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We investigated the attitude control of a towfish to enhance the image quality of its sound navigation ranging system. The target towfish is equipped with two elevators on the horizontal tail wing, and attitude control is performed using these actuators. In particular, when a high-resolution sonar system is mounted on the towfish, any irregular movement can cause defocusing; thus, attitude control of the towfish is essential. Because the towfish has no thrust of its own and moves by being connected to a mother vessel via a cable, its attitude must be controlled by comprehensively analyzing its towing force and equation of motion. Herein, we propose a method for calculating the region where the attitude of the towfish can be controlled based on changes in the center of gravity, towing speed, and towing point. We conducted a water tank test to verify this method and confirmed that the attitude of the towfish could be controlled in controllable areas but not in uncontrollable regions.

The phytohormone abscisic acid (ABA) plays crucial roles in various physiological processes, including responses to abiotic stresses, in plants. Recently, multiple ABA transporters were identified. The loss-of-function and gain-of-function mutants of these transporters show altered ABA sensitivity and stomata regulation, highlighting the importance of ABA transporters in ABA-mediated processes. However, how the activity of these transporters is regulated remains elusive. Here, we show that spatial regulation of ATP BINDING CASETTE G25 (ABCG25), an ABA exporter, is an important mechanism controlling its activity. ABCG25, as a soluble green fluorescent protein (sGFP) fusion, was subject to posttranslational regulation via clathrin-dependent and adaptor protein complex-2-dependent endocytosis followed by trafficking to the vacuole. The levels of sGFP:ABCG25 at the plasma membrane (PM) were regulated by abiotic stresses and exogenously applied ABA; PM-localized sGFP:ABCG25 decreased under abiotic stress conditions via activation of endocytosis in an ABA-independent manner, but increased upon application of exogenous ABA via activation of recycling from early endosomes in an ABA-dependent manner. Based on these findings, we propose that the spatial regulation of ABCG25 is an important component of the mechanism by which plants fine-tune cellular ABA levels according to cellular and environmental conditions.

This study presents a swarm-control algorithm to overcome the limitations inherent to single-object systems. The leader–follower swarm-control method was selected for its ease of mathematical interpretation and theoretical potential for the unlimited expansion of followers. However, a known drawback of this method is the risk of swarm collapse when the leader breaks down. To address this, a fault-coping algorithm was developed and supplemented to the leader–follower swarm-control method, which enabled the detection and responsive handling of failures, thereby ensuring mission continuity. Comprehensive data, including voltage, current, thruster speed, position, and heading angle were acquired and analyzed using sensors on unmanned surface vehicles (USVs) to monitor potential failures. In the case of a failure, such as thruster malfunction, the nearest USV seamlessly takes charge of the mission under the guidance of the fault-coping algorithm. The leader–follower swarm-control and fault-coping algorithms were successfully validated through actual sea area tests, which confirmed their operational efficacy. This study affirms the well-formed nature of the USV swarm formation and demonstrates the effectiveness of the fault-coping algorithm in ensuring normal mission performance under the virtual failure scenarios applied to the leader USV.

Lab-on-a-CD (LOCD) is gaining importance as a diagnostic platform due to being low-cost, easy-to-use, and portable. During LOCD usage, mixing and reaction are two processes that play an essential role in biochemical applications such as point-of-care diagnosis. In this paper, we numerically and experimentally investigate the effects of the Coriolis and Euler forces in the mixing chamber during the acceleration and deceleration of a rotating disk. The mixing performance is investigated under various conditions that have not been reported, such as rotational condition, chamber aspect ratio at a constant volume, and obstacle arrangement in the chamber. During disk acceleration and deceleration, the Euler force difference in the radial direction causes rotating flows, while the Coriolis force induces perpendicular vortices. Increasing the maximum rotational velocity improves the maximum rotational displacement, resulting in better mixing performance. A longer rotational period increases the interfacial area between solutions and enhances mixing. Mixing performance also improves when there is a substantial difference between Euler forces at the inner and outer radii. Furthermore, adding obstacles in the angular direction also passively promotes or inhibits mixing by configuration. This quantitative investigation provides valuable information for designing and developing high throughput and multiplexed point-of-care LOCDs.

Vascular access (VA), a renal failure therapy, is often performed using an arteriovenous (AV) graft for patients with veins and arteries that cannot be connected with autologous blood vessels. However, VA using AV grafts can change the blood flow and lead to intimal hyperplasia (IH), causing the damage on blood vessel and failure of VA. In our study, we investigated the effect of the anastomosis angle on blood vessel damage under various IH formation conditions. We simulated the blood flow near the anastomosis between vein and AV graft and quantitatively evaluated the blood vessel damage using hemodynamic factors, such as wall shear stress (WSS). Our results show that smaller anastomosis angle reduces damage to blood vessels and prevents IH formation and growth regardless of IH progression, shape, and position. These results can contribute to optimization of the anastomosis angle during VA surgery to improve a patient’s prognosis.

This study focuses on faults in the thrusters of unmanned surface vehicles, which are fatal to the integrity of their missions. As for the fault conditions, the breakage of the thruster blade and the entanglement of floating objects were selected, and a data-driven method was used to diagnose the faults. In the data-driven method, it is important to select the sensitive fault feature. In this study, vibration, current consumption, rotational speed and input voltage were selected as fault features. An experiment was conducted in an engineering water tank to obtain and analyze data on fault conditions to verify the validity of the selected features. In addition, a new fault diagnosis algorithm combining principal component analysis and Shannon entropy was applied for analyzing the correlations among fault features. This algorithm reduces the dimensionality of data while preserving their structure and characteristics, and diagnoses faults by quantifying entropy values. A fault is detected by comparing the entropy value and a predetermined threshold value, and is diagnosed by analyzing the entropy value and visualized 2D or 3D principal component results. Moreover, the fault diagnosis performance of the unmanned surface vehicle’s thruster was verified by analyzing the results for each fault condition.

The current study aims to understand the aero-thermal performance of a cooled cavity tip in a single stage transonic turbine. The squealer tip of the uncooled turbine blade was reduced to an aerodynamic loss with suppressing leakage flow. However, the aerodynamic loss study of the cooled turbine blade tip is rare. It is necessary to study the tip cavity of the cooled turbine blade. Depth, front blend radius and aft blend radius of the cavity were set as design variables, and 30 cases were chosen using design of experiments. These cases were calculated with conjugate heat transfer method. Approximation model was made using the Kriging method, and tip cavity shape was optimized with multidisciplinary design optimization. Average total pressure loss behind the trailing edge and cooling effectiveness of blade tip surface were set to the objective function. The aerodynamic optimization model decreased 1.6 % of total pressure loss, the heat transfer optimization model increased 1.3 % point of cooling effectiveness and aero-thermal optimization model were found. Volume of tip cavity becomes larger when three design variables are grown. Amount of tip leakage flow and its distribution over the tip region increases and total pressure loss and cooling effectiveness increase. In terms of heat transfer, blade tip without cavity is advantageous. Total pressure loss coefficient, however, also increases over 5 %. To improve both aero-thermal characteristics of cooled blade tip, the design using the multidisciplinary design optimization is recommended.

PurposeTo develop a hydrogel film containing bovine serum albumin (BSA)-coated silver nanoparticles (BSA/AgNP) and evaluate its applicability for topical photothermal treatment (PTT) of skin cancer.MethodsBSA/AgNP-loaded hydrogel films were prepared and their swelling, bioadhesive, mechanical, and photothermal properties were characterized in vitro and in vivo.ResultsThe synthesized BSA/AgNP exhibited a narrow size distribution with good size stability and, notably, possessed great photothermal activity that could stably maintain through repetitive laser irradiation. The BSA/AgNP-loaded hydrogel films showed favorable swelling, bioadhesive, tensile, and photothermal properties. Based on these results, when tested the anti-cancer effects in B16F10 s.c. tumor-bearing mice, the PTT with the topical treatment of BSA/AgNP-loaded hydrogel films could significantly inhibit the tumor growth by a single treatment with no apparent toxicity.ConclusionsOverall, the results of this study demonstrated that the BSA/AgNP-loaded hydrogel films may serve as an effective but safe topical PTT agent for the treatment of skin cancer.

The aerodynamic characteristics of S-ducts with various inlet shapes were analyzed using a commercial computational fluid dynamics tool. This study aimed to investigate the influence of the aspect ratio of inlet geometry for an RAE M 2129 S-duct. The computational results were validated using experimental data from the Aircraft Research Association. The performance of the S-duct was influenced by the location of the counter-rotating vortex on the engine face. When the center of the vortex was near the starboard side, the performance was poor. By contrast, performance increased as the counter-rotating vortex moved away from the starboard side. The center of the counter- rotating vortex of the upper half semicircular S-duct was far from the starboard side, whereas that of the lower half semicircular Sduct was near the starboard side. In conclusion, S-ducts with upper half semicircular shape had better performance than those with other inlet shapes. The AR(0.75,0) case delivered the best performance, whereas the AR(1,1) case exhibited the worst.