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"Johnson, David"
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Constructive controversy : theory, research, practice
\"Why do people make decisions based on their own perspective without considering alternative points of view? Do differences of opinion enhance or obstruct critical thinking? Is it wise to seek out people who disagree with you and listen to their objections to your conclusions? Focusing on the theory, research, and application of constructive controversy, this book analyses the nature of disagreement among members of decision-making groups, project teams, academic study groups, and other groups that are involved in solving problems. Johnson demonstrates that this theory is one of the most effective methods of enhancing creativity and innovation, decision making, teaching, and political discourse. The book includes entertaining and intriguing examples of how constructive controversy has been used in a variety of historical periods to advance creativity, achieve innovations, and guide democracies. It will be welcomed by students in the fields of social psychology, management/business studies, education, and communication studies\"-- Provided by publisher.
Book
The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts
The retinoblastoma (RB) tumor suppressor is known as a master regulator of the cell cycle. RB is mutated or functionally inactivated in the majority of human cancers. This transcriptional regulator exerts its function in cell cycle control through its interaction with the E2F family of transcription factors and with chromatin remodelers and modifiers that contribute to the repression of genes important for cell cycle progression. Over the years, studies have shown that RB participates in multiple processes in addition to cell cycle control. Indeed, RB is known to interact with over 200 different proteins and likely exists in multiple complexes. RB, in some cases, acts through its interaction with E2F1, other members of the pocket protein family (p107 and p130), and/or chromatin remodelers and modifiers. RB is a tumor suppressor with important chromatin regulatory functions that affect genomic stability. These functions include the role of RB in DNA repair, telomere maintenance, chromosome condensation and cohesion, and silencing of repetitive regions. In this review we will discuss recent advances in RB biology related to RB, partner proteins, and their non-transcriptional functions fighting back against genomic instability.
Journal Article
Water, water everywhere … but how does it affect the functional diversity of ectomycorrhizal fungi?
This article is a Commentary on Barnes et al., 220: 1172–1184.
Journal Article
Managing knowledge networks
\"The information context of the modern organization is rapidly evolving in the face of intense global competition. Information technologies, including databases, new telecommunications systems, and software for synthesizing information, make a vast array of information available to an ever expanding number of organizational members. Management's exclusive control over knowledge is steadily declining, in part because of the downsizing of organizations and the decline of the number of layers in an organizational hierarchy. These trends, as well as issues surrounding the Web 2.0 and social networking, mean that it is increasingly important that we understand how informal knowledge networks impact the generation, capturing, storing, dissemination, and application of knowledge. This innovative book provides a thorough analysis of knowledge networks, focusing on how relationships contribute to the creation of knowledge, its distribution within organizations, how it is diffused and transferred, and how people find it and share it collaboratively\"--Provided by publisher.
Book
Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial
There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD.
This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD. A total of 76 well-characterized older adults with probable AD (mean age 72.9 [7.7]) were enrolled and 68 participants completed the study. Exercise was conducted with supervision and monitoring by trained exercise specialists. Neuropsychological tests and surveys were conducted at baseline,13, and 26 weeks to assess memory and executive function composite scores, functional ability (Disability Assessment for Dementia), and depressive symptoms (Cornell Scale for Depression in Dementia). Cardiorespiratory fitness testing and brain MRI was performed at baseline and 26 weeks. Aerobic exercise was associated with a modest gain in functional ability (Disability Assessment for Dementia) compared to individuals in the ST group (X2 = 8.2, p = 0.02). There was no clear effect of intervention on other primary outcome measures of Memory, Executive Function, or depressive symptoms. However, secondary analyses revealed that change in cardiorespiratory fitness was positively correlated with change in memory performance and bilateral hippocampal volume.
Aerobic exercise in early AD is associated with benefits in functional ability. Exercise-related gains in cardiorespiratory fitness were associated with improved memory performance and reduced hippocampal atrophy, suggesting cardiorespiratory fitness gains may be important in driving brain benefits.
ClinicalTrials.gov NCT01128361.
Journal Article
Handling Missing Values in Longitudinal Panel Data With Multiple Imputation
This article offers an applied review of key issues and methods for the analysis of longitudinal panel data in the presence of missing values. The authors consider the unique challenges associated with attrition (survey dropout), incomplete repeated measures, and unknown observations of time. Using simulated data based on 4 waves of the Marital Instability Over the Life Course Study (n = 2,034), they applied a fixed effect regression model and an event-history analysis with time-varying covariates. They then compared results for analyses with nonimputed missing data and with imputed data both in long and in wide structures. Imputation produced improved estimates in the event-history analysis but only modest improvements in the estimates and standard errors of the fixed effects analysis. Factors responsible for differences in the value of imputation are examined, and recommendations for handling missing values in panel data are presented.
Journal Article
Thinking government : public administration and politics in Canada
\"Thinking Government: Public Administration and Politics in Canada, fourth edition, is a comprehensive introduction to public administration and public sector management. This book places Canadian government and public administration within its political context and covers such important topics as the institutions of the federal government, financial and human resources management, and accountability and responsibility. Fully updated throughout, Thinking Government, fourth edition, is perfect for Canadian public administration courses.\"-- Provided by publisher.
Book
Electronic cigarette power affects count concentration and particle size distribution of vaping aerosol
Electronic cigarettes (EC) have evolved rapidly toward higher powered devices that produce more vaping aerosol and a more satisfying vaping experience. This research characterized the particle size distribution and estimated the mass concentration of vaping aerosols produced at power outputs spanning the operating range typical of second generation variable voltage EC devices.
EC aerosol was characterized from a single coil atomizer powered by a variable voltage EC battery at the minimum and maximum dial settings (3.3, 11.2 Watts, W), and a lab controlled power supply (3-11.9 W). Aerosol particle size distribution was measured by a Scanning Mobility Particle Sizer and Aerodynamic Particle Sizer, spanning 16 nm to 19.8 μm. A mouth puff was simulated using a 100 mL glass syringe.
Consistent with prior studies, sub-micron EC aerosol size distributions were bimodal, with peaks at 40 and 200 nm, however a previously unreported third mode was observed at approximately 1000 nm. The ~1000 nm mode accounted for 7-20x the aerosol mass of the smaller modes. Increasing atomizer power decreased count concentration of particles <600 nm but increased particle count >600 nm. Particle mass distribution shifted toward micron sized particles with increasing power and increased the respirable fraction of aerosol, likely due to increased coagulation and condensation around nano-sized particles.
Vaping power greatly affects EC aerosol count and mass distribution. Mouth puffed EC aerosol spans a much wider particle size range than previously reported, although the major portion of the mass is still well within the alveolar size range the larger particles will deposit within the oro-pharyngeal cavity at 2-3x greater efficiency than in alveoli. These observations have major clinical implications, as aerosol particle size distribution determines deposition sites along the respiratory tract. The results of this experiment stress the need for further research to inform the design, regulation and use of e-cigarette products.
Journal Article