Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
10,657
result(s) for
"Jiang, Xiang"
Sort by:
فرص شبكة الجيل الخامس (5G) : أي فرص تحملها لنا شبكة الجيل الخامس (5G) ؟ وكيف نغتنم هذه الفرص ؟
يثير الجيل الخامس (5G) متابعة العالم بأسره ويحظى أيضا باهتمام في الصين من القمة إلى القاعدة، وكل ذلك يبرهن على أمر معين وهو ما يتحلى به الناس من تطلع عميق تجاه الجيل الخامس (5G) بعد أن عشنا الجيل الرابع من الاتصالات (4G) ونحن على ثقة بأن الجيل الخامس (5G) يمثل فرصة كبرى لتغيير العالم ؛ فما الفرص التي سيجلب لنا الجيل الخامس (5G) يا ترى ؟ ومتى ستظهر هذه الفرص ؟ وكيف تغتنمها ؟ ؛ بعد فترة طويلة من المراقبة والتحليل والإحساس ومن خلال رسم خط مستقيم من الفرص ونظرة استشرافية شاركنا خبير الاتصالات شيانغ لي قانغ فرص الجيل الخامس (5G)، وهذا لم يسمح للمزيد من الناس بمعرفة ما الذي يعنيه الجيل الخامس (5G) فحسب، بل اطلعوا بشكل أوضح على ما يكن أن ينجز الجيل الخامس (5G) واستوعبوا أكثر من ذلك ما يمكن أن يفعله كل واحد منا من خلال الجيل الخامس (5G)
BOOK
Exact non-Hermitian mobility edges and robust flat bands in two-dimensional Lieb lattices with imaginary quasiperiodic potentials
The mobility edge (ME) is a critical energy delineates the boundary between extended and localized states within the energy spectrum, and it plays a crucial role in understanding the metal–insulator transition in disordered or quasiperiodic systems. While there have been extensive studies on MEs in one-dimensional non-Hermitian (NH) quasiperiodic lattices recently, the investigation of exact NH MEs in two-dimensional (2D) cases remains rare. In the present study, we introduce a 2D dissipative Lieb lattice (DLL) model with imaginary quasiperiodic potentials applied solely to the vertices of the Lieb lattice. By mapping this DLL model to the 2D NH Aubry–André–Harper model, we analytically derive the exact ME and find it associated with the absolute eigenenergies. We find that the eigenvalues of extended states are purely imaginary when the quasiperiodic potential is strong enough. Additionally, we demonstrate that the introduction of imaginary quasiperiodic potentials does not disrupt the flat bands inherent in the system. Finally, we propose a theoretical framework for realizing our model using the Lindblad master equation. Our results pave the way for further investigation of exact NH MEs and flat bands in 2D dissipative quasiperiodic systems.
Journal Article
Antibody responses to SARS-CoV-2 in patients with COVID-19
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT–PCR results and for the identification of asymptomatic infections.
A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.
Journal Article
Nuclear receptor coactivator 6 promotes HTR‐8/SVneo cell invasion and migration by activating NF‐κB‐mediated MMP9 transcription
Objectives NCOA6 is a transcription coactivator; its deletion in mice results in growth retardation and lethality between 8.5 and 12.5 dpc with defects in the placenta. However, the transcription factor(s) and the mechanism(s) involved in the function of NCOA6 in placentation have not been elucidated. Here, the roles of NCOA6 in human cytotrophoblast invasion and migration were studied. Materials and Methods Human placenta tissues were collected from normal pregnancies and pregnancies complicated by early‐onset severe preeclampsia (sPE). Immunofluorescence, RT‐qPCR and Western blotting were used to determine NCOA6 expression. Transwell invasion/migration assays were performed to explore whether NCOA6 knockdown affected human placenta‐derived HTR‐8/SVneo cell invasion/migration. Gelatin zymography was performed to examine the change in the gelatinolytic activities of secreted MMP2 and MMP9. Luciferase reporter assays were used to explore whether NCOA6 coactivated NF‐κB‐mediated MMP9 transcription. Results NCOA6 is mainly expressed in the human placental trophoblast column, as well as in the EVTs. HTR‐8/SVneo cell invasion and migration were significantly attenuated after NCOA6 knockdown, and the secretion of MMP9 was decreased due to transcriptional suppression. NCOA6 was further found to coactivate NF‐κB‐mediated MMP9 transcription. Moreover, expression of NCOA6 was impaired in placentas of patients complicated by early‐onset sPE. Conclusions Thus, we demonstrated that NCOA6 is important for cytotrophoblast invasion/migration, at least partially, by activating NF‐κB‐mediated MMP9 transcription; the downregulation of NCOA6 may contribute to the pathogenesis of early‐onset sPE.
Journal Article
Localization and mobility edges in non-Hermitian continuous quasiperiodic systems
The mobility edge (ME) is a critical concept in Anderson localized systems, which marks the boundary between extended and localized states. Although the ME and localization phenomena have been extensively investigated in non-Hermitian (NH) quasiperiodic tight-binding models, they remain limited to NH continuum systems. Here, we study the ME and localization behaviors in a one-dimensional (1D) NH quasiperiodic continuous system, which is described by a Schrödinger equation with an incommensurable one-site potential and an imaginary vector potential. We find that the ME is located in the real spectrum and falls between the localized and extended states. Additionally, we show that under the periodic boundary condition, the energy spectrum always exhibits an open curve representing high-energy extended eigenstates characterized by a non-zero integer winding number. This complex spectrum topology is closely connected with the non-Hermitian skin effect (NHSE) observed under open boundary conditions, where the eigenstates of the bulk bands accumulate at the boundaries. We also analyze the critical behavior of the localization transition and obtain the critical potential strength accompanied by the critical exponent ν ≃ 1 / 3 . Furthermore, we investigate the expansion dynamics to dynamically probe the existence of NHSE and MEs, and outline a possible experimental implementation. Our study provides valuable inspiration for exploring MEs and localization behaviors in NH quasiperiodic continuous systems.
Journal Article
In Planta Functional Analysis and Subcellular Localization of the Oomycete Pathogen Plasmopara viticola Candidate RXLR Effector Repertoire
Downy mildew is one of the most destructive diseases of grapevine, causing tremendous economic loss in the grape and wine industry. The disease agent
is an obligate biotrophic oomycete, from which over 100 candidate RXLR effectors have been identified. In this study, 83 candidate RXLR effector genes (
) were cloned from the
isolate \"JL-7-2\" genome. The results of the yeast signal sequence trap assay indicated that most of the candidate effectors are secretory proteins. The biological activities and subcellular localizations of all the 83 effectors were analyzed via a heterologous
-mediated
expression system. Results showed that 52 effectors could completely suppress cell death triggered by elicitin, 10 effectors could partially suppress cell death, 11 effectors were unable to suppress cell death, and 10 effectors themselves triggered cell death. Live-cell imaging showed that the majority of the effectors (76 of 83) could be observed with informative fluorescence signals in plant cells, among which 34 effectors were found to be targeted to both the nucleus and cytosol, 29 effectors were specifically localized in the nucleus, and 9 effectors were targeted to plant membrane system. Interestingly, three effectors PvRXLR61, 86 and 161 were targeted to chloroplasts, and one effector PvRXLR54 was dually targeted to chloroplasts and mitochondria. However, western blot analysis suggested that only PvRXLR86 carried a cleavable
-terminal transit peptide and underwent processing
. Many effectors have previously been predicted to target organelles, however, to the best of our knowledge, this is the first study to provide experimental evidence of oomycete effectors targeted to chloroplasts and mitochondria.
Journal Article
Collapsing minerals; crackling noise of sandstone and coal, and the predictability of mining accidents
Mining accidents are sometimes preceded by high levels of crackling noise, which follow universal rules for the collapse of minerals. The archetypal test cases are sandstone and coal. Their collapse mechanism is almost identical to earthquakes: the crackling noise in large, porous samples follows a power law (Gutenberg-Richter) distribution P∼E-ε with energy exponents ε for near critical stresses of ε= 1.55 for dry and wet sandstone, and ε=1.32 for coal. The exponents of early stages are slightly increased, 1.7 (sandstone) and 1.5 (coal), and appear to represent the collapse of isolated, uncorrelated cavities. A significant increase of the acoustic emission, AE, activity was observed close to the final failure event, which acts as \"warning signal\" for the impending major collapse. Waiting times between events also follow power law distributions with exponents 2+ξ between 2 and 2.4. Aftershocks occur with probabilities described by Omori coefficients p between 0.84 (sandstone) and 1 (coal). The \"Bath's law\" predicts that the ratio between the magnitude of the main event and the largest aftershock is 1.2.Our experimental findings confirm this conjecture. Our results imply that acoustic warning methods are often possible within the context of mining safety measures, although it is not only the increase of crackling noise that can be used as early warning signal but also the change of the energy distribution of the crackling events.
Journal Article
Profiling the urinary microbiome in men with calcium-based kidney stones
Background
The dogma that urine is sterile in healthy individuals has been overturned by recent studies applying molecular-based methods. Mounting evidences indicate that dysbiosis of the urinary microbiota is associated with several urological diseases. In this study, we aimed to investigate the urinary microbiome of male patients with calcium-based kidney stones and compare it with those of healthy individuals.
Results
The diversity of the urinary microbiota in kidney stone patients was significantly lower than that of healthy controls based on the Shannon and Simpson index (
P
< 0.001 for both indices). The urinary microbiota structure also significantly differed between kidney stone patients and healthy controls (ANOSIM, R = 0.11,
P
< 0.001). Differential representation of inflammation associated bacteria (e.g.,
Acinetobacter
) and several enriched functional pathways were identified in the urine of kidney stones patients. Meanwhile, we found the species diversity, overall composition of microbiota and predicted functional pathways were similar between bladder urine and renal pelvis urine in kidney stone patients.
Conclusions
A marked dysbiosis of urinary microbiota in male patients with calcium-based kidney stones was observed, which may be helpful to interpret the association between bacteria and calcium-based kidney stones.
Journal Article
Highly homogeneous zero-index metamaterials make devices more compact and perform better
A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity antenna. Such a novel technique is a remarkable step forward to develop compact devices with better performance.
Journal Article
Multiomics identification of ALDH9A1 as a crucial immunoregulatory molecule involved in calcific aortic valve disease
Mitochondrial dysfunction and immune cell infiltration play crucial yet incompletely understood roles in the pathogenesis of calcific aortic valve disease (CAVD). This study aimed to identify immune-related mitochondrial genes critical to the pathological process of CAVD using multiomics approaches. The CIBERSORT algorithm was employed to evaluate immune cell infiltration characteristics in CAVD patients. An integrative analysis combining weighted gene coexpression network analysis (WGCNA), machine learning, and summary data-based Mendelian randomization (SMR) was performed to identify key mitochondrial genes implicated in CAVD. Spearman’s rank correlation analysis was also performed to assess the relationships between key mitochondrial genes and infiltrating immune cells. Compared with those in normal aortic valve tissue, an increased proportion of M0 macrophages and resting memory CD4 T cells, along with a decreased proportion of plasma cells and activated dendritic cells, were observed in CAVD patients. Additionally, eight key mitochondrial genes associated with CAVD, including
PDK4
,
LDHB
,
SLC25A36
,
ALDH9A1
,
ECHDC2
,
AUH
,
ALDH2
, and
BNIP3
, were identified through the integration of WGCNA and machine learning methods. Subsequent SMR analysis, incorporating multiomics data, such as expression quantitative trait loci (eQTLs) and methylation quantitative trait loci (mQTLs), revealed a significant causal relationship between
ALDH9A1
expression and a reduced risk of CAVD. Moreover,
ALDH9A1
expression was inversely correlated with M0 macrophages and positively correlated with M2 macrophages. These findings suggest that increased
ALDH9A1
expression is significantly associated with a reduced risk of CAVD and that it may exert its protective effects by modulating mitochondrial function and immune cell infiltration. Specifically,
ALDH9A1
may contribute to the shift from M0 macrophages to anti-inflammatory M2 macrophages, potentially mitigating the pathological progression of CAVD. In conclusion,
ALDH9A1
represents a promising molecular target for the diagnosis and treatment of CAVD. However, further validation through in vivo and n vitro studies is necessary to confirm its role in CAVD pathogenesis and therapeutic potential.
Journal Article