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Within the vast landscape of the Built Environment, where challenges of uncertainty abound, this paper ventures into a detailed exploration of antifragile planning. Antifragility, a concept rooted in the capacity of systems to not only withstand but also thrive in the face of volatility, stands as a beacon of resilience amidst the uncertainties of the Anthropocene. The paper offers a systematic examination of antifragile planning, specifically by concentrating on uncertainty as one of its key theoretical tenets and by exploring the implications of these principles within the context of the Anthropocene. After offering a systematic and comprehensive review of the literature, the analysis delves into several important themes in antifragile planning, including the recognition of limited predictive reliability, critiques of conventional responses to shocks such as urban resilience and smart cities, and the strategic elimination of potential fragilizers through a unique planning methodology. Furthermore, the paper discusses three key arguments challenging the efficacy of antifragility: the systemic approach, the classification of responses to perturbations, and the validity of adaptivity and optionality theses. Specifically, the gaps identified in the antifragile planning methodology reveal its shortcomings in addressing the complexity of cities, its failure to recognize the variety of responses to shocks and perturbations, and its neglect of broader urban relationalities, especially in relation to climate-induced uncertainty. Thus, it is asserted that antifragility remains urbocentric. For these reasons, the paper contends that rectifying the gaps detected in antifragility is necessary to address the uncertainty of the Anthropocene. By aligning largely with emerging posthumanist planning strategies, the paper emphasizes the significance of adopting a proactive approach that goes beyond merely suppressing natural events. This approach involves fostering urban intelligence, contextualizing urban materialities within broader planetary dynamics, and embracing exploratory design strategies that prioritize both the ethical and aesthetic dimensions of planning.

This study aims to bridge the fields of urban morphology and land use/land cover (LULC) mapping through a systematic analysis of their integration in recent research. The research employs systematic literature review (SLR) methodology combining quantitative and qualitative methods through four methodological steps: data search, data selection, data analysis, and data clustering. The analysis performed three distinct clustering patterns: (1) methods and tools, (2) data types, and (3) urban morphology aspects. The results reveal five distinct methodological approaches—Data-Driven Typological Decoding Approach, Quantitative Structural Metrics Approach, Predictive Spatiotemporal Transition Approach, Temporal Change Detection and Performance Approach, and Spatial Configuration and Density Analysis Approach—each contributing unique insights to urban form analysis. The findings demonstrate the multidimensional nature of urban form analysis, incorporating both social and temporal dimensions, while highlighting the essential role of change detection in understanding urban pattern evolution. This systematic review establishes a comprehensive framework for understanding the relationship between urban morphology and LULC mapping, providing valuable insights for future research integration.

Recent results from Round 9 of the European Social Survey (ESS) indicate that Serbia differs from other European countries in terms of justice and fairness. Whereas the Serbian people?s dissatisfaction relating to unjust income distribution, unfair employment chances and political institutions may not be surprising, these findings still raise a dozen questions. Situated within contemporary discussions on normativity in sociology and survey methodology, this paper aims to reassess the moral grammar of these judgments. By endorsing tenets of pragmatic sociology and its principal aim to recognize the plural modes of valuation and criticism and reflective capacities of social actors to judge and evaluate, this paper develops around few major points. First, we underline how most major approaches to axiology remain stuck in a co-determinist framework, thereby renewing a number of dualisms. Instead, we opt for a relational approach and further present how the theoretical model of Boltanski and Thev?not enables the locating of different assessments of worth. After setting our methodological framework against the ?externalist? epistemology, we explore our key assumption that the above-mentioned high rates come as a problem of a feasible ?truce? between the domestic regime and the civic polity, ruled by proclaimed legality, representativeness and impersonal character. We trace the problem of incorporating multiple arrangements as a problem of generality, by relating these to two layers of information acquired through the ESS. One involves the analysis of the domestic polity covering the household situation in terms of organization and unveiling the specific worth given to care and protection. Another layer is derived from regression analysis which affirms that the absence of fairness in civic polity correlates with a higher degree of worth given to the domestic one, but also that the latter situation depicts a deeper ontological puzzle about making a mild transition to the assumed ?horizontality? of civic matters.

The paper gives a historical account of the genesis of marginal social position explanations in the USA, with special emphasis on the characteristics, related to the generating of cultural factors in explanation. In this light, the two fundamental and interrelated concepts are being indentified - the culture of poverty and the underclass, whose conceptual genesis, in a causal manner, varies between structural and cultural grounding. Due the translation of perceived minority behavioural patterns into the dimensions used for defining the marginal social position, conceptual validity of the underclass has been heavily disputed. At the same time, dilemmas created by the implementation of cultural factors constructed in that way open up broader issues of the relationship between culture and structure, lines of determination and the possibility of a consistent explanation of marginal social position. Rad daje istorijski prikaz geneze objasnjenja marginalnog drustvenog polozaja u SAD, sa posebnim naglaskom na osobenosti koje se ticu generisanja kulturnog faktora u objasnjenju. U tom svetlu, identifikuju se dva temeljna i medjupovezana pojma- kultura siromastva i potklasa, a cija pojmovna geneza u uzrocnom smislu varira izmedju strukturnog i kulturnog utemeljenja. Usled prevodjenja percipiranih bihejvioralnih obrazaca manjina u dimenzije kojim se odredjuje marginalni drustveni polozaj, pojmovna valjanost potklase u velikoj meri biva osporena. Istovremeno, dileme stvorene implementacijom ovako konstruisanog kulturnog faktora otvaraju sira pitanja odnosa kulture i strukture, linija determinacije i mogucnosti konzistentnog objasnjenja marginalnog drustvenog polozaja.

This study investigates whether spa settlements can be analytically interpreted through a relational spascape framework that reveals structural and configurational patterns beyond conventional typological classifications. In the context of increasing interest in therapeutic landscapes and heritage-sensitive development, spa settlements represent complex spatial systems shaped by the interplay of natural resources, urban form, and socio-cultural practices, yet they remain insufficiently understood through existing analytical models. The methodology is based on a structured analytical design combining three urbanization dimensions (material transformation, territorial regulation, and everyday life) with six thematic fields, operationalized through graded cross-affiliation scoring. The empirical research is conducted on a sample of 12 spa settlements in Serbia, selected to reflect diverse geographical, morphological, and developmental conditions. Statistical calibration was performed using Principal Component Analysis (PCA) and hierarchical clustering to identify underlying structural relationships and configurational groupings. The results indicate that spa settlements operate as multi-affiliated relational entities rather than fixed typologies, exhibiting dimension-specific structural logics and forming distinct configurational families depending on the analytical perspective applied. PCA reveals differentiated internal structures across dimensions, while clustering confirms the absence of a single stable typology. The findings support a relational understanding of spa settlements as dynamic spatial systems characterized by shifting alignments of material, regulatory, and experiential factors. Beyond the Serbian context, the study offers a transferable methodological framework that connects qualitative urban interpretation with quantitative spatial analysis, contributing to heritage-sensitive planning, territorial governance, and the management of spa systems as relational clusters.

This study investigates the intersection of digital tools and methods with the built environment disciplinary framework, focusing on Urban Planning and Development (UPD), Architecture, Engineering, and Construction (AEC), and Cultural Heritage (CH) domains. Using a systematic literature review of 29 solution-oriented documents, the research applies both bibliometric and in-depth content analysis to identify methodological patterns. Co-occurrence mapping revealed four thematic clusters—Data Integration and User-Centric Analysis, Advanced 3D Spatial Analysis and Processing, Real-Time Interaction and Digital Twin Support, and 3D Visualization—each corresponding to distinct stages in a digital workflow, from data acquisition to interactive communication. Comparative and interdependency analyses demonstrated that these clusters operate in a sequential yet interconnected manner, with Data Integration forming the foundation for analysis, simulation, and visualization tasks. While current solutions are robust within individual stages, they remain fragmented, indicating a need for systemic interoperability. The findings underscore the opportunity to develop integrated digital platforms that synthesize these clusters, enabling more comprehensive observation, management, and planning of the built environment. Such integration could strengthen decision-making frameworks, enhance public participation, and advance sustainable, smart city development.

Background: Chronic kidney disease (CKD) is a progressive, irreversible impairment of kidney function due to various etiologies. Numerous studies have shown that sodium-glucose cotransporter-2 inhibitors (SGLT2i) slow the progression of CKD, due to their pleiotropic effects. Therefore, there has been an increase in interest in their effects not only on kidney function but also on other parameters in patients with CKD. The aim of the study was to examine the effects of SGLT2i on serum lipid values and kidney function in patients with CKD undergoing SGLT2i treatment. Methods: This study was a retrospective data analysis of 75 patients with CKD on SGLT2i treatment. We compared the values of biochemical parameters, renal function outcomes, and blood pressure at two time points: baseline and 24 months after. Results: Total cholesterol (Chol) significantly decreased in all patients, while triglyceride (Tg) and low-density lipoprotein cholesterol (LDLc) levels also decreased in all patients. High-density lipoprotein cholesterol (HDLc) levels increased, but this increase was not significant. Creatinine clearance (Ccr) significantly decreased, and serum urea (Sur) significantly increased in all patients. The proteinuria (Prt) levels did not change significantly. The results showed that the diastolic blood pressure (DBP) significantly decreased in all patients. Conclusions: This study showed that the use of SGLT2i reduced total Chol in all patients with CKD during the 24-month follow-up, regardless of diabetes mellitus (DM) status. No significant differences were observed for the Tg, LDLc, and HDLc values.

Membranous nephropathy (MN) is the most prevalent cause of nephrotic syndrome (NS) in adults, and it can be primary (idiopathic) with an unknown cause or secondary due to a variety of conditions (lupus, infections, malignancies, medications, etc.). It progresses to chronic kidney disease (CKD) in up to 60% of patients, and 10 to 30% develop end-stage kidney disease (ESKD). This retrospective study examines the importance of specific factors, including baseline demographic and clinical data, kidney biopsy PH findings, and selected biochemical parameters, influencing MN outcomes after 10 years of follow-up. The cohort included 94 individuals in whom a diagnosis of MN was established by percutaneous biopsy of the left kidney’s lower pole at the University Clinical Center of Serbia (UCCS) between 2008 and 2013. According to the outcomes, patients were divided into three groups: the recovery (Rec) group, with complete remission, including normal serum creatinine (Scr) and proteinuria (Prt), the group with development of chronic kidney disease (CKD), and the group with development of end-stage kidney disease (ESKD). Nephropathologists graded pathohistological (PH) results from I to III based on the observed PH findings. During the follow-up period, 33 patients were in the Rec group, CKD developed in 53 patients, and ESKD developed in 8 patients. Baseline creatinine clearance levels (Ccr), Scr, and uric acid (urate) were found to be significantly associated with the outcomes (p < 0.001). The lowest values of baseline Scr and urate were observed in the Rec group. The presence of acute kidney injury (AKI) or CKD at the time of kidney biopsy was associated with the more frequent development of ESKD (p = 0.02). Lower Ccr was associated with a higher likelihood of progressing to CKD (B = −0.021, p = 0.014), whereas older age independently predicted progression to ESKD (B = 0.02, p = 0.032). Based on this study, it was concluded that the most important biochemical and clinical factors that are associated with the outcomes of this disease are the values of Scr, Ccr, and urate and the existence of CKD at the time of kidney biopsy. Unlike most previous studies, the presence of HTN had no statistical significance in the outcome of the disease.