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"Jin, Dongdong"
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Magnetic micro and nanorobot swarms : from fundamentals to applications
Focused on the attractive emerging field of micro-/nanorobot swarms (microswarms). It introduces fundamental understandings of various microswarms, including pattern generation, transformation, locomotion, and imaging. This book also demonstrates applications of micro-/nanorobot swarms in different fields, such as biomedical, environmental, and electrical applications. The detailed theoretical analysis and experimental demonstrations in this book provide readers ranging from students to researchers with a realistic picture of progress achieved in the field of micro-/nanorobot swarms.
Book
Active generation and magnetic actuation of microrobotic swarms in bio-fluids
In nature, various types of animals will form self-organised large-scale structures. Through designing wireless actuation methods, microrobots can emulate natural swarm behaviours, which have drawn extensive attention due to their great potential in biomedical applications. However, as the prerequisite for their in-vivo applications, whether microrobotic swarms can take effect in bio-fluids with complex components has yet to be fully investigated. In this work, we first categorise magnetic active swarms into three types, and individually investigate the generation and navigation behaviours of two types of the swarms in bio-fluids. The influences of viscosities, ionic strengths and mesh-like structures are studied. A strategy is then proposed to select the optimised swarms in different fluidic environments based on their physical properties, and the results are further validated in various bio-fluids. Moreover, we also realise the swarm generation and navigation in bovine eyeballs, which also validates the proposed prediction in the ex-vivo environment.
Although microrobotic swarms are attractive for biomedical applications, controlling their collective movement in specific bio-fluids is difficult. Here, the authors report navigated locomotion and collective behaviors of magnetic field- and medium-induced micro-robotic swarms in various bio-fluids.
Journal Article
Embodied intelligence weaves a better future
Microrobots can interact intelligently with their environment and complete specific tasks by well-designed incorporation of responsive materials. Recent work demonstrates how swarms of microbots with specifically tuned surface chemistry can remove a hormone pollutant from a solution by coalescing it into a web.
Journal Article
Dynamic morphological transformations in soft architected materials via buckling instability encoded heterogeneous magnetization
The geometric reconfigurations in three-dimensional morphable structures have a wide range of applications in flexible electronic devices and smart systems with unusual mechanical, acoustic, and thermal properties. However, achieving the highly controllable anisotropic transformation and dynamic regulation of architected materials crossing different scales remains challenging. Herein, we develop a magnetic regulation approach that provides an enabling technology to achieve the controllable transformation of morphable structures and unveil their dynamic modulation mechanism as well as potential applications. With buckling instability encoded heterogeneous magnetization profiles inside soft architected materials, spatially and temporally programmed magnetic inputs drive the formation of a variety of anisotropic morphological transformations and dynamic geometric reconfiguration. The introduction of magnetic stimulation could help to predetermine the buckling states of soft architected materials, and enable the formation of definite and controllable buckling states without prolonged magnetic stimulation input. The dynamic modulations can be exploited to build systems with switchable fluidic properties and are demonstrated to achieve capabilities of fluidic manipulation, selective particle trapping, sensitivity-enhanced biomedical analysis, and soft robotics. The work provides new insights to harness the programmable and dynamic morphological transformation of soft architected materials and promises benefits in microfluidics, programmable metamaterials, and biomedical applications.
The dynamic transformation in soft architected materials often brings in unusual properties. Here, Zhang et al. present magneto-elastomers with 3D heterogeneous magnetization profiles encoded by buckling instability to achieve the dynamic regulation.
Journal Article
Reactive wetting enabled anchoring of non-wettable iron oxide in liquid metal for miniature soft robot
Magnetic liquid metal (LM) soft robots attract considerable attentions because of distinctive immiscibility, deformability and maneuverability. However, conventional LM composites relying on alloying between LM and metallic magnetic powders suffer from diminished magnetism over time and potential safety risk upon leakage of metallic components. Herein, we report a strategy to composite inert and biocompatible iron oxide (Fe
3
O
4
) magnetic nanoparticles into eutectic gallium indium LM via reactive wetting mechanism. To address the intrinsic interfacial non-wettability between Fe
3
O
4
and LM, a silver intermediate layer was introduced to fuse with indium component into Ag
x
In
y
intermetallic compounds, facilitating the anchoring of Fe
3
O
4
nanoparticles inside LM with improved magnetic stability. Subsequently, a miniature soft robot was constructed to perform various controllable deformation and locomotion behaviors under actuation of external magnetic field. Finally, practical feasibility of applying LM soft robot in an ex vivo porcine stomach was validated under in-situ monitoring by endoscope and X-ray imaging.
Interfacial non-wettability between biocompatible iron oxide and liquid metal caused by the substantial mismatch in surface energy remains an issue. Here, the authors introduce a silver intermediate layer to reduce compositional mismatch and improve the wetting ability between iron oxide and liquid metal.
Journal Article
Reconfigurable Liquid‐Bodied Miniature Machines: Magnetic Control and Microrobotic Applications
Soft miniature machines demonstrate multimodal actuation and morphology change capabilities in narrow spaces smaller than their dimension. The wirelessly controlled soft‐bodied features make them promising candidates for microrobotic manipulation and targeted operation in a noninvasive manner. Liquid‐bodied machine offers an ultrasoft body with extreme deformability owing to its fluid nature, enabling adaptive navigation with smooth contact with objects and environmental restrictions. Over the last decade of development, significant research progress has been achieved in wirelessly controlling liquid‐bodied machines for diverse manipulation applications. Herein, an overview of the recent research results in magnetic control methods and diverse microrobotic applications of liquid‐bodied machines is provided. Considering the control mechanisms and application challenges, ferrofluid‐based, liquid metal‐based, and liquid marble‐based machines are mainly discussed with a brief discussion on droplet‐based machines. The connection between control methods and applications is highlighted with a detailed analysis of machine–object and machine–environment interactions. The current challenges and research opportunities on liquid‐bodied miniature machines are outlined, aiming at designing intelligent liquid‐bodied machine‐based microrobotic systems and promoting the development of small‐scale robotics.
Recent developments and challenges of liquid‐bodied miniature machines with ultrasoft body and extreme deformability are highlighted. Especially cutting‐edge advancement in magnetic control methods and diverse microrobotic applications are reviewed and discussed. The connection between control and applications is highlighted with a detailed analysis. It provides insights on designing intelligent liquid‐bodied machine‐based microrobotic systems and promoting the development of small‐scale robotics.
Journal Article
Ultrasonic‐Enabled Nondestructive and Substrate‐Independent Liquid Metal Ink Sintering
Printing or patterning particle‐based liquid metal (LM) ink is a good strategy to overcome poor wettability of LM for its circuits’ preparation in flexible and printed electronics. Subsequently, a crucial step is to recover conductivity of LM circuits consisting of insulating LM micro/nano‐particles. However, most widely used mechanical sintering methods based on hard contact such as pressing, may not be able to contact the LM patterns' whole surface conformally, leading to insufficient sintering in some areas. Hard contact may also break delicate shapes of the printed patterns. Hereby, an ultrasonic‐assisted sintering strategy that can not only preserve original morphology of the LM circuits but also sinter circuits on various substrates of complex surface topography is proposed. The influencing factors of the ultrasonic sintering are investigated empirically and interpreted with theoretical understanding by simulation. LM circuits encapsulated inside soft elastomer are successfully sintered, proving feasibility in constructing stretchable or flexible electronics. By using water as energy transmission medium, remote sintering without any direct contact with substrate is achieved, which greatly protect LM circuits from mechanical damage. In virtue of such remote and non‐contact manipulation manner, the ultrasonic sintering strategy would greatly advance the fabrication and application scenarios of LM electronics.
An ultrasonic sintering strategy is developed for recovering conductivity of liquid metal (LM) ink circuits on various substrates, which can be readily used to fabricate LM based printed and flexible electronics, for those patterned on complex or curved surfaces.
Journal Article
Active Micro/Nanoparticles in Colloidal Microswarms
Colloidal microswarms have attracted increasing attention in the last decade due to their unique capabilities in various complex tasks. Thousands or even millions of tiny active agents are gathered with distinctive features and emerging behaviors, demonstrating fascinating equilibrium and non-equilibrium collective states. In recent studies, with the development of materials design, remote control strategies, and the understanding of pair interactions between building blocks, microswarms have shown advantages in manipulation and targeted delivery tasks with high adaptability and on-demand pattern transformation. This review focuses on the recent progress in active micro/nanoparticles (MNPs) in colloidal microswarms under the input of an external field, including the response of MNPs to external fields, MNP–MNP interactions, and MNP–environment interactions. A fundamental understanding of how building blocks behave in a collective system provides the foundation for designing microswarm systems with autonomy and intelligence, aiming for practical application in diverse environments. It is envisioned that colloidal microswarms will significantly impact active delivery and manipulation applications on small scales.
Journal Article
Beyond surface tension-dominated water surface jumping
Water surface jumping motions of semi-aquatic insects are primarily rely on surface tension-dominated jumping mechanism to achieve impressive jumping performance. However, this mechanism faces an inherent physical constraint: the propulsion force must remain below the threshold required to break the water surface, limiting efficient momentum acquisition. Herein, we present a water surface jumping strategy that addresses the limitations of surface tension-dominated mechanism. Our approach allows the engineered jumper to achieve a record-breaking jumping height of 18 body lengths (63 cm) and take-off velocity of 100.6 body length/s (3.52 m/s). This strategy is built on three key design principles: (I) superhydrophobic body for floating on water surface, (II) light-weight, high-power actuation module capable of providing significant propulsion force within an ultrashort time, (III) well-engineered momentum transmission system for efficient kinetic energy transfer. The developed soft jumper based on these design principles advances the development of water environment related robotics.
Semi-aquatic robots rely on surface tension for propulsion, which implies that breaking the water surface is a limitation. Here, the authors developed a soft robot with a superhydrophobic body, achieving high jumping height and take-off velocity.
Journal Article
High-fat diet promotes tumor growth in the patient-derived orthotopic xenograft (PDOX) mouse model of ER positive endometrial cancer
Endometrial cancer, one of the common gynecological malignancies, is affected by several influencing factors. This study established a unique patient-derived orthotopic xenograft (PDOX) nude mouse model for the study of influencing factors in ER positive endometrial cancer. The aim of this study was to demonstrate that a high-fat diet can affect the growth of ER positive endometrial cancer PDOX model tumors. The tumor tissues were expanded by subcutaneous transplantation in nude mice, and then the subcutaneous tumor tissues were orthotopically implanted into the nude mouse uterus to establish the PDOX model. After modeling, they were divided into high-fat diet group and normal diet group for 8 weeks of feeding, which showed that high-fat diet significantly promoted tumor growth (P < 0.001) and increased the protein expression level of ERα in tumor tissues. This study demonstrates that PDOX models of endometrial cancer can embody the role of dietary influences on tumor growth and that this model has the potential for preclinical studies of cancer promoting factors.
Journal Article