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"Jiang, Jing-Jing"
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Impact of music learning on students’ psychological development with mediating role of self-efficacy and self-esteem
Professionals and academics have recently placed a greater emphasis on comprehending the elements that go into improving students’ psychological wellbeing. Students frequently face major obstacles as a result of the rigorous nature of academic life, which can result in problems like tension, depression and other psychological health concerns. These complications have a long-lasting influence on their future aspirations in addition to affecting their academic achievement. This study determined the effects of music learning on students’ academic performance and psychological well-being. The mediating role of self-efficacy and self-esteem are also examined in this study. The data is collected from 326 students in Chinese universities and applied structural equation modeling for empirical analysis. The findings show that music education improves the students’ psychological well-being, which in turn improves their academic performance. Additionally, psychological health is a major factor in improving the academic performance. There is significant mediating impact of self-efficacy and self-esteem in relationship between mental well-being and music education. To improve students’ psychological health, it is suggested that policy makers should consider the integration of music education into academic settings.
Journal Article
Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin
Ergothioneine, a sulfur-containing micromolecular histidine derivative, has attracted increasing attention from scholars since it was confirmed in the human body. In the human body, ergothioneine is transported and accumulated specifically through OCTN-1, especially in the mitochondria and nucleus, suggesting that it can target damaged cells and tissues as an antioxidant. It shows excellent antioxidant, anti-inflammatory effects, and anti-aging properties, and inhibits melanin production. It is a mega antioxidant that may participate in the antioxidant network system and promote the reducing glutathione regeneration cycle. This review summarizes studies on the antioxidant effects of ergothioneine on various free radicals in vitro to date and systematically introduces its biological activities and potential mechanisms, mostly in dermatology. Additionally, the application of ergothioneine in cosmetics is briefly summarized. Lastly, we propose some problems that require solutions to understand the mechanism of action of ergothioneine. We believe that ergothioneine has good prospects in the food and cosmetics industries, and can thus meet some needs of the health and beauty industry.
Journal Article
Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?
The outbreak of a novel corona Virus Disease 2019 (COVID-19) in the city of Wuhan, China has resulted in more than 1.7 million laboratory confirmed cases all over the world. Recent studies showed that SARS-CoV-2 was likely originated from bats, but its intermediate hosts are still largely unknown. In this study, we assembled the complete genome of a coronavirus identified in 3 sick Malayan pangolins. The molecular and phylogenetic analyses showed that this pangolin coronavirus (pangolin-CoV-2020) is genetically related to the SARS-CoV-2 as well as a group of bat coronaviruses but do not support the SARS-CoV-2 emerged directly from the pangolin-CoV-2020. Our study suggests that pangolins are natural hosts of Betacoronaviruses. Large surveillance of coronaviruses in pangolins could improve our understanding of the spectrum of coronaviruses in pangolins. In addition to conservation of wildlife, minimizing the exposures of humans to wildlife will be important to reduce the spillover risks of coronaviruses from wild animals to humans.
Journal Article
H2S Alleviates Salinity Stress in Cucumber by Maintaining the Na+/K+ Balance and Regulating H2S Metabolism and Oxidative Stress Response
Salinity stress from soil or irrigation water can significantly limit the growth and development of plants. Emerging evidence suggests that hydrogen sulfide (H2S), as a versatile signal molecule, can ameliorate salt stress-induced adverse effects. However, the possible physiological mechanism underlying H2S-alleviated salt stress in cucumber remains unclear. Here, a pot experiment was conducted with an aim to examine the possible mechanism of H2S in enhancement of cucumber salt stress tolerance. The results showed that H2S ameliorated salt-induced growth inhibition and alleviated the reduction in photosynthetic attributes, chlorophyll fluorescence and stomatal parameters. Meanwhile H2S increased the endogenous H2S level concomitant with increased activities of D/L-cysteine desulfhydrase and β-cyanoalanine synthase and decreased activities of O-acetyl-L-serine(thiol)lyase under excess NaCl. Notably, H2S maintained Na+ and K+ homeostasis via regulation of the expression of PM H+-ATPase , SOS1 and SKOR at the transcriptional level under excess NaCl. Moreover, H2S alleviated salt-induced oxidative stress as indicated by lowered lipid peroxidation and reactive oxygen species accumulation through an enhanced antioxidant system. Altogether, these results demonstrated that application of H2S could protect cucumber seedlings against salinity stress, likely by keeping the Na+/K+ balance, controlling the endogenous H2S level by regulating the H2S synthetic and decomposition enzymes, and preventing oxidative stress by enhancing the antioxidant system under salinity stress.
Journal Article
Rhodobacter azotoformans LPS (RAP99-LPS) Is a TLR4 Agonist That Inhibits Lung Metastasis and Enhances TLR3-Mediated Chemokine Expression
The lipopolysaccharides (LPSs) of Rhodobacter are reported to be TLR4 antagonists. Accordingly, the extract of Rhodobacter azotoformans (RAP99) is used as a health supplement for humans and animals in Japan to regulate immune responses in vivo . We previously analyzed the LPS structure of RAP99 (RAP99-LPS) and found it is different from that of E. coli -LPS but similar to lipid A from Rhodobacter sphaeroides (RSLA), a known antagonist of TLR4, with both having three C14 fatty acyl groups, two C10 fatty acyl groups, and two phosphates. Here we show that RAP99-LPS has an immune stimulatory activity and acts as a TLR4 agonist. Pretreatment of RAP99-LPS suppressed E. coli -LPS-mediated weight loss, suggesting it is an antagonist against E. coli -LPS like other LPS isolated from Rhodobacter . However, injections of RAP99-LPS caused splenomegaly and increased immune cell numbers in C57BL/6 mice but not in C3H/HeJ mice, suggesting that RAP99-LPS stimulates immune cells via TLR4. Consistently, RAP99-LPS suppressed the lung metastasis of B16F1 tumor cells and enhanced the expression of TLR3-mediated chemokines. These results suggest that RAP99-LPS is a TLR4 agonist that enhances the activation status of the immune system to promote anti-viral and anti-tumor activity in vivo .
Journal Article
50% efficacy dose of intravenous lidocaine in supressing sufentanil-induced cough in children: a randomised controlled trial
Background
Opioids such as sufentanil are used as anaesthetics due to their rapid action and superior analgesic effect. However, sufentanil induces a huge cough in paediatric patients. In contrast, intravenous (IV) lidocaine suppresses opioid-induced cough in children, but its use is limited due to anaesthetists’ concern about its toxicity. Therefore, this study aimed to evaluate the effect of dose-dependent IV lidocaine on sufentanil-induced cough (SIC) in paediatric patients.
Methods
A total of 188 patients aged 3–12 years scheduled for elective tonsillectomy with or without adenoidectomy were enrolled and divided into four groups depending on different dose of lidocaine: A (0 mg.kg-1), B (1 mg.kg-1), C (1.5 mg.kg-1), and D (2 mg.kg-1). The primary outcome was the SIC grade observed during the induction of general anaesthesia. The secondary outcomes were the incidence of SIC, mean arterial pressure, and heart rate at T0, T1, T2, T3, T4, and T5.
Results
The SIC grade was significantly different between groups A and D (
P
= 0.04) and between groups B and D (
P
= 0.03). Moreover, the incidence of SIC in groups A, B, C, and D was 81%, 87%, 68%, and 64%, respectively, and the difference between groups B and C (
P
= 0.03) and between groups B and D (
P
= 0.0083) was statistically significant. No statistical differences were observed in the hemodynamic parameters between the groups. The incidence of severe cough was statistically different between group D and group A (
P
< 0.0001), between group D and group B (
P
< 0.0001), and between group D and group C (
P
< 0.0001) respectively.
Conclusions
Lidocaine suppresses SIC in a dose-dependent manner without severe adverse events. IV lidocaine can be used in paediatric patients safely and efficiently, and the median effective dose was 1.75 mg/kg.
Trial registration
This study was approved by the Institutional Review Board of Yichang Central People’s Hospital (HEC-KYJJ-2020-038-02), The trial was registered at
www.chictr.org.cn
(ChiCTR2100053006).
Journal Article
Illustration image style transfer method design based on improved cyclic consistent adversarial network
To improve the expressiveness and realism of illustration images, the experiment innovatively combines the attention mechanism with the cycle consistency adversarial network and proposes an efficient style transfer method for illustration images. The model comprehensively utilizes the image restoration and style transfer capabilities of the attention mechanism and the cycle consistency adversarial network, and introduces an improved attention module, which can adaptively highlight the key visual elements in the illustration, thereby maintaining artistic integrity during the style transfer process. Through a series of quantitative and qualitative experiments, high-quality style transfer is achieved, especially while retaining the original features of the illustration. The results show that when running on the Monet2photo dataset, when the system iterates to 72 times, the loss function value of the research method approaches the target value of 0.00. On the Horse2zebra dataset, as the sample size increases, the research method has the smallest FID value, and the value approaches 40.00 infinitely. With the change of peak signal-to-noise ratio, the accuracy of the research algorithm has been greater than 95.00%. Practical application found that the color of the image obtained by the research method is more gorgeous and the line features are more obvious. The above results all show that the research method has achieved more satisfactory results in the task of style transfer of illustration images, especially in terms of the accuracy of style transfer and the retention of image details.
Journal Article
Intravenous lidocaine enhances the efficacy of ondansetron and dexamethasone in postoperative vomiting prophylaxis among high-risk children
A combination of dexamethasone, ondansetron, and total intravenous anaesthesia (TIVA) is recommended as prophylaxis for preventing postoperative vomiting (POV) in high-risk children. Implementing TIVA in paediatric patients undergoing anaesthesia presents challenges due to its excessive inter-individual variability and difficult estimation. Regarding lidocaine’s antiemetic effect in paediatric patients, incorporating lidocaine can mitigate POV in high-risk children. Among 204 children undergoing elective tonsillectomy (with/without adenoidectomy), those with postoperative vomiting score ≥ 4 was randomised into Group C (saline) and Group L (lidocaine). The primary outcome was POV incidence within the first 24 h after surgery. The POV incidence differed among 15 patients in Group C (14.7%) and 5 in Group L (4.9%) presenting with one or more episodes of POV (
P
= 0.019). The secondary outcome was the number of coughs within the first 30 min after surgery. The number of coughs within the first 30 min after surgery significantly differed between Group L (0 [0–0.125]) and Group C (1 [0–2]) (
P
= 0.007). Significant between-group differences in the time to extubation were also observed, with a 3-min longer time in Group L. A lower percentage of patients experienced adverse events in Group C (2.2%) compared with Group L (1.1%) (
P
= 0.567); no severe events occurred. Adding intravenous lidocaine to ondansetron and dexamethasone was effective in reducing the POV incidence and extubation coughs in high-risk children following volatile anaesthesia for tonsillectomy.
Journal Article