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Research on the effect of oral contraceptive (OC) use on the risk of depression shows inconsistent findings, especially in adult OC users. One possible reason for this inconsistency is the omission of women who discontinue OCs due to adverse mood effects, leading to healthy user bias. To address this issue, we aim to estimate the risk of depression that is associated with the initiation of OCs as well as the effect of OC use on lifetime risk of depression. This is a population-based cohort study based on data from 264,557 women from the UK Biobank. Incidence of depression was addressed via interviews, inpatient hospital or primary care data. The hazard ratio (HR) between OC use and incident depression was estimated by multivariable Cox regression with OC use as a time-varying exposure. To validate causality, we examined familial confounding in 7,354 sibling pairs. We observed that the first 2 years of OC use were associated with a higher rate of depression compared to never users (HR = 1.71, 95% confidence interval [CI]: 1.55-1.88). Although the risk was not as pronounced beyond the first 2 years, ever OC use was still associated with an increased lifetime risk of depression (HR = 1.05, 95% CI: 1.01-1.09). Previous OC use were associated with a higher rate of depression compared to never users, with adolescent OC users driving the increased hazard (HR = 1.18, 95% CI: 1.12-1.25). No significant association were observed among adult OC users who had previously used OCs (HR = 1.00, 95% CI: 0.95-1.04). Notably, the sibling analysis provided further evidence for a causal effect of OC use on the risk of depression. Our findings suggest that the use of OCs, particularly during the first 2 years, increases the risk of depression. Additionally, OC use during adolescence might increase the risk of depression later in life. Our results are consistent with a causal relationship between OC use and depression, as supported by the sibling analysis. This study highlights the importance of considering the healthy user bias as well as family-level confounding in studies of OC use and mental health outcomes. Physicians and patients should be aware of this potential risk when considering OCs, and individualized risk-benefit assessments should be conducted.

The widespread use of low-temperature polymer electrolyte membrane fuel cells for mobile applications will require significant reductions in the amount of expensive Pt contained within their cathodes, which drive the oxygen reduction reaction (ORR). Although progress has been made in this respect, further reductions through the development of more active and stable electrocatalysts are still necessary. Here we describe a new set of ORR electrocatalysts consisting of Pd or Pt alloyed with early transition metals such as Sc or Y. They were identified using density functional theory calculations as being the most stable Pt- and Pd-based binary alloys with ORR activity likely to be better than Pt. Electrochemical measurements show that the activity of polycrystalline Pt 3 Sc and Pt 3 Y electrodes is enhanced relative to pure Pt by a factor of 1.5–1.8 and 6–10, respectively, in the range 0.9–0.87 V. Improvements in the activity and stability of catalysts for oxygen reduction reactions are needed to make low-temperature, polymer electrolyte membrane fuel-cells viable for mobile applications. Pt 3 Sc and Pt 3 Y are shown experimentally to have greater catalytic activity than pure Pt after being identified through computational investigation of Pt- and Pd-based alloys.

Improved energy efficiency in supply chains can reduce both environmental impact and lifecycle costs, and thus becomes a competitive advantage in the work towards a sustainable global economy. Viewing the supply chain as a system provides the holistic perspective needed to avoid sub-optimal energy use. This article studies measures relating to technology and management that can increase energy efficiency in the supply chains of five aluminium products made in Sweden. Additionally, energy efficiency potentials related to the flows of material, energy, and knowledge between the actors in the supply chains are studied. Empirical data was collected using focus group interviews and one focus group per product was completed. The results show that there are several areas for potential energy efficiency improvement; for example, product design, communication and collaboration, transportation, and reduced material waste. Demands from other actors that can have direct or indirect effects on energy use in the supply chains were identified. Despite the fact that companies can save money through improved energy efficiency, demands from customers and the authorities would provide the additional incentives needed for companies to work harder to improve energy efficiency.

Sweden’s goal of 100% renewable electricity generation by 2040 requires investments in intermittent electricity production (e.g. wind power). However, increasing the share of intermittent electricity production presents challenges, including reduced flexibility of electricity production. A strategy for overcoming this issue is developing flexibility in electricity consumption. This study analyses the potential for using flexible industrial processes, heat pumps (HP), and combined heat and power (CHP) plants in Swedish district heating systems to increase the share of wind power capacity without compromising grid stability. The simulation tool EnergyPLAN was used to assess the potential contribution of these strategies. The analysis includes a range of annual wind power production between 45 and 60 TWh. The required electricity imports and critical excess electricity (that can neither be used nor exported due to transmission line limitations) were used to evaluate the system’s stability. Managing the operation of CHP plants, HPs, and industrial processes in a flexible way is challenging, but these strategies may still play a decisive role in increasing the share of renewable electricity production and reducing demand peaks in cities. Whilst HP regulation is better at reducing excess electricity production at lower wind power capacities (from 32 to 15% for the analysed interval of wind power production), CHP regulation becomes more relevant when wind power capacity increases (from 14 to 39%). Like HP regulation, flexibility in electricity demand in industrial processes had a greater percentage contribution at lower wind power capacities. Combining HP, CHP regulation, and flexible electricity demands in industry can reduce excess electricity production by 68–80% and electricity imports by 14–26%. Wind power contributing to grid stabilisation reduces excess electricity production but does not reduce electricity imports.

During and post pandemic more people spent time in their second homes, which is expected to have led to higher energy use for heating. The knowledge of energy performance, heating systems, energy renovation and use patterns of second homes is still poor. The aim of the research is therefore to compile available information from building registers but also to empirically investigate user patterns, heating source and the renovation and energy efficiency measures carried out in second homes. A first step is to synthesize existing knowledge and develop a method for a broad mapping in a next step. The methods used are analysing statistics from national building registers and collecting information from owners/users through a pre-survey that is developed and tested. In this paper statistics on Swedish second homes and results from a pre-survey responded by 92 second homes owners/users are reported. From statistics, the energy performance and the main heating source for second homes with an EPC are identified. Despite the limited sample, the results from the pre-survey give an indication of user patterns, energy renovation measures carried out, and also whether the owners care about cultural values. Based on the experience from the pre-survey, a national survey has been initiated in Sweden.

The majority of nitrogen in forest soils is found in organic matter–protein complexes. Ectomycorrhizal fungi (EMF) are thought to have a key role in decomposing and mobilizing nitrogen from such complexes. However, little is known about the mechanisms governing these processes, how they are regulated by the carbon in the host plant and the availability of more easily available forms of nitrogen sources. Here we used spectroscopic analyses and transcriptome profiling to examine how the presence or absence of glucose and/or ammonium regulates decomposition of litter material and nitrogen mobilization by the ectomycorrhizal fungus Paxillus involutus . We found that the assimilation of nitrogen and the decomposition of the litter material are triggered by the addition of glucose. Glucose addition also resulted in upregulation of the expression of genes encoding enzymes involved in oxidative degradation of polysaccharides and polyphenols, peptidases, nitrogen transporters and enzymes in pathways of the nitrogen and carbon metabolism. In contrast, the addition of ammonium to organic matter had relatively minor effects on the expression of transcripts and the decomposition of litter material, occurring only when glucose was present. On the basis of spectroscopic analyses, three major types of chemical modifications of the litter material were observed, each correlated with the expression of specific sets of genes encoding extracellular enzymes. Our data suggest that the expression of the decomposition and nitrogen assimilation processes of EMF can be tightly regulated by the host carbon supply and that the availability of inorganic nitrogen as such has limited effects on saprotrophic activities.

Mutations of the COL2A1 gene have been identified in patients with Perthes' disease. Several studies have hypothesised a connection between Perthes' disease and collagen synthesis disorders, especially COL2A1-related disorders, but no large studies on the subject have been made. The aim of this study was thus to discover if there is a connection between patients presenting with Perthes' disease, and collagen synthesis disorders. A secondary aim was to see if the children with both disorders had less optimal birth characteristics than the rest. Swedish national registers were used to collect data on children diagnosed with Perthes' disease or a collagen synthesis disorder. These registers include all births in Sweden, and data from both outpatient and in-hospital visits. A wide range of data is included besides diagnoses. All children with follow-up data to the age of 15 years were included. Pearson's chi-square was used for analysis. Statistical significance was further analysed with Fisher's Exact Test. In total, 3488 children with either diagnosis were included. 1620 children had only Perthes disease, while 1808 children had only a collagen synthesis disorder. Five children were found to have both the diagnosis Perthes' disease and a collagen synthesis disorder. One child was large for their gestational age and none of the children had a low birthweight. Two of the children were moderately preterm. The distinct lack of overlap in such a large body of material raises doubt about a connection between the presentation of Perthes' disease and collagen synthesis disorders, either COL2A1-related or not. We could not find an overrepresentation of less optimal birth characteristics either.

Background Mutations of the COL2A1 gene have been identified in patients with Perthes’ disease. Several studies have hypothesised a connection between Perthes’ disease and collagen synthesis disorders, especially COL2A1-related disorders, but no large studies on the subject have been made. The aim of this study was thus to discover if there is a connection between patients presenting with Perthes’ disease, and collagen synthesis disorders. A secondary aim was to see if the children with both disorders had less optimal birth characteristics than the rest. Methods Swedish national registers were used to collect data on children diagnosed with Perthes’ disease or a collagen synthesis disorder. These registers include all births in Sweden, and data from both outpatient and in-hospital visits. A wide range of data is included besides diagnoses. All children with follow-up data to the age of 15 years were included. Pearson’s chi-square was used for analysis. Statistical significance was further analysed with Fisher’s Exact Test. Results In total, 3433 children with either diagnosis were included. 1620 children had only Perthes disease, while 1808 children had only a collagen synthesis disorder. Five children were found to have both the diagnosis Perthes’ disease and a collagen synthesis disorder. One child was large for their gestational age and none of the children had a low birthweight. Two of the children were moderately preterm. Conclusions The distinct lack of overlap in such a large body of material raises doubt about a connection between the presentation of Perthes’ disease and collagen synthesis disorders, either COL2A1-related or not. We could not find an overrepresentation of less optimal birth characteristics either.

Biogas production through anaerobic digestion may play an important role in a circular economy because of the opportunity to produce a renewable fuel from organic waste. However, the production of biogas may require energy in the form of heat and electricity. Therefore, resource-effective biogas production must consider both biological and energy performance. For the individual biogas plant to improve its energy performance, a robust methodology to analyse and evaluate the energy demand on a detailed level is needed. Moreover, to compare the energy performance of different biogas plants, a methodology with a consistent terminology, system boundary and procedure is vital. The aim of this study was to develop a methodology for analysing the energy demand in biogas plants on a detailed level. In the methodology, the energy carriers are allocated to: (1) sub-processes (e.g., pretreatment, anaerobic digestion, gas cleaning), (2) unit processes (e.g., heating, mixing, pumping, lighting) and (3) a combination of these. For a thorough energy analysis, a combination of allocations is recommended. The methodology was validated by applying it to two different biogas plants. The results show that the methodology is applicable to biogas plants with different configurations of their production system.