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Although previous neuroimaging evidence has confirmed the brain functional disturbances in thyroid‐associated ophthalmopathy (TAO), the dynamic characteristics of brain activity and functional connectivity (FC) in TAO were rarely concerned. The present study aims to investigate the alterations of temporal variability of brain activity and FC in TAO using resting‐state functional magnetic resonance imaging (rs‐fMRI). Forty‐seven TAO patients and 30 age‐, gender‐, education‐, and handedness‐matched healthy controls (HCs) were enrolled and underwent rs‐fMRI scanning. The dynamic amplitude of low‐frequency fluctuation (dALFF) was first calculated using a sliding window approach to characterize the temporal variability of brain activity. Based on the dALFF results, seed‐based dynamic functional connectivity (dFC) analysis was performed to identify the temporal variability of efficient communication between brain regions in TAO. Additionally, correlations between dALFF and dFC and the clinical indicators were analyzed. Compared with HCs, TAO patients displayed decreased dALFF in the left superior occipital gyrus (SOG) and cuneus (CUN), while showing increased dALFF in the left triangular part of inferior frontal gyrus (IFGtriang), insula (INS), orbital part of inferior frontal gyrus (ORBinf), superior temporal gyrus (STG) and temporal pole of superior temporal gyrus (TPOsup). Furthermore, TAO patients exhibited decreased dFC between the left STG and the right middle occipital gyrus (MOG), as well as decreased dFC between the left TPOsup and the right calcarine fissure and surrounding cortex (CAL) and MOG. Correlation analyses showed that the altered dALFF in the left SOG/CUN was positively related to visual acuity (r = .409, p = .004), as well as the score of QoL for visual functioning (r = .375, p = .009). TAO patients developed abnormal temporal variability of brain activity in areas related to vision, emotion, and cognition, as well as reduced temporal variability of FC associated with vision deficits. These findings provided additional insights into the neurobiological mechanisms of TAO. We explored the spatiotemporal alterations of both brain activity and connectivity in thyroid‐associated ophthalmopathy (TAO) by using dynamic amplitude of low‐frequency fluctuation and dynamic functional connectivity, respectively. We also identified correlations between the abnormal dynamic brain activity in the left occipital area and the visual deficits in TAO patients.

Double holography has been proved to be a powerful method in comprehending the spacetime entanglement. In this paper we investigate the doubly holographic construction in dS 2 spacetime. We find that in this model there exists a new extremal surface besides the Hartman–Maldacena surface and the island surface, which could lead to a more complex phase structure. We then propose a generalized mutual entropy to interpret the phase transition. However, this extremal surface has a subtle property that the length of a part of the geodesic is negative when this saddle is dominant. This is because the negative part of the geodesic is within the horizon of the bulk geometry. We move to the AdS 2 spacetime and find this subtlety still exists. We purpose a simple solution to this issue.

Quantum memory networks as an intermediate stage in the development of a quantum internet1 will enable a number of significant applications2-5. To connect and entangle remote quantum memories, it is best to use photons. In previous experiments6-13, entanglement of two memory nodes has been achieved via photon interference. Going beyond the state of the art by entangling many quantum nodes at a distance is highly sought after. Here, we report the entanglement of three remote quantum memories via three-photon interference. We employ laser-cooled atomic ensembles and make use of a ring cavity to enhance the overall efficiency of our memory–photon entanglement. By interfering three single photons from three separate set-ups, we create entanglement of three memories and three photons. Then, by measuring the photons and applying feed-forward, we achieve heralded entanglement between the three memories. Our experiment may be employed as a building block to construct larger and complex quantum networks14,15.The entanglement of three remote quantum memories based on 87Rb atoms is created via three-photon interference by enhancing the memory–photon entanglement in ring cavities, demonstrating a genuine quantum network involving more than two quantum nodes.

Objectives To evaluate the combined performance of orbital MRI and intracranial visual pathway diffusion kurtosis imaging (DKI) in diagnosing dysthyroid optic neuropathy (DON). Methods We retrospectively enrolled 61 thyroid-associated ophthalmopathy (TAO) patients, including 25 with DON (40 eyes) and 36 without DON (72 eyes). Orbital MRI–based apical muscle index (MI), diameter index (DI) of the optic nerve (ON), area index (AI) of the ON, apparent diffusion coefficient (ADC) and signal intensity ratio (SIR) of the ON, DKI-based kurtosis fractional anisotropy (KFA) and mean kurtosis (MK) of the optic tract (OT), optic radiation (OR), and Brodmann areas (BAs) 17, 18, and 19 were measured and compared between groups. The diagnostic performances of models were evaluated using receiver operating characteristic curve analyses and compared using the DeLong test. Results TAO patients with DON had significantly higher apical MI, apical AI, and SIR of the ON, but significantly lower ADC of the ON than those without DON ( p  < 0.05). Meanwhile, the DON group exhibited significantly lower KFA across the OT, OR, BA17, BA18, and BA19 and lower MK at the OT and OR than the non-DON group ( p  < 0.05). The model integrating orbital MRI and intracranial visual pathway DKI parameters performed the best in diagnosing DON (AUC = 0.926), with optimal diagnostic sensitivity (80%) and specificity (94.4%), followed by orbital MRI combination (AUC = 0.890), and then intracranial visual pathway DKI combination (AUC = 0.832). Conclusion Orbital MRI and intracranial visual pathway DKI can both assist in diagnosing DON. Combining orbital and intracranial imaging parameters could further optimize diagnostic efficiency. Clinical relevance statement The novel finding could bring novel insights into the precise diagnosis and treatment of dysthyroid optic neuropathy, accordingly, contributing to the improvement of the patients’ prognosis and quality of life in the future. Key Points • Orbital MRI and intracranial visual pathway diffusion kurtosis imaging can both assist in diagnosing dysthyroid optic neuropathy. • Combining orbital MRI and intracranial visual pathway diffusion kurtosis imaging optimized the diagnostic efficiency of dysthyroid optic neuropathy.

Abstract Context Dysthyroid optic neuropathy (DON) is a serious vision-threatening complication of thyroid-associated ophthalmopathy (TAO). Exploration of the underlying mechanisms of DON is critical for its timely clinical diagnosis. Objective We hypothesized that TAO patients with DON may have altered brain functional networks. We aimed to explore the alterations of static and dynamic functional connectomes in patients with and without DON using resting-state functional magnetic resonance imaging with the graph theory method. Methods A cross-sectional study was conducted at a grade A tertiary hospital with 66 TAO patients (28 DON and 38 non-DON) and 30 healthy controls (HCs). Main outcome measures included topological properties of functional networks. Results For static properties, DON patients exhibited lower global efficiency (Eg), local efficiency, normalized clustering coefficient, small-worldness (σ), and higher characteristic path length (Lp) than HCs. DON and non-DON patients both exhibited varying degrees of abnormalities in nodal properties. Meanwhile, compared with non-DON, DON patients exhibited abnormalities in nodal properties in the orbitofrontal cortex and visual network (VN). For dynamic properties, the DON group exhibited higher variance in Eg and Lp than non-DON and HC groups. A strengthened subnetwork with VN as the core was identified in the DON cohort. Significant correlations were found between network properties and clinical variables. For distinguishing DON, the combination of static and dynamic network properties exhibited optimal diagnostic performance. Conclusion Functional network alterations were observed both in DON and non-DON patients, providing novel insights into the underlying neural mechanisms of disease. Functional network properties may be potential biomarkers for reflecting the progression of TAO from non-DON to DON.

Abstract Objective To investigate the brain structural and functional alterations in patients with thyroid-associated ophthalmopathy (TAO) before and after glucocorticoid therapy, using voxel-based morphometry (VBM) as well as resting-state functional magnetic resonance imaging (MRI) with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo). Methods Between 2019 and 2022, 32 patients with TAO and 23 healthy controls underwent pre-therapy MRI in Nanjing, China. Intravenous glucocorticoid therapy was administered to all patients. At 3 months after end of therapy, 26 patients were available for rescanned MRI. VBM, ALFF, and ReHo were used to evaluate the brain structural and functional differences. Results Before therapy, TAO patients showed significantly decreased gray matter volume (GMV) in the left orbital part of superior frontal gyrus (ORBsup) and medial superior frontal gyrus (SFGmed) than healthy controls. Patients had higher ALFF values in bilateral gyrus rectus and olfactory cortex and lower values in bilateral cuneus. Patients also showed decreased ReHo values in bilateral lingual gyrus. After therapy, increased GMV in the left anterior cingulate gyrus and SFGmed, increased ALFF values in bilateral cuneus and superior occipital gyrus, and increased ReHo values in bilateral SFGmed were found in TAO patients compared to the pre-therapy cohort. Compared to controls, decreased GMV in left ORBsup was observed in post-therapy TAO patients. Conclusion Our results indicated that TAO might cause functional and structural deficits in the visual and emotional regions of the brain, with recovery in the former and partial restoration in the latter after effective glucocorticoid therapy. These findings may lead to deeper understanding of the pathophysiological mechanism behind TAO.

With a phenomenal amount of marine debris being retrieved from the coast and sea, an initiative to engage in marine debris recycling, particularly of plastic debris, has been on the governmental agenda in Taiwan in recent years. Consumers purchasing products made from marine debris is a critical driver behind this initiative. It is therefore important to understand the factors influencing consumers’ purchase intentions towards these products. By employing the Theory of Planned Behavior (TPB), this paper aims to decode the factors and thereby infer potential measures to enhance consumers’ purchase intentions for these specific products in Taiwan, where recycling marine debris is at the beginning stage. By conducting a questionnaire survey, the study collected a total of 392 valid samples and found that a high percentage of respondents had not heard of marine debris labels as well as having never bought products made from marine debris. In addition, by testing the hypotheses using binary logit regression, the study found that ‘environmental attitude’, ‘perceived price’, ‘availability’, and ‘marine debris label’ were the major factors that significantly influenced consumers’ intentions to purchase these products. With a view to increasing market penetration of these products, this paper highlights the need to strengthen environmental education, subsidize manufacturers in the production of products, promote labels and enhance product availability, and enhance public participation in marine conservation activities.

To assess the role of dynamic contrast-enhanced (DCE)-MRI of the extraocular muscles (EOMs) for determining the activity of thyroid-associated ophthalmopathy (TAO) and treatment response to glucocorticoids (GCs). We prospectively enrolled 65 patients with TAO (41 active, 82 eyes; 24 inactive, 48 eyes). Twenty-two active patients completed the GC treatment and follow-up assessment, including 15 patients (30 eyes) and 7 patients (14 eyes), defined as responsive and unresponsive, respectively. Model-free (time to peak [TTP], area under the curve [AUC], and Slope ) and model-based (K , K , and V ) parameters of EOMs in embedded simplified histogram analyses were calculated and compared between groups. Multivariable logistic regression analysis was used to identify the independent predictors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the diagnostic performance. Active patients exhibited significantly higher TTP at the 10th percentile (-10th), TTP-mean, and TTP at the 90th percentile (-90th); AUC-10th, AUC-mean, AUC-90th, and AUC-max; K -10th and K -mean; and V -10th, V -mean, V -90th, and V -max than inactive patients ( < 0.05). Responsive patients exhibited significantly lower TTP-min; higher K -mean and K -max; and higher K -10th, K -mean, and K -max than unresponsive patients ( < 0.05). TTP-mean and V -mean were independent variables for determining disease activity ( = 0.017 and 0.022, respectively). A combination of the two parameters could determine active TAO with moderate performance (AUROC = 0.687). TTP-min and K -mean were independent predictors of the response to GCs ( = 0.023 and 0.004, respectively), uniting which could determine the response to GCs with decent performance (AUROC = 0.821). DCE-MRI-derived model-free and model-based parameters of EOMs can assist in the evaluation of TAO. In particular, TTP-mean and V -mean could be useful for determining the activity of TAO, whereas TTP-min and K -mean could be promising biomarkers for determining the response to GCs.