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How to grow more vegetables* : (and fruits, nuts, berries, grains, and other crops) *than you ever thought possible on less land than you can imagine
\"The world's leading resource on biointensive, sustainable, high-yield organic gardening is thoroughly updated throughout, with new sections on using 12 percent less water and increasing compost power.\"-- Provided by publisher.
Book
THE DESIGN OF EVOLUTIONARY ALGORITHMS: A COMPUTER SCIENCE PERSPECTIVE ON THE COMPATIBILITY OF EVOLUTION AND DESIGN
The effectiveness of evolutionary algorithms is one of the issues discussed in The Compatibility of Evolution and Design, where it is argued that such algorithms are only effective when stringent preconditions are met. This article considers this issue from the perspective of computer science. It explores the properties of problems that can be effectively solved by evolutionary algorithms, and the extent to which such algorithms need to be carefully adjusted. Although there are important differences between the study of evolutionary algorithms in computer science and the study of biological evolution, it is argued that the experience of computer science can help to strengthen the claim that evolutionary mechanisms generally require a considerable degree of fine‐tuning.
Journal Article
Agile Sales
Shelving Guide: Business and Management/Sales and Marketing/Agile Methodology
The Agile philosophy has grown and achieved success initially through the technology design and development teams of some of the world’s largest, most successful organizations. Recently, it has been adopted by the marketing departments of these organizations and others, and new techniques are evolving for defining, engaging, and providing customers amazing and unique experiences.
Sales teams are becoming disrupted by technology and the differentiated experiences marketing teams are providing for their customers online using Agile techniques. Sales organizations have been looking for a way to avoid disruption and get back into the game with value. Sales teams are now beginning to adopt Agile, which is enabling these teams to revolutionize the way they engage customers with value and delightful experiences which result in greater value for the customers and themselves.
This book outlines how Agile can help sales teams develop a culture of innovation focused on their customers. This book takes the reader through the customer’s buying journey (Agile technique), outlining tips and tricks that have come from Agile deployments within sales functions to help them get started.
The key benefit for the reader is the introduction of a proven philosophy and techniques that will help them avoid disruption, elevate themselves from the commodity trap, and achieve success again. This book provides the reader insights into how to achieve sustainable change using real-life case examples. The reader will also experience enjoyment and delight from the stories told and case examples provided.
eBook
Agile Sales
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- List of Figures -- Figure I.1 Agile Sales -- Figure 1.1 Pareto Principle and 80/20 Rule -- Figure 1.2 Persona Map -- Figure 1.3 Personal Map of Driven Bob -- Figure 1.4 Customer Contextual Interview Form -- Figure 1.5 Empathy Map -- Figure 2.1 Catch Ball Process -- Figure 3.1 Multi-Level RVMs -- Figure 3.2 Scrum Board -- Figure 3.3 Winson Group's Values and Behavior -- Figure 3.4 Team Behavior Change Tracker -- Figure 3.5 Burn-Up Watermelon Chart -- Figure 3.6 Ingham's Daily Operations Review Board -- Figure 3.7 Ingham's Action List -- Figure 4.1 Quality Kanban Flow -- Figure 4.2 Push-Based Production System Overburdened -- Figure 4.3 Sales Pipeline -- Figure 4.4 Pull-Bases Sales Opportunity Pipeline Using Kanban Approach -- Figure 4.5 Sales Performance Bell Curve -- Figure 4.6 Sales Opportunity Kanban Using Post-Its -- Figure 4.7 Salesforce CRM Opportunity Kanban -- Figure 5.1 Deming Cycle -- Figure 5.2 Sprint Cycles -- Figure 5.3 Sprint Kanban -- Figure 5.4 Sprint Kanban Card -- Figure 5.5 PICK Chart -- Figure 5.6 5 Whys Root Cause Analysis -- Figure 6.1 Change Pareto Principle Bell Curve -- Figure 6.2 Time Management Matrix (Covey, 1989) -- Figure 6.3 Front-Line Leader Standard Work Form -- Figure 6.4 Coaching Process -- Figure 7.1 The Customer's Journey -- Figure 8.1 Sales Pipeline Cohort Chart -- Figure 8.2 Key Elements for Understanding Your Customer -- Figure 8.3 CameraPro's Visual Customer Journey -- Figure 8.4 Customer Initial Perception -- Figure 8.5 Touchpoint Comparison -- Figure 8.6 Hard to Get Meeting Process -- Figure 9.1 Formal Pre-Meeting Question Planning Template -- Figure 9.2 Simple Bullet-Point-Checklist Approach -- Figure 9.3 Deep-Dive Questioning Iceberg -- Figure 9.4 5 Whys -- Figure 10.1 Customer Journey Map, Signet.
Book
Classifying the Complexity of Constraints Using Finite Algebras
Many natural combinatorial problems can be expressed as constraint satisfaction problems. This class of problems is known to be NP-complete in general, but certain restrictions on the form of the constraints can ensure tractability. Here we show that any set of relations used to specify the allowed forms of constraints can be associated with a finite universal algebra and we explore how the computational complexity of the corresponding constraint satisfaction problem is connected to the properties of this algebra. Hence, we completely translate the problem of classifying the complexity of restricted constraint satisfaction problems into the language of universal algebra. We introduce a notion of \"tractable algebra,\" and investigate how the tractability of an algebra relates to the tractability of the smaller algebras which may be derived from it, including its subalgebras and homomorphic images. This allows us to reduce significantly the types of algebras which need to be classified. Using our results we also show that if the decision problem associated with a given collection of constraint types can be solved efficiently, then so can the corresponding search problem. We then classify all finite strictly simple surjective algebras with respect to tractability, obtaining a dichotomy theorem which generalizes Schaefer's dichotomy for the generalized satisfiability problem. Finally, we suggest a possible general algebraic criterion for distinguishing the tractable and intractable cases of the constraint satisfaction problem.
Journal Article
Agile Sales
This book outlines how Agile can help sales teams develop a culture of innovation focused on their customers. The book takes the reader through the customer buying journey (Agile technique) outlining tips and tricks that have come from Agile deployments within sales functions to help them get started.
eBook
Antibiotic collateral sensitivity is contingent on the repeatability of evolution
Antibiotic resistance represents a growing health crisis that necessitates the immediate discovery of novel treatment strategies. One such strategy is the identification of collateral sensitivities, wherein evolution under a first drug induces susceptibility to a second. Here, we report that sequential drug regimens derived from in vitro evolution experiments may have overstated therapeutic benefit, predicting a collaterally sensitive response where cross-resistance ultimately occurs. We quantify the likelihood of this phenomenon by use of a mathematical model parametrised with combinatorially complete fitness landscapes for
Escherichia coli
. Through experimental evolution we then verify that a second drug can indeed stochastically exhibit either increased susceptibility or increased resistance when following a first. Genetic divergence is confirmed as the driver of this differential response through targeted and whole genome sequencing. Taken together, these results highlight that the success of evolutionarily-informed therapies is predicated on a rigorous probabilistic understanding of the contingencies that arise during the evolution of drug resistance.
The evolution of resistance to an antibiotic can render bacteria more susceptible, or more resistant, to a second antibiotic. Here, Nichol et al. provide evidence that the final outcome can be fairly stochastic and depends on the shape of the evolutionary fitness landscape.
Journal Article
Agile sales
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- List of Figures -- Figure I.1 Agile Sales -- Figure 1.1 Pareto Principle and 80/20 Rule -- Figure 1.2 Persona Map -- Figure 1.3 Personal Map of Driven Bob -- Figure 1.4 Customer Contextual Interview Form -- Figure 1.5 Empathy Map -- Figure 2.1 Catch Ball Process -- Figure 3.1 Multi-Level RVMs -- Figure 3.2 Scrum Board -- Figure 3.3 Winson Group's Values and Behavior -- Figure 3.4 Team Behavior Change Tracker -- Figure 3.5 Burn-Up Watermelon Chart -- Figure 3.6 Ingham's Daily Operations Review Board
Book
Identifying paediatric sepsis: the difficulties in following recommended practice and the creation of our own pathway
Correspondence to Dr Rebecca Powell, Paediatric Emergency Department, Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX, UK; rebecca.powell7@nhs.net, bexpowell83@icloud.com As part of the development of new sepsis guidelines in response to the national Commissioning for Quality and Innovation (CQUIN) and new National Institute for Health and Care Excellence (NICE) guidelines on sepsis in Paediatrics, we undertook a retrospective audit comparing the new guidelines to previous cases that had attended the emergency department (ED). Large cohort study from Australia looking at the feverish child concluded that the most significant predictor was ‘… for all serious bacterial infections, appearing generally unwell was the strongest diagnostic marker, with raised temperature, no fluid intake in the previous 24 hours, increased capillary refill time, and chronic disease also predictive’.1 As a response to the audit and CQUIN, we have created our own flow chart and sepsis pathway (see online supplementary file 1) to minimise unnecessary investigations as well as correctly identifying children who need emergency interventions. The accuracy of clinical symptoms and signs for the diagnosis of serious bacterial infection in young febrile children: prospective cohort study of 15 781 febrile illnesses.
Journal Article