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HighlightsThe squid pen-derived aerogel with intrinsic electropositivity is prepared to electrostatically assemble carbon nano-onion with low escape energy.Under the guidance of PNM model, the interface polarization is reinforced from the aspect of porous skeleton, nanomaterials and multilayer construction.Benefiting from boosted Maxwell-Wagner-Sillars effect, the aerogel and film display remarkable electromagnetic wave absorption (−50.83 dB) and electromagnetic interference shielding performance (66.66 dB), respectively.The rational construction of microstructure and composition with enhanced Maxwell-Wagner-Sillars effect (MWSE) is still a challenging direction for reinforcing electromagnetic wave (EMW) absorption performance, and the related EMW attenuation mechanism has rarely been elucidated. Herein, MWSE boosted β-chitin/carbon nano-onions/Ni–P composites is prepared according to the heterointerface engineering strategy via facile layer-by-layer electrostatic assembly and electroless plating techniques. The heterogeneous interface is reinforced from the aspect of porous skeleton, nanomaterials and multilayer construction. The composites exhibit competitive EMW response mechanism between the conductive loss and the polarization/magnetic loss, as describing like the story of “The Hare and the Tortoise”. As a result, the composites not only achieve a minimum reflection loss (RLmin) of − 50.83 dB and an effective bandwidth of 6.8 GHz, but also present remarkable EMW interference shielding effectiveness of 66.66 dB. In addition, diverse functions such as good thermal insulation, infrared shielding and photothermal performance were also achieved in the hybrid composites as a result of intrinsic morphology and chemicophysics properties. Therefore, we believe that the boosted MWSE open up a novel orientation toward developing multifunctional composites with high-efficient EMW response and thermal management.

To objectively analyze the patterns and characteristics of personal safety incidents in China’s power grid enterprises, the study examines the patterns of personal safety incidents in power grid companies from 2014 to 2024, focusing on accident types, spatial distribution, temporal distribution, professional fields, and causative factors.The results indicate that from 2014 to 2024, the overall trends in the number of personal safety incidents and fatalities in power grid enterprises remained stable. However, there is a slight rebound in the occurrence of major incidents. The primary types of accidents involve electric shocks, falls from heights, and injuries caused by falling objects. Guangxi, Yunnan, and Inner Mongolia are identified as provinces with a high frequency of personal safety accidents, while Jiangxi, Liaoning, and Henan exhibit relatively high fatality rates. Compared to other regions, the South China region demonstrates a higher incidence of personal safety accidents, whereas the Central China region records the highest fatality rate.April and May are peak months for accidents each year, with high-risk periods occurring daily from 9:00 to 10:00 and 15:00 to 16:00. The frequency of accidents in the field of power production is significantly higher than in power construction, with incident counts 18.4% higher and fatalities 3.37% higher. Unsafe human behaviors and management deficiencies are the primary causes of accidents. Notably, management deficiencies are more likely to contribute to the occurrence of unsafe behaviors.

One of the most basic molecular photophysical processes is that of spin transitions and intersystem crossing between excited states surfaces. The change in spin states affects the spatial distribution of electron density through the spin orbit coupling interaction. The subsequent nuclear reorganization reports on the full extent of the spin induced change in electron distribution, which can be treated similarly to intramolecular charge transfer with effective reaction coordinates depicting the spin transition. Here, single-crystal [Fe II (bpy) 3 ](PF 6 ) 2 , a prototypical system for spin crossover (SCO) dynamics, is studied using ultrafast electron diffraction in the single-photon excitation regime. The photoinduced SCO dynamics are resolved, revealing two distinct processes with a (450 ± 20)-fs fast component and a (2.4 ± 0.4)-ps slow component. Using principal component analysis, we uncover the key structural modes, ultrafast Fe–N bond elongations coupled with ligand motions, that define the effective reaction coordinate to fully capture the relevant molecular reorganization. Electron spin is a fundamental property of molecules, and changes in spin state affect both molecular structure and dynamics. Here, the authors resolve, by ultrafast electron diffraction, the nuclear reorganization stabilizing spin transitions in a [Fe II (bpy) 3 ](PF 6 ) 2 crystal.

Cryo-electron tomography (cryoET) is a powerful tool for exploring the molecular structure of large organisms. However, technical challenges still limit cryoET applications on large samples. In particular, localization and cutting out objects of interest from a large tissue sample are still difficult steps. In this study, we report a sample thinning strategy and workflow for tissue samples based on cryo-focused ion beam (cryoFIB) milling. This workflow provides a full solution for isolating objects of interest by starting from a millimeter-sized tissue sample and ending with hundred-nanometer-thin lamellae. The workflow involves sample fixation, pre-sectioning, a two-step milling strategy, and localization of the object of interest using cellular secondary electron imaging (CSEI). The milling strategy consists of two steps, a coarse milling step to improve the milling efficiency, followed by a fine milling step. The two-step milling creates a furrow–ridge structure with an additional conductive Pt layer to reduce the beam-induced charging issue. CSEI is highlighted in the workflow, which provides on-the-fly localization during cryoFIB milling. Tests of the complete workflow were conducted to demonstrate the high efficiency and high feasibility of the proposed method.

This study investigates the role of the digital economy in promoting sustainable prosperity across Chinese provinces from 2011 to 2020. The research develops an innovative theoretical framework that integrates resource-based view (RBV) and open innovation theories, examining how digital technologies contribute to economic growth, social equity, and efficient resource distribution. Utilizing a longitudinal panel analysis, we explore the direct and indirect effects of the digital economy on sustainable prosperity, focusing on the prosperity degree, equality degree, and sharing degree. Our findings show that the digital economy significantly enhances all three dimensions of sustainable prosperity, with coefficients of 0.693 for sustainable prosperity, 1.959 for prosperity degree, 2.048 for equality degree, and 1.360 for sharing degree, all statistically significant at the 1% level. Moreover, the study reveals the mediating roles of resource allocation efficiency and technological innovation in these effects, demonstrating how digitalization drives broader economic and social benefits. The results also underscore the potential of the digital economy to reduce regional disparities and foster urban-rural integration. This research contributes to the literature by combining RBV and open innovation theories with a spatial analysis, offering new insights into how digital transformation can promote inclusive and sustainable growth. The findings provide important implications for policymakers seeking to leverage digital technologies for balanced regional development. Plain language summary How digital growth is fueling economic and social progress in China From 2011 to 2020, our study examined how China’s growing digital landscape has been influencing economic growth and societal well-being across different regions. We focused on the development of the digital economy—like improvements in internet and technology infrastructure—and its effects on creating a prosperous, fair, and resource-efficient society. Our findings reveal that advancements in digital technology not only boost the economy directly by enhancing businesses and services but also indirectly by improving how resources are distributed and used more efficiently. This has important implications, especially for rural areas, highlighting the need for better digital access to bridge the gap between urban and rural communities. The insights from our research suggest that strategic digital-focused policies can promote more inclusive growth and help achieve long-term sustainable development goals across China. This study offers valuable lessons for policymakers and business leaders looking to harness the power of digital innovation for broader social and economic benefits.

African swine fever (ASF), caused by African swine fever virus (ASFV), has inflicted severe economic losses on China’s pig industry. Existing ASFV nucleic acid detection methods struggle to identify infected pigs in the pre-viremic stage, especially for recently emerged recombinant ASFV strains that exhibit delayed clinical symptoms and prolonged virus shedding, posing great challenges to ASF prevention and control. To fit the problem, this study established a TaqMan duplex quantitative polymerase chain reaction (qPCR) assay targeting the ASFV p72 gene and porcine Hp gene for early diagnosis of ASFV infection. The qPCR reaction system (20 μL) and conditions were optimized and showed high sensitivity, with detection limits of 1.42 × 101 copies/μL for Hp and 2.23 × 101 copies/μL for ASFV, as well as excellent specificity and reproducibility. Serum cDNA samples from pigs infected with virulent or recombinant ASFV strains were tested, and the result showed that Hp was detectable as early as 1 day post-infection (DPI), however ASFV remained undetectable until 3DPI. Then cDNA samples from cohabitation infection were tested and 80% samples were Hp-positive, although ASFV test was negative.In conclusion, this duplex qPCR assay for simultaneous detection of Hp and ASFV enables pre-viremia diagnosis of ASF, providing a valuable tool for early screening of ASFV-infected pigs.

Background Given the widespread occurrence of ethical dilemmas and moral distress in healthcare, it is crucial for educators to strengthen nursing students’ ethical education. However, there is little published research on the best practices for teaching nursing ethics. This study aims to determine whether the Presentation-Assimilation-Discussion (PAD) mode, compared to traditional lecture-based learning (LBL) teaching, increases nursing students’ moral sensitivity and ethical decision-making skills. Methods A total of 100 eligible nursing students were randomized into two groups: the PAD model group ( n  = 50) and the LBL group ( n  = 50). Their moral sensitivity and ethical decision-making skills were evaluated using the Moral Sensitivity Questionnaire-Revised Chinese Version (MSQ-R-CV) and the Chinese Version of Judgment About Nursing Decision (JAND-CV), both before and after the course, and again three months later. Results After the course, the PAD group showed significantly higher scores in moral sensitivity and ethical decision-making compared to the LBL group, both immediately and at the 3-month follow-up ( p  < 0.05). Specifically, the PAD group demonstrated greater improvements in total scores and in most subdimensions, including moral responsibility, moral burden, ethical choice, and ethical action. While both groups showed some degree of improvement after the intervention, the changes were more substantial and longer-lasting in the PAD group. Conclusion This study confirms that the PAD model is an effective method for teaching nursing ethics and developing nursing students’ moral sensitivity and ethical decision-making skills. Registration This randomized trial was registered in Chinese Clinical Registry Center, under code (ChiCTR2400086717) in 07/09/2024.

Roaming-mediated isomerization is a universal reaction mechanism in photochemistry, yet solvent-dependent pathways of roaming intermediates remain poorly understood, particularly for environmentally relevant halogen compounds involved in ozone depletion. Here, using femtosecond time-resolved X-ray solution scattering, we resolve the solvent-dependent roaming dynamics of CHBr 3 in methanol and methylcyclohexane. By combining multi-method experimental analysis, machine learning-assisted ab initio molecular dynamics simulations, and density functional theory calculations, we uncover distinct solvent-steered reaction pathways. In methanol, roaming enhances solute-solvent interactions, leading to solvolysis before a stable isomer forms. In methylcyclohexane, roaming facilitates isomerization to a long-lived iso-CHBr 2 -Br product. Direct dissociation into CHBr 2  + Br competes with both pathways in either solvent. By tracking bond-length oscillations and angular dynamics in real time, we visualize how the condensed-phase environment governs the branching ratio between competing pathways. Our findings establish solute-solvent interactions as key factors controlling roaming-mediated reactions in CHBr 3 , with broad implications for photochemical outcomes in solution. Femtosecond X-ray solution scattering reveals how solvent environments direct the outcome of ultrafast roaming reactions in bromoform, determining whether transient hot isomers undergo rapid solvolysis or rearrange into long-lived isomeric products.

Background Endobronchial microwave ablation via flexible catheter offers the potential for local therapy for inoperable peripheral lung cancer. The study aimed to evaluate the feasibility and safety of navigation bronchoscopy‐guided water‐cooled microwave ablation catheter for nonsurgical peripheral lung cancer. Methods This was a prospective single arm pilot study. Patients with early stage or multiple primary peripheral lung cancer who were nonsurgical candidates for surgery were enrolled in the study. Bronchoscopic microwave ablation was performed via a flexible water‐cooled microwave ablation antenna under the guidance of navigation bronchoscopy. Radial probe endobronchial ultrasound combined with fluoroscopy was used to confirm the position. Treatment outcomes were evaluated based on follow‐up chest CT and positron emission tomography scans. Primary endpoints were technical success and safety. Secondary endpoints were complete ablation rate, 2‐year local control rate, and progression‐free survival. Results Thirteen patients were enrolled in the study from April 2018 to July 2019. A total of 19 sessions of microwave ablation were performed on 14 tumors under the guidance of navigation bronchoscopy. The technical success was 100%. Treatment‐related complications occurred in two patients. The complete ablation rate was 78.6% (11/14). The 2‐year local control rate was 71.4%. Median progression‐free survival was 33 months for all patients. Conclusions In this pilot study, bronchoscopic microwave ablation appears to be feasible with acceptable occurrence of complication in the treatment of peripheral lung cancer under the guidance of navigation bronchoscopy. Thirteen patients with early stage or multiple primary nonsurgical peripheral lung cancer underwent navigation bronchoscopy‐guided water‐cooled microwave ablation. Technical success was 100%. Treatment‐related complications occurred in two patients. The study demonstrated that bronchoscopic microwave ablation was feasible in the treatment of peripheral lung cancer.

African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although the envelope protein CD2v of ASFV has been implicated in immunomodulation, the molecular mechanisms underlying CD2v-mediated immunoregulation remain unclear. In this study, we generated a stable CD2v-expressing porcine macrophage (PAM-CD2v) line and investigated the CD2v-dependent transcriptomic landscape using RNA-seq. GO terms enrichment analysis and gene set enrichment analysis revealed that CD2v predominantly affected the organization and assembly process of the extracellular matrix. Wound healing and Transwell assays showed that CD2v inhibited swine macrophage migration. Further investigation revealed a significant decrease in the expression of transcription factor early growth response 1 (EGR1) through inhibiting the activity of extracellular signal-regulated kinase 1 and 2 (ERK1/2). Notably, EGR1 knockout in swine macrophages restricted cell migration, whereas EGR1 overexpression in PAM-CD2v restored the ability of macrophage migration, suggesting that CD2v inhibits swine macrophage motility by downregulating EGR1 expression. Furthermore, we performed chromatin immunoprecipitation and sequencing for EGR1 and the histone mark H3K27 acetylation (H3K27ac), and we found that EGR1 co-localized with the activated histone modification H3K27ac neighboring the transcriptional start sites. Further analysis indicated that EGR1 and H3K27ac co-occupy the promoter regions of cell locomotion-related genes. Finally, by treating various derivatives of swine macrophages with lipopolysaccharides, we showed that depletion of EGR1 decreased the expression of inflammatory cytokines including TNFα, IL1α, IL1β, IL6, and IL8, which play essential roles in inflammation and host immune response. Collectively, our results provide new insights into the immunomodulatory mechanism of ASFV CD2v.