Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,875
result(s) for
"Jensen, Christopher"
Sort by:
Creep leap crunch! : a food chain story
\"In this nonfiction picture book, discover how the animal kindgdom's food chain takes shape, from the lowly worm to the mighty king of the jungle\"-- Provided by publisher.
CHILDBOOK
The Oneiro- and the Hagio-: Teaching about Dreams from the Standpoint of Comparative Hagiology
This paper explores the potentially fruitful interplay between a set of practical and theoretical approaches developed to teach post-secondary students about accounts of dreams and of exemplars, in cases where these phenomena have been deemed significant by specific religious discourse communities. Incorporating insights from his participation in the Comparative Hagiology group, the author suggests—in particular—that the expanded perspective on hagiography proposed by Rondolino, Hollander, and others can serve as a fruitful vantage from which to survey both of these phenomena in the classroom, revealing some intriguing correspondences between them. The author concludes by proposing some ways that the comparative hagiological classroom could be a particularly productive learning environment, and one that directly addresses some of the challenges of contemporary post-secondary education (from both the instructors’ and students’ perspectives).
Journal Article
Voltage-driven motion of nitrogen ions: a new paradigm for magneto-ionics
Magneto-ionics, understood as voltage-driven ion transport in magnetic materials, has largely relied on controlled migration of oxygen ions. Here, we demonstrate room-temperature voltage-driven nitrogen transport (
i.e
., nitrogen magneto-ionics) by electrolyte-gating of a CoN film. Nitrogen magneto-ionics in CoN is compared to oxygen magneto-ionics in Co
3
O
4
. Both materials are nanocrystalline (face-centered cubic structure) and show reversible voltage-driven ON-OFF ferromagnetism. In contrast to oxygen, nitrogen transport occurs uniformly creating a plane-wave-like migration front, without assistance of diffusion channels. Remarkably, nitrogen magneto-ionics requires lower threshold voltages and exhibits enhanced rates and cyclability. This is due to the lower activation energy for ion diffusion and the lower electronegativity of nitrogen compared to oxygen. These results may open new avenues in applications such as brain-inspired computing or iontronics in general.
In magneto-ionics, ion migration through the material is used to change the materials magnetic properties. Typically oxygen is used as the mobile ion. In this manuscript, the authors demonstrate controlled migration of nitrogen in a CoN film, expanding the possibilities of magneto-ionics.
Journal Article
Effectiveness of screening colonoscopy in reducing the risk of death from right and left colon cancer: a large community-based study
ObjectiveScreening colonoscopy's effectiveness in reducing colorectal cancer mortality risk in community populations is unclear, particularly for right-colon cancers, leading to recommendations against its use for screening in some countries. This study aimed to determine whether, among average-risk people, receipt of screening colonoscopy reduces the risk of dying from both right-colon and left-colon/rectal cancers.DesignWe conducted a nested case–control study with incidence-density matching in screening-eligible Kaiser Permanente members. Patients who were 55–90 years old on their colorectal cancer death date during 2006–2012 were matched on diagnosis (reference) date to controls on age, sex, health plan enrolment duration and geographical region. We excluded patients at increased colorectal cancer risk, or with prior colorectal cancer diagnosis or colectomy. The association between screening colonoscopy receipt in the 10-year period before the reference date and colorectal cancer death risk was evaluated while accounting for other screening exposures.ResultsWe analysed 1747 patients who died from colorectal cancer and 3460 colorectal cancer-free controls. Compared with no endoscopic screening, receipt of a screening colonoscopy was associated with a 67% reduction in the risk of death from any colorectal cancer (adjusted OR (aOR)=0.33, 95% CI 0.21 to 0.52). By cancer location, screening colonoscopy was associated with a 65% reduction in risk of death for right-colon cancers (aOR=0.35, CI 0.18 to 0.65) and a 75% reduction for left-colon/rectal cancers (aOR=0.25, CI 0.12 to 0.53).ConclusionsScreening colonoscopy was associated with a substantial and comparably decreased mortality risk for both right-sided and left-sided cancers within a large community-based population.
Journal Article
Adenoma Detection Rate and Risk of Colorectal Cancer and Death
The proportion of a physician's screening colonoscopies that detect at least one adenoma (the adenoma detection rate) is a quality measure. In this study involving 136 gastroenterologists, the adenoma detection rate was inversely associated with patients' risk of interval colorectal cancer.
Colonoscopy is a commonly used primary or follow-up screening test to detect colorectal cancer,
1
–
3
the second leading cause of death from cancer in the United States.
4
,
5
Colonoscopy can reduce the risk of death from colorectal cancer through detection of tumors at an earlier, more treatable stage and through removal of precancerous adenomas.
3
,
6
Conversely, failure to detect adenomas during colonoscopy may increase the subsequent risk of cancer.
The adenoma detection rate, the proportion of screening colonoscopies performed by a physician that detect at least one histologically confirmed colorectal adenoma or adenocarcinoma, has been recommended as a quality benchmark . . .
Journal Article
LIM Domains Target Actin Regulators Paxillin and Zyxin to Sites of Stress Fiber Strain
Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochastic, highly localized strain events, characterized by thinning and elongation within a discrete region of stress fiber. Previous work showed the LIM-domain adaptor protein, zyxin, is essential for repair and stabilization of these sites. Using live imaging, we show paxillin, another LIM-domain adaptor protein, is also recruited to stress fiber strain sites. Paxillin recruitment to stress fiber strain sites precedes zyxin recruitment. Zyxin and paxillin are each recruited independently of the other. In cells lacking paxillin, actin recovery is abrogated, resulting in slowed actin recovery and increased incidence of catastrophic stress fiber breaks. For both paxillin and zyxin, the LIM domains are necessary and sufficient for recruitment. This work provides further evidence of the critical role of LIM-domain proteins in responding to mechanical stress in the actin cytoskeleton.
Journal Article
Association between Improved Colorectal Screening and Racial Disparities
In this study involving non-Hispanic Black members and non-Hispanic White members of the Kaiser Permanente Northern California health plan from 2000 through 2019, colorectal cancer screening increased markedly among both Black members and White members, and racial disparities in colorectal cancer incidence and mortality were virtually eliminated.
Journal Article
The staged competition innovation theory
Innovation is critical to technological progress and has many theories to explain its processes. Organised competition has been shown empirically to provide an alternative pathway for innovation within an industry, increasing innovation rates and radicalness. This research introduces and develops the new staged competition innovation theory which builds on the well-understood diffusion of innovation theory and the Technology-Organisation-Environment framework to explain how decision-making and technological, organisational, and environmental characteristics of industry-based competition can drive innovation activity. The new theory comprises three principles that demonstrate how a well-designed staged competition provides: (1) a unique innovation mechanism away from parent industry constraints, (2) a unique agile environment that can increase innovation development, and (3) a return pathway for adoption back to the parent industry. Principle 2 addresses the specific competition environment criteria required to drive innovation, beginning with a co-dependency between organiser and teams in providing team confidence and a mutually beneficial outcome for both parties. Relative advantage drives teams to innovate by generating competitive pressure, while a variable solution space due to competition specific rules and competition brief clarity direct innovation efforts. Finally, competition repetition provides ongoing innovation transfer between teams within the competition and to the parent industry.
Journal Article
Improved functional assessment in cancer patients using home-based digital technologies
Accurate assessment of performance status (PS) in oncology care is crucial for improving clinical decisions, therapy selection and anticipated risks of treatment toxicity. While physical function is traditionally assessed in the clinic, in-clinic instruments do not capture the full spectrum of daily functioning. Digital health technologies (DHTs) can address this limitation by passively monitoring patients in their daily environment. Our study showed at-home physical activity and gait metrics from DHTs were associated with self-reported PS in participants with cancer, and these metrics had greater discriminatory power than in-clinic measures among this cohort. The DHT-derived metrics were also significantly correlated with patient-reported-outcomes, and used of the devices was broadly acceptable to study participants. Therefore, integrating DHTs into oncological practice could significantly refine how PS is measured and utilized, ultimately enhancing treatment decision-making and clinical outcomes. (ClinicalTrials.gov NCT03952767).
Journal Article