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"Johnson, Hannah"
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Enough to go around : a story of generosity
When Kevin learns that not everyone has enough to eat, like the full meals he enjoys with his family every night, he organizes a food drive at school.
Book
Copper: toxicological relevance and mechanisms
Copper (Cu) is a vital mineral essential for many biological processes. The vast majority of all Cu in healthy humans is associated with enzyme prosthetic groups or bound to proteins. Cu homeostasis is tightly regulated through a complex system of Cu transporters and chaperone proteins. Excess or toxicity of Cu, which is associated with the pathogenesis of hepatic disorder, neurodegenerative changes and other disease conditions, can occur when Cu homeostasis is disrupted. The capacity to initiate oxidative damage is most commonly attributed to Cu-induced cellular toxicity. Recently, altered cellular events, including lipid metabolism, gene expression, alpha-synuclein aggregation, activation of acidic sphingomyelinase and release of ceramide, and temporal and spatial distribution of Cu in hepatocytes, as well as Cu-protein interaction in the nerve system, have been suggested to play a role in Cu toxicity. However, whether these changes are independent of, or secondary to, an altered cellular redox state of Cu remain to be elucidated.
Journal Article
Violent ends : a novel in seventeen points of view
Relates how one boy--who had friends, enjoyed reading, playing saxophone in the band, and had never been in trouble before--became a monster capable of entering his high school with a loaded gun and firing on his classmates, as told from the viewpoints of several victims. Each perspective is written by a different writer of young adult fiction.
Book
Psychosocial Elements of Physical Therapy
Physical therapists know that their patients are more than just a list of symptoms. They are people first, often with a complex mix of medical and psychiatric circumstances, who may receive a wide range of care from a team of professionals. Keeping this in mind,
Psychosocial Elements of Physical Therapy: The Connection of Body to Mind
is both a textbook and a clinical resource for physical therapist students and clinicians practicing in any patient population with psychological concerns or disorders. Inside, Dr. Hannah Johnson provides an essential introduction of psychosocial concepts, general treatment approaches for culturally sensitive care, and selected classes of mental illness as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). A complete review of the current research and evidence base provides students a strong foundation to build their careers on, but can also act as a crash-course in the most recent literature for the busy clinician. Features: Clear, concise language and layout for efficient learning Application-based review questions Real world case studies to apply critical thinking skills Evidence-based practical tests and measures Vocabulary terms that facilitate interdisciplinary teamwork
Psychosocial Elements of Physical Therapy: The Connection of Body to Mind
provides physical therapist students and clinicians with an efficient yet comprehensive guide to helping patients with psychological concerns or disorders.
eBook
Taking shape : abstraction from the Arab world, 1950s-1980s
\"'Taking Shape: Abstraction from the Arab World, 1950s-1980s' investigates the development of abstraction in West Asia and North Africa via paintings, sculpture, and drawings made during a period of rapid industrialization, several wars and mass migrations, new state formations, and the rise and fall of Arab nationalism(s). Examining how a diverse group of artists mined the region's rich artistic heritage as well as the expressive capacities of line, color, and texture, this book highlights various abstract practices that arose in the Arab world and its diaspora in the mid-20th century. Alongside vibrant images of nearly ninety works--all drawn from the remarkable collection of the Barjeel Art Foundation, based in Sharjah, United Arab Emirates--'Taking Shape' featuers nine essays by leading scholars who are rethinking art-historical canons and expanding discourses around global modernism.\" --publisher's description, lower cover.
Book
Latent Toxoplasmosis Effects on Rodents and Humans: How Much Is Real and How Much Is Media Hype
Toxoplasma gondii is a ubiquitous, intracellular protozoan parasite with a broad range of intermediate hosts, including humans and rodents. In many hosts, T. gondii establishes a latent long-term infection by converting from its rapidly dividing or lytic form to its slowly replicating and encysting form. In humans and rodents, the major organ for encystment is the central nervous system (CNS), which has led many to investigate how this persistent CNS infection might influence rodent and human behavior and, more recently, neurodegenerative diseases. Toxoplasma gondii is a ubiquitous, intracellular protozoan parasite with a broad range of intermediate hosts, including humans and rodents. In many hosts, T. gondii establishes a latent long-term infection by converting from its rapidly dividing or lytic form to its slowly replicating and encysting form. In humans and rodents, the major organ for encystment is the central nervous system (CNS), which has led many to investigate how this persistent CNS infection might influence rodent and human behavior and, more recently, neurodegenerative diseases. Given the interest in this topic, here we seek to take a global approach to the data for and against the effects of latent T. gondii on behavior and neurodegeneration and the proposed mechanisms that might underlie behavior modifications.
Journal Article
Unleashing the Potential of MXene‐Based Flexible Materials for High‐Performance Energy Storage Devices
Since the initial discovery of Ti3C2 a decade ago, there has been a significant surge of interest in 2D MXenes and MXene‐based composites. This can be attributed to the remarkable intrinsic properties exhibited by MXenes, including metallic conductivity, abundant functional groups, unique layered microstructure, and the ability to control interlayer spacing. These properties contribute to the exceptional electrical and mechanical performance of MXenes, rendering them highly suitable for implementation as candidate materials in flexible and wearable energy storage devices. Recently, a substantial number of novel research has been dedicated to exploring MXene‐based flexible materials with diverse functionalities and specifically designed structures, aiming to enhance the efficiency of energy storage systems. In this review, a comprehensive overview of the synthesis and fabrication strategies employed in the development of these diverse MXene‐based materials is provided. Furthermore, an in‐depth analysis of the energy storage applications exhibited by these innovative flexible materials, encompassing supercapacitors, Li‐ion batteries, Li–S batteries, and other potential avenues, is conducted. In addition to presenting the current state of the field, the challenges encountered in the implementation of MXene‐based flexible materials are also highlighted and insights are provided into future research directions and prospects. This paper delves into MXene materials' synthesis methods and their versatile applications in energy storage, spanning supercapacitors, Li‐ion, and Li–S batteries, discovering the current landscape, hurdles, and exciting research opportunities in this dynamic field.
Journal Article
Neurologic Complications of Poverty: the Associations Between Poverty as a Social Determinant of Health and Adverse Neurologic Outcomes
Purpose of ReviewIncreasing attention has been paid in recent decades to social determinants of health as a risk factor for disease development and disease severity. While traditionally heart disease, family history, lipid profile, and tobacco use have all been associated with increased risk of neurological disease, numerous studies now show that the influence of poverty may be just as strong a risk factor. This study summarizes the recent literature on poverty as it contributes to neurological disease.Recent FindingsChildren growing up in poverty have increased risk for cognitive deficits and behavioral disorders as reported by Noble et al. (Dev Sci. 9(6):642–54, 2006) and Farah et al. (Brain Res. 1110(1):166–74, 2006) as well as worse outcomes when it comes to epilepsy management and disease course as discussed by Camfield et al. (Epilepsia. 57(11):1826–33, 2016). In adulthood, as the number of social determinants of health increases, the incidence of stroke and severe stroke increases significantly as reported by Reshetnyak et al. (Stroke. 51:2445–53, 2020) as does exposure to neurologically significant infectious diseases and incidence of dementia as reported by Sumilo et al. (Rev Med Virol. 18(2):81–95, 2008) and Zuelsdorff et al. (Alzheimer’s Dement. 6(1):e12039, 2020).SummarySocial determinants of health including poverty should be considered a risk factor for disease. More attention is needed from clinicians as well as from a public health perspective to address this disparity.
Journal Article
Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition
The epithelial-mesenchymal transition (EMT) has been implicated in conferring stem cell properties and therapeutic resistance to cancer cells. Therefore, identification of drugs that can reprogram EMT may provide new therapeutic strategies. Here, we report that cells derived from claudin-low mammary tumors, a mesenchymal subtype of triple-negative breast cancer, exhibit a distinctive organoid structure with extended “spikes” in 3D matrices. Upon a miR-200 induced mesenchymal-epithelial transition (MET), the organoids switch to a smoother round morphology. Based on these observations, we developed a morphological screening method with accompanying analytical pipelines that leverage deep neural networks and nearest neighborhood classification to screen for EMT-reversing drugs. Through screening of a targeted epigenetic drug library, we identified multiple class I HDAC inhibitors and Bromodomain inhibitors that reverse EMT. These data support the use of morphological screening of mesenchymal mammary tumor organoids as a platform to identify drugs that reverse EMT.
The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and exploited for screening drugs that reverse EMT.
Journal Article
Altering phosphorylation in cancer through PP2A modifiers
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promoting tumor progression. Considerable research has been undertaken to discover molecules capable of modulating PP2A activity in cancer. Because PP2A is capable of immense substrate specificity across many cellular processes, the therapeutic targeting of PP2A in cancer can be completed through either enzyme inhibitors or activators. PP2A modulators likewise tend to be effective in drug-resistant cancers and work synergistically with other known cancer therapeutics. In this review, we will discuss the patterns of PP2A deregulation in cancer, and its known downstream signaling pathways important for cancer regulation, along with many activators and inhibitors of PP2A known to inhibit cancer progression.
Journal Article