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Scholars have extensively documented social class differences in students’ relationships with educational institutions through their interactions with authority figures and the unequal institutional advantages these interactions yield. However, little is known about whether or how social class also shapes students’ peer interactions in ways that produce these inequalities. Using a qualitative case study of an elite engineering school in which I draw on participant observation and interviews with 88 undergraduates and six administrators, I argue that social class context—a proxy for social class—shapes the peer help-seeking and help-giving (collaborative) strategies students use, which can create inequalities in the institutional advantages they secure in the form of academic help, support, and learning opportunities. Focusing specifically on the social class context of students’ high schools, I find that compared to their less-privileged counterparts, privileged students—who came from class-advantaged high school contexts where they became familiar with collaboration and upper-middle-class cultural signals—more easily collaborated with their college classmates and displayed signals that communicated they were “good” collaborators. The findings highlight new mechanisms through which inequalities are reproduced in educational institutions and make theoretical contributions to research on cultural capital, inequality, and education.

In Dual Transformation, innovation and growth consultant Scott Anthony and his coauthors, Clark Gilbert and Mark Johnson, propose a practical and sustainable approach to one of the greatest challenges facing leaders today: transforming your business in the face of imminent disruption. Dual Transformation illustrates the inevitable rise and fall of companies in the age of technological change. But, more importantly, it shows you how your company can come out of a market shift stronger and more profitable. Anthony, Gilbert, and Johnson build upon the lessons of Xerox, Apple, Barnes & Noble, and a case study from Gilbert's first-hand experience transforming his own media and publishing company, to describe the process of successfully weathering the digital age by adapting a current business model to the new marketplace. The book offers critical insight to responding to disruptive shock with three value propositions: (A) repositioning today's business to maximize resilience, (B) creating a new growth engine, and (C) taking advantage of assets to result in creative new markets. With great change comes great opportunity, and this book will get you there with tools to reshape your business model.-- Provided by publisher

Drawing on interviews with 38 black and Latino/a engineering students at a predominantly white, elite university, I use a cultural analytic framework to explicate the role of pre-college integration in the heterogeneous psychosocial and academic experiences of students of color on predominantly white campuses. I identify three cultural strategies students of color adopt to navigate the university’s ethnoracially segregated peer network landscape and more specifically, engage majority-white academic peer networks: integration, marginalized segregation, and social adaptation. Integrators, who hail from predominantly white high schools, engage majority-white academic networks with ease, do not experience ethnoracial marginalization, and form predominantly white networks in college. Marginalized segregators, who come from predominantly black, Latino/a, or mixed high schools, exhibit discomfort engaging majority-white academic networks, experience ethnoracial marginalization, and form predominantly same-race or co-ethnic networks in college. Finally, social adapters, who come from high schools with varying ethnoracial compositions, manage their experiences with ethnoracial marginalization to engage majority-white academic networks with ease, and the ethnoracial composition of their college networks varies. The findings extend previous scholarship on the experiences of black and Latino/a students on predominantly white campuses and uncover the cultural processes that contribute to the reproduction of inequality among students of color.

Drought stress has adverse effects on growth, water relations, photosynthesis and yield of groundnut. WRKY transcription factors (TFs) are the plant-specific TFs which regulate several down-stream stress-responsive genes and play an essential role in plant biotic and abiotic stress responses. We found that gene is highly up-regulated under drought stress conditions and therefore isolated a new gene from a drought-adapted horsegram ( Lam. Verdc.). Conserved domain studies revealed that protein encoded by this gene contains highly conserved regions of two WRKY domains and two C2H2 zinc-finger motifs. The fusion protein localization studies of transient 3-YFP revealed its nuclear localization. Overexpression of TF gene in groundnut ( L.) showed increased tolerance to drought stress compared to wild-type (WT) plants. groundnut transgenics displayed lesser and delayed wilting symptoms than WT plants after 10-days of drought stress imposition. The transgenic groundnut plants expressing showed less accumulation of malondialdehyde, hydrogen peroxide (H O ), and superoxide anion (O ), accompanied by more free proline, total soluble sugar content, and activities of antioxidant enzymes than WT plants under drought stress. Moreover, a series of stress-related , and genes found up-regulated in the transgenic groundnut plants. The study demonstrates that nuclear-localized TF regulates the expression of stress-responsive genes and the activity of ROS scavenging enzymes which results in improved drought tolerance in groundnut. We conclude that may serve as a new putative candidate gene for the improvement of stress resistance in plants.

\"In ten years of existence and only eight years of recording history, John Lennon, Paul McCartney, George Harrison and Ringo Starr recorded twelve albums, composed more than 200 songs and revolutionized the world of music. Hundreds of books have explored this mythical group but The Beatles in Comics proposes an altogether different discovery. Through this volume, you'll be able to relive their greatest successes but also discover often overlooked anecdotes. From the Quarrymen to the split-up, through Beatlemania, here's the story of the Beatles told in a new light, through comics and fascinating fact-filled chapters.\"--Page 4 of cover.

IntroductionArtificial stone is an increasingly popular material used to fabricate kitchen and bathroom benchtops. Cutting and grinding artificial stone is associated with generation of very high levels of respirable crystalline silica, and the frequency of cases of severe silicosis associated with this exposure is rapidly increasing.AimTo report the characteristics of a clinical series of Australian workers with artificial stone-associated silicosis.MethodsRespiratory physicians voluntarily reported cases of artificial stone-associated silicosis identified in their clinical practices. Physicians provided information including occupational histories, respiratory function tests, chest radiology and histopathology reports, when available.ResultsSeven male patients were identified with a median age of 44 years (range 26–61). All were employed in small kitchen and bathroom benchtop fabrication businesses with an average of eight employees (range 2–20). All workplaces primarily used artificial stone, and dust control measures were poor. All patients were involved in dry cutting artificial stone. The median duration of exposure prior to symptoms was 7 years (range 4–10). Six patients demonstrated radiological features of progressive massive fibrosis. These individuals followed up over a median follow-up period of 16 months (IQR 21 months) demonstrated rapid decline in prebronchodilator forced expiratory volume in 1 s of 386 mL/year (SD 204 mL) and forced vital capacity of 448 mL/year (SD 312 mL).ConclusionsThis series of silicosis in Australian workers further demonstrates the risk-associated high-silica content artificial stone. Effective dust control and health surveillance measures need to be stringently implemented and enforced in this industry.

Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly used treatments. We aimed to assess whether combining the treatments would be more effective than hormonal therapy alone. In this multicentre, open-label randomised trial, 102 hospitals (Australia [three], Germany [11], New Zealand [two], Switzerland [three], and the UK [83]) enrolled infants who had a clinical diagnosis of infantile spasms and a hypsarrhythmic (or similar) EEG no more than 7 days before enrolment. Participants were randomly assigned (1:1) by a secure website to receive hormonal therapy with vigabatrin or hormonal therapy alone. If parents consented, there was an additional randomisation (1:1) of type of hormonal therapy used (prednisolone or tetracosactide depot). Block randomisation was stratified for hormonal treatment and risk of developmental impairment. Parents and clinicians were not masked to therapy, but investigators assessing electro-clinical outcome were masked to treatment allocation. Minimum doses were prednisolone 10 mg four times a day or intramuscular tetracosactide depot 0·5 mg (40 IU) on alternate days with or without vigabatrin 100 mg/kg per day. The primary outcome was cessation of spasms, which was defined as no witnessed spasms on and between day 14 and day 42 from trial entry, as recorded by parents and carers in a seizure diary. Analysis was by intention to treat. The trial is registered with The International Standard Randomised Controlled Trial Number (ISRCTN), number 54363174, and the European Union Drug Regulating Authorities Clinical Trials (EUDRACT), number 2006-000788-27. Between March 7, 2007, and May 22, 2014, 766 infants were screened and, of those, 377 were randomly assigned to hormonal therapy with vigabatrin (186) or hormonal therapy alone (191). All 377 infants were assessed for the primary outcome. Between days 14 and 42 inclusive no spasms were witnessed in 133 (72%) of 186 patients on hormonal therapy with vigabatrin compared with 108 (57%) of 191 patients on hormonal therapy alone (difference 15·0%, 95% CI 5·1–24·9, p=0·002). Serious adverse reactions necessitating hospitalisation occurred in 33 infants (16 on hormonal therapy alone and 17 on hormonal therapy with vigabatrin). The most common serious adverse reaction was infection occurring in five infants on hormonal therapy alone and four on hormonal therapy with vigabatrin. There were no deaths attributable to treatment. Hormonal therapy with vigabatrin is significantly more effective at stopping infantile spasms than hormonal therapy alone. The 4 week period of spasm cessation required to achieve a primary clinical response to treatment suggests that the effect seen might be sustained, but this needs to be confirmed at the 18 month follow-up. The Castang Foundation, Bath Unit for Research in Paediatrics, National Institute of Health Research, the Royal United Hospitals Bath NHS Foundation Trust, the BRONNER-BENDUNG Stifung/Gernsbach, and University Children's Hospital Zurich.

An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the number of DSBs generated per meiosis is genetically determined and that this ability to maintain a pre-determined DSB level, or \"DSB homeostasis\", might be a property of the meiotic program. Here, we present direct evidence that Rec114, an evolutionarily conserved essential component of the meiotic DSB-machinery, interacts with DSB hotspot DNA, and that Tel1 and Mec1, the budding yeast ATM and ATR, respectively, down-regulate Rec114 upon meiotic DSB formation through phosphorylation. Mimicking constitutive phosphorylation reduces the interaction between Rec114 and DSB hotspot DNA, resulting in a reduction and/or delay in DSB formation. Conversely, a non-phosphorylatable rec114 allele confers a genome-wide increase in both DSB levels and in the interaction between Rec114 and the DSB hotspot DNA. These observations strongly suggest that Tel1 and/or Mec1 phosphorylation of Rec114 following Spo11 catalysis down-regulates DSB formation by limiting the interaction between Rec114 and DSB hotspots. We also present evidence that Ndt80, a meiosis specific transcription factor, contributes to Rec114 degradation, consistent with its requirement for complete cessation of DSB formation. Loss of Rec114 foci from chromatin is associated with homolog synapsis but independent of Ndt80 or Tel1/Mec1 phosphorylation. Taken together, we present evidence for three independent ways of regulating Rec114 activity, which likely contribute to meiotic DSBs-homeostasis in maintaining genetically determined levels of breaks.