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In 1951, married Australian writers Charmian Clift and George Johnston, feeling stifled by post- war conservatism, left Sydney behind to find a more ‘authentic’ way of living. They went first to London, the mecca for Australian literary expatriates, where there was no shortage of work and culture, but where they quickly felt trapped by the ‘rat-race’ mentality of a modern city. So in 1954 they left again, this time for the Greek islands, disposing of material possessions and cutting many of their personal ties. Hoping for a permanent shift from mundane to romantic, they embraced the shining ideals offered by Greek island life: other-worldly beauty; ‘simple’ Greek lifestyles, and freedom from the many pressures of the ‘real’ world.

Blue rubber bleb nevus syndrome (BRBNS) is a congenital disorder with characteristic venous anomalies that can present with varying degree of blood loss. The most clinically significant symptoms in adults include gastrointestinal (GI) bleeding and iron deficiency anemia. Severe complications can include intestinal torsion, intussusception, and even perforation, with each leading to significant morbidity and mortality. This report serves to give a brief understanding of this rare disease along with current diagnostic and therapeutic options.

Abstract Context BRAFV600E mutant thyroid cancers are often refractory to radioiodine (RAI). Objectives To investigate the utility and molecular underpinnings of enhancing lesional iodide uptake with the BRAF inhibitor vemurafenib in patients with RAI-refractory (RAIR). Design This was a pilot trial that enrolled from June 2014 to January 2016. Setting Academic cancer center. Patients Patients with RAIR, BRAF mutant thyroid cancer. Intervention Patients underwent thyrotropin-stimulated iodine-124 (124I) positron emission tomography scans before and after ~4 weeks of vemurafenib. Those with increased RAI concentration exceeding a predefined lesional dosimetry threshold (124I responders) were treated with iodine-131 (131I). Response was evaluated with imaging and serum thyroglobulin. Three patients underwent research biopsies to evaluate the impact of vemurafenib on mitogen-activated protein kinase (MAPK) signaling and thyroid differentiation. Main Outcome Measure The proportion of patients in whom vemurafenib increased RAI incorporation to warrant 131I. Results Twelve BRAF mutant patients were enrolled; 10 were evaluable. Four patients were 124I responders on vemurafenib and treated with 131I, resulting in tumor regressions at 6 months. Analysis of research tumor biopsies demonstrated that vemurafenib inhibition of the MAPK pathway was associated with increased thyroid gene expression and RAI uptake. The mean pretreatment serum thyroglobulin value was higher among 124I responders than among nonresponders (30.6 vs 1.0 ng/mL; P = 0.0048). Conclusions Vemurafenib restores RAI uptake and efficacy in a subset of BRAF mutant RAIR patients, probably by upregulating thyroid-specific gene expression via MAPK pathway inhibition. Higher baseline thyroglobulin values among responders suggest that tumor differentiation status may be a predictor of vemurafenib benefit. The BRAF inhibitor vemurafenib increased radioiodine uptake in a subset of patients with BRAF mutant, radioiodine-refractory thyroid cancer.

Government and business scandals have had myriad ripple effects, not the least of which has been to illuminate the shadow side of organizational and individual agendas. As a result, leaders find themselves more heavily scrutinized, and in an ever more uncomfortable position of having to serve many masters, a good number of which may well be in conflict. In a world and workplace in need of visionary leadership and meaning -- trends to which no leader is immune -- the opportunities of the mastery path can become a significant focal point and source of inspiration. In chaos theory, the \"strange attractor\" plays an organizing role, as the order or pattern at the heart of what appears to be chaos. New-era leaders are catalyzed and fueled by several inner-attractors that organize and mobilize the leaders' priorities and activities -- vision, intention, courage and mastery.

The provisioning of user context information between service endpoints is central to realizing massive immersive participation on an Internet of Things. This information must in turn be provisioned to endpoints with minimal overhead costs. Where this is achieved through centralized repositories of context information there arises issues of scalability and availability. Where distributed approaches have been proposed, information dissemination has been optimized relative to the underlying network properties. In this paper, the authors extend the Distributed Context Protocol to support subscriptions relative to an entity-application-entity triple, minimizing the number of subscriptions required and through application specific optimization minimize the overall cost of delivering user context information to service endpoints.

Massive Immersive Participation is enriched through the use of context information describing the dynamic states and relations among people places and things. This in turn mandates the creation of methods and models for establishing and supporting these relationships. Previous approaches are undermined by their limited interpretation of context centric relations and subsequently do not offer support for multi-criteria relationships. In this paper, we extend on our previous work on establishing multi-criteria context relationships, to adding the support required for maintaining these relationships over heterogeneous and dynamic context information. We introduce a query language that supports an extended publish-subscribe approach and define solutions for dynamically evaluating and adjusting these relationships while minimizing overall costs.

Massive Immersive Participation is enriched through the use of context information describing the dynamic states and relations among people places and things. This in turn mandates the creation of methods and models for establishing and supporting these relationships. Previous approaches are undermined by their limited interpretation of context centric relations and subsequently do not offer support for multi-criteria relationships. In this paper, we extend on our previous work on establishing multi-criteria context relationships, to adding the support required for maintaining these relationships over heterogeneous and dynamic context information. We introduce a query language that supports an extended publish-subscribe approach and define solutions for maintaining, evaluating and adjusting these relationships while minimizing overall costs.

Most, if not all, of the issues and challenges facing leaders and organizations point to the need for a culture of integrity, leadership, adaptability, creativity, engagement, respect, and camaraderie. Each of these, in turn, relies upon a foundation of skillful communication. The degree to which leaders and transformation-agents embody, communicate, foster, and require such skillfulness will define the degree of success the organization will have in meeting its greatest challenges and aligning action with the vision and values of the organization. By leading into a culture of deep inquiry and skillful listening, leaders can strengthen the foundation from which all else stems. To do this requires shifting the culture. To begin, leaders should take an honest and penetrating look at how dysfunction shows up within them, their group, and their organizational culture and then seek nontraditional sources of insight about system evolution.

Memory forensics provides cutting edge technology to help investigate digital attacks Memory forensics is the art of analyzing computer memory (RAM) to solve digital crimes. As a follow-up to the best seller Malware Analyst's Cookbook, experts in the fields of malware, security, and digital forensics bring you a step-by-step guide to memory forensics—now the most sought after skill in the digital forensics and incident response fields.