Explore the vast range of titles available.

\"For nearly sixty years, Richard Artschwager (b. 1923) has undertaken an unrelenting investigation of art's ability to mediate contemporary experience and perception. Although his work, which includes sculpture, painting, prints, and drawing, is often characterized as having elements of Pop Art, Minimalism, and Conceptual Art, his practice defies easy categorization and his oeuvre is not entirely understood. In Richard Artschwager! the breadth of the artist's idealistic, diverse work, and unconventional materials, such as Formica, rubberized hair, and Celotex, is fully illustrated and explored for the first time.The four essays in this volume illuminate previously unaddressed aspects of Artschwager's work, including his response to life in the age of mechanical reproduction, the relationship of his work to mainstream art, and his recent work's connection with Post-Impressionism. These texts, along with new photographs, previously unpublished archival images, and details of his materials, offer a compelling new look at one of the most singular artists of the 20th century and why he remains a highly influential figure today\"-- Provided by publisher.

Health care increasingly depends on information and communication technology. This offers both opportunities and challenges when designing connected health systems. While individual studies examined particular cases, there is a limited synthesis of insights across projects. The objective of this paper is to explore these opportunities and challenges by examining 6 diverse connected health projects and synthesizing lessons from an expert workshop. To achieve this, we conducted a full-day workshop that brought together 6 connected health projects. The workshop used an iterative and participatory process which included paper submissions and presentations and facilitated discussions, and a gallery walk to enable cross-case comparison and collaborative reflection. Thematic analysis of workshop outputs was then used to synthesize key opportunities and challenges in designing connected health systems. The 6 projects represented a variety of design methods and approaches to connected health, and their discussion surfaced both opportunities and challenges in this domain. Key opportunities include improving data integration and usability, enhancing collaboration across stakeholders, using a user-centered and iterative design process, addressing complexity in sociotechnical systems, sustainability, and adopting digital infrastructures for seamless communication. Participants also identified important challenges, namely exchange of information, interoperability, and communication; ethical considerations, rules, and regulations; understanding design, evaluation, and standards; actionable data, reliability, quality, and trust in data; and stakeholder involvement. The contribution of this paper lies in the synthesis of insights across multiple projects and perspectives to provide practical guidance for researchers, designers, and policymakers. By highlighting opportunities and challenges in designing connected health systems, the findings emphasize the importance of patient-centered, sustainable, and collaborative design approaches while also pointing to the need to address persistent barriers. Advancing connected health will require adopting iterative and inclusive design processes that prioritize patient-centeredness, sustainability, and collaboration across health care systems.

Objective Complex ablative maxillary and mandibular defects often require osseous free flap reconstruction. Workhorse options include the fibula, scapula, and osteocutaneous radial forearm flap (OCRFF). The choice of donor site for harvest should be driven not only by reconstructive goals but also by donor site morbidity. The goal of this study is to evaluate the long‐term postoperative musculoskeletal morbidity at the donor site after osseous free flap harvest. Study Design Cohort study and cross‐sectional analysis. Methods A retrospective review of patients who underwent free flap harvest at 1 of the 3 donor sites from 2015 through 2021 was performed. An additional cross‐sectional analysis at ≥1 year postoperatively was performed from 2021 to 2022 using validated patient‐reported orthopedic surveys: Disabilities of the Arm, Shoulder, and Hand for scapula or OCRFF harvest, and Foot and Ankle Ability Measure for fibula harvest. Setting Single, high‐volume tertiary care institution. Results Among 731 eligible patients, 162 (22.1%) answered the telephone surveys and were included. Functional differences between operated and nonoperated sides were 18.5% (scapula, n = 33), 13.5% (OCRFF, n = 29), and 10% (fibula, n = 98). Postoperative physical therapy (for all donor sites), ipsilateral neck dissection (for scapula and OCRFF), and extent of bony resection (for OCRFF) were not factors associated with long‐term morbidity. Acute donor site complications were most common in fibula patients and were associated with worse long‐term functional outcomes (7.5% difference; 95% confidence interval, −14.0 to −1; P = .03). Conclusion There is acceptable long‐term musculoskeletal morbidity at the donor site after osseous free flap harvest, and patients should be counseled appropriately.

We used intensive modern proteomics approaches to identify predictive proteins in ovary cancer. We identify up-regulated proteins in both serum and peritoneal fluid. To evaluate the overall performance of the approach we track the behavior of 20 validated markers across these experiments. Mass spectrometry based quantitative proteomics following extensive protein fractionation was used to compare serum of women with serous ovarian cancer to healthy women and women with benign ovarian tumors. Quantitation was achieved by isotopically labeling cysteine amino acids. Label-free mass spectrometry was used to compare peritoneal fluid taken from women with serous ovarian cancer and those with benign tumors. All data were integrated and annotated based on whether the proteins have been previously validated using antibody-based assays. We selected 54 quantified serum proteins and 358 peritoneal fluid proteins whose case-control differences exceeded a predefined threshold. Seventeen proteins were quantified in both materials and 14 are extracellular. Of 19 validated markers that were identified all were found in cancer peritoneal fluid and a subset of 7 were quantified in serum, with one of these proteins, IGFBP1, newly validated here. Proteome profiling applied to symptomatic ovarian cancer cases identifies a large number of up-regulated serum proteins, many of which are or have been confirmed by immunoassays. The number of currently known validated markers is highest in peritoneal fluid, but they make up a higher percentage of the proteins observed in both serum and peritoneal fluid, suggesting that the 10 additional markers in this group may be high quality candidates.

Objective To describe our modifications to the submental island flap (SMIF) in a case series that demonstrates improved reproducibility, shortened length of stay (LOS), and reduced utilization of hospital resources. Study Design This retrospective case series with chart review included adult patients who underwent resection of malignant or benign tumors resulting in lateral facial, parotid, or temporal bone defects, which were reconstructed with SMIF. Setting A tertiary‐care academic referral center. Methods Retrospective case series included all adult patients who underwent SMIF reconstruction between March 2020 and August 2021. Patient demographic and clinical data were collected. Primary outcomes were measures of hospital utilization including duration of surgery, LOS, and postoperative outcomes. Results Twenty‐eight patients were included with a mean age of 71.7 years. Eighty percent were male. All patients underwent parotidectomy, and the mean operative time was 347 minutes. The median LOS was 2.5 days (range 0‐16 days). Seventy‐five percent of the flaps drained into the internal jugular vein, and 25% drained into the external jugular vein. No patients required reoperation or readmission. All flaps survived. Conclusion SMIFs are a safe and effective option for reconstruction of lateral facial, parotid, and temporal bone defects. Compared to free flap reconstruction, SMIFs offer reduced length of surgery, decreased use of health care resources, and lower rate of reoperation. As health care resource allocation is increasingly important, the SMIF offers an excellent alternative to free flap reconstruction of lateral defects.

The development of the mammary gland requires the coordinated expression of hormones and growth factors. Likewise, some transformed breast cells continue to respond to these same extracellular signals. Thus, understanding the mechanisms that control normal development of tissues can lead to new therapeutic targets. The insulin-like growth factor (IGF) system plays an important role in the normal development and function of the mammary gland. Accumulating evidence suggests that the IGFs are also key regulators of the malignant phenotype. The IGFs stimulate proliferation, promote survival, and enhance metastatic potential of breast cancer cells. Although multiple receptors for the IGFs have been identified, the IGFs primarily exert their biologic effects through ligation of the type I IGF receptor tyrosine kinase (IGF1R). IGF binding to the IGF1R initiates an intracellular signaling cascade that leads to changes in gene expression and cell biology. This review will focus on the evidence that the IGF1R is a relevant treatment target in breast cancer.

A case study was completed to complete a usability evaluation following the ISO standards and heuristic evaluation on a prototype for a newly defined central pharmacist position at Akademiska Sjukhuset. From this study, it was found that there were several unique issues that were identified only in the usability study that were not found in the heuristic analysis: assessment of patient warnings, the time it takes to evaluate the warnings and the evaluation methods the test subjects used. This information is important for further design and development and showed that usability testing for domain experts added value to early development.