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"Jimenez, David"
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Superman : President Luthor
His fame bolstered after helping to rebuild Gotham City after an earthquake, billionaire Lex Luthor decides to run for the highest office in the land, the American presidency.
Book
The Dozen Things Experimental Economists Should Do (More of)
What was once broadly viewed as an impossibility—learning from experimental data in economics—has now become commonplace. Governmental bodies, think tanks, and corporations around the world employ teams of experimental researchers to answer their most pressing questions. For their part, in the past two decades academics have begun to more actively partner with organizations to generate data via field experimentation. Although this revolution in evidence-based approaches has served to deepen the economic science, recently a credibility crisis has caused even the most ardent experimental proponents to pause. This study takes a step back from the burgeoning experimental literature and introduces 12 actions that might help to alleviate this credibility crisis and raise experimental economics to an even higher level. In this way, we view our \"12 action wish list\" as discussion points to enrich the field.
Journal Article
Temporal Differences in MicroRNA Expression Patterns in Astrocytes and Neurons after Ischemic Injury
MicroRNAs (miRNAs) are small, non-protein-coding RNA molecules that modulate gene translation. Their expression is altered in many central nervous system (CNS) injuries suggesting a role in the cellular response to stress. Current studies in brain tissue have not yet described the cell-specific temporal miRNA expression patterns following ischemic injury. In this study, we analyzed the expression alterations of a set of miRNAs in neurons and astrocytes subjected to 60 minutes of ischemia and collected at different time-points following this injury. To mimic ischemic conditions and reperfusion in vitro, cortical primary neuronal and astrocytic cultures prepared from fetal rats were first placed in oxygen and glucose deprived (OGD) medium for 60 minutes, followed by their transfer into normoxic pre-conditioned medium. Total RNA was extracted at different time-points after the termination of the ischemic insult and the expression levels of miRNAs were measured. In neurons exposed to OGD, expression of miR-29b was upregulated 2-fold within 6 h and up to 4-fold at 24 h post-OGD, whereas induction of miR-21 was upregulated 2-fold after 24 h when compared to expression in neurons under normoxic conditions. In contrast, in astrocytes, miR-29b and miR-21 were upregulated only after 12 h. MiR-30b, 107, and 137 showed expression alteration in astrocytes, but not in neurons. Furthermore, we show that expression of miR-29b was significantly decreased in neurons exposed to Insulin-Like Growth Factor I (IGF-I), a well documented neuroprotectant in ischemic models. Our study indicates that miRNAs expression is altered in neurons and astrocytes after ischemic injury. Furthermore, we found that following OGD, specific miRNAs have unique cell-specific temporal expression patterns in CNS. Therefore the specific role of each miRNA in different intracellular processes in ischemic brain and the relevance of their temporal and spatial expression patterns warrant further investigation that may lead to novel strategies for therapeutic interventions.
Journal Article
Use of Oxone® as a Potential Catalyst in Biodiesel Production from Palm Fatty Acid Distillate (PFAD)
Palm fatty acid distillate PFAD is an example of potential low-cost palm biofuel second generation feedstock, most used as a source of fatty acid for non-food applications in industry. Catalytic application of Oxone® salt was used in the present study for the esterification reaction of PFAD for biodiesel production for the first time. After optimizing the conversion rate, was possible to observe that, among the process variables studied [Oxone® concentration (%), temperature (°C) and reaction time (h)], Oxone® concentration was the only significant variable for the fatty acid ethyl esters (FAEEs) generation response variable. A > 90% conversion rate was reached with 15% Oxone® at 42 °C, using a PFAD:ethanol molar ratio of 1:5 at 12 h reaction time. The reaction system has a series of advantages, such as mild conditions, simple operation, green and high conversion. As alternative for make the biodiesel production as sustainable as possible.Graphic Abstract
Journal Article
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
During the peak of hospitalizations of patients with severe Covid-19 in Italy and Spain in March, a group of researchers in these and other countries obtained and analyzed samples, resulting in the identification of two chromosomal loci associated with the disorder.
Journal Article
Data-Driven Fault Diagnosis for Electric Drives: A Review
The need to manufacture more competitive equipment, together with the emergence of the digital technologies from the so-called Industry 4.0, have changed many paradigms of the industrial sector. Presently, the trend has shifted to massively acquire operational data, which can be processed to extract really valuable information with the help of Machine Learning or Deep Learning techniques. As a result, classical Condition Monitoring methodologies, such as model- and signal-based ones are being overcome by data-driven approaches. Therefore, the current paper provides a review of these data-driven active supervision strategies implemented in electric drives for fault detection and diagnosis (FDD). Hence, first, an overview of the main FDD methods is presented. Then, some basic guidelines to implement the Machine Learning workflow on which most data-driven strategies are based, are explained. In addition, finally, the review of scientific articles related to the topic is provided, together with a discussion which tries to identify the main research gaps and opportunities.
Journal Article
Rapamycin Treatment Improves Neuron Viability in an In Vitro Model of Stroke
Ischemic stroke is the leading cause of serious, long-term adult disability and is associated with sensorimotor and cognitive impairments due to neuronal degeneration. Currently, recombinant tissue plasminogen activator (rTPA) is the only FDA-approved medical therapy for treatment of patients with acute ischemic stroke. However, rTPA can only be given within 3 hours of symptom onset, and only 2% of patients are eligible. Therefore, there is an urgent need for novel neuroprotective treatment options for ischemic stroke. An emerging treatment for a diverse range of neurological disorders associated with neurodegeneration is rapamycin, a key modulator of the mammalian target of rapamycin (mTOR) pathway. The mTOR pathway is the primary regulator of the cellular response to nutrient availability, changes in energy status and stress as seen following ischemia and reperfusion. However, rapamycin's effects on mTORC1 and mTORC2 are poorly understood in neurons. In the current study we show that rapamycin can prevent the activation of both mTORC1 and mTORC2 in cortical neurons and improve cell survival following oxygen glucose deprivation (OGD), an in vitro model of ischemic stroke. This work further supports the investigation of rapamycin as a novel neuroprotectant for ischemic stroke.
Journal Article
Effect of Silk Fibroin as a Sustainable Solvent on the Extraction of Bixin from Annatto Seeds (Bixa orellana L.)
Bixin, an apocarotenoid from Bixa orellana seeds, is a valuable natural pigment with industrial and pharmacological applications. Traditional extraction methods rely on organic solvents, but eco-friendly alternatives like silk fibroin solution (SFS) are emerging. This study evaluated SFS for bixin extraction from annatto seeds, optimizing conditions using Box-Behnken Design (BBD). The optimal parameters 1.5% SFS, 60 °C, and 60 min yielded 10.87 mg/mL (liquid extract of annatto seeds, LEAS + SFS) and 150.72 mg/g (solid extract of annatto seeds, SEAS + SFS). Cell viability was assessed in human dermal fibroblasts (HDFn) and RAW 264.7 murine macrophages via MTT assay. After 24 and 72 h, LEAS + SFS, SEAS + SFS, purified bixin (PB), and SFS maintained >70% viability in HDFn cells. Similarly, RAW 264.7 cells showed >70% viability after 24 h, indicating low cytotoxicity. These results highlight the biocompatibility of SFS-extracted bixin, supporting its potential in food, cosmetics, and biomedicine. The study demonstrates that SFS is an effective, sustainable alternative to traditional solvents, offering high extraction efficiency and minimal toxicity. This method aligns with green chemistry principles, providing a promising solution for bixin production.
Journal Article
Assessing downscaling techniques for frequency analysis, total precipitation and rainy day estimation in CMIP6 simulations over hydrological years
General circulation models generate climate simulations on grids with resolutions ranging from 50 to 600 km. The resulting coarse spatial resolution of the model outcomes requires post-processing routines to ensure reliable climate information for practical studies, prompting the widespread application of downscaling techniques. However, assessing the effectiveness of multiple downscaling techniques is essential, as their accuracy varies depending on the objectives of the analysis and the characteristics of the case study. In this context, this study aims to evaluate the performance of downscaling the daily precipitation series in the Metropolitan Region of Belo Horizonte (MRBH), Brazil, with the final scope of performing frequency analyses and estimating total precipitation and the number of rainy days per hydrological year at both annual and multiannual levels. To develop this study, 78 climate model simulations with a horizontal resolution of 100 km, which participated in the SSP1-2.6 and/or SSP5-8.5 scenarios of CMIP6, are employed. The results highlight that adjusting the simulations from the general circulation models by the delta method, quantile mapping and regression trees produces accurate results for estimating the total precipitation and number of rainy days. Finally, it is noted that employing downscaled precipitation series through quantile mapping and regression trees also yields promising results in terms of the frequency analyses.
Journal Article
Metal-organic frameworks for biological applications
Metal-organic frameworks (MOFs) have emerged as exciting potential new candidates for application across nanomedicine, with the first example now in a phase II human clinical trial. MOFs have a range of desirable properties that make them suitable for various applications, including drug delivery, imaging and new treatment modalities, often in concert. In this Primer, we present an overview of the application of MOFs in biomedicine, focusing on drug delivery and imaging, but highlighting the chemical and structural versatility that is enabling their implementation in emerging treatment modalities and new biological applications. We discuss best practices in synthesis, characterization and application, including ongoing issues with reproducibility and limitations of applications, ending with an outlook of the field.
Journal Article