS was associated with a 54% decrease in MnSOD and 47% increase in NOX2 protein compared to the other groups.
Conclusions: Our findings indicated that DIM enhances the sensitivity of breast cancer cells to DOC treatment by increasing ROS, which led to decreased cell survival and apoptosis.
Journal Article
The age of American unreason in a culture of lies
From the Publisher: A cultural history of the last forty years, The Age of American Unreason focuses on the convergence of social forces-usually treated as separate entities-that has created a perfect storm of anti-rationalism. These include the upsurge of religious fundamentalism, with more political power today than ever before; the failure of public education to create an informed citizenry; and the triumph of video over print culture. Sparing neither the right nor the left, Jacoby asserts that Americans today have embraced a universe of \"junk thought\" that makes almost no effort to separate fact from opinion.
BOOK
Alger Hiss and the Battle for History
Books on Whittaker Chambers and Alger Hiss abound, as countless scholars have labored to uncover the facts behind Chambers's shocking accusation before the House Committee on Un-American Activities in the summer of 1948-that Alger Hiss, a former rising star in the State Department, had been a Communist and engaged in espionage.
In this highly original work, Susan Jacoby turns her attention to the Hiss case, including his trial and imprisonment for perjury, as a mirror of shifting American political views and passions. Unfettered by political ax-grinding, the author examines conflicting responses, from scholars and the media on both the left and the right, and the ways in which they have changed from 1948 to our present post-Cold War era. With a brisk, engaging style, Jacoby positions the case in the politics of the post-World War II era and then explores the ways in which generations of liberals and conservatives have put Chambers and Hiss to their own ideological uses. An iconic event of the McCarthy era, the case of Alger Hiss fascinates political intellectuals not only because of its historical significance but because of its timeless relevance to equally fierce debates today about the difficult balance between national security and respect for civil liberties.
eBook
Escherichia coli sepsis increases hepatic apolipoprotein B secretion by inhibiting degradation
Sepsis leads to hypertriglyceridemia in both humans and animals. Previously, we reported that plasma very low density lipoprotein apolipoprotein (apo) B and hepatic production of apoB increased during Escherichia coli sepsis. The present experiments were undertaken to determine whether the altered hepatic secretion of apoB was associated with an increase in synthesis or a decrease in degradation rate. Sepsis was induced in male, Lewis rats (225–275 g) by intravenous injection of 3.8×108 live E. coli colonies/100 g body. Twenty‐four hours later rats were sacrificed, and primary hepatocytes were prepared and incubated overnight with 35S‐methionine. Hepatocytes from E. coli‐treated rats secreted twice as much apoB‐48 and total apoB than the hepatocytes from control rats. Escherichia coli sepsis increased celular triglyceride mass by 86%, which was due to a stimulation in triglyceride synthesis from newly synthesized fatty acids, measured by 3H2O incorporation into triglycerides. The apoB synthesis rate, apoB mRNA levels, and apoB mRNA editing were not altered during E. coli sepsis. The pulse‐chase experiments showed that the rate of apoB degradation decreased in E. coli‐treated rats. These findings demonstrate that the secretion of apoB is regulated posttranslationally during E. coli sepsis by decreasing the degradation of newly synthesized apoB, which contributes to the development of hypertriglyceridemia.
Journal Article
CONCLUSION
On the Fourth of July weekend in 2000, theNew York Timespublished a conversation about patriotism between Norman Podhoretz, the longtime neoconservative warrior and editor ofCommentary, and Victor Navasky, who, as publisher of theNation, was as strongly identified with the political and cultural left as Podhoretz was with the right. In one exchange, the moderator quoted Samuel Johnson’s remark that patriotism “is the last refuge of a scoundrel” and asked both men whether patriotism had “gone out of style” in the United States. Podhoretz, as befitted the author of a forthcoming book titledMy Love Affair with
Book Chapter